Click here to switch to the map view.

The map label for this gene is ahpC

Identifier: 15672319

GI number: 15672319

Start: 335384

End: 335947

Strand: Direct

Name: ahpC

Synonym: L135351

Alternate gene names: 15672319

Gene position: 335384-335947 (Clockwise)

Preceding gene: 15672318

Following gene: 15672320

Centisome position: 14.18

GC content: 38.48

Gene sequence:

>564_bases
ATGTCATTAGTAGGTAAAAAAATAGAAGAATTTTCAACAGATGCTTATCTTGGTGGGAAATTTATTAAAGTTTCCGATAA
AGACTTTTATGGAAAATGGTCTGTGCTTTGTTTCTATCCAGCAGACTTTTCATTTGTTTGTCCGACAGAGTTAGAAGATT
TAGAAGAAACTTATCCAACCTTGAAATCGCTTGGTGTAGAAGTTTACTCAGCTTCAACTGACACCCATTTTGTCCATGCT
GCTTGGCATGAACATAGTGATGCTATTTCAAAAATTACTTATCCAATGCTTGCAGACCCTTCACAAAAAATTTCACGTGC
TTTTGATGTTCTTGATGAAGAAGCAGGATTGGCTCAACGTGGAACATTTATTATTGACCCAGACGGTGTGATTCAAGCGC
TTGAAATTACGGCTGATGGTATTGGACGTGATGCAAGTCAATTGGTCGATAAGATTAAAGCTGCTCAATATGTGCGTAAT
CATCCAGGGGAAGTTTGTCCCGCTAAGTGGAAAGAGGACGGAGCAAGTCTTCACGTTGGTATTGACCTTGTAGGTAAAAT
ATAG

Upstream 100 bases:

>100_bases
ATGCAATAGTTTGTAAGTTTTTGAACAAATTAATTGATTCTTCATTTTATTCTTGAGATAATTTAATAGTAAAGCTTTAA
AGAAGAAAAAGGAGAATCTT

Downstream 100 bases:

>100_bases
AATAAAAAAAGTGAGTCTTGGCTCACTTTATTTGTCTTTAGAAACTTAATGACAGAAAGGTTTAATATGATTTTAGATGA
AACTCTTCGTGCTCAGTTGA

Product: alkyl hydroperoxide reductase

Products: NA

Alternate protein names: Alkyl hydroperoxide reductase protein C22; General stress protein 22; Peroxiredoxin; Thioredoxin peroxidase [H]

Number of amino acids: Translated: 187; Mature: 186

Protein sequence:

>187_residues
MSLVGKKIEEFSTDAYLGGKFIKVSDKDFYGKWSVLCFYPADFSFVCPTELEDLEETYPTLKSLGVEVYSASTDTHFVHA
AWHEHSDAISKITYPMLADPSQKISRAFDVLDEEAGLAQRGTFIIDPDGVIQALEITADGIGRDASQLVDKIKAAQYVRN
HPGEVCPAKWKEDGASLHVGIDLVGKI

Sequences:

>Translated_187_residues
MSLVGKKIEEFSTDAYLGGKFIKVSDKDFYGKWSVLCFYPADFSFVCPTELEDLEETYPTLKSLGVEVYSASTDTHFVHA
AWHEHSDAISKITYPMLADPSQKISRAFDVLDEEAGLAQRGTFIIDPDGVIQALEITADGIGRDASQLVDKIKAAQYVRN
HPGEVCPAKWKEDGASLHVGIDLVGKI
>Mature_186_residues
SLVGKKIEEFSTDAYLGGKFIKVSDKDFYGKWSVLCFYPADFSFVCPTELEDLEETYPTLKSLGVEVYSASTDTHFVHAA
WHEHSDAISKITYPMLADPSQKISRAFDVLDEEAGLAQRGTFIIDPDGVIQALEITADGIGRDASQLVDKIKAAQYVRNH
PGEVCPAKWKEDGASLHVGIDLVGKI

Specific function: Directly reduces organic hydroperoxides in its reduced dithiol form [H]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32483377, Length=170, Percent_Identity=40.5882352941176, Blast_Score=133, Evalue=7e-32,
Organism=Homo sapiens, GI5802974, Length=170, Percent_Identity=40.5882352941176, Blast_Score=133, Evalue=8e-32,
Organism=Homo sapiens, GI32189392, Length=182, Percent_Identity=35.7142857142857, Blast_Score=127, Evalue=6e-30,
Organism=Homo sapiens, GI4505591, Length=172, Percent_Identity=34.3023255813954, Blast_Score=117, Evalue=5e-27,
Organism=Homo sapiens, GI32455266, Length=172, Percent_Identity=34.3023255813954, Blast_Score=117, Evalue=5e-27,
Organism=Homo sapiens, GI32455264, Length=172, Percent_Identity=34.3023255813954, Blast_Score=117, Evalue=5e-27,
Organism=Homo sapiens, GI5453549, Length=160, Percent_Identity=35.625, Blast_Score=113, Evalue=1e-25,
Organism=Homo sapiens, GI33188454, Length=82, Percent_Identity=41.4634146341463, Blast_Score=74, Evalue=9e-14,
Organism=Escherichia coli, GI1786822, Length=187, Percent_Identity=58.8235294117647, Blast_Score=243, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI17554494, Length=177, Percent_Identity=39.5480225988701, Blast_Score=140, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI193204376, Length=183, Percent_Identity=37.7049180327869, Blast_Score=134, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI32565831, Length=183, Percent_Identity=37.7049180327869, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323613, Length=185, Percent_Identity=34.0540540540541, Blast_Score=109, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6320661, Length=177, Percent_Identity=32.7683615819209, Blast_Score=106, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6319407, Length=175, Percent_Identity=26.2857142857143, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21357347, Length=189, Percent_Identity=36.5079365079365, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI17738015, Length=173, Percent_Identity=38.150289017341, Blast_Score=134, Evalue=4e-32,
Organism=Drosophila melanogaster, GI17157991, Length=174, Percent_Identity=36.7816091954023, Blast_Score=123, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24641739, Length=174, Percent_Identity=36.7816091954023, Blast_Score=123, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24656348, Length=173, Percent_Identity=35.2601156069364, Blast_Score=121, Evalue=3e-28,
Organism=Drosophila melanogaster, GI17864676, Length=173, Percent_Identity=35.2601156069364, Blast_Score=121, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24581278, Length=163, Percent_Identity=27.6073619631902, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR017559
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 20603; Mature: 20472

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLVGKKIEEFSTDAYLGGKFIKVSDKDFYGKWSVLCFYPADFSFVCPTELEDLEETYPT
CCCCHHHHHHHCCCCEECCEEEEECCCCCCCCEEEEEEECCCCCEECCCHHHHHHHHHHH
LKSLGVEVYSASTDTHFVHAAWHEHSDAISKITYPMLADPSQKISRAFDVLDEEAGLAQR
HHHCCEEEEECCCCCEEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCC
GTFIIDPDGVIQALEITADGIGRDASQLVDKIKAAQYVRNHPGEVCPAKWKEDGASLHVG
CCEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEE
IDLVGKI
EEEECCC
>Mature Secondary Structure 
SLVGKKIEEFSTDAYLGGKFIKVSDKDFYGKWSVLCFYPADFSFVCPTELEDLEETYPT
CCCHHHHHHHCCCCEECCEEEEECCCCCCCCEEEEEEECCCCCEECCCHHHHHHHHHHH
LKSLGVEVYSASTDTHFVHAAWHEHSDAISKITYPMLADPSQKISRAFDVLDEEAGLAQR
HHHCCEEEEECCCCCEEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCC
GTFIIDPDGVIQALEITADGIGRDASQLVDKIKAAQYVRNHPGEVCPAKWKEDGASLHVG
CCEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEE
IDLVGKI
EEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 8180695; 8012595 [H]