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The map label for this gene is hemN

Identifier: 13357834

GI number: 13357834

Start: 309018

End: 310082

Strand: Reverse

Name: hemN

Synonym: UU274

Alternate gene names: 13357834

Gene position: 310082-309018 (Counterclockwise)

Preceding gene: 13357850

Following gene: 13357824

Centisome position: 41.25

GC content: 21.22

Gene sequence:

>1065_bases
ATGATTTTTAACAAAAAAACTAAACATTTATACATTCATATTCCATTTTGTAACTATATTTGTATATTTTCTGATTTTAA
ACGTATTTTAAAAACTCCTCAAACAAAAAAATTTTTTAAGAATTTTTTAGAAAATATTAAAATGCACATTAATAATTTTA
AAATAAAGCAATTTAAAACAATCTACTTAGGCGGAGGTGTTCCAAATTGTTTAAACAATCAAGAATTAGAAATTTTATTA
AAAACAATTTCTCCTTATGTTGATGATAATTGCGAATATACCATTGAATGTAATCCTGAATTAATAAATCAAACTCAAAT
TAATCTCTTCAAAAAATACAAAATTAATCGCATTAGTCTTAACGTTCAATCAATGAATAATGATGTGTTAAAACAAATGA
ATTTTATTCATACAAATCAAGATAGTAAAAAAGCGATTAATTTATTACATAAAAACGGATTGTATAATGTGTCTTGTGAT
TTTTTATTTTGCATATCAATCTTAACATTAAAAGACTTAGATGATGTTTTTAATTTTATTTTAAATCATAAAATTAATCA
TGTTAGTTTTTATAGTTTAGAAATTAAAGAACAGTCACTTTTAAAAAAGTACCATATTACTATCGATGAAGAAAAAGAAA
TTGAACAAATGAATTATATAATTAATAAATTTGCAGGATTAAATTTTCATCGTTATGAAGTATGTAATTGAACAAATAAC
TTCAGATATATTGCAAAACATAACTTAGCTTATTGACGAACTGAAGACTGGGCCGCAATAGGATGGGGAGCACATGGCTA
TGAAAAAAATATTGTATATTTTTTTGATGGATCTATAAAAAACCCTATATTAATTAAAAAAGTATTAACAAAACACGAAT
TATATCAACAAATTTTAATGATGGGTTTAAGGTTAAAAGATGGATTAAATCTAAATAAAAAAATTAATTATGAAGCTTAT
TCATATTTTAAAAATCAATTGAAACACGTTAGTATTAATAAAAAAAATCATCTTCTTATTGATGATTTAAATTTACTAAA
TTTAACTATTTTAGATATATTTTAA

Upstream 100 bases:

>100_bases
CGATTTTTCTAATAATATTAACTTGCGGAGCAATTGTTTTATTAGTTTTTGTTATTACTGAATTATTTAGATTATTAAGT
GCATAATTAATCTCTATTTT

Downstream 100 bases:

>100_bases
TTAATAATAAACAAATCTAGTAAGAATTGTGTTGAACTTTTTAAGGATTCACTATTACTTAAACCAAAATATAAACCTAA
AATCAAAATTAATAAAACAA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MIFNKKTKHLYIHIPFCNYICIFSDFKRILKTPQTKKFFKNFLENIKMHINNFKIKQFKTIYLGGGVPNCLNNQELEILL
KTISPYVDDNCEYTIECNPELINQTQINLFKKYKINRISLNVQSMNNDVLKQMNFIHTNQDSKKAINLLHKNGLYNVSCD
FLFCISILTLKDLDDVFNFILNHKINHVSFYSLEIKEQSLLKKYHITIDEEKEIEQMNYIINKFAGLNFHRYEVCNWTNN
FRYIAKHNLAYWRTEDWAAIGWGAHGYEKNIVYFFDGSIKNPILIKKVLTKHELYQQILMMGLRLKDGLNLNKKINYEAY
SYFKNQLKHVSINKKNHLLIDDLNLLNLTILDIF

Sequences:

>Translated_354_residues
MIFNKKTKHLYIHIPFCNYICIFSDFKRILKTPQTKKFFKNFLENIKMHINNFKIKQFKTIYLGGGVPNCLNNQELEILL
KTISPYVDDNCEYTIECNPELINQTQINLFKKYKINRISLNVQSMNNDVLKQMNFIHTNQDSKKAINLLHKNGLYNVSCD
FLFCISILTLKDLDDVFNFILNHKINHVSFYSLEIKEQSLLKKYHITIDEEKEIEQMNYIINKFAGLNFHRYEVCN*TNN
FRYIAKHNLAY*RTEDWAAIGWGAHGYEKNIVYFFDGSIKNPILIKKVLTKHELYQQILMMGLRLKDGLNLNKKINYEAY
SYFKNQLKHVSINKKNHLLIDDLNLLNLTILDIF
>Mature_354_residues
MIFNKKTKHLYIHIPFCNYICIFSDFKRILKTPQTKKFFKNFLENIKMHINNFKIKQFKTIYLGGGVPNCLNNQELEILL
KTISPYVDDNCEYTIECNPELINQTQINLFKKYKINRISLNVQSMNNDVLKQMNFIHTNQDSKKAINLLHKNGLYNVSCD
FLFCISILTLKDLDDVFNFILNHKINHVSFYSLEIKEQSLLKKYHITIDEEKEIEQMNYIINKFAGLNFHRYEVCN*TNN
FRYIAKHNLAY*RTEDWAAIGWGAHGYEKNIVYFFDGSIKNPILIKKVLTKHELYQQILMMGLRLKDGLNLNKKINYEAY
SYFKNQLKHVSINKKNHLLIDDLNLLNLTILDIF

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=270, Percent_Identity=21.8518518518519, Blast_Score=92, Evalue=8e-19,
Organism=Escherichia coli, GI1789325, Length=292, Percent_Identity=27.3972602739726, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI87082341, Length=136, Percent_Identity=25.7352941176471, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 41758; Mature: 41758

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFNKKTKHLYIHIPFCNYICIFSDFKRILKTPQTKKFFKNFLENIKMHINNFKIKQFKT
CCCCCCCCEEEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCEEEEEEEE
IYLGGGVPNCLNNQELEILLKTISPYVDDNCEYTIECNPELINQTQINLFKKYKINRISL
EEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEECCHHHHCCHHHHHHHHEEEEEEEE
NVQSMNNDVLKQMNFIHTNQDSKKAINLLHKNGLYNVSCDFLFCISILTLKDLDDVFNFI
EEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHHHHH
LNHKINHVSFYSLEIKEQSLLKKYHITIDEEKEIEQMNYIINKFAGLNFHRYEVCNTNNF
HHCCCCEEEEEEEEECHHHHHHHHCEEECCHHHHHHHHHHHHHHCCCCEEEEEEECCCCE
RYIAKHNLAYRTEDWAAIGWGAHGYEKNIVYFFDGSIKNPILIKKVLTKHELYQQILMMG
EEEEECCCEEECCCCEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHC
LRLKDGLNLNKKINYEAYSYFKNQLKHVSINKKNHLLIDDLNLLNLTILDIF
CHHCCCCCCCCEECHHHHHHHHHHHHEEEECCCCEEEEECCCEEEEEEEEEC
>Mature Secondary Structure
MIFNKKTKHLYIHIPFCNYICIFSDFKRILKTPQTKKFFKNFLENIKMHINNFKIKQFKT
CCCCCCCCEEEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCEEEEEEEE
IYLGGGVPNCLNNQELEILLKTISPYVDDNCEYTIECNPELINQTQINLFKKYKINRISL
EEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEECCHHHHCCHHHHHHHHEEEEEEEE
NVQSMNNDVLKQMNFIHTNQDSKKAINLLHKNGLYNVSCDFLFCISILTLKDLDDVFNFI
EEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHHHHH
LNHKINHVSFYSLEIKEQSLLKKYHITIDEEKEIEQMNYIINKFAGLNFHRYEVCNTNNF
HHCCCCEEEEEEEEECHHHHHHHHCEEECCHHHHHHHHHHHHHHCCCCEEEEEEECCCCE
RYIAKHNLAYRTEDWAAIGWGAHGYEKNIVYFFDGSIKNPILIKKVLTKHELYQQILMMG
EEEEECCCEEECCCCEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHC
LRLKDGLNLNKKINYEAYSYFKNQLKHVSINKKNHLLIDDLNLLNLTILDIF
CHHCCCCCCCCEECHHHHHHHHHHHHEEEECCCCEEEEECCCEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]