Click here to switch to the map view.

The map label for this gene is Not Available

Identifier: 16519873

GI number: 16519873

Start: 304245

End: 305762

Strand: Reverse

Name: Not Available

Synonym: NGR_a02320

Alternate gene names: 16519873

Gene position: 305762-304245 (Counterclockwise)

Preceding gene: 16519872

Following gene: 16519878

Centisome position: 57.03

GC content: 58.96

Gene sequence:

>1518_bases
ATGAAGGGCGGGTTTTCGTTGAACAGCGAACTGCAACTGGAAGCCGATGCGGTGATAATCGGTTCCGGCGCGGGCGGTGC
AAGCGTTGCTGATGTACTTACAGCTGCCGGTTTATATGTGATCATGCTTGAAGAAGGTGGGCATGTTCCCTCATCATCGG
CTTCTCCTTTCGCGAGTGAAGCATTCGCGGCAGCCTGGCGCGGCGGAGGATTAACCGCGGCGATCGGCCGCCCCCCTATT
GCTTATGCGGAGGGCCGCTGCGTTGGGGGAGGGACAGAAATCAACAGCGCGATTGCCCAGCGCGCCGATAGCGACCTCCT
TGATCAATGGCGCAAGCTTTACAAGATCGAGAATTTTACCCCGGACGAACTGTCGCAATATTATGGTCGCGCGGAGACAA
CGGTGAATGCGAGCCTGACCCCCGGCCCACTCGGGCGTCCCACCGACATTCTGCGGCTGGGTGGGGAAGCGCTTGGCTGG
AAAGTTTCGGAGCTGAAACGGGGGCAGCGTGACTGCAAGGGCGCCAATCGGTGTTCTTTCATTTGTCCGAATGGTGCCAA
GCAGTCGATGGCGGTGACCCTTCTCCCAAAGTCGATGGATCGCGGCATGCGGCTGCTTGCGCGAACGCGCGTAGACAAGA
TCCGTATCGAGAAAGGACGTGCCGCAGTGGTCGTCGCTCAGTTGCAGGACGCCGGCGGACAGGGCGTGCACGTGCGCGTA
AAAGCGGGACTTGTGTTTGTCTGCGCGGGAGCAATTCATACGCCAGCGCTTTTGCGTCGTTCTGGCCTGCGTAAACGCAT
TGGCGATACCCTGCGCATTCATCCGACGATCAGAGCGACGGCACTTTTTGATGAACCCGTTGATGCGCACCAGTCGCGCC
TTCCGCTGACAGCCGTTACCGAATTCATGCCCGAGCAGCGCATAGGCGGGTCGGTGTTCACGCCGGCTGTCTTTGGCCTT
TCACTTGCGGAAGACTGGACCAATCGCGGCGATCTGATGCAGGCTTGGCGTTTATGCGGCTCTTATTACGGCATGATACG
ACCGCGCGGAGTGGGTTCAGTGAGACCTCTTCCCGGTATTAATGAACCGCTTGTCAGTTTCAAACTCGCGCCTGAGGACT
GGATCTCTTTGGGCCAGGTTCTCACCCTCCTCGGACAGGCGATGTTTGCGGCCGGTGCCCGGAAGGTAATCCCAAGTATA
TCGGGCCACGAGGGCTGGACAAACCCTGATGAGGTCGATGAATTCCGGAACAAGCCTCTGCCTGAAAAAGCGACCAACCT
GATGACCATACATCTGTTTTCCACCTGCCCACCCGGCGAGCATCGGGACGCTTGTGCAGTCGACAGTTACGGACGTGTGC
GGGGCGTCGAAAACCTCTTTGTCGCCGATGGCAGCGTCATTCCTGAGGCGCCCGGCGTCAATCCCCAGATGACGATCATG
GCTCTGGCGTTCCGGATAGCGGAAGCGGCACTCAGTCATTCCTCTCGAGAACGCGCCCAATCGGCCGCAAGGGAGTAA

Upstream 100 bases:

>100_bases
GCCTTTATCGCTCGATGACGCTGCTTGCATTTTATGATGAAGCGCCGGTAGCCGAAAAGCTGTTGGCTGCACGGCCTGCT
CAAACCTCATAGGCTTGAAT

Downstream 100 bases:

>100_bases
GTGTTATACATTAAGGTCCAGTAGTGAGGACCGGGAATTGCAGCCCAGGGGAACTATCGATAAATGCGCCACTTGCCCTT
CTTCTCGGAAACAAGCTTGT

Product: GMC-type oxidoreductase

Products: Betaine Aldehyde; Reduced Acceptor. [C]

Alternate protein names: NA

Number of amino acids: Translated: 505; Mature: 505

Protein sequence:

>505_residues
MKGGFSLNSELQLEADAVIIGSGAGGASVADVLTAAGLYVIMLEEGGHVPSSSASPFASEAFAAAWRGGGLTAAIGRPPI
AYAEGRCVGGGTEINSAIAQRADSDLLDQWRKLYKIENFTPDELSQYYGRAETTVNASLTPGPLGRPTDILRLGGEALGW
KVSELKRGQRDCKGANRCSFICPNGAKQSMAVTLLPKSMDRGMRLLARTRVDKIRIEKGRAAVVVAQLQDAGGQGVHVRV
KAGLVFVCAGAIHTPALLRRSGLRKRIGDTLRIHPTIRATALFDEPVDAHQSRLPLTAVTEFMPEQRIGGSVFTPAVFGL
SLAEDWTNRGDLMQAWRLCGSYYGMIRPRGVGSVRPLPGINEPLVSFKLAPEDWISLGQVLTLLGQAMFAAGARKVIPSI
SGHEGWTNPDEVDEFRNKPLPEKATNLMTIHLFSTCPPGEHRDACAVDSYGRVRGVENLFVADGSVIPEAPGVNPQMTIM
ALAFRIAEAALSHSSRERAQSAARE

Sequences:

>Translated_505_residues
MKGGFSLNSELQLEADAVIIGSGAGGASVADVLTAAGLYVIMLEEGGHVPSSSASPFASEAFAAAWRGGGLTAAIGRPPI
AYAEGRCVGGGTEINSAIAQRADSDLLDQWRKLYKIENFTPDELSQYYGRAETTVNASLTPGPLGRPTDILRLGGEALGW
KVSELKRGQRDCKGANRCSFICPNGAKQSMAVTLLPKSMDRGMRLLARTRVDKIRIEKGRAAVVVAQLQDAGGQGVHVRV
KAGLVFVCAGAIHTPALLRRSGLRKRIGDTLRIHPTIRATALFDEPVDAHQSRLPLTAVTEFMPEQRIGGSVFTPAVFGL
SLAEDWTNRGDLMQAWRLCGSYYGMIRPRGVGSVRPLPGINEPLVSFKLAPEDWISLGQVLTLLGQAMFAAGARKVIPSI
SGHEGWTNPDEVDEFRNKPLPEKATNLMTIHLFSTCPPGEHRDACAVDSYGRVRGVENLFVADGSVIPEAPGVNPQMTIM
ALAFRIAEAALSHSSRERAQSAARE
>Mature_505_residues
MKGGFSLNSELQLEADAVIIGSGAGGASVADVLTAAGLYVIMLEEGGHVPSSSASPFASEAFAAAWRGGGLTAAIGRPPI
AYAEGRCVGGGTEINSAIAQRADSDLLDQWRKLYKIENFTPDELSQYYGRAETTVNASLTPGPLGRPTDILRLGGEALGW
KVSELKRGQRDCKGANRCSFICPNGAKQSMAVTLLPKSMDRGMRLLARTRVDKIRIEKGRAAVVVAQLQDAGGQGVHVRV
KAGLVFVCAGAIHTPALLRRSGLRKRIGDTLRIHPTIRATALFDEPVDAHQSRLPLTAVTEFMPEQRIGGSVFTPAVFGL
SLAEDWTNRGDLMQAWRLCGSYYGMIRPRGVGSVRPLPGINEPLVSFKLAPEDWISLGQVLTLLGQAMFAAGARKVIPSI
SGHEGWTNPDEVDEFRNKPLPEKATNLMTIHLFSTCPPGEHRDACAVDSYGRVRGVENLFVADGSVIPEAPGVNPQMTIM
ALAFRIAEAALSHSSRERAQSAARE

Specific function: Can Catalyze The Oxidation Of Choline To Betaine Aldehyde And Betaine Aldehyde To Glycine Betaine At The Same Rate. [C]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y4NJ_RHISN (P55582)

Other databases:

- EMBL:   U00090
- RefSeq:   NP_443993.1
- ProteinModelPortal:   P55582
- SMR:   P55582
- GeneID:   962379
- GenomeReviews:   U00090_GR
- KEGG:   rhi:NGR_a02320
- HOGENOM:   HBG655914
- ProtClustDB:   CLSK544539
- InterPro:   IPR000172
- InterPro:   IPR007867

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N

EC number: 1.1.99.1 [C]

Molecular weight: Translated: 54001; Mature: 54001

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: PS00623 GMC_OXRED_1

Important sites: ACT_SITE 431-431

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGGFSLNSELQLEADAVIIGSGAGGASVADVLTAAGLYVIMLEEGGHVPSSSASPFASE
CCCCCCCCCCEEEEECEEEEECCCCCHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCHHH
AFAAAWRGGGLTAAIGRPPIAYAEGRCVGGGTEINSAIAQRADSDLLDQWRKLYKIENFT
HHHHHHCCCCEEEECCCCCCEECCCEEECCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCC
PDELSQYYGRAETTVNASLTPGPLGRPTDILRLGGEALGWKVSELKRGQRDCKGANRCSF
HHHHHHHHCCCCCEEECCCCCCCCCCCHHHHHHCCHHHCCCHHHHHCCHHHCCCCCCCEE
ICPNGAKQSMAVTLLPKSMDRGMRLLARTRVDKIRIEKGRAAVVVAQLQDAGGQGVHVRV
ECCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHEEEECCCEEEEEEEECCCCCCCEEEEE
KAGLVFVCAGAIHTPALLRRSGLRKRIGDTLRIHPTIRATALFDEPVDAHQSRLPLTAVT
ECCEEEEECCHHHHHHHHHHHHHHHHHCCCEEECCCEEEEEEECCCHHHHHHCCCHHHHH
EFMPEQRIGGSVFTPAVFGLSLAEDWTNRGDLMQAWRLCGSYYGMIRPRGVGSVRPLPGI
HHCCHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NEPLVSFKLAPEDWISLGQVLTLLGQAMFAAGARKVIPSISGHEGWTNPDEVDEFRNKPL
CCCHHEEEECHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCHHHHHHHHCCCC
PEKATNLMTIHLFSTCPPGEHRDACAVDSYGRVRGVENLFVADGSVIPEAPGVNPQMTIM
CHHHCCEEEEEEEECCCCCCCCCCCCCCCCCHHCCCCEEEEECCCCCCCCCCCCCHHHHH
ALAFRIAEAALSHSSRERAQSAARE
HHHHHHHHHHHHCHHHHHHHHHCCC
>Mature Secondary Structure
MKGGFSLNSELQLEADAVIIGSGAGGASVADVLTAAGLYVIMLEEGGHVPSSSASPFASE
CCCCCCCCCCEEEEECEEEEECCCCCHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCHHH
AFAAAWRGGGLTAAIGRPPIAYAEGRCVGGGTEINSAIAQRADSDLLDQWRKLYKIENFT
HHHHHHCCCCEEEECCCCCCEECCCEEECCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCC
PDELSQYYGRAETTVNASLTPGPLGRPTDILRLGGEALGWKVSELKRGQRDCKGANRCSF
HHHHHHHHCCCCCEEECCCCCCCCCCCHHHHHHCCHHHCCCHHHHHCCHHHCCCCCCCEE
ICPNGAKQSMAVTLLPKSMDRGMRLLARTRVDKIRIEKGRAAVVVAQLQDAGGQGVHVRV
ECCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHEEEECCCEEEEEEEECCCCCCCEEEEE
KAGLVFVCAGAIHTPALLRRSGLRKRIGDTLRIHPTIRATALFDEPVDAHQSRLPLTAVT
ECCEEEEECCHHHHHHHHHHHHHHHHHCCCEEECCCEEEEEEECCCHHHHHHCCCHHHHH
EFMPEQRIGGSVFTPAVFGLSLAEDWTNRGDLMQAWRLCGSYYGMIRPRGVGSVRPLPGI
HHCCHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NEPLVSFKLAPEDWISLGQVLTLLGQAMFAAGARKVIPSISGHEGWTNPDEVDEFRNKPL
CCCHHEEEECHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCHHHHHHHHCCCC
PEKATNLMTIHLFSTCPPGEHRDACAVDSYGRVRGVENLFVADGSVIPEAPGVNPQMTIM
CHHHCCEEEEEEEECCCCCCCCCCCCCCCCCHHCCCCEEEEECCCCCCCCCCCCCHHHHH
ALAFRIAEAALSHSSRERAQSAARE
HHHHHHHHHHHHCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Coenzyme Q [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 7 {choline}} 1.1 {phenazine}} [C]

Substrates: Choline; Acceptor [C]

Specific reaction: Choline + Acceptor = Betaine Aldehyde + Reduced Acceptor. [C]

General reaction: Redox reaction [C]

Inhibitor: 2-Dimethylaminoethanol; Betaine aldehyde; Monoethanolamine; Semicarbazide [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9163424