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Identifier: 15645732

GI number: 15645732

Start: 1182706

End: 1184409

Strand: Reverse

Name: Not Available

Synonym: HP1118

Alternate gene names: 15645732

Gene position: 1184409-1182706 (Counterclockwise)

Preceding gene: 15645733

Following gene: 15645731

Centisome position: 71.01

GC content: 43.49

Gene sequence:

>1704_bases
ATGAGACGGAGTTTTTTGAAAACGATTGGCTTGGGTGTGATAGCACTCTTTTTGGGTTTGTTAAACCCTTTGAGTGCGGC
GAGTTACCCCCCCATTAAAAACACTAAAGTAGGCTTAGCCCTTTCTAGCCACCCGCTAGCTAGTGAGATCGGGCAAAAGG
TTTTAGAAGAGGGAGGTAATGCGATTGATGCGGCTGTAGCGATAGGTTTTGCTCTTGCGGTTGTCCATCCGGCAGCAGGC
AATATTGGTGGAGGCGGTTTTGCGGTTATCCATTTGGCTAATGGTGAAAATGTTGCGTTAGATTTTAGAGAAAAAGCCCC
CTTAAAAGCCACTAAAAACATGTTTTTAGACAAGCAAGGCAATGTAGTCCCTAAACTCAGCGAAGATGGCTATTTGGCGG
CCGGGGTTCCTGGAACGGTGGCAGGCATGGAAGCGATGCTGAAAAAATACGGCACTAAAAAACTATCGCAACTCATTGAT
CCTGCCATTAAATTGGCTGAAAATGGTTATGCGATTTCACAAAGACAAGCAGAAACCCTAAAGGAAGCAAGGGAGCGGTT
TTTAAAATACAGTTCTAGCAAAAAGTATTTTTTTAAAAAAGGCCATCTTGATTATCAAGAAGGGGATTTGTTTGTCCAAA
AAGATTTAGCCAAGACTTTGAATCAAATCAAAACGCTAGGCGCTAAAGGCTTTTATCAAGGGCAAGTCGCTGAGCTTATT
GAGAAAGACATGAAAAAAAATGGAGGGATTATCACTAAAGAAGATTTAGCCAGTTACAATGTGAAATGGCGCAAACCCGT
GGTAGGGAGTTATCGTGGGTATAAGATCATTTCTATGTCGCCGCCAAGTTCGGGAGGCACGCATTTGATCCAGATTTTAA
ATGTCATGGAAAATGCGGATTTAAGCGCCCTTGGGTATGGGGCTTCTAAGAATATCCATATCGCTGCCGAAGCGATGCGT
CAGGCTTATGCGGATAGATCGGTTTATATGGGAGACGCTGATTTTGTTTCGGTGCCGGTGGATAAATTGATTAATAAAGC
GTATGCCAAAAAGATTTTTGACACTATCCAGCCAGATACGGTTACGCCAAGCTCTCAAATCAAACCAGGAATGGGGCAGT
TGCATGAGGGGAGCAATACCACGCATTATTCTGTAGCGGACAGGTGGGGGAATGCAGTCAGCGTTACTTACACCATTAAC
GCTTCTTATGGAAGCGCTGCCAGTATTGATGGGGCAGGATTTTTATTGAACAATGAAATGGATGATTTTTCCATCAAGCC
AGGGAATCCCAATCTCTATGGTTTAGTAGGGGGCGATGCGAATGCGATTGAAGCCAATAAGCGCCCTTTAAGCTCCATGT
CGCCTACGATTGTGTTGAAAAACAATAAGGTTTTTTTGGTGGTGGGAAGCCCTGGAGGGTCTAGGATTATCACTACGGTG
CTGCAAGTGATTTCTAATGTCATTGATTATAATATGAATATTTCTGAAGCGGTTTCAGCCCCAAGATTTCACATGCAATG
GCTCCCTGATGAATTAAGGATTGAAAAGTTTGGCATGCCCGCTGATGTGAAAGACAACCTCACTAAAATGGGCTATCAAA
TCGTTACTAAGCCGGTCATGGGTGATGTGAATGCGATCCAAGTTTTGCCTAAAACTAAAGGGAGCGTTTTCTATGGTTCA
ACGGATCCAAGGAAAGAATTTTAA

Upstream 100 bases:

>100_bases
ATTAATAGCATCATGTAAGTTATAAGCGAGAGAGTGTTTTGTAAAGCTTGTGTTATAATAACAAAGAAATTTTAAGCGTA
ACTGATTGAAAGGAAAACAG

Downstream 100 bases:

>100_bases
TTCTTTGTCATATACAGGTTTTTAATCCTATTTAGCCTTATTTTTTGGGATGGAGGGGGGCTTTTTAGCGAGAAAATCTT
AAATTTAGTTTTAAAATTCA

Product: gamma-glutamyltranspeptidase (ggt)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 567; Mature: 567

Protein sequence:

>567_residues
MRRSFLKTIGLGVIALFLGLLNPLSAASYPPIKNTKVGLALSSHPLASEIGQKVLEEGGNAIDAAVAIGFALAVVHPAAG
NIGGGGFAVIHLANGENVALDFREKAPLKATKNMFLDKQGNVVPKLSEDGYLAAGVPGTVAGMEAMLKKYGTKKLSQLID
PAIKLAENGYAISQRQAETLKEARERFLKYSSSKKYFFKKGHLDYQEGDLFVQKDLAKTLNQIKTLGAKGFYQGQVAELI
EKDMKKNGGIITKEDLASYNVKWRKPVVGSYRGYKIISMSPPSSGGTHLIQILNVMENADLSALGYGASKNIHIAAEAMR
QAYADRSVYMGDADFVSVPVDKLINKAYAKKIFDTIQPDTVTPSSQIKPGMGQLHEGSNTTHYSVADRWGNAVSVTYTIN
ASYGSAASIDGAGFLLNNEMDDFSIKPGNPNLYGLVGGDANAIEANKRPLSSMSPTIVLKNNKVFLVVGSPGGSRIITTV
LQVISNVIDYNMNISEAVSAPRFHMQWLPDELRIEKFGMPADVKDNLTKMGYQIVTKPVMGDVNAIQVLPKTKGSVFYGS
TDPRKEF

Sequences:

>Translated_567_residues
MRRSFLKTIGLGVIALFLGLLNPLSAASYPPIKNTKVGLALSSHPLASEIGQKVLEEGGNAIDAAVAIGFALAVVHPAAG
NIGGGGFAVIHLANGENVALDFREKAPLKATKNMFLDKQGNVVPKLSEDGYLAAGVPGTVAGMEAMLKKYGTKKLSQLID
PAIKLAENGYAISQRQAETLKEARERFLKYSSSKKYFFKKGHLDYQEGDLFVQKDLAKTLNQIKTLGAKGFYQGQVAELI
EKDMKKNGGIITKEDLASYNVKWRKPVVGSYRGYKIISMSPPSSGGTHLIQILNVMENADLSALGYGASKNIHIAAEAMR
QAYADRSVYMGDADFVSVPVDKLINKAYAKKIFDTIQPDTVTPSSQIKPGMGQLHEGSNTTHYSVADRWGNAVSVTYTIN
ASYGSAASIDGAGFLLNNEMDDFSIKPGNPNLYGLVGGDANAIEANKRPLSSMSPTIVLKNNKVFLVVGSPGGSRIITTV
LQVISNVIDYNMNISEAVSAPRFHMQWLPDELRIEKFGMPADVKDNLTKMGYQIVTKPVMGDVNAIQVLPKTKGSVFYGS
TDPRKEF
>Mature_567_residues
MRRSFLKTIGLGVIALFLGLLNPLSAASYPPIKNTKVGLALSSHPLASEIGQKVLEEGGNAIDAAVAIGFALAVVHPAAG
NIGGGGFAVIHLANGENVALDFREKAPLKATKNMFLDKQGNVVPKLSEDGYLAAGVPGTVAGMEAMLKKYGTKKLSQLID
PAIKLAENGYAISQRQAETLKEARERFLKYSSSKKYFFKKGHLDYQEGDLFVQKDLAKTLNQIKTLGAKGFYQGQVAELI
EKDMKKNGGIITKEDLASYNVKWRKPVVGSYRGYKIISMSPPSSGGTHLIQILNVMENADLSALGYGASKNIHIAAEAMR
QAYADRSVYMGDADFVSVPVDKLINKAYAKKIFDTIQPDTVTPSSQIKPGMGQLHEGSNTTHYSVADRWGNAVSVTYTIN
ASYGSAASIDGAGFLLNNEMDDFSIKPGNPNLYGLVGGDANAIEANKRPLSSMSPTIVLKNNKVFLVVGSPGGSRIITTV
LQVISNVIDYNMNISEAVSAPRFHMQWLPDELRIEKFGMPADVKDNLTKMGYQIVTKPVMGDVNAIQVLPKTKGSVFYGS
TDPRKEF

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=479, Percent_Identity=32.3590814196242, Blast_Score=213, Evalue=5e-55,
Organism=Homo sapiens, GI73915090, Length=479, Percent_Identity=32.3590814196242, Blast_Score=213, Evalue=5e-55,
Organism=Homo sapiens, GI73915096, Length=479, Percent_Identity=32.3590814196242, Blast_Score=213, Evalue=5e-55,
Organism=Homo sapiens, GI73915094, Length=479, Percent_Identity=32.3590814196242, Blast_Score=213, Evalue=5e-55,
Organism=Homo sapiens, GI113429324, Length=477, Percent_Identity=30.8176100628931, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI113429326, Length=481, Percent_Identity=30.3534303534304, Blast_Score=186, Evalue=8e-47,
Organism=Homo sapiens, GI109148539, Length=473, Percent_Identity=28.9640591966173, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI153266885, Length=552, Percent_Identity=25.5434782608696, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI153266901, Length=548, Percent_Identity=26.0948905109489, Blast_Score=136, Evalue=6e-32,
Organism=Homo sapiens, GI153266907, Length=551, Percent_Identity=24.8638838475499, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI30581157, Length=176, Percent_Identity=38.0681818181818, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI30581155, Length=176, Percent_Identity=38.0681818181818, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI218505805, Length=174, Percent_Identity=34.4827586206897, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI310124095, Length=174, Percent_Identity=31.0344827586207, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1789856, Length=537, Percent_Identity=52.7001862197393, Blast_Score=559, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI212646519, Length=499, Percent_Identity=35.0701402805611, Blast_Score=249, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI72000294, Length=499, Percent_Identity=35.0701402805611, Blast_Score=249, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI193208247, Length=551, Percent_Identity=33.3938294010889, Blast_Score=224, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI193208245, Length=551, Percent_Identity=33.3938294010889, Blast_Score=224, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17506189, Length=546, Percent_Identity=32.6007326007326, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17542894, Length=493, Percent_Identity=32.4543610547667, Blast_Score=195, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI72001495, Length=228, Percent_Identity=32.0175438596491, Blast_Score=109, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI72001497, Length=228, Percent_Identity=32.0175438596491, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17564448, Length=437, Percent_Identity=25.858123569794, Blast_Score=96, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6323330, Length=523, Percent_Identity=31.5487571701721, Blast_Score=188, Evalue=2e-48,
Organism=Drosophila melanogaster, GI161077496, Length=538, Percent_Identity=33.457249070632, Blast_Score=228, Evalue=6e-60,
Organism=Drosophila melanogaster, GI18859893, Length=521, Percent_Identity=31.6698656429942, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI45551474, Length=542, Percent_Identity=29.8892988929889, Blast_Score=210, Evalue=3e-54,
Organism=Drosophila melanogaster, GI161077880, Length=542, Percent_Identity=29.8892988929889, Blast_Score=210, Evalue=3e-54,
Organism=Drosophila melanogaster, GI24642670, Length=542, Percent_Identity=29.8892988929889, Blast_Score=210, Evalue=3e-54,
Organism=Drosophila melanogaster, GI24642666, Length=542, Percent_Identity=29.8892988929889, Blast_Score=210, Evalue=3e-54,
Organism=Drosophila melanogaster, GI161077878, Length=542, Percent_Identity=29.8892988929889, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI18859741, Length=531, Percent_Identity=28.060263653484, Blast_Score=162, Evalue=5e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 61152; Mature: 61152

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRSFLKTIGLGVIALFLGLLNPLSAASYPPIKNTKVGLALSSHPLASEIGQKVLEEGGN
CCHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCC
AIDAAVAIGFALAVVHPAAGNIGGGGFAVIHLANGENVALDFREKAPLKATKNMFLDKQG
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCEEEEECCCCCCCHHHHHHHCCCCC
NVVPKLSEDGYLAAGVPGTVAGMEAMLKKYGTKKLSQLIDPAIKLAENGYAISQRQAETL
CCCCCCCCCCEEEECCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCEEHHHHHHHH
KEARERFLKYSSSKKYFFKKGHLDYQEGDLFVQKDLAKTLNQIKTLGAKGFYQGQVAELI
HHHHHHHHHCCCCCCEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHH
EKDMKKNGGIITKEDLASYNVKWRKPVVGSYRGYKIISMSPPSSGGTHLIQILNVMENAD
HHHHHHCCCEEEHHHHHCCCCEECCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCC
LSALGYGASKNIHIAAEAMRQAYADRSVYMGDADFVSVPVDKLINKAYAKKIFDTIQPDT
CCEECCCCCCCEEHHHHHHHHHHCCCCEEECCCCEEECCHHHHHHHHHHHHHHHHCCCCC
VTPSSQIKPGMGQLHEGSNTTHYSVADRWGNAVSVTYTINASYGSAASIDGAGFLLNNEM
CCCHHCCCCCCCCCCCCCCCEEEEHHHHCCCEEEEEEEEECCCCCCCCCCCCEEEECCCC
DDFSIKPGNPNLYGLVGGDANAIEANKRPLSSMSPTIVLKNNKVFLVVGSPGGSRIITTV
CCCEECCCCCCEEEEECCCCCEECCCCCCCCCCCCEEEEECCEEEEEEECCCCHHHHHHH
LQVISNVIDYNMNISEAVSAPRFHMQWLPDELRIEKFGMPADVKDNLTKMGYQIVTKPVM
HHHHHHHHHCCCCHHHHHCCCCCEEECCCHHHHHHHCCCCCCHHHHHHHHCHHHEECCCC
GDVNAIQVLPKTKGSVFYGSTDPRKEF
CCCCEEEEEECCCCCEEECCCCCCCCC
>Mature Secondary Structure
MRRSFLKTIGLGVIALFLGLLNPLSAASYPPIKNTKVGLALSSHPLASEIGQKVLEEGGN
CCHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCC
AIDAAVAIGFALAVVHPAAGNIGGGGFAVIHLANGENVALDFREKAPLKATKNMFLDKQG
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCEEEEECCCCCCCHHHHHHHCCCCC
NVVPKLSEDGYLAAGVPGTVAGMEAMLKKYGTKKLSQLIDPAIKLAENGYAISQRQAETL
CCCCCCCCCCEEEECCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCEEHHHHHHHH
KEARERFLKYSSSKKYFFKKGHLDYQEGDLFVQKDLAKTLNQIKTLGAKGFYQGQVAELI
HHHHHHHHHCCCCCCEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHH
EKDMKKNGGIITKEDLASYNVKWRKPVVGSYRGYKIISMSPPSSGGTHLIQILNVMENAD
HHHHHHCCCEEEHHHHHCCCCEECCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCC
LSALGYGASKNIHIAAEAMRQAYADRSVYMGDADFVSVPVDKLINKAYAKKIFDTIQPDT
CCEECCCCCCCEEHHHHHHHHHHCCCCEEECCCCEEECCHHHHHHHHHHHHHHHHCCCCC
VTPSSQIKPGMGQLHEGSNTTHYSVADRWGNAVSVTYTINASYGSAASIDGAGFLLNNEM
CCCHHCCCCCCCCCCCCCCCEEEEHHHHCCCEEEEEEEEECCCCCCCCCCCCEEEECCCC
DDFSIKPGNPNLYGLVGGDANAIEANKRPLSSMSPTIVLKNNKVFLVVGSPGGSRIITTV
CCCEECCCCCCEEEEECCCCCEECCCCCCCCCCCCEEEEECCEEEEEEECCCCHHHHHHH
LQVISNVIDYNMNISEAVSAPRFHMQWLPDELRIEKFGMPADVKDNLTKMGYQIVTKPVM
HHHHHHHHHCCCCHHHHHCCCCCEEECCCHHHHHHHCCCCCCHHHHHHHHCHHHEECCCC
GDVNAIQVLPKTKGSVFYGSTDPRKEF
CCCCEEEEEECCCCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]