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The map label for this gene is gpmA

Identifier: 15672318

GI number: 15672318

Start: 334509

End: 335210

Strand: Direct

Name: gpmA

Synonym: L0011

Alternate gene names: 15672318

Gene position: 334509-335210 (Clockwise)

Preceding gene: 15672317

Following gene: 15672319

Centisome position: 14.14

GC content: 40.46

Gene sequence:

>702_bases
ATGCCAAAATTAGTATTTGCACGTCACGGTGAATCTGAATGGAATCTTGCTAACCTTTTCACAGGTTGGGCTGACGTTGA
CCTTTCTGAAAACGGAACTAAACAAGCGATTGAAGCTGGTAAATTGATTAAAGAAGCTGGAATCGAATTTGATATTGCTT
ACACTTCAGTATTGAAACGTGCTATCAAAACAACTAACCTTGCTCTTGAATATTCAGACCAACTTTGGGTACCAGTTGTT
AAATCATGGCGCTTGAACGAACGTCACTACGGTGGTTTGACAGGTTTGAACAAAGCTGACGCTGCTGCAAAACATGGTGA
TGAACAAGTTCACATCTGGCGTCGTTCATATGATGTATTGCCACCAGCAATGGATCATGATGATAAATATACAGCTCACG
GAGACCGTCGTTACGCTGGTCTTGAAGATTCATTGATTCCTGATGCTGAAAACCTCAAAGTTACTTTGGAACGTGCTCTT
CCATTCTGGGAAGACCAAATCGCTCCAGCTTTGAAAGAAGGAAAAAATGTCTTCGTTGGTGCTCACGGTAACTCAATCCG
TGCACTCGTTAAACAAATCAAAAAACTTTCTGATGACGAAATTATGGATGTTGAAATCCCTAACTTCCCACCACTTGTTT
TCGAATTTGATGACAACTTGAACGTTCAAAACGAATACTACTTGGCTCCTAAAAAAGCATAA

Upstream 100 bases:

>100_bases
AAATAAAAGCTAGAAAAAAAAGGAAAAATGTAGTAAAATTAACTTTGTAAATGAACGAACTAAATTTCGTTCAAGTAAAA
ATAAACGGAGAATACACAAA

Downstream 100 bases:

>100_bases
TATTTGAATGAAAATACTCTAAGTTATAGTAGATACTCATCTATTTAGGACTTAGAGTGTTTTTTTGTAATCAATGCAAT
AGTTTGTAAGTTTTTGAACA

Product: phosphoglyceromutase

Products: NA

Alternate protein names: BPG-dependent PGAM; PGAM; Phosphoglyceromutase; dPGM

Number of amino acids: Translated: 233; Mature: 232

Protein sequence:

>233_residues
MPKLVFARHGESEWNLANLFTGWADVDLSENGTKQAIEAGKLIKEAGIEFDIAYTSVLKRAIKTTNLALEYSDQLWVPVV
KSWRLNERHYGGLTGLNKADAAAKHGDEQVHIWRRSYDVLPPAMDHDDKYTAHGDRRYAGLEDSLIPDAENLKVTLERAL
PFWEDQIAPALKEGKNVFVGAHGNSIRALVKQIKKLSDDEIMDVEIPNFPPLVFEFDDNLNVQNEYYLAPKKA

Sequences:

>Translated_233_residues
MPKLVFARHGESEWNLANLFTGWADVDLSENGTKQAIEAGKLIKEAGIEFDIAYTSVLKRAIKTTNLALEYSDQLWVPVV
KSWRLNERHYGGLTGLNKADAAAKHGDEQVHIWRRSYDVLPPAMDHDDKYTAHGDRRYAGLEDSLIPDAENLKVTLERAL
PFWEDQIAPALKEGKNVFVGAHGNSIRALVKQIKKLSDDEIMDVEIPNFPPLVFEFDDNLNVQNEYYLAPKKA
>Mature_232_residues
PKLVFARHGESEWNLANLFTGWADVDLSENGTKQAIEAGKLIKEAGIEFDIAYTSVLKRAIKTTNLALEYSDQLWVPVVK
SWRLNERHYGGLTGLNKADAAAKHGDEQVHIWRRSYDVLPPAMDHDDKYTAHGDRRYAGLEDSLIPDAENLKVTLERALP
FWEDQIAPALKEGKNVFVGAHGNSIRALVKQIKKLSDDEIMDVEIPNFPPLVFEFDDNLNVQNEYYLAPKKA

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate

COG id: COG0588

COG function: function code G; Phosphoglycerate mutase 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily

Homologues:

Organism=Homo sapiens, GI50593010, Length=220, Percent_Identity=55, Blast_Score=263, Evalue=9e-71,
Organism=Homo sapiens, GI4505753, Length=220, Percent_Identity=55.4545454545455, Blast_Score=251, Evalue=5e-67,
Organism=Homo sapiens, GI71274132, Length=220, Percent_Identity=53.1818181818182, Blast_Score=238, Evalue=4e-63,
Organism=Homo sapiens, GI4502445, Length=222, Percent_Identity=46.3963963963964, Blast_Score=215, Evalue=3e-56,
Organism=Homo sapiens, GI40353764, Length=222, Percent_Identity=46.3963963963964, Blast_Score=215, Evalue=3e-56,
Organism=Homo sapiens, GI310129614, Length=161, Percent_Identity=58.3850931677019, Blast_Score=184, Evalue=8e-47,
Organism=Escherichia coli, GI1786970, Length=229, Percent_Identity=53.2751091703057, Blast_Score=254, Evalue=5e-69,
Organism=Saccharomyces cerevisiae, GI6322697, Length=232, Percent_Identity=50, Blast_Score=245, Evalue=5e-66,
Organism=Saccharomyces cerevisiae, GI6324516, Length=281, Percent_Identity=33.4519572953737, Blast_Score=131, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6320183, Length=285, Percent_Identity=30.5263157894737, Blast_Score=128, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6324857, Length=195, Percent_Identity=26.1538461538462, Blast_Score=72, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24646216, Length=221, Percent_Identity=51.131221719457, Blast_Score=238, Evalue=2e-63,
Organism=Drosophila melanogaster, GI85725270, Length=221, Percent_Identity=52.0361990950226, Blast_Score=229, Evalue=1e-60,
Organism=Drosophila melanogaster, GI85725272, Length=221, Percent_Identity=52.0361990950226, Blast_Score=229, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24650981, Length=221, Percent_Identity=52.0361990950226, Blast_Score=229, Evalue=1e-60,
Organism=Drosophila melanogaster, GI28571817, Length=218, Percent_Identity=39.4495412844037, Blast_Score=169, Evalue=1e-42,
Organism=Drosophila melanogaster, GI28571815, Length=218, Percent_Identity=39.4495412844037, Blast_Score=169, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24648979, Length=218, Percent_Identity=39.4495412844037, Blast_Score=169, Evalue=1e-42,

Paralogues:

None

Copy number: 960 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GPMA_LACLA (Q9CIM0)

Other databases:

- EMBL:   AE005176
- PIR:   H86666
- RefSeq:   NP_266492.1
- ProteinModelPortal:   Q9CIM0
- SMR:   Q9CIM0
- PhosSite:   Q9CIM0
- GeneID:   1113947
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0011
- NMPDR:   fig|272623.1.peg.344
- HOGENOM:   HBG658938
- OMA:   TGWKDPD
- ProtClustDB:   PRK14117
- BioCyc:   LLAC272623:L0011-MONOMER
- BRENDA:   5.4.2.1
- GO:   GO:0006096
- HAMAP:   MF_01039
- InterPro:   IPR013078
- InterPro:   IPR005952
- PANTHER:   PTHR11931
- SMART:   SM00855
- TIGRFAMs:   TIGR01258

Pfam domain/function: PF00300 PGAM

EC number: =5.4.2.1

Molecular weight: Translated: 26330; Mature: 26199

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00175 PG_MUTASE

Important sites: ACT_SITE 9-9 ACT_SITE 182-182

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKLVFARHGESEWNLANLFTGWADVDLSENGTKQAIEAGKLIKEAGIEFDIAYTSVLKR
CCCEEEEECCCCCCCHHHHCCCCEECCCCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHH
AIKTTNLALEYSDQLWVPVVKSWRLNERHYGGLTGLNKADAAAKHGDEQVHIWRRSYDVL
HHHHHCEEEEECCCCCEEHHHCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCC
PPAMDHDDKYTAHGDRRYAGLEDSLIPDAENLKVTLERALPFWEDQIAPALKEGKNVFVG
CCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCEEEHHHCCCCHHHHHHHHHHCCCEEEEE
AHGNSIRALVKQIKKLSDDEIMDVEIPNFPPLVFEFDDNLNVQNEYYLAPKKA
ECCCHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCCCCEEEECCCCC
>Mature Secondary Structure 
PKLVFARHGESEWNLANLFTGWADVDLSENGTKQAIEAGKLIKEAGIEFDIAYTSVLKR
CCEEEEECCCCCCCHHHHCCCCEECCCCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHH
AIKTTNLALEYSDQLWVPVVKSWRLNERHYGGLTGLNKADAAAKHGDEQVHIWRRSYDVL
HHHHHCEEEEECCCCCEEHHHCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCC
PPAMDHDDKYTAHGDRRYAGLEDSLIPDAENLKVTLERALPFWEDQIAPALKEGKNVFVG
CCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCEEEHHHCCCCHHHHHHHHHHCCCEEEEE
AHGNSIRALVKQIKKLSDDEIMDVEIPNFPPLVFEFDDNLNVQNEYYLAPKKA
ECCCHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471