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The map label for this gene is degQ [C]

Identifier: 16273177

GI number: 16273177

Start: 1335673

End: 1337073

Strand: Reverse

Name: degQ [C]

Synonym: HI1259

Alternate gene names: 16273177

Gene position: 1337073-1335673 (Counterclockwise)

Preceding gene: 30995434

Following gene: 16273168

Centisome position: 73.06

GC content: 38.62

Gene sequence:

>1401_bases
ATGAAAAAAACACGTTTTGTATTAAATAGTATTGCACTTGGATTAAGTGTATTAAGCACATCATTTGTTGCTCATGTTGC
TCAAGCCACTTTGCCAAGTTTTGTTTCAGAACAAAACAGTCTTGCACCGATGTTAGAAAAAGTACAACCTGCCGTTGTCA
CTCTTTCCGTTGAAGGAAAAGCTAAAGTAGATTCTCGTTCTCCTTTCCTAGACGATATTCCTGAAGAATTTAAATTCTTC
TTTGGCGATCGTTTTGCCGAACAATTTGGTGGGCGTGGAGAATCAAAGCGTAACTTCCGTGGTTTAGGTTCTGGTGTCAT
TATTAATGCAAGCAAAGGCTATGTTTTAACCAATAATCATGTTATTGATGGAGCTGATAAAATTACCGTGCAATTACAAG
ATGGGCGTGAATTTAAAGCAAAATTAGTGGGTAAGGATGAACAATCAGATATTGCATTAGTACAGCTTGAAAAACCAAGT
AATTTAACAGAAATCAAATTTGCTGATTCCGACAAATTACGCGTAGGCGATTTCACTGTTGCAATCGGTAATCCATTTGG
TTTAGGTCAAACTGTGACATCAGGTATTGTTTCTGCATTGGGTCGTTCAACAGGTTCTGACAGTGGCACTTATGAAAACT
ATATTCAAACCGATGCAGCAGTAAACCGAGGTAATTCGGGTGGTGCATTAGTCAATCTAAATGGCGAACTTATTGGAATT
AATACCGCAATTATTTCTCCAAGCGGTGGCAATGCAGGAATTGCCTTTGCGATTCCAAGTAATCAAGCAAGCAATTTAGT
GCAACAAATTTTAGAATTTGGTCAAGTGCGTCGCGGATTGCTTGGTATTAAAGGGGGCGAACTCAATGCTGATTTAGCCA
AAGCCTTTAATGTAAGCGCGCAACAAGGTGCATTTGTAAGTGAAGTTTTACCGAAATCTGCTGCTGAAAAAGCAGGACTT
AAAGCGGGCGATATTATCACGGCGATGAACGGTCAAAAAATCTCAAGTTTCGCTGAAATTCGTGCAAAAATCGCAACCAC
TGGTGCAGGCAAAGAGATTAGCTTGACTTACTTACGTGATGGCAAATCCCACGACGTTAAAATGAAATTACAAGCGGATG
ATAGTAGCCAACTTTCCTCAAAAACTGAGTTGCCTGCATTAGATGGCGCAACATTGAAAGACTACGATGCTAAAGGCGTT
AAAGGAATTGAAATCACAAAAATTCAACCTAATTCGCTAGCTGCACAACGTGGTTTAAAATCGGGCGATATTATTATTGG
TATTAATCGTCAAATGATCGAAAACATTCGTGAATTAAATAAAGTGCTTGAAACTGAACCGTCAGCAGTTGCACTTAATA
TTTTACGAGGTGACAGTAATTTCTATTTATTAGTGCAATAA

Upstream 100 bases:

>100_bases
TTTCCTTTTAAACAAGATAATTTGCTCTCCTCTTATTGAACATTTTTTTTATTTTTTTGTCTTACAGACCACGTTATCTG
AAATTTATTTTGGAGTATTT

Downstream 100 bases:

>100_bases
TCTGCTTGATATATTTAAGAAAAAAGTCCGATCACAATGATCGGGCTTCTTTTTATGCAGCAATCGTTCTTAACAAATCC
ACCACAAATTCTAACCGCAC

Product: periplasmic serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MKKTRFVLNSIALGLSVLSTSFVAHVAQATLPSFVSEQNSLAPMLEKVQPAVVTLSVEGKAKVDSRSPFLDDIPEEFKFF
FGDRFAEQFGGRGESKRNFRGLGSGVIINASKGYVLTNNHVIDGADKITVQLQDGREFKAKLVGKDEQSDIALVQLEKPS
NLTEIKFADSDKLRVGDFTVAIGNPFGLGQTVTSGIVSALGRSTGSDSGTYENYIQTDAAVNRGNSGGALVNLNGELIGI
NTAIISPSGGNAGIAFAIPSNQASNLVQQILEFGQVRRGLLGIKGGELNADLAKAFNVSAQQGAFVSEVLPKSAAEKAGL
KAGDIITAMNGQKISSFAEIRAKIATTGAGKEISLTYLRDGKSHDVKMKLQADDSSQLSSKTELPALDGATLKDYDAKGV
KGIEITKIQPNSLAAQRGLKSGDIIIGINRQMIENIRELNKVLETEPSAVALNILRGDSNFYLLVQ

Sequences:

>Translated_466_residues
MKKTRFVLNSIALGLSVLSTSFVAHVAQATLPSFVSEQNSLAPMLEKVQPAVVTLSVEGKAKVDSRSPFLDDIPEEFKFF
FGDRFAEQFGGRGESKRNFRGLGSGVIINASKGYVLTNNHVIDGADKITVQLQDGREFKAKLVGKDEQSDIALVQLEKPS
NLTEIKFADSDKLRVGDFTVAIGNPFGLGQTVTSGIVSALGRSTGSDSGTYENYIQTDAAVNRGNSGGALVNLNGELIGI
NTAIISPSGGNAGIAFAIPSNQASNLVQQILEFGQVRRGLLGIKGGELNADLAKAFNVSAQQGAFVSEVLPKSAAEKAGL
KAGDIITAMNGQKISSFAEIRAKIATTGAGKEISLTYLRDGKSHDVKMKLQADDSSQLSSKTELPALDGATLKDYDAKGV
KGIEITKIQPNSLAAQRGLKSGDIIIGINRQMIENIRELNKVLETEPSAVALNILRGDSNFYLLVQ
>Mature_466_residues
MKKTRFVLNSIALGLSVLSTSFVAHVAQATLPSFVSEQNSLAPMLEKVQPAVVTLSVEGKAKVDSRSPFLDDIPEEFKFF
FGDRFAEQFGGRGESKRNFRGLGSGVIINASKGYVLTNNHVIDGADKITVQLQDGREFKAKLVGKDEQSDIALVQLEKPS
NLTEIKFADSDKLRVGDFTVAIGNPFGLGQTVTSGIVSALGRSTGSDSGTYENYIQTDAAVNRGNSGGALVNLNGELIGI
NTAIISPSGGNAGIAFAIPSNQASNLVQQILEFGQVRRGLLGIKGGELNADLAKAFNVSAQQGAFVSEVLPKSAAEKAGL
KAGDIITAMNGQKISSFAEIRAKIATTGAGKEISLTYLRDGKSHDVKMKLQADDSSQLSSKTELPALDGATLKDYDAKGV
KGIEITKIQPNSLAAQRGLKSGDIIIGINRQMIENIRELNKVLETEPSAVALNILRGDSNFYLLVQ

Specific function: Protease With A Shared Specificity With Degp. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains

Homologues:

Organism=Homo sapiens, GI4506141, Length=252, Percent_Identity=38.0952380952381, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI22129776, Length=261, Percent_Identity=36.0153256704981, Blast_Score=152, Evalue=9e-37,
Organism=Homo sapiens, GI24308541, Length=317, Percent_Identity=29.3375394321767, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI7019477, Length=329, Percent_Identity=31.6109422492401, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI1789629, Length=471, Percent_Identity=57.7494692144374, Blast_Score=498, Evalue=1e-142,
Organism=Escherichia coli, GI1786356, Length=483, Percent_Identity=53.8302277432712, Blast_Score=478, Evalue=1e-136,
Organism=Escherichia coli, GI1789630, Length=281, Percent_Identity=39.5017793594306, Blast_Score=190, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24646839, Length=306, Percent_Identity=32.3529411764706, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTOA_HAEIN (P45129)

Other databases:

- EMBL:   L42023
- PIR:   A64113
- RefSeq:   NP_439414.1
- ProteinModelPortal:   P45129
- SMR:   P45129
- GeneID:   950193
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1259
- NMPDR:   fig|71421.1.peg.1204
- TIGR:   HI_1259
- HOGENOM:   HBG585708
- OMA:   IQIADSD
- ProtClustDB:   CLSK870225
- BioCyc:   HINF71421:HI_1259-MONOMER
- GO:   GO:0006508
- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940
- PRINTS:   PR00834
- SMART:   SM00228
- TIGRFAMs:   TIGR02037

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin; SSF50156 PDZ; SSF50494 Pept_Ser_Cys

EC number: 3.4.21.-

Molecular weight: Translated: 49435; Mature: 49435

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: PS50106 PDZ

Important sites: ACT_SITE 120-120 ACT_SITE 150-150 ACT_SITE 226-226

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTRFVLNSIALGLSVLSTSFVAHVAQATLPSFVSEQNSLAPMLEKVQPAVVTLSVEGK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCEEEEEEECCC
AKVDSRSPFLDDIPEEFKFFFGDRFAEQFGGRGESKRNFRGLGSGVIINASKGYVLTNNH
CCCCCCCCCHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCEEEECCE
VIDGADKITVQLQDGREFKAKLVGKDEQSDIALVQLEKPSNLTEIKFADSDKLRVGDFTV
EECCCCEEEEEEECCCCEEHEECCCCCCCCEEEEEEECCCCCEEEEECCCCCEEECEEEE
AIGNPFGLGQTVTSGIVSALGRSTGSDSGTYENYIQTDAAVNRGNSGGALVNLNGELIGI
EECCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCEEEEE
NTAIISPSGGNAGIAFAIPSNQASNLVQQILEFGQVRRGLLGIKGGELNADLAKAFNVSA
EEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHCCCC
QQGAFVSEVLPKSAAEKAGLKAGDIITAMNGQKISSFAEIRAKIATTGAGKEISLTYLRD
CCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHEEECCCCCEEEEEEEEC
GKSHDVKMKLQADDSSQLSSKTELPALDGATLKDYDAKGVKGIEITKIQPNSLAAQRGLK
CCCCCEEEEEECCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHCCCC
SGDIIIGINRQMIENIRELNKVLETEPSAVALNILRGDSNFYLLVQ
CCCEEEECCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEC
>Mature Secondary Structure
MKKTRFVLNSIALGLSVLSTSFVAHVAQATLPSFVSEQNSLAPMLEKVQPAVVTLSVEGK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCEEEEEEECCC
AKVDSRSPFLDDIPEEFKFFFGDRFAEQFGGRGESKRNFRGLGSGVIINASKGYVLTNNH
CCCCCCCCCHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCEEEECCE
VIDGADKITVQLQDGREFKAKLVGKDEQSDIALVQLEKPSNLTEIKFADSDKLRVGDFTV
EECCCCEEEEEEECCCCEEHEECCCCCCCCEEEEEEECCCCCEEEEECCCCCEEECEEEE
AIGNPFGLGQTVTSGIVSALGRSTGSDSGTYENYIQTDAAVNRGNSGGALVNLNGELIGI
EECCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCEEEEE
NTAIISPSGGNAGIAFAIPSNQASNLVQQILEFGQVRRGLLGIKGGELNADLAKAFNVSA
EEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHCCCC
QQGAFVSEVLPKSAAEKAGLKAGDIITAMNGQKISSFAEIRAKIATTGAGKEISLTYLRD
CCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHEEECCCCCEEEEEEEEC
GKSHDVKMKLQADDSSQLSSKTELPALDGATLKDYDAKGVKGIEITKIQPNSLAAQRGLK
CCCCCEEEEEECCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHCCCC
SGDIIIGINRQMIENIRELNKVLETEPSAVALNILRGDSNFYLLVQ
CCCEEEECCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800