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The map label for this gene is pheA

Identifier: 15668818

GI number: 15668818

Start: 567093

End: 567911

Strand: Reverse

Name: pheA

Synonym: MJ0637

Alternate gene names: 15668818

Gene position: 567911-567093 (Counterclockwise)

Preceding gene: 15668819

Following gene: 15668803

Centisome position: 34.11

GC content: 27.11

Gene sequence:

>819_bases
ATGAATAAAGCAGTTATTTATACATTACCAAAAGGAACGTATAGTGAAAAAGCTACAAAGAAATTTTTAGACTACATTGA
TGGAGATTATAAAATAGATTATTGCAATTCCATATATGATGTGTTTGAAAGAGTAGATAACAATGGCTTAGGAGTTGTTC
CAATAGAAAACTCTATTGAAGGTTCTGTATCTTTAACTCAAGATTTATTATTGCAATTTAAAGATATTAAAATATTAGGA
GAGTTAGCTTTGGATATACACCACAATTTAATTGGTTATGATAAAAATAAGATAAAGACAGTTATTTCTCATCCGCAGGC
ATTAGCTCAATGTAGAAATTATATAAAAAAGCACGGTTGGGATGTTAAAGCAGTGGAAAGCACAGCTAAGGCTGTGAAAA
TTGTTGCTGAAAGTAAAGATGAAACTTTAGGAGCTATTGGCTCAAAGGAATCTGCAGAACATTATAATTTAAAAATATTG
GATGAAAATATTGAAGATTATAAAAATAATAAGACAAGGTTTATTTTAATTGGTAAAAAAGTTAAATTTAAATATCATCC
AAAAAATTATAAAGTTTCAATTGTTTTTGAGTTAAAAGAAGATAAACCTGGAGCTTTATATCATATTTTAAAGGAGTTTG
CTGAAAGAAATATAAATTTAACAAGGATTGAGTCAAGACCTTCAAAAAAGAGGTTGGGAACTTACATATTTTACATTGAC
TTTGAAAATAATAAGGAAAAGTTAGAAGAAATTTTAAAATCTTTGGAGAGGCATACAACATTTATCAATCTTTTAGGAAA
ATACCCAGTTTTTGATTAA

Upstream 100 bases:

>100_bases
TTTTATCAAAAATCATAGAATATTGGAAGCCAGTGGATAAAAAACTCTCAAAAATTTTTAAAAATAAAGGGCAGTTTTTA
ATTATTGAGATGGTGAAAGA

Downstream 100 bases:

>100_bases
TTATTTTTTTGTTCTTTGTTTTTATGACCTGAACTCTTTATAAAATATGTCAGTTGATGGATGAACTTCCATGAAGTTGT
TATAAACATCTATCCCCCTA

Product: prephenate dehydratase

Products: NA

Alternate protein names: PDT; MjPDT

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MNKAVIYTLPKGTYSEKATKKFLDYIDGDYKIDYCNSIYDVFERVDNNGLGVVPIENSIEGSVSLTQDLLLQFKDIKILG
ELALDIHHNLIGYDKNKIKTVISHPQALAQCRNYIKKHGWDVKAVESTAKAVKIVAESKDETLGAIGSKESAEHYNLKIL
DENIEDYKNNKTRFILIGKKVKFKYHPKNYKVSIVFELKEDKPGALYHILKEFAERNINLTRIESRPSKKRLGTYIFYID
FENNKEKLEEILKSLERHTTFINLLGKYPVFD

Sequences:

>Translated_272_residues
MNKAVIYTLPKGTYSEKATKKFLDYIDGDYKIDYCNSIYDVFERVDNNGLGVVPIENSIEGSVSLTQDLLLQFKDIKILG
ELALDIHHNLIGYDKNKIKTVISHPQALAQCRNYIKKHGWDVKAVESTAKAVKIVAESKDETLGAIGSKESAEHYNLKIL
DENIEDYKNNKTRFILIGKKVKFKYHPKNYKVSIVFELKEDKPGALYHILKEFAERNINLTRIESRPSKKRLGTYIFYID
FENNKEKLEEILKSLERHTTFINLLGKYPVFD
>Mature_272_residues
MNKAVIYTLPKGTYSEKATKKFLDYIDGDYKIDYCNSIYDVFERVDNNGLGVVPIENSIEGSVSLTQDLLLQFKDIKILG
ELALDIHHNLIGYDKNKIKTVISHPQALAQCRNYIKKHGWDVKAVESTAKAVKIVAESKDETLGAIGSKESAEHYNLKIL
DENIEDYKNNKTRFILIGKKVKFKYHPKNYKVSIVFELKEDKPGALYHILKEFAERNINLTRIESRPSKKRLGTYIFYID
FENNKEKLEEILKSLERHTTFINLLGKYPVFD

Specific function: L-phenylalanine biosynthesis. [C]

COG id: COG0077

COG function: function code E; Prephenate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate dehydratase domain

Homologues:

Organism=Escherichia coli, GI1788951, Length=268, Percent_Identity=30.5970149253731, Blast_Score=128, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6324013, Length=324, Percent_Identity=25, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PHEA_METJA (Q58054)

Other databases:

- EMBL:   L77117
- PIR:   E64379
- RefSeq:   NP_247621.1
- ProteinModelPortal:   Q58054
- SMR:   Q58054
- GeneID:   1451503
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0637
- NMPDR:   fig|243232.1.peg.658
- TIGR:   MJ0637
- HOGENOM:   HBG693866
- OMA:   NCTRFVL
- ProtClustDB:   PRK11898
- BioCyc:   MJAN243232:MJ_0637-MONOMER
- BRENDA:   4.2.1.51
- InterPro:   IPR002912
- InterPro:   IPR001086
- InterPro:   IPR018528

Pfam domain/function: PF01842 ACT; PF00800 PDT

EC number: =4.2.1.51

Molecular weight: Translated: 31415; Mature: 31415

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: PS00857 PREPHENATE_DEHYDR_1; PS00858 PREPHENATE_DEHYDR_2; PS51171 PREPHENATE_DEHYDR_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKAVIYTLPKGTYSEKATKKFLDYIDGDYKIDYCNSIYDVFERVDNNGLGVVPIENSIE
CCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCEEEEEECCCCC
GSVSLTQDLLLQFKDIKILGELALDIHHNLIGYDKNKIKTVISHPQALAQCRNYIKKHGW
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHCCC
DVKAVESTAKAVKIVAESKDETLGAIGSKESAEHYNLKILDENIEDYKNNKTRFILIGKK
CCHHHHHHHHHHHHEECCCCCHHHCCCCCCCCCCEEEEEECCCHHHHCCCCEEEEEEEEE
VKFKYHPKNYKVSIVFELKEDKPGALYHILKEFAERNINLTRIESRPSKKRLGTYIFYID
EEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEEE
FENNKEKLEEILKSLERHTTFINLLGKYPVFD
ECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNKAVIYTLPKGTYSEKATKKFLDYIDGDYKIDYCNSIYDVFERVDNNGLGVVPIENSIE
CCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCEEEEEECCCCC
GSVSLTQDLLLQFKDIKILGELALDIHHNLIGYDKNKIKTVISHPQALAQCRNYIKKHGW
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHCCC
DVKAVESTAKAVKIVAESKDETLGAIGSKESAEHYNLKILDENIEDYKNNKTRFILIGKK
CCHHHHHHHHHHHHEECCCCCHHHCCCCCCCCCCEEEEEECCCHHHHCCCCEEEEEEEEE
VKFKYHPKNYKVSIVFELKEDKPGALYHILKEFAERNINLTRIESRPSKKRLGTYIFYID
EEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEEE
FENNKEKLEEILKSLERHTTFINLLGKYPVFD
ECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087