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Identifier: 16520005

GI number: 16520005

Start: 122680

End: 123786

Strand: Reverse

Name: Not Available

Synonym: NGR_a01000

Alternate gene names: 16520005

Gene position: 123786-122680 (Counterclockwise)

Preceding gene: 16520004

Following gene: 16520006

Centisome position: 23.09

GC content: 53.66

Gene sequence:

>1107_bases
ATGGAGAGAACTATGTCTGATGCAAAGCTGCAACGCGTACTTTCGTCTCTTACGGAAGTGTACAGACAGCTAAATTCTCT
GCCGTCCAGTCAGCCATCTGACGCCGGCTATGTCAAACTCGATACAAACGAGAATCCATTTGCGTTGCCAAAAGCGGTAA
TGCAGAGCGCAGTTGCTGCTCTCGAGCGGCAGTATTTATATCCAGAGGATGACAACATCAGTTTGCGGGAAGCCGCCGCT
GCGTCCTATGATCTTTCCGCGGATCAGGTGATCGCCGGTAACGGTTCGTCCGAACTTCTTTCGCTCATATATAAAGCATT
CCTTGGTCCGGGTGACAGTGTCGCGATGCTGTCGCCCGGCTTTGCATACAACCGCAAGCTCGCCCAGTTGCAAGGTGCTC
GATTACTTGAAATCAAATGGGGCGAGTCGTCCTTGTTGCCGATACACGAATTGCTCTTCGGTCCTGCAAAGCAGGCAAAG
TTCATCCTGCTGGCTAATCCGAACAACCCGACAGGAACATTTGTCCCGATTGCTGATATTGAAAGCCTCGTCGCACTATC
TGACCAGTTGGTGGTACTCGATGAGGCCTACGTGGACTTCGCTCCCGACAGCGCTCTGCGTCTCGTTAACCGCTATTCGA
ATCTTCTGCTCTTAAGAACGTTTTCGAAGAGCTATGCGGCGGCCGGCATTCGCGTCGGCTTCGGCTTCGGTCATCCTGAG
GTGATAGGGAGGCTGCGCAATATCCAGAACATGTTCAATATGAATGTGATCGGCCATGCGGTTGGCGTCAGCATCCTGGC
CCACCGCGCCACCTATAATGAGAACCACCGCCATATCAGGCATGAGAGAGAGCGGGTGAGGGTGGCGCTGTCGCGACTTG
GGTTCTCTGTAACGCCCTCCCATGCAAACTTTTTGCTGGCGCGGGTGCCTGCAGGACGAGACGGCGTTTGGTGGCACGCC
TGCTTGAAACGGAAAAAGATACTCGTGGCCGTTCTTCCCGATGAAGGTCTGGAAGATTGCATTCGCGTCAGCATCGGGAC
GAAACCACAAATGGATGCGTTTCTTGCGGCTGTCGAGGACATTTCGGGAGCTCAGCAATCTCGATGA

Upstream 100 bases:

>100_bases
AATAGAAGAACGCTCATCAAGTTGGAGTCAGTGAATGTGCGGCACTGTTAGCCCAACTCGCGTTGACTGTCGGACAAAGC
GACTATCCTCTAGGAATTGA

Downstream 100 bases:

>100_bases
TGGGACCGTATAGCAGCTTCAGGCTCGGCTCTTTTGCACGTGGGAAAAGACAGTGGCGACAGGAAAGAGAGCGACAACCG
GAAGACTGGTCTCCCACAGC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MERTMSDAKLQRVLSSLTEVYRQLNSLPSSQPSDAGYVKLDTNENPFALPKAVMQSAVAALERQYLYPEDDNISLREAAA
ASYDLSADQVIAGNGSSELLSLIYKAFLGPGDSVAMLSPGFAYNRKLAQLQGARLLEIKWGESSLLPIHELLFGPAKQAK
FILLANPNNPTGTFVPIADIESLVALSDQLVVLDEAYVDFAPDSALRLVNRYSNLLLLRTFSKSYAAAGIRVGFGFGHPE
VIGRLRNIQNMFNMNVIGHAVGVSILAHRATYNENHRHIRHERERVRVALSRLGFSVTPSHANFLLARVPAGRDGVWWHA
CLKRKKILVAVLPDEGLEDCIRVSIGTKPQMDAFLAAVEDISGAQQSR

Sequences:

>Translated_368_residues
MERTMSDAKLQRVLSSLTEVYRQLNSLPSSQPSDAGYVKLDTNENPFALPKAVMQSAVAALERQYLYPEDDNISLREAAA
ASYDLSADQVIAGNGSSELLSLIYKAFLGPGDSVAMLSPGFAYNRKLAQLQGARLLEIKWGESSLLPIHELLFGPAKQAK
FILLANPNNPTGTFVPIADIESLVALSDQLVVLDEAYVDFAPDSALRLVNRYSNLLLLRTFSKSYAAAGIRVGFGFGHPE
VIGRLRNIQNMFNMNVIGHAVGVSILAHRATYNENHRHIRHERERVRVALSRLGFSVTPSHANFLLARVPAGRDGVWWHA
CLKRKKILVAVLPDEGLEDCIRVSIGTKPQMDAFLAAVEDISGAQQSR
>Mature_368_residues
MERTMSDAKLQRVLSSLTEVYRQLNSLPSSQPSDAGYVKLDTNENPFALPKAVMQSAVAALERQYLYPEDDNISLREAAA
ASYDLSADQVIAGNGSSELLSLIYKAFLGPGDSVAMLSPGFAYNRKLAQLQGARLLEIKWGESSLLPIHELLFGPAKQAK
FILLANPNNPTGTFVPIADIESLVALSDQLVVLDEAYVDFAPDSALRLVNRYSNLLLLRTFSKSYAAAGIRVGFGFGHPE
VIGRLRNIQNMFNMNVIGHAVGVSILAHRATYNENHRHIRHERERVRVALSRLGFSVTPSHANFLLARVPAGRDGVWWHA
CLKRKKILVAVLPDEGLEDCIRVSIGTKPQMDAFLAAVEDISGAQQSR

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=328, Percent_Identity=27.7439024390244, Blast_Score=102, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6322075, Length=280, Percent_Identity=26.7857142857143, Blast_Score=92, Evalue=9e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_RHISN (P55683)

Other databases:

- EMBL:   U00090
- RefSeq:   NP_444125.1
- ProteinModelPortal:   P55683
- SMR:   P55683
- GeneID:   962488
- GenomeReviews:   U00090_GR
- KEGG:   rhi:NGR_a01000
- HOGENOM:   HBG646350
- ProtClustDB:   CLSK506468
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 40422; Mature: 40422

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERTMSDAKLQRVLSSLTEVYRQLNSLPSSQPSDAGYVKLDTNENPFALPKAVMQSAVAA
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHH
LERQYLYPEDDNISLREAAAASYDLSADQVIAGNGSSELLSLIYKAFLGPGDSVAMLSPG
HHHHCCCCCCCCCCHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCEEEECCC
FAYNRKLAQLQGARLLEIKWGESSLLPIHELLFGPAKQAKFILLANPNNPTGTFVPIADI
CHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHCCCCCCCEEEEEECCCCCCCCEEEHHHH
ESLVALSDQLVVLDEAYVDFAPDSALRLVNRYSNLLLLRTFSKSYAAAGIRVGFGFGHPE
HHHHHHCCCEEEEEHHHHCCCCHHHHHHHHHHHCEEEEEEHHHHHHHCCEEEECCCCCHH
VIGRLRNIQNMFNMNVIGHAVGVSILAHRATYNENHRHIRHERERVRVALSRLGFSVTPS
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEECCC
HANFLLARVPAGRDGVWWHACLKRKKILVAVLPDEGLEDCIRVSIGTKPQMDAFLAAVED
CCCEEEEECCCCCCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHH
ISGAQQSR
HCCCCCCC
>Mature Secondary Structure
MERTMSDAKLQRVLSSLTEVYRQLNSLPSSQPSDAGYVKLDTNENPFALPKAVMQSAVAA
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHH
LERQYLYPEDDNISLREAAAASYDLSADQVIAGNGSSELLSLIYKAFLGPGDSVAMLSPG
HHHHCCCCCCCCCCHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCEEEECCC
FAYNRKLAQLQGARLLEIKWGESSLLPIHELLFGPAKQAKFILLANPNNPTGTFVPIADI
CHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHCCCCCCCEEEEEECCCCCCCCEEEHHHH
ESLVALSDQLVVLDEAYVDFAPDSALRLVNRYSNLLLLRTFSKSYAAAGIRVGFGFGHPE
HHHHHHCCCEEEEEHHHHCCCCHHHHHHHHHHHCEEEEEEHHHHHHHCCEEEECCCCCHH
VIGRLRNIQNMFNMNVIGHAVGVSILAHRATYNENHRHIRHERERVRVALSRLGFSVTPS
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEECCC
HANFLLARVPAGRDGVWWHACLKRKKILVAVLPDEGLEDCIRVSIGTKPQMDAFLAAVED
CCCEEEEECCCCCCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHH
ISGAQQSR
HCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424