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The map label for this gene is gcp

Identifier: 15672277

GI number: 15672277

Start: 293530

End: 294570

Strand: Direct

Name: gcp

Synonym: L93500

Alternate gene names: 15672277

Gene position: 293530-294570 (Clockwise)

Preceding gene: 15672276

Following gene: 15672278

Centisome position: 12.41

GC content: 39.19

Gene sequence:

>1041_bases
ATGAAAGATAATTATATATTAGCCTTTGAAACTTCATGTGATGAAACTTCAGTGGCAATTTTAAAGAATGGAAATGAATT
ATTATGTAATATCATTGCCAGTCAAATCAATAGTCATAAACGCTTTGGTGGAGTTGTGCCAGAAATTGCCAGCCGTCATC
ACGTCGAACAAATTACTGTTTGTATTGAAGCAGCACTTGAAGAAGCAGAAATTTCGGCTGACCAACTGACGGCCGTTGCG
GTGACCGAAGGTCCAGGCTTAAATGGCGCTTTGTTAGTTGGAATCATGGCAGCAAAAACTTTTGCATGGGCAAATCATCT
TCCTTTGATTCCAGTTAATCACATGGCCGGTCATTTGATGGCTGCAAGTTTAGTGGATACCATTGAATATCCAGCTATGG
CCCTTTTGGTTTCAGGTGGACATTCTGAACTTGTTTACGTAGAAAAAGAAGGAAGCTATAAAAAAGTTGGTGAAACTCGT
GACGATGCTGCCGGTGAAGCTTATGATAAAGTTGGTCGAGTGATGGGCCTGACTTATCCGAGTGGAAAAGTCATTGATGA
ATTAGCACACAAAGGAGCTGATACTTACAATTTCCCACGAGCAATGATGAACACACATGAAGTAGAATTTAGCTTCTCAG
GCTTAAAATCAGCCTTTATTAATCTCGTTCATAACGAAAATCAAAAAGGAAATGACGTGATTGCTGATGATTTAGAAAAT
TTAGCTGCTTCCTTTCAAGCTGCGGTCGTCGATGTCCTTATGGCCAAAACCAAATTAGCCATGGAAAAATACCCAGTAAA
AACGCTAATAATTGGCGGTGGAGTATCAGCAAATCAAGGCTTACGCGAACGTTTGTCAGCAGAAATTACTGACGAAAAGT
TAATTATTCCTCCTTTAAGACTCTGTGGTGACAATGCTGGAATGATTGCAGCAGCAGCATATATCGAATGGAAAAAAGGT
TTAGAAAATGTTCAAGCAGGATTAGATTTAAATGCAAAACCTAGTCTCGTTTTTGAAGACATAGAAGAAGGAGAAGTTTA
A

Upstream 100 bases:

>100_bases
GTTATGAAAAATTTGGTTTTAAGATTTATCATACAAGAAAAAATTATTATGACAAACCTCTTGAAGATGCTTTGTTAATG
AGAAAAGAGCAATTTTAAAA

Downstream 100 bases:

>100_bases
TGATGAAATTAATTGGAAAACTTCAAAATGGCATGACCTTTACTGAAGAATTTGACGGAGTCAACGATTTCCTAGCCCTT
CAACAAAGCGATTATAATGC

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MKDNYILAFETSCDETSVAILKNGNELLCNIIASQINSHKRFGGVVPEIASRHHVEQITVCIEAALEEAEISADQLTAVA
VTEGPGLNGALLVGIMAAKTFAWANHLPLIPVNHMAGHLMAASLVDTIEYPAMALLVSGGHSELVYVEKEGSYKKVGETR
DDAAGEAYDKVGRVMGLTYPSGKVIDELAHKGADTYNFPRAMMNTHEVEFSFSGLKSAFINLVHNENQKGNDVIADDLEN
LAASFQAAVVDVLMAKTKLAMEKYPVKTLIIGGGVSANQGLRERLSAEITDEKLIIPPLRLCGDNAGMIAAAAYIEWKKG
LENVQAGLDLNAKPSLVFEDIEEGEV

Sequences:

>Translated_346_residues
MKDNYILAFETSCDETSVAILKNGNELLCNIIASQINSHKRFGGVVPEIASRHHVEQITVCIEAALEEAEISADQLTAVA
VTEGPGLNGALLVGIMAAKTFAWANHLPLIPVNHMAGHLMAASLVDTIEYPAMALLVSGGHSELVYVEKEGSYKKVGETR
DDAAGEAYDKVGRVMGLTYPSGKVIDELAHKGADTYNFPRAMMNTHEVEFSFSGLKSAFINLVHNENQKGNDVIADDLEN
LAASFQAAVVDVLMAKTKLAMEKYPVKTLIIGGGVSANQGLRERLSAEITDEKLIIPPLRLCGDNAGMIAAAAYIEWKKG
LENVQAGLDLNAKPSLVFEDIEEGEV
>Mature_346_residues
MKDNYILAFETSCDETSVAILKNGNELLCNIIASQINSHKRFGGVVPEIASRHHVEQITVCIEAALEEAEISADQLTAVA
VTEGPGLNGALLVGIMAAKTFAWANHLPLIPVNHMAGHLMAASLVDTIEYPAMALLVSGGHSELVYVEKEGSYKKVGETR
DDAAGEAYDKVGRVMGLTYPSGKVIDELAHKGADTYNFPRAMMNTHEVEFSFSGLKSAFINLVHNENQKGNDVIADDLEN
LAASFQAAVVDVLMAKTKLAMEKYPVKTLIIGGGVSANQGLRERLSAEITDEKLIIPPLRLCGDNAGMIAAAAYIEWKKG
LENVQAGLDLNAKPSLVFEDIEEGEV

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=358, Percent_Identity=30.7262569832402, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI8923380, Length=319, Percent_Identity=28.5266457680251, Blast_Score=115, Evalue=6e-26,
Organism=Escherichia coli, GI1789445, Length=333, Percent_Identity=42.9429429429429, Blast_Score=256, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI17557464, Length=325, Percent_Identity=35.3846153846154, Blast_Score=154, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI71995670, Length=324, Percent_Identity=30.8641975308642, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6320099, Length=358, Percent_Identity=29.0502793296089, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6322891, Length=354, Percent_Identity=28.5310734463277, Blast_Score=105, Evalue=8e-24,
Organism=Drosophila melanogaster, GI20129063, Length=334, Percent_Identity=33.2335329341317, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI21357207, Length=352, Percent_Identity=29.2613636363636, Blast_Score=123, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_LACLA (Q9CIR1)

Other databases:

- EMBL:   AE005176
- PIR:   G86661
- RefSeq:   NP_266451.1
- ProteinModelPortal:   Q9CIR1
- SMR:   Q9CIR1
- MEROPS:   M22.001
- GeneID:   1113905
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L93500
- NMPDR:   fig|272623.1.peg.303
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- ProtClustDB:   PRK09604
- BioCyc:   LLAC272623:L93500-MONOMER
- BRENDA:   3.4.24.57
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 37179; Mature: 37179

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDNYILAFETSCDETSVAILKNGNELLCNIIASQINSHKRFGGVVPEIASRHHVEQITV
CCCCEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
CIEAALEEAEISADQLTAVAVTEGPGLNGALLVGIMAAKTFAWANHLPLIPVNHMAGHLM
HHHHHHHHHHCCHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHH
AASLVDTIEYPAMALLVSGGHSELVYVEKEGSYKKVGETRDDAAGEAYDKVGRVMGLTYP
HHHHHHHHHCCEEEEEEECCCCEEEEEECCCCHHHCCCCCCCCCHHHHHHHHHHHEECCC
SGKVIDELAHKGADTYNFPRAMMNTHEVEFSFSGLKSAFINLVHNENQKGNDVIADDLEN
CCHHHHHHHHCCCCCCCCCHHHHCCCEEEEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
LAASFQAAVVDVLMAKTKLAMEKYPVKTLIIGGGVSANQGLRERLSAEITDEKLIIPPLR
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHCCCCCCCEEECCCHH
LCGDNAGMIAAAAYIEWKKGLENVQAGLDLNAKPSLVFEDIEEGEV
HCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCC
>Mature Secondary Structure
MKDNYILAFETSCDETSVAILKNGNELLCNIIASQINSHKRFGGVVPEIASRHHVEQITV
CCCCEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
CIEAALEEAEISADQLTAVAVTEGPGLNGALLVGIMAAKTFAWANHLPLIPVNHMAGHLM
HHHHHHHHHHCCHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHH
AASLVDTIEYPAMALLVSGGHSELVYVEKEGSYKKVGETRDDAAGEAYDKVGRVMGLTYP
HHHHHHHHHCCEEEEEEECCCCEEEEEECCCCHHHCCCCCCCCCHHHHHHHHHHHEECCC
SGKVIDELAHKGADTYNFPRAMMNTHEVEFSFSGLKSAFINLVHNENQKGNDVIADDLEN
CCHHHHHHHHCCCCCCCCCHHHHCCCEEEEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
LAASFQAAVVDVLMAKTKLAMEKYPVKTLIIGGGVSANQGLRERLSAEITDEKLIIPPLR
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHCCCCCCCEEECCCHH
LCGDNAGMIAAAAYIEWKKGLENVQAGLDLNAKPSLVFEDIEEGEV
HCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471