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The map label for this gene is prs [H]

Identifier: 15594889

GI number: 15594889

Start: 553992

End: 555212

Strand: Direct

Name: prs [H]

Synonym: BB0544

Alternate gene names: 15594889

Gene position: 553992-555212 (Clockwise)

Preceding gene: 15594888

Following gene: 15594890

Centisome position: 60.83

GC content: 30.47

Gene sequence:

>1221_bases
GTGAATTTACTTAAAAAGAAATCAATAGGAATTATTGCTTGTCCTGGGGGTAGGGTTTTTGCTAGTAAAATAATAGAAGA
GCTTGACAGAATATTTATAAATATTGAAAATGAGATTATAGAGAGCATATGCCAAGATTCTAAAGCCTTAAAGGAAGAAA
TTTTTAAGATTGAAAAAGTTTTATCTCCTTTTTTAGAAGGACTTAGTTTGTCTACTCTTAAAAGCAAAGAGCCTTTAGAA
ATTCCTGTAAAATTTGTTAAATTTGCCAATGGTGAATTTAAAACAGAAATTTTAAAAACAATCAGAAATAAGGATATTTT
TATTGTTCAAGATGTTGCTAATGCTTATGAAGTTGAGATAAACAGTAGCGAAAAAATAATTATGACGGTTAATGATCACA
TAATGAATTTAATGACAACAATAGATGCCTGTATGCAGGCCAAAGCCAATTCTGTTAGTGTTATTATCCCGTCTTATCCT
TATTCAAGACAAGATAAAAAGCATTCAAGAGAATGCTTAACAGCAAGTCTTATTGGAAGATTTTTAGAAGAGTTGGGCAT
TAGACATATTTTAACCCTAGATATTCACTCAAAGGCTATTGAGAATGTCTTTAGGAAAGTTTATTTTGAAAATTTAAATG
TTTCTTATGAAATCTTTAATTCTCTTAAGGATTTAATCGACATTAGAGATTCTAATTTAGTTATTGTTTCACCCGATACA
GGTGCTGTAAGTAGAAATAAATTTTTTGCATCAAGCCTTAAGAGCCCTCTTGCTTTGCTTTATAAGGAGAGAGATTATTC
AAGAGTTTCAAATGATGTTGCTGATTCAAATATTTCTGTAACCAAGCTTTTAGGAGATGTCGAAGGCAAGAATGTTTTTA
TGAGTGACGACATGTTAGCTACTGGGGGCACTCTAATTAAGGCAATGAAATTACTTAAAAGCATGGGTGCTAAGAAGATT
ATATGTGGGATTAGTTTGCCGTTTTTCAATGGAGATGCTATTAAATATTTTGATAAAGCTTATGAGGAGGGATTTTTTTA
TAAAATAATTGGAACAAATGCTGTTTGTCATAATGATGAATTAATAAATAAACCTTGGTATCATGAGGCTAATGTTGCGC
CTCTTTTTGCGGAGGCAATATTTGCAATTTATAATAAAGTTGGTTTGCAAAAAATTCTTGATAGAAAGGATGATATTCAA
AAATTGATTACCAAGGGTTAA

Upstream 100 bases:

>100_bases
GACCTTGCTTTAAAAAATTTTAGTCATATTTGTGTGTATAAGTTTTATTAATTAGTAAATTAAGATTGTTAAGATTTTCT
AAAAAAGAACGAGGAGCTGG

Downstream 100 bases:

>100_bases
TTTATGAATGCTCTTAGTATTGATATTGGTACCAGTGTTTTAAAGGCAGCATTAGTTAGTTCTAAAAATGGAGTTTTAAG
TTATATTGATGTTAGTTACT

Product: phosphoribosylpyrophosphate synthetase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MNLLKKKSIGIIACPGGRVFASKIIEELDRIFINIENEIIESICQDSKALKEEIFKIEKVLSPFLEGLSLSTLKSKEPLE
IPVKFVKFANGEFKTEILKTIRNKDIFIVQDVANAYEVEINSSEKIIMTVNDHIMNLMTTIDACMQAKANSVSVIIPSYP
YSRQDKKHSRECLTASLIGRFLEELGIRHILTLDIHSKAIENVFRKVYFENLNVSYEIFNSLKDLIDIRDSNLVIVSPDT
GAVSRNKFFASSLKSPLALLYKERDYSRVSNDVADSNISVTKLLGDVEGKNVFMSDDMLATGGTLIKAMKLLKSMGAKKI
ICGISLPFFNGDAIKYFDKAYEEGFFYKIIGTNAVCHNDELINKPWYHEANVAPLFAEAIFAIYNKVGLQKILDRKDDIQ
KLITKG

Sequences:

>Translated_406_residues
MNLLKKKSIGIIACPGGRVFASKIIEELDRIFINIENEIIESICQDSKALKEEIFKIEKVLSPFLEGLSLSTLKSKEPLE
IPVKFVKFANGEFKTEILKTIRNKDIFIVQDVANAYEVEINSSEKIIMTVNDHIMNLMTTIDACMQAKANSVSVIIPSYP
YSRQDKKHSRECLTASLIGRFLEELGIRHILTLDIHSKAIENVFRKVYFENLNVSYEIFNSLKDLIDIRDSNLVIVSPDT
GAVSRNKFFASSLKSPLALLYKERDYSRVSNDVADSNISVTKLLGDVEGKNVFMSDDMLATGGTLIKAMKLLKSMGAKKI
ICGISLPFFNGDAIKYFDKAYEEGFFYKIIGTNAVCHNDELINKPWYHEANVAPLFAEAIFAIYNKVGLQKILDRKDDIQ
KLITKG
>Mature_406_residues
MNLLKKKSIGIIACPGGRVFASKIIEELDRIFINIENEIIESICQDSKALKEEIFKIEKVLSPFLEGLSLSTLKSKEPLE
IPVKFVKFANGEFKTEILKTIRNKDIFIVQDVANAYEVEINSSEKIIMTVNDHIMNLMTTIDACMQAKANSVSVIIPSYP
YSRQDKKHSRECLTASLIGRFLEELGIRHILTLDIHSKAIENVFRKVYFENLNVSYEIFNSLKDLIDIRDSNLVIVSPDT
GAVSRNKFFASSLKSPLALLYKERDYSRVSNDVADSNISVTKLLGDVEGKNVFMSDDMLATGGTLIKAMKLLKSMGAKKI
ICGISLPFFNGDAIKYFDKAYEEGFFYKIIGTNAVCHNDELINKPWYHEANVAPLFAEAIFAIYNKVGLQKILDRKDDIQ
KLITKG

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506129, Length=300, Percent_Identity=30.6666666666667, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI84875539, Length=303, Percent_Identity=30.3630363036304, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI4506127, Length=300, Percent_Identity=31, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI28557709, Length=300, Percent_Identity=29.3333333333333, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI4506133, Length=327, Percent_Identity=25.3822629969419, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI194018537, Length=319, Percent_Identity=25.3918495297806, Blast_Score=99, Evalue=7e-21,
Organism=Escherichia coli, GI1787458, Length=306, Percent_Identity=29.4117647058824, Blast_Score=143, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI25149168, Length=300, Percent_Identity=30.6666666666667, Blast_Score=131, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17554704, Length=300, Percent_Identity=30.6666666666667, Blast_Score=131, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI17554702, Length=300, Percent_Identity=30.6666666666667, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71989924, Length=300, Percent_Identity=30.6666666666667, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17570245, Length=316, Percent_Identity=24.0506329113924, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320946, Length=304, Percent_Identity=31.25, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6319403, Length=311, Percent_Identity=31.1897106109325, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6321776, Length=320, Percent_Identity=29.375, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6322667, Length=204, Percent_Identity=27.9411764705882, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21355239, Length=300, Percent_Identity=32.6666666666667, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI45551540, Length=323, Percent_Identity=30.3405572755418, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI281362873, Length=334, Percent_Identity=26.3473053892216, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24651454, Length=334, Percent_Identity=26.3473053892216, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24651458, Length=334, Percent_Identity=26.3473053892216, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24651456, Length=334, Percent_Identity=26.3473053892216, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24651462, Length=353, Percent_Identity=25.2124645892351, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24651464, Length=353, Percent_Identity=25.2124645892351, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI45552010, Length=353, Percent_Identity=25.2124645892351, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 45750; Mature: 45750

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLKKKSIGIIACPGGRVFASKIIEELDRIFINIENEIIESICQDSKALKEEIFKIEKV
CCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHH
LSPFLEGLSLSTLKSKEPLEIPVKFVKFANGEFKTEILKTIRNKDIFIVQDVANAYEVEI
HHHHHCCCCCHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCCCEEEEE
NSSEKIIMTVNDHIMNLMTTIDACMQAKANSVSVIIPSYPYSRQDKKHSRECLTASLIGR
CCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHH
FLEELGIRHILTLDIHSKAIENVFRKVYFENLNVSYEIFNSLKDLIDIRDSNLVIVSPDT
HHHHCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCC
GAVSRNKFFASSLKSPLALLYKERDYSRVSNDVADSNISVTKLLGDVEGKNVFMSDDMLA
CCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEEEECCCCHH
TGGTLIKAMKLLKSMGAKKIICGISLPFFNGDAIKYFDKAYEEGFFYKIIGTNAVCHNDE
CCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCEEEEECCCEEECCCH
LINKPWYHEANVAPLFAEAIFAIYNKVGLQKILDRKDDIQKLITKG
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure
MNLLKKKSIGIIACPGGRVFASKIIEELDRIFINIENEIIESICQDSKALKEEIFKIEKV
CCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHH
LSPFLEGLSLSTLKSKEPLEIPVKFVKFANGEFKTEILKTIRNKDIFIVQDVANAYEVEI
HHHHHCCCCCHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCCCEEEEE
NSSEKIIMTVNDHIMNLMTTIDACMQAKANSVSVIIPSYPYSRQDKKHSRECLTASLIGR
CCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHH
FLEELGIRHILTLDIHSKAIENVFRKVYFENLNVSYEIFNSLKDLIDIRDSNLVIVSPDT
HHHHCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCC
GAVSRNKFFASSLKSPLALLYKERDYSRVSNDVADSNISVTKLLGDVEGKNVFMSDDMLA
CCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEEEECCCCHH
TGGTLIKAMKLLKSMGAKKIICGISLPFFNGDAIKYFDKAYEEGFFYKIIGTNAVCHNDE
CCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCEEEEECCCEEECCCH
LINKPWYHEANVAPLFAEAIFAIYNKVGLQKILDRKDDIQKLITKG
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]