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The map label for this gene is pdxH

Identifier: 99080989

GI number: 99080989

Start: 1235783

End: 1236388

Strand: Direct

Name: pdxH

Synonym: TM1040_1148

Alternate gene names: 99080989

Gene position: 1235783-1236388 (Clockwise)

Preceding gene: 99080983

Following gene: 99080990

Centisome position: 38.61

GC content: 57.76

Gene sequence:

>606_bases
ATGTCTGATCGTGAAGGACTCTTTGGCGGCGATGATCCGTTTGAGATCGCCCGCAAGTGGCTGGCAGAGGCCACCGAGAC
CGAAATCAACGACCCCAATGCCATTGCGCTTGCGACCGTGGATGCCTCCGGCATGCCCAACAGCCGCATGGTGTTGCTGA
AGGAAATCGAAGACGCTGCCTTTGTGTTCTATACCAACTATGAGAGCGCCAAGGCACAGGAGATCGAGGCCAGCGGCACC
GCGTCCTTTGTGATGCACTGGAAATCCCTGCGTCGCCAGATCCGCGTGCGCGGACATGTCACCAAGGAAAACGGACCGCA
GGCGGATGAGTATTTTGCGTCCCGCTCGCTCAAGAGCCGTCTTGGGGCCTGGGCCTCCAAGCAGTCGCAGCCGCTCGCCT
CGCGCAGCGCCCTGATGGCAGAGGTGGCCAAGATCACTGCCCAGAAAGGTCCAAATCCGAAGCGCCCGGAATTCTGGGGC
GGCTACCGGATCACACCGATTGAAATTGAATTTTGGGCGGATGGGGCCTTTCGATTGCACGACCGTTTTGTGTGGCGAAA
AAATACTTCACATGATAATTGGACAATCACGCGTCTTAGCCCGTAA

Upstream 100 bases:

>100_bases
TACTCGCTCTTGTGGGGGCGTTCAATCGGGCAGAACGTCCCCCTTTCCAACGGCCTGCAAGGCCACTAGATGTATGCGCA
AGCAGTAGGGAAACACCATT

Downstream 100 bases:

>100_bases
GATCACCGTGAAAACGCCCATGGGCCACTCTGTGGCTCCTGACTCTTTTGCTCTTGAACTCCGATATGGATTTCGCGCAG
GTAGGCGGGCATCACGGAAA

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 201; Mature: 200

Protein sequence:

>201_residues
MSDREGLFGGDDPFEIARKWLAEATETEINDPNAIALATVDASGMPNSRMVLLKEIEDAAFVFYTNYESAKAQEIEASGT
ASFVMHWKSLRRQIRVRGHVTKENGPQADEYFASRSLKSRLGAWASKQSQPLASRSALMAEVAKITAQKGPNPKRPEFWG
GYRITPIEIEFWADGAFRLHDRFVWRKNTSHDNWTITRLSP

Sequences:

>Translated_201_residues
MSDREGLFGGDDPFEIARKWLAEATETEINDPNAIALATVDASGMPNSRMVLLKEIEDAAFVFYTNYESAKAQEIEASGT
ASFVMHWKSLRRQIRVRGHVTKENGPQADEYFASRSLKSRLGAWASKQSQPLASRSALMAEVAKITAQKGPNPKRPEFWG
GYRITPIEIEFWADGAFRLHDRFVWRKNTSHDNWTITRLSP
>Mature_200_residues
SDREGLFGGDDPFEIARKWLAEATETEINDPNAIALATVDASGMPNSRMVLLKEIEDAAFVFYTNYESAKAQEIEASGTA
SFVMHWKSLRRQIRVRGHVTKENGPQADEYFASRSLKSRLGAWASKQSQPLASRSALMAEVAKITAQKGPNPKRPEFWGG
YRITPIEIEFWADGAFRLHDRFVWRKNTSHDNWTITRLSP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=208, Percent_Identity=35.5769230769231, Blast_Score=124, Evalue=6e-29,
Organism=Escherichia coli, GI1787926, Length=192, Percent_Identity=40.1041666666667, Blast_Score=154, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17553712, Length=196, Percent_Identity=36.734693877551, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6319509, Length=196, Percent_Identity=39.2857142857143, Blast_Score=140, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24644901, Length=205, Percent_Identity=39.5121951219512, Blast_Score=133, Evalue=8e-32,
Organism=Drosophila melanogaster, GI45551845, Length=205, Percent_Identity=39.5121951219512, Blast_Score=133, Evalue=8e-32,
Organism=Drosophila melanogaster, GI24644903, Length=168, Percent_Identity=27.9761904761905, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_SILST (Q1GHI5)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_613143.1
- ProteinModelPortal:   Q1GHI5
- SMR:   Q1GHI5
- STRING:   Q1GHI5
- GeneID:   4078444
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_1148
- NMPDR:   fig|292414.1.peg.3717
- eggNOG:   COG0259
- HOGENOM:   HBG327559
- OMA:   HWSGFRI
- PhylomeDB:   Q1GHI5
- ProtClustDB:   CLSK933776
- BioCyc:   SSP292414:TM1040_1148-MONOMER
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 22721; Mature: 22590

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 49-49 BINDING 52-52 BINDING 54-54 BINDING 71-71 BINDING 111-111 BINDING 115-115 BINDING 119-119

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDREGLFGGDDPFEIARKWLAEATETEINDPNAIALATVDASGMPNSRMVLLKEIEDAA
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCEEEEEECCCCE
FVFYTNYESAKAQEIEASGTASFVMHWKSLRRQIRVRGHVTKENGPQADEYFASRSLKSR
EEEEECCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHH
LGAWASKQSQPLASRSALMAEVAKITAQKGPNPKRPEFWGGYRITPIEIEFWADGAFRLH
HHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEEECCCEEEEE
DRFVWRKNTSHDNWTITRLSP
EEEEEECCCCCCCEEEEEECC
>Mature Secondary Structure 
SDREGLFGGDDPFEIARKWLAEATETEINDPNAIALATVDASGMPNSRMVLLKEIEDAA
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCEEEEEECCCCE
FVFYTNYESAKAQEIEASGTASFVMHWKSLRRQIRVRGHVTKENGPQADEYFASRSLKSR
EEEEECCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHH
LGAWASKQSQPLASRSALMAEVAKITAQKGPNPKRPEFWGGYRITPIEIEFWADGAFRLH
HHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEEECCCEEEEE
DRFVWRKNTSHDNWTITRLSP
EEEEEECCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA