Definition | Methanocaldococcus jannaschii DSM 2661 chromosome, complete genome. |
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Accession | NC_000909 |
Length | 1,664,970 |
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The map label for this gene is hemC
Identifier: 15668749
GI number: 15668749
Start: 505220
End: 506098
Strand: Reverse
Name: hemC
Synonym: MJ0569
Alternate gene names: 15668749
Gene position: 506098-505220 (Counterclockwise)
Preceding gene: 15668750
Following gene: 15668747
Centisome position: 30.4
GC content: 31.29
Gene sequence:
>879_bases ATGATTAGAATAGGGACAAGAGGTAGTAAATTGGCATTATATCAAGCTAACAAAGTGGCTGAACTATTAAAAAATCTTGG TTATAAGGTAGAAATAAAGATAATTAAAACTACTGGAGATAGGGTTTTAGATAAAAAGCTATCGGATATAGGTATTGGCG TTTTTACAAAGGAGTTAGATTTAGCCATGTTAAATAACGAAATTGATATAGCAGTTCATAGCTTAAAAGACATTCCAACT ATTTGGAATGAAAATTTAATGGTTGGGGCTGTTTTGGAGAGAGATAGCTATCACGACTTGCTAATATGGAATAAGGATAT AGATTTTAATGAAGATAGTAAAATAGTTATAGGAACTTCAAGTATGAGGAGGAGGGCTTTTTTAAAGTTTATTTATCCAA ATGCAAAATTTGAGTTATTGAGGGGAAATGTAGATACAAGATTAAGAAAGCTAAAAGAAGGGCTTTATGATGCTATTGTT TTATCTGAAGCTGGAATAATAAGATTGGGAGTTAGTTTAGAGGATTTTAACTATAAAAGATTGGATATCCTTCCAGCTCC TGCTCAAGGAATTATAGCCGTTGCTTGCAAAAGAGATGATGAGGAAATGAAAAGCATCTTAAAAGAGATTAACCATGAAA GAACTTACTTAGAGAGTTTATGTGAAAGAACTGCATTAAATGAATTTGGAGGAGGTTGTAGTGTTCCATTTGGAGCTTTA GCAGTTTATGATGAAAAAAATGAGTTATTAAAATTAAAAGCTGCAGTTGTTACCAACGATGAGTTAAAAAATGCCTCTGG AGAGGTTAAATGTAAAATTGATGAGATTGATAAGGCAGTTGAATTAGGGAAAAAAATTGGACTAAAATTAAAAAATTAA
Upstream 100 bases:
>100_bases GAGGATAGAGGTTGTTGAGGCAGAGATAGAATGGCATGAAACTTGGGGAATTTACCATATAAAAAAGGCAAAATTGGTTG ATAAAGAATAAAGGGAGATT
Downstream 100 bases:
>100_bases ACTTTATCTTTAAATTTCTCCATAAAAATTTTTAATCTCTCTAATATTTCATCTGATAATGCATGTTCTAATTTGCAAGC TTCTTCAGATGCTGTTTTTT
Product: porphobilinogen deaminase
Products: NA
Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase
Number of amino acids: Translated: 292; Mature: 292
Protein sequence:
>292_residues MIRIGTRGSKLALYQANKVAELLKNLGYKVEIKIIKTTGDRVLDKKLSDIGIGVFTKELDLAMLNNEIDIAVHSLKDIPT IWNENLMVGAVLERDSYHDLLIWNKDIDFNEDSKIVIGTSSMRRRAFLKFIYPNAKFELLRGNVDTRLRKLKEGLYDAIV LSEAGIIRLGVSLEDFNYKRLDILPAPAQGIIAVACKRDDEEMKSILKEINHERTYLESLCERTALNEFGGGCSVPFGAL AVYDEKNELLKLKAAVVTNDELKNASGEVKCKIDEIDKAVELGKKIGLKLKN
Sequences:
>Translated_292_residues MIRIGTRGSKLALYQANKVAELLKNLGYKVEIKIIKTTGDRVLDKKLSDIGIGVFTKELDLAMLNNEIDIAVHSLKDIPT IWNENLMVGAVLERDSYHDLLIWNKDIDFNEDSKIVIGTSSMRRRAFLKFIYPNAKFELLRGNVDTRLRKLKEGLYDAIV LSEAGIIRLGVSLEDFNYKRLDILPAPAQGIIAVACKRDDEEMKSILKEINHERTYLESLCERTALNEFGGGCSVPFGAL AVYDEKNELLKLKAAVVTNDELKNASGEVKCKIDEIDKAVELGKKIGLKLKN >Mature_292_residues MIRIGTRGSKLALYQANKVAELLKNLGYKVEIKIIKTTGDRVLDKKLSDIGIGVFTKELDLAMLNNEIDIAVHSLKDIPT IWNENLMVGAVLERDSYHDLLIWNKDIDFNEDSKIVIGTSSMRRRAFLKFIYPNAKFELLRGNVDTRLRKLKEGLYDAIV LSEAGIIRLGVSLEDFNYKRLDILPAPAQGIIAVACKRDDEEMKSILKEINHERTYLESLCERTALNEFGGGCSVPFGAL AVYDEKNELLKLKAAVVTNDELKNASGEVKCKIDEIDKAVELGKKIGLKLKN
Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
COG id: COG0181
COG function: function code H; Porphobilinogen deaminase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the HMBS family
Homologues:
Organism=Homo sapiens, GI20149500, Length=252, Percent_Identity=37.3015873015873, Blast_Score=155, Evalue=5e-38, Organism=Homo sapiens, GI66933009, Length=252, Percent_Identity=37.3015873015873, Blast_Score=155, Evalue=6e-38, Organism=Escherichia coli, GI48994974, Length=246, Percent_Identity=38.6178861788618, Blast_Score=159, Evalue=2e-40, Organism=Saccharomyces cerevisiae, GI6319996, Length=273, Percent_Identity=36.996336996337, Blast_Score=143, Evalue=3e-35, Organism=Drosophila melanogaster, GI20130425, Length=246, Percent_Identity=37.8048780487805, Blast_Score=151, Evalue=4e-37,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): HEM3_METJA (Q57989)
Other databases:
- EMBL: L77117 - PIR: A64371 - RefSeq: NP_247548.1 - ProteinModelPortal: Q57989 - SMR: Q57989 - GeneID: 1451434 - GenomeReviews: L77117_GR - KEGG: mja:MJ_0569 - NMPDR: fig|243232.1.peg.585 - TIGR: MJ0569 - HOGENOM: HBG624842 - OMA: DADILEM - ProtClustDB: PRK00072 - BioCyc: MJAN243232:MJ_0569-MONOMER - BRENDA: 2.5.1.61 - HAMAP: MF_00260 - InterPro: IPR000860 - InterPro: IPR022419 - InterPro: IPR022417 - InterPro: IPR022418 - Gene3D: G3DSA:3.30.160.40 - PANTHER: PTHR11557 - PIRSF: PIRSF001438 - PRINTS: PR00151 - TIGRFAMs: TIGR00212
Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC; SSF54782 Porphobil_deam
EC number: =2.5.1.61
Molecular weight: Translated: 32784; Mature: 32784
Theoretical pI: Translated: 7.93; Mature: 7.93
Prosite motif: PS00533 PORPHOBILINOGEN_DEAM
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.4 %Cys (Translated Protein) 1.7 %Met (Translated Protein) 3.1 %Cys+Met (Translated Protein) 1.4 %Cys (Mature Protein) 1.7 %Met (Mature Protein) 3.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MIRIGTRGSKLALYQANKVAELLKNLGYKVEIKIIKTTGDRVLDKKLSDIGIGVFTKELD CEEECCCCCEEEEEEHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHCCCEEEEHHHH LAMLNNEIDIAVHSLKDIPTIWNENLMVGAVLERDSYHDLLIWNKDIDFNEDSKIVIGTS HEEECCCCEEEEECHHCCCHHHCCCEEEEEEECCCCCCEEEEECCCCCCCCCCEEEEECC SMRRRAFLKFIYPNAKFELLRGNVDTRLRKLKEGLYDAIVLSEAGIIRLGVSLEDFNYKR HHHHHHHHEEECCCCEEEEEECCHHHHHHHHHHHHHHEEHCCCCCEEEEEEEEECCCCEE LDILPAPAQGIIAVACKRDDEEMKSILKEINHERTYLESLCERTALNEFGGGCSVPFGAL EEEECCCCCCEEEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCEE AVYDEKNELLKLKAAVVTNDELKNASGEVKCKIDEIDKAVELGKKIGLKLKN EEECCCCCEEEEEEEEEECHHHCCCCCEEEEEHHHHHHHHHHHHHCCCEECC >Mature Secondary Structure MIRIGTRGSKLALYQANKVAELLKNLGYKVEIKIIKTTGDRVLDKKLSDIGIGVFTKELD CEEECCCCCEEEEEEHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHCCCEEEEHHHH LAMLNNEIDIAVHSLKDIPTIWNENLMVGAVLERDSYHDLLIWNKDIDFNEDSKIVIGTS HEEECCCCEEEEECHHCCCHHHCCCEEEEEEECCCCCCEEEEECCCCCCCCCCEEEEECC SMRRRAFLKFIYPNAKFELLRGNVDTRLRKLKEGLYDAIVLSEAGIIRLGVSLEDFNYKR HHHHHHHHEEECCCCEEEEEECCHHHHHHHHHHHHHHEEHCCCCCEEEEEEEEECCCCEE LDILPAPAQGIIAVACKRDDEEMKSILKEINHERTYLESLCERTALNEFGGGCSVPFGAL EEEECCCCCCEEEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCEE AVYDEKNELLKLKAAVVTNDELKNASGEVKCKIDEIDKAVELGKKIGLKLKN EEECCCCCEEEEEEEEEECHHHCCCCCEEEEEHHHHHHHHHHHHHCCCEECC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 8688087