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The map label for this gene is cbr

Identifier: 15672128

GI number: 15672128

Start: 143347

End: 144132

Strand: Reverse

Name: cbr

Synonym: L143350

Alternate gene names: 15672128

Gene position: 144132-143347 (Counterclockwise)

Preceding gene: 15672129

Following gene: 15672127

Centisome position: 6.09

GC content: 34.48

Gene sequence:

>786_bases
ATGAAAACACTTATCACTGGCGAAAATAAAGGAATTGGTTTTGCACTTGCTCAAAACCTTGGTCATCGCGGCTATGAAGT
CTTGGTCGGAGCCCGTAATGAAACGCGTGGACAAGAAGCCGTTGAAAAGCTGAAAGCCGAAGGAATTACTGCCAAATTTG
TCAAAGTAGATTTAGATGACTTAAATCAATTGACGAGTCTGTCAGCACTAACAGATATTGATTTACTTATTAATAATGCT
GGAATTTCTGGGAATATTCATTCAGATAAAGGGCACCTTGATATGGAAAAATCAGCTTTTGATTATTCAACAACTGATTT
AGAAGAAACAATTAAAACCAATTTTTTGGGAACACATGCTGTGATCAAAGAACTTCTTCCACATTCACTGACAGAAAATG
CTAAAATTATTAACATCACCGTACCCGTTTCTCAAGAATATTGGATGCCACTTGCTTATGTCACTTCAAAAGCTGCACAA
AATGCCATGACCTTTGCTTTTGGTCATCAATTCAAAAAAGATAAATCTAAAAAACAAATCTTTGCTGTTATGCCTGGTGC
AGTTGCAACAGATTTGAACGGTGCAAAAGTTGGGGATAGTCCGTTTGTAAAATCTCCTGAAGAAACAGCTCAAATGATTA
GTAAATTTATTTTTGATGACAAAAATCATAATGCTCAAATTATTAATTTTGACGGAACAATTTATGATAACTATGAACCA
GGCTTACGTAACAAAGTCATTAAAGATGTCGCTAAAAATGGTTTAAAGCGTAAATTTAAAAAATAA

Upstream 100 bases:

>100_bases
TTATCTGGAGATTGGCACCGTCACTGGTTTTTAAATTCCAATCTAATTGACCAACAACAAATGTCTAAAGGCGACAACTA
AAACTCAAAGGAGAAAAATC

Downstream 100 bases:

>100_bases
ATAAAAAAGTTACTGACAGATTAGTCAGCAACTTTTTTATTTATTTTTTGAAAAAAGCGTAAGCAAATCTTAACATTTAT
GATAAAATAATTCCATGGAA

Product: carbonyl reductase

Products: D-Gluconate; Nicotinamide adenine dinucleotide phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MKTLITGENKGIGFALAQNLGHRGYEVLVGARNETRGQEAVEKLKAEGITAKFVKVDLDDLNQLTSLSALTDIDLLINNA
GISGNIHSDKGHLDMEKSAFDYSTTDLEETIKTNFLGTHAVIKELLPHSLTENAKIINITVPVSQEYWMPLAYVTSKAAQ
NAMTFAFGHQFKKDKSKKQIFAVMPGAVATDLNGAKVGDSPFVKSPEETAQMISKFIFDDKNHNAQIINFDGTIYDNYEP
GLRNKVIKDVAKNGLKRKFKK

Sequences:

>Translated_261_residues
MKTLITGENKGIGFALAQNLGHRGYEVLVGARNETRGQEAVEKLKAEGITAKFVKVDLDDLNQLTSLSALTDIDLLINNA
GISGNIHSDKGHLDMEKSAFDYSTTDLEETIKTNFLGTHAVIKELLPHSLTENAKIINITVPVSQEYWMPLAYVTSKAAQ
NAMTFAFGHQFKKDKSKKQIFAVMPGAVATDLNGAKVGDSPFVKSPEETAQMISKFIFDDKNHNAQIINFDGTIYDNYEP
GLRNKVIKDVAKNGLKRKFKK
>Mature_261_residues
MKTLITGENKGIGFALAQNLGHRGYEVLVGARNETRGQEAVEKLKAEGITAKFVKVDLDDLNQLTSLSALTDIDLLINNA
GISGNIHSDKGHLDMEKSAFDYSTTDLEETIKTNFLGTHAVIKELLPHSLTENAKIINITVPVSQEYWMPLAYVTSKAAQ
NAMTFAFGHQFKKDKSKKQIFAVMPGAVATDLNGAKVGDSPFVKSPEETAQMISKFIFDDKNHNAQIINFDGTIYDNYEP
GLRNKVIKDVAKNGLKRKFKK

Specific function: Catalyzes the NADPH-dependent reduction of long chain acyl-CoA to the corresponding aldehyde [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4502599, Length=261, Percent_Identity=28.735632183908, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI4502601, Length=146, Percent_Identity=35.6164383561644, Blast_Score=81, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.69 [C]

Molecular weight: Translated: 28791; Mature: 28791

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLITGENKGIGFALAQNLGHRGYEVLVGARNETRGQEAVEKLKAEGITAKFVKVDLDD
CCCEECCCCCCCHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEEEECHHH
LNQLTSLSALTDIDLLINNAGISGNIHSDKGHLDMEKSAFDYSTTDLEETIKTNFLGTHA
HHHHHHHHHHHHHHHEEECCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHH
VIKELLPHSLTENAKIINITVPVSQEYWMPLAYVTSKAAQNAMTFAFGHQFKKDKSKKQI
HHHHHHHHHHCCCCEEEEEEEECCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEE
FAVMPGAVATDLNGAKVGDSPFVKSPEETAQMISKFIFDDKNHNAQIINFDGTIYDNYEP
EEECCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCEEECCCCC
GLRNKVIKDVAKNGLKRKFKK
CHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKTLITGENKGIGFALAQNLGHRGYEVLVGARNETRGQEAVEKLKAEGITAKFVKVDLDD
CCCEECCCCCCCHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEEEECHHH
LNQLTSLSALTDIDLLINNAGISGNIHSDKGHLDMEKSAFDYSTTDLEETIKTNFLGTHA
HHHHHHHHHHHHHHHEEECCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHH
VIKELLPHSLTENAKIINITVPVSQEYWMPLAYVTSKAAQNAMTFAFGHQFKKDKSKKQI
HHHHHHHHHHCCCCEEEEEEEECCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEE
FAVMPGAVATDLNGAKVGDSPFVKSPEETAQMISKFIFDDKNHNAQIINFDGTIYDNYEP
EEECCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCEEECCCCC
GLRNKVIKDVAKNGLKRKFKK
CHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+; NADH; NADP+; NADPH [C]

Metal ions: Mn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 20 {D-gluconate}} 0.006 {NADPH}} 0.9 {5-keto-D-gluconate}} 0.02 {NADP+}} [C]

Substrates: 5-Dehydro-D-gluconate; H+; Nicotinamide adenine dinucleotide phosphate - reduced [C]

Specific reaction: 5-Dehydro-D-gluconate + H+ + Nicotinamide adenine dinucleotide phosphate - reduced <==> D-Gluconate + Nicotinamide adenine dinucleotide phosphate [C]

General reaction: Redox reaction [C]

Inhibitor: Cd2+; Cs2+; Cu2+; Divalent metal ions; Hg2+; Ni2+; p-Chloromercuribenzoate; Sn2+; Sulfhydryl reagents [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA