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The map label for this gene is ung

Identifier: 15672216

GI number: 15672216

Start: 232719

End: 233378

Strand: Direct

Name: ung

Synonym: L32653

Alternate gene names: 15672216

Gene position: 232719-233378 (Clockwise)

Preceding gene: 15672215

Following gene: 15672219

Centisome position: 9.84

GC content: 40.3

Gene sequence:

>660_bases
ATGAAGAAAACAGATTGGTCACAACCCTTACGCAATCGATTAGCAGAAGATTATTTTCCTAAAATGATTGAATTTATCAA
TCAGACTTATCAAGAGGGCAAAGTATATCCACCAGAAAATCAAATTTTTCGGGCGATTGAATTGACTCCTTTGGCACAAA
CAAAGGTTATCATTGTTGGGCAAGACCCTTACCCTCAGCCCGGGAAAGCTCAAGGCTTGGCTTTTTCTTATCCTGCTACT
TTCAAAGTGAATCGTCCAGACTCGATTGTTAATATCCAAAAAGAATTGCGTGAGGAAGGTTTTTCTAAAGATGACAGTGA
TTTGACGGCTTGGGCCGAACAAGGTGTTTTACTTCTAAACGCAGTTCTGACCGTACCTGAGTTTGCTTCAAATGCCCATG
CTGGTAAAATTTGGGAACCGTTGACAGACGAAATTATCAAGATTGCCTCAGATGATGAGCGACCAAAAGTTTTCATTCTT
TGGGGTGGTTTTGCTAGAAAGAAAGCCAAACTAATTGATGGAAGTAAGCATCTCATACTAGAAGCGGCGCATCCGTCACC
TTTGTCAGCAAGTCGTGGATTTTTTGGTTCGCATCCTTTCTCAAAAACCAATGAATTTCTGGTTGAATCTGGTCAAAGTC
CAATTGATTGGAGTAAATAA

Upstream 100 bases:

>100_bases
AATTTCATCATCGAGAAATTTATATCAGTGATTTCAGAAAGACAGCAACAGAAAAATTGAAAACAACCCTCCGAATTTTT
GTGGAGAGAGGACAAGAAAA

Downstream 100 bases:

>100_bases
AAACAGTCTGATTTGACTGTTTTTTTATTTATTTAAAAATAAAGAACGATTTTTCCATGTGCGTGACGATTCATCTGTAA
GTTGATTGCTTCCAAATAGT

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MKKTDWSQPLRNRLAEDYFPKMIEFINQTYQEGKVYPPENQIFRAIELTPLAQTKVIIVGQDPYPQPGKAQGLAFSYPAT
FKVNRPDSIVNIQKELREEGFSKDDSDLTAWAEQGVLLLNAVLTVPEFASNAHAGKIWEPLTDEIIKIASDDERPKVFIL
WGGFARKKAKLIDGSKHLILEAAHPSPLSASRGFFGSHPFSKTNEFLVESGQSPIDWSK

Sequences:

>Translated_219_residues
MKKTDWSQPLRNRLAEDYFPKMIEFINQTYQEGKVYPPENQIFRAIELTPLAQTKVIIVGQDPYPQPGKAQGLAFSYPAT
FKVNRPDSIVNIQKELREEGFSKDDSDLTAWAEQGVLLLNAVLTVPEFASNAHAGKIWEPLTDEIIKIASDDERPKVFIL
WGGFARKKAKLIDGSKHLILEAAHPSPLSASRGFFGSHPFSKTNEFLVESGQSPIDWSK
>Mature_219_residues
MKKTDWSQPLRNRLAEDYFPKMIEFINQTYQEGKVYPPENQIFRAIELTPLAQTKVIIVGQDPYPQPGKAQGLAFSYPAT
FKVNRPDSIVNIQKELREEGFSKDDSDLTAWAEQGVLLLNAVLTVPEFASNAHAGKIWEPLTDEIIKIASDDERPKVFIL
WGGFARKKAKLIDGSKHLILEAAHPSPLSASRGFFGSHPFSKTNEFLVESGQSPIDWSK

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI6224979, Length=215, Percent_Identity=43.7209302325581, Blast_Score=184, Evalue=7e-47,
Organism=Homo sapiens, GI19718751, Length=215, Percent_Identity=43.7209302325581, Blast_Score=184, Evalue=7e-47,
Organism=Escherichia coli, GI1788934, Length=216, Percent_Identity=42.1296296296296, Blast_Score=174, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17556304, Length=218, Percent_Identity=44.954128440367, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6323620, Length=236, Percent_Identity=38.5593220338983, Blast_Score=149, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_LACLA (Q9CIX2)

Other databases:

- EMBL:   AE005176
- PIR:   B86654
- RefSeq:   NP_266390.1
- ProteinModelPortal:   Q9CIX2
- SMR:   Q9CIX2
- GeneID:   1113843
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L32653
- NMPDR:   fig|272623.1.peg.242
- HOGENOM:   HBG605450
- OMA:   GAHAQKK
- ProtClustDB:   PRK05254
- BioCyc:   LLAC272623:L32653-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 24629; Mature: 24629

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 62-62

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTDWSQPLRNRLAEDYFPKMIEFINQTYQEGKVYPPENQIFRAIELTPLAQTKVIIVG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEEEEECCCCCEEEEEEC
QDPYPQPGKAQGLAFSYPATFKVNRPDSIVNIQKELREEGFSKDDSDLTAWAEQGVLLLN
CCCCCCCCCCCCEEEECCCEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHH
AVLTVPEFASNAHAGKIWEPLTDEIIKIASDDERPKVFILWGGFARKKAKLIDGSKHLIL
HHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHCCCCCEEEE
EAAHPSPLSASRGFFGSHPFSKTNEFLVESGQSPIDWSK
EECCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKKTDWSQPLRNRLAEDYFPKMIEFINQTYQEGKVYPPENQIFRAIELTPLAQTKVIIVG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEEEEECCCCCEEEEEEC
QDPYPQPGKAQGLAFSYPATFKVNRPDSIVNIQKELREEGFSKDDSDLTAWAEQGVLLLN
CCCCCCCCCCCCEEEECCCEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHH
AVLTVPEFASNAHAGKIWEPLTDEIIKIASDDERPKVFILWGGFARKKAKLIDGSKHLIL
HHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHCCCCCEEEE
EAAHPSPLSASRGFFGSHPFSKTNEFLVESGQSPIDWSK
EECCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471