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The map label for this gene is pepD [H]

Identifier: 15594953

GI number: 15594953

Start: 634581

End: 636011

Strand: Direct

Name: pepD [H]

Synonym: BB0608

Alternate gene names: 15594953

Gene position: 634581-636011 (Clockwise)

Preceding gene: 15594952

Following gene: 15594955

Centisome position: 69.68

GC content: 30.12

Gene sequence:

>1431_bases
ATGAGTATTGTAATTGATTCTTTTAAAGAGATATCAAAAATTCCAAGATGTTCAAAAAATATTAAAGGAATTATTAATTT
TATTAAGCAGAGAGCCAAAAAATTTGGTTATTCTTTTAAAGAAGATCGTGTTGGTAATATTGTAGTGCAGATAAAATCAA
ATAATAATATTGATATGCATCCTATTATTTTACAATCTCATGTTGATATGGTTTGCGAAAAGAATGAATCCAGTTTGCAT
AATTTTGAAACAGATCCAATTGAAATTGTTGAAGAGGATGGATATCTTAAAGCAGTAGGGACCACCCTCGGAGCTGATAA
TGGGATTGGAGTAGCTATGATGTTGGGGATTATGAGTGAAGCCAATAATTTTCCTCATCCCGATTTAGAACTTCTATTTA
CCGTTGATGAAGAAATAGGTTTAATAGGTGCTCTTGGTCTTGATTCTAATTTATGTAGTGGTAAAAGCCTCATTAATCTT
GATGGAGAGGAAGAGGGTTATTTTTTAGTTGGTTGTGCGGGATCAAGACTTGTAGAAATTGTTTTTTCTCCTAAGTATAG
CCTTGTAACGAAAAAAACAAAGGTAGAAATTTTGTTTAAAGGGCTTAAAGGTGGCCATTCTGGGGCAGATATTCATTTAG
ATTTGGCAAATTCTTTAAAATTAATGTTTTTTGCTCTTTTTGAAATTAAGGCAAATCTTAATTTTGAGATTGAAGGCATT
TTTGGTGGAAATAGTAGCAATGCAATTCCAATTGAAGCCAAGGCTTTAATCTTTATAGATGATAATGATTATGATTTATT
AAATAAAGAGCTTAAACTGTTCGTACTTAAAGTTAAAAGTGCATATTCTCTTGAAGATGAATTTGATATTATTGTTAATA
AAAGAGAATTTTCATCAGTTAAAGTTCTTGATGAAAATAGCAAAAATAAGCTTTTAAATATGGGAATGGGATTTTTACAT
GGAGTTCAAAAAGTAGAAAATTATGAAAATAAGCTTATAAAGACCTCTTTAAATTTTTCAAGTCTTTTGAGAATGCAAGA
CGATTATATTTTTACTTTTTTAATAAGATCTTTATTGGATTTAGACAAAGAGTATGTTTGCAATCATTTACAATCAATAA
GTGATTTGTCGGGAGCTAATTTGCGTGTAATTTATGATGATCCTTCTTGGCAGCCTGATAAGAATAGCAATCTTTTAAAA
CATCTTCAAGAAGTGTATAAAGAGATGTATCTTGAAGATGCTAATGTTTCCACAATACATGCAGGTCTTGAAACAGGCAT
AATATCTTCTAGATTGGGAGGTATAGAATCTGTTACCCTTGGGCCTTGGATTGAATGGCCTCATACTACTAGGGAAAGAG
TAAATATTTCTTCAACTATTAGAGTTTATGATTTTTTGAAAAAAAGCTTAGAAAGATTTCAAAAATTTTAG

Upstream 100 bases:

>100_bases
TATTGAATGAATTTAAAGATTAATTTAGTATATTATATTATTAATTATAAATTAAATCCAAGTATATTTATGGATTTAAT
TTAATCAAAGGAAAGTTATT

Downstream 100 bases:

>100_bases
TTTTGAAAAAAATTAATATTTTATTATAAATTTTTTAATAAAAGTCTTATGGCTTTTATTATTTTTATCTTTTATTGACT
TAGGAATTAAATATTTATAA

Product: aminoacyl-histidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MSIVIDSFKEISKIPRCSKNIKGIINFIKQRAKKFGYSFKEDRVGNIVVQIKSNNNIDMHPIILQSHVDMVCEKNESSLH
NFETDPIEIVEEDGYLKAVGTTLGADNGIGVAMMLGIMSEANNFPHPDLELLFTVDEEIGLIGALGLDSNLCSGKSLINL
DGEEEGYFLVGCAGSRLVEIVFSPKYSLVTKKTKVEILFKGLKGGHSGADIHLDLANSLKLMFFALFEIKANLNFEIEGI
FGGNSSNAIPIEAKALIFIDDNDYDLLNKELKLFVLKVKSAYSLEDEFDIIVNKREFSSVKVLDENSKNKLLNMGMGFLH
GVQKVENYENKLIKTSLNFSSLLRMQDDYIFTFLIRSLLDLDKEYVCNHLQSISDLSGANLRVIYDDPSWQPDKNSNLLK
HLQEVYKEMYLEDANVSTIHAGLETGIISSRLGGIESVTLGPWIEWPHTTRERVNISSTIRVYDFLKKSLERFQKF

Sequences:

>Translated_476_residues
MSIVIDSFKEISKIPRCSKNIKGIINFIKQRAKKFGYSFKEDRVGNIVVQIKSNNNIDMHPIILQSHVDMVCEKNESSLH
NFETDPIEIVEEDGYLKAVGTTLGADNGIGVAMMLGIMSEANNFPHPDLELLFTVDEEIGLIGALGLDSNLCSGKSLINL
DGEEEGYFLVGCAGSRLVEIVFSPKYSLVTKKTKVEILFKGLKGGHSGADIHLDLANSLKLMFFALFEIKANLNFEIEGI
FGGNSSNAIPIEAKALIFIDDNDYDLLNKELKLFVLKVKSAYSLEDEFDIIVNKREFSSVKVLDENSKNKLLNMGMGFLH
GVQKVENYENKLIKTSLNFSSLLRMQDDYIFTFLIRSLLDLDKEYVCNHLQSISDLSGANLRVIYDDPSWQPDKNSNLLK
HLQEVYKEMYLEDANVSTIHAGLETGIISSRLGGIESVTLGPWIEWPHTTRERVNISSTIRVYDFLKKSLERFQKF
>Mature_475_residues
SIVIDSFKEISKIPRCSKNIKGIINFIKQRAKKFGYSFKEDRVGNIVVQIKSNNNIDMHPIILQSHVDMVCEKNESSLHN
FETDPIEIVEEDGYLKAVGTTLGADNGIGVAMMLGIMSEANNFPHPDLELLFTVDEEIGLIGALGLDSNLCSGKSLINLD
GEEEGYFLVGCAGSRLVEIVFSPKYSLVTKKTKVEILFKGLKGGHSGADIHLDLANSLKLMFFALFEIKANLNFEIEGIF
GGNSSNAIPIEAKALIFIDDNDYDLLNKELKLFVLKVKSAYSLEDEFDIIVNKREFSSVKVLDENSKNKLLNMGMGFLHG
VQKVENYENKLIKTSLNFSSLLRMQDDYIFTFLIRSLLDLDKEYVCNHLQSISDLSGANLRVIYDDPSWQPDKNSNLLKH
LQEVYKEMYLEDANVSTIHAGLETGIISSRLGGIESVTLGPWIEWPHTTRERVNISSTIRVYDFLKKSLERFQKF

Specific function: Dipeptidase with broad substrate specificity [H]

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=479, Percent_Identity=32.5678496868476, Blast_Score=249, Evalue=3e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 53577; Mature: 53446

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIVIDSFKEISKIPRCSKNIKGIINFIKQRAKKFGYSFKEDRVGNIVVQIKSNNNIDMH
CCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCC
PIILQSHVDMVCEKNESSLHNFETDPIEIVEEDGYLKAVGTTLGADNGIGVAMMLGIMSE
EEEHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCEEEEEEHHCCCCCCCHHHHHHHHHHH
ANNFPHPDLELLFTVDEEIGLIGALGLDSNLCSGKSLINLDGEEEGYFLVGCAGSRLVEI
CCCCCCCCEEEEEEECCCCCEEEEECCCCCCCCCCEEEECCCCCCCEEEEEECCCEEEEE
VFSPKYSLVTKKTKVEILFKGLKGGHSGADIHLDLANSLKLMFFALFEIKANLNFEIEGI
EECCCCCEEECHHEEEEEEECCCCCCCCCEEEEEHHHHHHHHHHHHHHHEECCCEEEEEE
FGGNSSNAIPIEAKALIFIDDNDYDLLNKELKLFVLKVKSAYSLEDEFDIIVNKREFSSV
ECCCCCCEEEEEEEEEEEEECCCHHHHHHCEEEEEEEECCCCCCCCCEEEEEECCCCCEE
KVLDENSKNKLLNMGMGFLHGVQKVENYENKLIKTSLNFSSLLRMQDDYIFTFLIRSLLD
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHCCCHHHHHHHHHHHH
LDKEYVCNHLQSISDLSGANLRVIYDDPSWQPDKNSNLLKHLQEVYKEMYLEDANVSTIH
CCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEE
AGLETGIISSRLGGIESVTLGPWIEWPHTTRERVNISSTIRVYDFLKKSLERFQKF
CCHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SIVIDSFKEISKIPRCSKNIKGIINFIKQRAKKFGYSFKEDRVGNIVVQIKSNNNIDMH
CEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCC
PIILQSHVDMVCEKNESSLHNFETDPIEIVEEDGYLKAVGTTLGADNGIGVAMMLGIMSE
EEEHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCEEEEEEHHCCCCCCCHHHHHHHHHHH
ANNFPHPDLELLFTVDEEIGLIGALGLDSNLCSGKSLINLDGEEEGYFLVGCAGSRLVEI
CCCCCCCCEEEEEEECCCCCEEEEECCCCCCCCCCEEEECCCCCCCEEEEEECCCEEEEE
VFSPKYSLVTKKTKVEILFKGLKGGHSGADIHLDLANSLKLMFFALFEIKANLNFEIEGI
EECCCCCEEECHHEEEEEEECCCCCCCCCEEEEEHHHHHHHHHHHHHHHEECCCEEEEEE
FGGNSSNAIPIEAKALIFIDDNDYDLLNKELKLFVLKVKSAYSLEDEFDIIVNKREFSSV
ECCCCCCEEEEEEEEEEEEECCCHHHHHHCEEEEEEEECCCCCCCCCEEEEEECCCCCEE
KVLDENSKNKLLNMGMGFLHGVQKVENYENKLIKTSLNFSSLLRMQDDYIFTFLIRSLLD
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHCCCHHHHHHHHHHHH
LDKEYVCNHLQSISDLSGANLRVIYDDPSWQPDKNSNLLKHLQEVYKEMYLEDANVSTIH
CCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEE
AGLETGIISSRLGGIESVTLGPWIEWPHTTRERVNISSTIRVYDFLKKSLERFQKF
CCHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]