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The map label for this gene is panF [H]

Identifier: 15595159

GI number: 15595159

Start: 860440

End: 861774

Strand: Direct

Name: panF [H]

Synonym: BB0814

Alternate gene names: 15595159

Gene position: 860440-861774 (Clockwise)

Preceding gene: 15595158

Following gene: 15595160

Centisome position: 94.48

GC content: 25.84

Gene sequence:

>1335_bases
TTGTTATTAAATAAATATTTTCTTGCAAATCGAAATATTAATTTTATTGTTATGGCTTTGTTATTTTCTTCTAGCTATAT
TAGTGCTAGTAGTTTTATTTCCGGTCCCTCTGCTGTTTATAAGTATGGATTATCTTTTATATTATTAGCTACCATACAAA
TTCCTACAACTTTAATTGTTTTTATTATTGTTGGTCAGAGATTAAATCGCGAATCAAAAAAAATTAATGCAATTAATATT
ATTGATTATATTAGGCATAGATATGAAAGTGATTTTTTGGCGTTAATGAGTGGATTTGTATTGATTTTTTTTTCAATGTT
TTTGATTTCTGCCCAATTAATAGGTGGTGCCAAACTTATAGAAGTTTTTTGGGGTATTGATTACGTAGTTGGTCTTACTT
TTTTTGCCTTCTTGGTTTTTATTTATGTATTTTTTGGCGGCTTTAAGGCAGTAGCTTATACGGATTTGATTCAAGGATTT
TTAATGCTAGTTTCATCCGTTATTTTGTTTTCCAAGATGCTAGATTTGGGAGGGGGTATTAATAATTTATTCAAAACAGC
AACGTCTAGCTTAGATAAAAGCCTTTTACTTCCTTCAAATGCTGACTTAAAGCCACAATATATAATTTCTTTTTGGATAT
TAATAGGAATAGGAATACTAGGGCAGCCTCAGATTATTAATAATTTTATAGCATTTAAAGATGAGAATGCTATAAAATTT
TCTCTTCCCATTTCTACTTTTATTATTAGCTTTTTAATTGTTTTGATGCATTTAATAGGGTTTTTTGCTATTATTCTTTT
TCCAGATTTAAGTCCAAATGATAAAGTTGTTTTAAATGTGGCTTTAAAAGTTTTAAATCCTTTTTCTTGTTTTATGTTTT
TTATAGGTCTTTTATCTGCAATAATGTCTACAGTGGATTCAAATTTGCTATTAATAACATCTGTTTTAATAAAGTCAATA
TTTATTTATAAAGAAGATTTAAAAGAAGATGTAAAGATTGGCAGAATAATAATGATTTCTAATATTTTTTTTATTTTAAT
AATACTTATATTTTCTCTCTTTCCTCCCAATTTTTTATTCTTTATTAATATTTTTGCCTTTGGAGCTTTGGAAGTTTCGT
TTTTCCCTATTATTGTTTTTGGACTTTATTTAAATTTTGTAAGCAAAATAGCGGCTTTTGCTTCTATGTTTTTAGGGTTA
ATATTTTATTTGTCCATTTTATTCTTTGGTTTAAATATTTGGTTTTTTCACCCCGTTTTTCCATCATTTTTTGTTTCTAT
ATTTACATTTTTAGTAGTTAATTTTTTTTGTAAAAAAAATAGTAAGGTTTGTTAG

Upstream 100 bases:

>100_bases
TTTGGTTTGTTTTTTTATTTTAGTAATTAGTAAAACTTGATACATTATTGATATTTTTTTATTTTTAGATTTTCTTAAAA
AAAGAAATAGAGGTAGGTTT

Downstream 100 bases:

>100_bases
GGGTATTTTTTGCGTTTGGATAAATATATTTTTTTAGAAGTGCTTGCTAATGATAATGGCAAGCGACTAGATTCAATTTT
AATTAAAATTTTAAATTTTT

Product: sodium/panthothenate symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MLLNKYFLANRNINFIVMALLFSSSYISASSFISGPSAVYKYGLSFILLATIQIPTTLIVFIIVGQRLNRESKKINAINI
IDYIRHRYESDFLALMSGFVLIFFSMFLISAQLIGGAKLIEVFWGIDYVVGLTFFAFLVFIYVFFGGFKAVAYTDLIQGF
LMLVSSVILFSKMLDLGGGINNLFKTATSSLDKSLLLPSNADLKPQYIISFWILIGIGILGQPQIINNFIAFKDENAIKF
SLPISTFIISFLIVLMHLIGFFAIILFPDLSPNDKVVLNVALKVLNPFSCFMFFIGLLSAIMSTVDSNLLLITSVLIKSI
FIYKEDLKEDVKIGRIIMISNIFFILIILIFSLFPPNFLFFINIFAFGALEVSFFPIIVFGLYLNFVSKIAAFASMFLGL
IFYLSILFFGLNIWFFHPVFPSFFVSIFTFLVVNFFCKKNSKVC

Sequences:

>Translated_444_residues
MLLNKYFLANRNINFIVMALLFSSSYISASSFISGPSAVYKYGLSFILLATIQIPTTLIVFIIVGQRLNRESKKINAINI
IDYIRHRYESDFLALMSGFVLIFFSMFLISAQLIGGAKLIEVFWGIDYVVGLTFFAFLVFIYVFFGGFKAVAYTDLIQGF
LMLVSSVILFSKMLDLGGGINNLFKTATSSLDKSLLLPSNADLKPQYIISFWILIGIGILGQPQIINNFIAFKDENAIKF
SLPISTFIISFLIVLMHLIGFFAIILFPDLSPNDKVVLNVALKVLNPFSCFMFFIGLLSAIMSTVDSNLLLITSVLIKSI
FIYKEDLKEDVKIGRIIMISNIFFILIILIFSLFPPNFLFFINIFAFGALEVSFFPIIVFGLYLNFVSKIAAFASMFLGL
IFYLSILFFGLNIWFFHPVFPSFFVSIFTFLVVNFFCKKNSKVC
>Mature_444_residues
MLLNKYFLANRNINFIVMALLFSSSYISASSFISGPSAVYKYGLSFILLATIQIPTTLIVFIIVGQRLNRESKKINAINI
IDYIRHRYESDFLALMSGFVLIFFSMFLISAQLIGGAKLIEVFWGIDYVVGLTFFAFLVFIYVFFGGFKAVAYTDLIQGF
LMLVSSVILFSKMLDLGGGINNLFKTATSSLDKSLLLPSNADLKPQYIISFWILIGIGILGQPQIINNFIAFKDENAIKF
SLPISTFIISFLIVLMHLIGFFAIILFPDLSPNDKVVLNVALKVLNPFSCFMFFIGLLSAIMSTVDSNLLLITSVLIKSI
FIYKEDLKEDVKIGRIIMISNIFFILIILIFSLFPPNFLFFINIFAFGALEVSFFPIIVFGLYLNFVSKIAAFASMFLGL
IFYLSILFFGLNIWFFHPVFPSFFVSIFTFLVVNFFCKKNSKVC

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG4145

COG function: function code H; Na+/panthothenate symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=467, Percent_Identity=29.1220556745182, Blast_Score=127, Evalue=3e-29,
Organism=Escherichia coli, GI87082237, Length=438, Percent_Identity=33.5616438356164, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1787251, Length=415, Percent_Identity=26.0240963855422, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1790503, Length=468, Percent_Identity=22.6495726495727, Blast_Score=95, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 50177; Mature: 50177

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLNKYFLANRNINFIVMALLFSSSYISASSFISGPSAVYKYGLSFILLATIQIPTTLIV
CCCCCHHHCCCCCHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FIIVGQRLNRESKKINAINIIDYIRHRYESDFLALMSGFVLIFFSMFLISAQLIGGAKLI
HHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
EVFWGIDYVVGLTFFAFLVFIYVFFGGFKAVAYTDLIQGFLMLVSSVILFSKMLDLGGGI
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
NNLFKTATSSLDKSLLLPSNADLKPQYIISFWILIGIGILGQPQIINNFIAFKDENAIKF
HHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEE
SLPISTFIISFLIVLMHLIGFFAIILFPDLSPNDKVVLNVALKVLNPFSCFMFFIGLLSA
ECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHH
IMSTVDSNLLLITSVLIKSIFIYKEDLKEDVKIGRIIMISNIFFILIILIFSLFPPNFLF
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
FINIFAFGALEVSFFPIIVFGLYLNFVSKIAAFASMFLGLIFYLSILFFGLNIWFFHPVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PSFFVSIFTFLVVNFFCKKNSKVC
HHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLLNKYFLANRNINFIVMALLFSSSYISASSFISGPSAVYKYGLSFILLATIQIPTTLIV
CCCCCHHHCCCCCHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FIIVGQRLNRESKKINAINIIDYIRHRYESDFLALMSGFVLIFFSMFLISAQLIGGAKLI
HHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
EVFWGIDYVVGLTFFAFLVFIYVFFGGFKAVAYTDLIQGFLMLVSSVILFSKMLDLGGGI
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
NNLFKTATSSLDKSLLLPSNADLKPQYIISFWILIGIGILGQPQIINNFIAFKDENAIKF
HHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEE
SLPISTFIISFLIVLMHLIGFFAIILFPDLSPNDKVVLNVALKVLNPFSCFMFFIGLLSA
ECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHH
IMSTVDSNLLLITSVLIKSIFIYKEDLKEDVKIGRIIMISNIFFILIILIFSLFPPNFLF
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
FINIFAFGALEVSFFPIIVFGLYLNFVSKIAAFASMFLGLIFYLSILFFGLNIWFFHPVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PSFFVSIFTFLVVNFFCKKNSKVC
HHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2193919; 9278503; 8226664 [H]