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The map label for this gene is rnc

Identifier: 15595050

GI number: 15595050

Start: 740685

End: 741425

Strand: Direct

Name: rnc

Synonym: BB0705

Alternate gene names: 15595050

Gene position: 740685-741425 (Clockwise)

Preceding gene: 15595049

Following gene: 15595052

Centisome position: 81.33

GC content: 31.04

Gene sequence:

>741_bases
TTGATGAAAAAAAAATCTTCTGATTTTTGTTTGTGTAATGAAAGAAAATCTCAATTGAGTAAATTTTTGGAAAATTTGAG
CATTGACTTTAGTAATTTTGATTTATTGAATACAGCATTGTGTCATTCGTCGTATTCTAATGAGTTGGATCAAAAATCTA
GTAATAATGAGAGATTAGAATTTTTGGGAGATTCTGTGCTTAATTTGATTATTACAGATCATCTTTATAAAACTTATCCA
AATAAAAGTGAAGGAGAGCTCAGTAAGGCCAGATCTTATATTGTTAGTGAAGATTCCCTATCTAATATTGCTAGAGAGAT
TAATCTTGGTTCTTATATTTTGCTAGGTAGAGGGGAGGAGAGTAATGATGGTCGAAATAAAAAAGGCATTCTTGCAGATG
CTATTGAAGCTTTTGTAGGCGCTATTTATCTTGATAGTGGGTTTTCAAGAGCAACAGAATTTGTGGTTGGACTTTTTGAT
ATGTATATAAGATTGATGTTTAATAGGGGGGATTTTAAAGATTATAAGAGTTTGTTGCAAGAATATGTTCAAAAGAAATA
TAAAATCTCGCCAAGTTATAAGCTAGACAAGGAAATAGGTCCAGACCATGATAAAGTTTTTTGTGTGGAACTTTATGTTG
GAGAAAATTTTATATCAAATGGAAAGGGCAAATCTAAAAAAGAAGCCGAAATGAGAGCGGCTGAAGTAGCTTTAAAAGCT
ATGGAAAACATTAACCTTTAA

Upstream 100 bases:

>100_bases
ATTTGCTTGAAGAGGCCTTTGATGATAAGATTCCAGAGAATGAAGCCAATGAATTTGAGACGGTAGGCGATGTTGTTAAT
TTTATTAAAAAGAGAAAGGG

Downstream 100 bases:

>100_bases
GGTTTTGATTTTTTTTATAAGATAATTTTTAGTATTAAGCTTGGGATTTTCAATTACACATCTTAGTAGCATATTTAAAA
TTTTACCTATATTTTTGTTT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MMKKKSSDFCLCNERKSQLSKFLENLSIDFSNFDLLNTALCHSSYSNELDQKSSNNERLEFLGDSVLNLIITDHLYKTYP
NKSEGELSKARSYIVSEDSLSNIAREINLGSYILLGRGEESNDGRNKKGILADAIEAFVGAIYLDSGFSRATEFVVGLFD
MYIRLMFNRGDFKDYKSLLQEYVQKKYKISPSYKLDKEIGPDHDKVFCVELYVGENFISNGKGKSKKEAEMRAAEVALKA
MENINL

Sequences:

>Translated_246_residues
MMKKKSSDFCLCNERKSQLSKFLENLSIDFSNFDLLNTALCHSSYSNELDQKSSNNERLEFLGDSVLNLIITDHLYKTYP
NKSEGELSKARSYIVSEDSLSNIAREINLGSYILLGRGEESNDGRNKKGILADAIEAFVGAIYLDSGFSRATEFVVGLFD
MYIRLMFNRGDFKDYKSLLQEYVQKKYKISPSYKLDKEIGPDHDKVFCVELYVGENFISNGKGKSKKEAEMRAAEVALKA
MENINL
>Mature_246_residues
MMKKKSSDFCLCNERKSQLSKFLENLSIDFSNFDLLNTALCHSSYSNELDQKSSNNERLEFLGDSVLNLIITDHLYKTYP
NKSEGELSKARSYIVSEDSLSNIAREINLGSYILLGRGEESNDGRNKKGILADAIEAFVGAIYLDSGFSRATEFVVGLFD
MYIRLMFNRGDFKDYKSLLQEYVQKKYKISPSYKLDKEIGPDHDKVFCVELYVGENFISNGKGKSKKEAEMRAAEVALKA
MENINL

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=242, Percent_Identity=30.1652892561983, Blast_Score=101, Evalue=7e-22,
Organism=Homo sapiens, GI155030236, Length=242, Percent_Identity=30.1652892561983, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI1788920, Length=225, Percent_Identity=35.1111111111111, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI193202651, Length=229, Percent_Identity=28.3842794759825, Blast_Score=104, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17506883, Length=229, Percent_Identity=28.3842794759825, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI17137682, Length=230, Percent_Identity=31.304347826087, Blast_Score=98, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_BORBU (O51648)

Other databases:

- EMBL:   AE000783
- PIR:   H70187
- RefSeq:   NP_212839.1
- ProteinModelPortal:   O51648
- SMR:   O51648
- EnsemblBacteria:   EBBORT00000008960
- GeneID:   1195558
- GenomeReviews:   AE000783_GR
- KEGG:   bbu:BB0705
- NMPDR:   fig|224326.1.peg.1089
- TIGR:   BB_0705
- GeneTree:   EBGT00050000007579
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- PhylomeDB:   O51648
- ProtClustDB:   PRK00102
- BioCyc:   BBUR224326:BB_0705-MONOMER
- BRENDA:   3.1.26.3
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 27942; Mature: 27942

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKKKSSDFCLCNERKSQLSKFLENLSIDFSNFDLLNTALCHSSYSNELDQKSSNNERLE
CCCCCCCCCEEECHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHH
FLGDSVLNLIITDHLYKTYPNKSEGELSKARSYIVSEDSLSNIAREINLGSYILLGRGEE
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCC
SNDGRNKKGILADAIEAFVGAIYLDSGFSRATEFVVGLFDMYIRLMFNRGDFKDYKSLLQ
CCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
EYVQKKYKISPSYKLDKEIGPDHDKVFCVELYVGENFISNGKGKSKKEAEMRAAEVALKA
HHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEECCHHHCCCCCCCHHHHHHHHHHHHHHH
MENINL
HHHCCC
>Mature Secondary Structure
MMKKKSSDFCLCNERKSQLSKFLENLSIDFSNFDLLNTALCHSSYSNELDQKSSNNERLE
CCCCCCCCCEEECHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHH
FLGDSVLNLIITDHLYKTYPNKSEGELSKARSYIVSEDSLSNIAREINLGSYILLGRGEE
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCC
SNDGRNKKGILADAIEAFVGAIYLDSGFSRATEFVVGLFDMYIRLMFNRGDFKDYKSLLQ
CCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
EYVQKKYKISPSYKLDKEIGPDHDKVFCVELYVGENFISNGKGKSKKEAEMRAAEVALKA
HHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEECCHHHCCCCCCCHHHHHHHHHHHHHHH
MENINL
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9403685