Definition | Methanocaldococcus jannaschii DSM 2661 chromosome, complete genome. |
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Accession | NC_000909 |
Length | 1,664,970 |
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The map label for this gene is purA
Identifier: 15668741
GI number: 15668741
Start: 495585
End: 496622
Strand: Direct
Name: purA
Synonym: MJ0561
Alternate gene names: 15668741
Gene position: 495585-496622 (Clockwise)
Preceding gene: 15668739
Following gene: 15668748
Centisome position: 29.77
GC content: 36.9
Gene sequence:
>1038_bases GTGAAAAAGGTGGTTTTATTGACTTGCACCATTATTGTTGGAGGACAATGGGGAGATGAAGGAAAAGGAAAGATAATAAG CTATATTTGTGATAAAGACAAGCCATCAATTATTGCAAGAGGAGGAGTAGGACCAAACGCTGGGCATACTGTAAATATTG GTGGAAAAAGTTATGGAATTAGAATGATACCTACAGGATTCCCATACAAAGAGGCAAAGTTGGCTATAGGGGCTGGTGTT TTGGTAGATCCAGAAGTTTTGTTAAAAGAGGTAGAGATGCTTAAAGACTTTAATGTTAAAGAGAGATTGATTGTAGATTA TAGATGTGGAATTATTGAAGAGAAGCATAAAATTATGGACAGAAAAGATGAGCACTTGGCTAAAGAGATTGGAACTACTG GAAGCGGCTGTGGCCCTGCAAACGTTGATAGAGTGTTGAGGATTTTAAAGCAGGCAAAGGATATTGAAGAGCTTAAAGAA TTTTTAGGAGATGTCTCTGAAGAGGTTAATAATGCATTGGATAGAGGAGAAAATGTTTTAATTGAAGGAACACAGGGAAC TTTACTCTCTTTATATTATGGAACCTATCCTTATGTAACATCCAAGGATACAACAGCTTCATCATTTGCCGCTGATGTTG GAATCGGCCCTACAAAAGTTGATGAGGTTATAGTTGTCTTTAAAACCTTCCCTACAAGAGTTGGTGCTGGGCCATTTCCA ACTGAAATGTCATTAGAAGAGGCAGAGAGCTTGGGAATTGTTGAGTATGGAACAGTTACTGGAAGAAGGAGAAGAGTTGG CTATTTTGACTTTGAATTAGCAAGGAAAGCTTGTAGGTTGAATGGAGCAACACAGATTGCTTTAACTGGATTAGATAAAT ACGATAAAGAGTGTTATGGAGTAACTGAATATAATAAGCTAAGTGAAAAAGCTAAAGAATTTATAAACAAGATTGAAGAA GTTACTGGAGTTCCAGTAACTATAATCTCCACAGGTCCAGAAATGCACCAAACAATTGATTTAAGAAATGAGCTATAA
Upstream 100 bases:
>100_bases TATAAAAAACTTATAATAACTTACTTGCCATACATTGGAAATTCTTAATATTAATTAACTTTAAATATTACAATTACAAA AAAATATAAGGTTTTGAACA
Downstream 100 bases:
>100_bases AATTTAACTAAATTTCATATTATATTAGATAATCTTTTTTAAGGTTAATATAAACCATGCCTAACTAAATCGGAATTACT GAAACGCTATCTTTTATAAT
Product: adenylosuccinate synthetase
Products: NA
Alternate protein names: AMPSase; AdSS; IMP--aspartate ligase
Number of amino acids: Translated: 345; Mature: 345
Protein sequence:
>345_residues MKKVVLLTCTIIVGGQWGDEGKGKIISYICDKDKPSIIARGGVGPNAGHTVNIGGKSYGIRMIPTGFPYKEAKLAIGAGV LVDPEVLLKEVEMLKDFNVKERLIVDYRCGIIEEKHKIMDRKDEHLAKEIGTTGSGCGPANVDRVLRILKQAKDIEELKE FLGDVSEEVNNALDRGENVLIEGTQGTLLSLYYGTYPYVTSKDTTASSFAADVGIGPTKVDEVIVVFKTFPTRVGAGPFP TEMSLEEAESLGIVEYGTVTGRRRRVGYFDFELARKACRLNGATQIALTGLDKYDKECYGVTEYNKLSEKAKEFINKIEE VTGVPVTIISTGPEMHQTIDLRNEL
Sequences:
>Translated_345_residues MKKVVLLTCTIIVGGQWGDEGKGKIISYICDKDKPSIIARGGVGPNAGHTVNIGGKSYGIRMIPTGFPYKEAKLAIGAGV LVDPEVLLKEVEMLKDFNVKERLIVDYRCGIIEEKHKIMDRKDEHLAKEIGTTGSGCGPANVDRVLRILKQAKDIEELKE FLGDVSEEVNNALDRGENVLIEGTQGTLLSLYYGTYPYVTSKDTTASSFAADVGIGPTKVDEVIVVFKTFPTRVGAGPFP TEMSLEEAESLGIVEYGTVTGRRRRVGYFDFELARKACRLNGATQIALTGLDKYDKECYGVTEYNKLSEKAKEFINKIEE VTGVPVTIISTGPEMHQTIDLRNEL >Mature_345_residues MKKVVLLTCTIIVGGQWGDEGKGKIISYICDKDKPSIIARGGVGPNAGHTVNIGGKSYGIRMIPTGFPYKEAKLAIGAGV LVDPEVLLKEVEMLKDFNVKERLIVDYRCGIIEEKHKIMDRKDEHLAKEIGTTGSGCGPANVDRVLRILKQAKDIEELKE FLGDVSEEVNNALDRGENVLIEGTQGTLLSLYYGTYPYVTSKDTTASSFAADVGIGPTKVDEVIVVFKTFPTRVGAGPFP TEMSLEEAESLGIVEYGTVTGRRRRVGYFDFELARKACRLNGATQIALTGLDKYDKECYGVTEYNKLSEKAKEFINKIEE VTGVPVTIISTGPEMHQTIDLRNEL
Specific function: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP
COG id: COG0104
COG function: function code F; Adenylosuccinate synthase
Gene ontology:
Cell location: Cytoplasm
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the adenylosuccinate synthetase family
Homologues:
Organism=Homo sapiens, GI22748717, Length=340, Percent_Identity=32.3529411764706, Blast_Score=152, Evalue=5e-37, Organism=Homo sapiens, GI34577063, Length=344, Percent_Identity=31.3953488372093, Blast_Score=144, Evalue=1e-34, Organism=Homo sapiens, GI40316944, Length=305, Percent_Identity=30.8196721311475, Blast_Score=125, Evalue=7e-29, Organism=Escherichia coli, GI1790620, Length=425, Percent_Identity=35.5294117647059, Blast_Score=222, Evalue=3e-59, Organism=Caenorhabditis elegans, GI25146555, Length=425, Percent_Identity=30.3529411764706, Blast_Score=186, Evalue=2e-47, Organism=Caenorhabditis elegans, GI25146553, Length=425, Percent_Identity=30.3529411764706, Blast_Score=186, Evalue=2e-47, Organism=Saccharomyces cerevisiae, GI6324109, Length=423, Percent_Identity=29.5508274231678, Blast_Score=182, Evalue=8e-47, Organism=Drosophila melanogaster, GI21356033, Length=369, Percent_Identity=30.3523035230352, Blast_Score=147, Evalue=1e-35,
Paralogues:
None
Copy number: 940 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]
Swissprot (AC and ID): PURA_METJA (Q57981)
Other databases:
- EMBL: L77117 - PIR: A64370 - RefSeq: NP_247540.1 - ProteinModelPortal: Q57981 - SMR: Q57981 - GeneID: 1451426 - GenomeReviews: L77117_GR - KEGG: mja:MJ_0561 - NMPDR: fig|243232.1.peg.577 - TIGR: MJ0561 - HOGENOM: HBG658237 - OMA: YVLGIIK - ProtClustDB: PRK04293 - BioCyc: MJAN243232:MJ_0561-MONOMER - BRENDA: 6.3.4.4 - GO: GO:0005737 - HAMAP: MF_00011 - InterPro: IPR018220 - InterPro: IPR001114 - PANTHER: PTHR11846 - SMART: SM00788 - TIGRFAMs: TIGR00184
Pfam domain/function: PF00709 Adenylsucc_synt
EC number: =6.3.4.4
Molecular weight: Translated: 37821; Mature: 37821
Theoretical pI: Translated: 5.37; Mature: 5.37
Prosite motif: PS01266 ADENYLOSUCCIN_SYN_1; PS00513 ADENYLOSUCCIN_SYN_2; PS00014 ER_TARGET
Important sites: ACT_SITE 19-19 ACT_SITE 49-49 BINDING 133-133 BINDING 147-147 BINDING 185-185 BINDING 200-200 BINDING 262-262 BINDING 264-264
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.7 %Cys (Translated Protein) 1.7 %Met (Translated Protein) 3.5 %Cys+Met (Translated Protein) 1.7 %Cys (Mature Protein) 1.7 %Met (Mature Protein) 3.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKKVVLLTCTIIVGGQWGDEGKGKIISYICDKDKPSIIARGGVGPNAGHTVNIGGKSYGI CCEEEEEEEEEEEECCCCCCCCCCEEEEEECCCCCCEEEECCCCCCCCCEEEECCCCCCE RMIPTGFPYKEAKLAIGAGVLVDPEVLLKEVEMLKDFNVKERLIVDYRCGIIEEKHKIMD EECCCCCCCCCCEEEECCCCEECHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHC RKDEHLAKEIGTTGSGCGPANVDRVLRILKQAKDIEELKEFLGDVSEEVNNALDRGENVL CHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEE IEGTQGTLLSLYYGTYPYVTSKDTTASSFAADVGIGPTKVDEVIVVFKTFPTRVGAGPFP EECCCCCEEEEEECCCCEEECCCCCHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCC TEMSLEEAESLGIVEYGTVTGRRRRVGYFDFELARKACRLNGATQIALTGLDKYDKECYG CCCCHHHHHHCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCHHHHHHCC VTEYNKLSEKAKEFINKIEEVTGVPVTIISTGPEMHQTIDLRNEL CCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCC >Mature Secondary Structure MKKVVLLTCTIIVGGQWGDEGKGKIISYICDKDKPSIIARGGVGPNAGHTVNIGGKSYGI CCEEEEEEEEEEEECCCCCCCCCCEEEEEECCCCCCEEEECCCCCCCCCEEEECCCCCCE RMIPTGFPYKEAKLAIGAGVLVDPEVLLKEVEMLKDFNVKERLIVDYRCGIIEEKHKIMD EECCCCCCCCCCEEEECCCCEECHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHC RKDEHLAKEIGTTGSGCGPANVDRVLRILKQAKDIEELKEFLGDVSEEVNNALDRGENVL CHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEE IEGTQGTLLSLYYGTYPYVTSKDTTASSFAADVGIGPTKVDEVIVVFKTFPTRVGAGPFP EECCCCCEEEEEECCCCEEECCCCCHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCC TEMSLEEAESLGIVEYGTVTGRRRRVGYFDFELARKACRLNGATQIALTGLDKYDKECYG CCCCHHHHHHCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCHHHHHHCC VTEYNKLSEKAKEFINKIEEVTGVPVTIISTGPEMHQTIDLRNEL CCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 8688087