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The map label for this gene is lpd [H]

Identifier: 99080937

GI number: 99080937

Start: 1174730

End: 1176124

Strand: Direct

Name: lpd [H]

Synonym: TM1040_1096

Alternate gene names: 99080937

Gene position: 1174730-1176124 (Clockwise)

Preceding gene: 99080936

Following gene: 99080938

Centisome position: 36.7

GC content: 60.22

Gene sequence:

>1395_bases
ATGGCCGCAGCATCCTATGACGTGATCGTAATCGGCGCAGGCCCCGGCGGCTATGTTGCCGCGATCCGCGCTTCGCAACT
TGGGCTCAAGACCTGCGTGGTTGAGCGCGAGCACCTGGGCGGCATCTGCCTCAACTGGGGCTGTATCCCCACCAAGGCGC
TGTTGCGGTCCTCGGAAGTGTTTCACCTGATGGAGCGGGCCAAGGATTTTGGTCTCAAGGCCGAGAACATTGGGTATGAT
CTGGGCGCTGTGGTGAAACGCTCGCGCGGGGTGGCCAAGCAGCTCTCGTCCGGGGTCAAAGGTCTGCTGAAGAAGCACAA
GATCGACGTCATCATGGGCGAAGCCACACTCCCCGCAAAGGGGAAGGTCGCGGTCAAGACCGACAAGGGCTCCGAAGAGC
TGACGGGCAAGAATATCATTCTCGCCACCGGCGCACGGGCGCGTGAACTGCCCGGCCTCGAGGCGGATGGCGATCTGGTC
TGGACCTACAAGCACGCCCTTGATCCCAAGCGCATGCCCAAAAAACTTCTGGTCATCGGCTCCGGCGCAATCGGCATCGA
ATTTGCGAGCTTCTACAACACCTTGGGTGCGGATACGACCGTCGTTGAAGTGATGGAACGGGTGCTTCCCGTCGAGGACG
AGGAAATCTCCAAATTCGCCAAGAAGGCCTTTGAAAAGCAGGGCATGAAGATCATGCAAAAGGCGATGGTCAAGCAGCTT
GATCGCGCCTCTGGCAAGGTCACGGCGCATATCGAAGTGGGCGGCAAGGTCGAAAAACACGAGTTTGACACCGTGATTTC
CGCGGTGGGGATCGTCGGCAACGTCGAGGGGCTCGGGCTTGAGGGGCTGGGCGTCAAGATTGACCGCACCCATGTGATCA
CCGATGAATACTGCCGCACGGGTGTCGACGGGCTCTATGCCATTGGCGACATCGCGGGTGCCCCCTGGCTTGCGCACAAG
GCGAGCCACGAGGGCGTCATGGTGGCCGAGCTGATCGCGGGCAAACATGCGCATCCGGTGAAGCCCGAAAGCATCGCGGG
CTGCACCTATTGTCATCCGCAGGTGGCCTCTGTGGGCTACACCGAAGCCAAGGCCAAGGAGCTGGGCTACAAGGTCAAAG
TGGGCCGTTTCCCCTTTATTGGCAATGGCAAGGCGATCGCGCTCGGAGAGCCCGAGGGCCTGATCAAGACCGTCTTTGAC
GAGAAAACCGGCGAGCTGTTGGGCGCGCATATGATCGGCGCCGAAGTCACCGAACTGATCCAGGGCTATGTGGTCGGGCG
CCAGCTGGAAACCACAGAAGAAGACCTGATGAATACGGTCTTCCCGCATCCGACTCTGTCCGAGATGATGCACGAAAGCG
TGCTGGACGCCTTTGACCGGGTGATCCACATCTGA

Upstream 100 bases:

>100_bases
AGCAGGGGCAGGGCGGCGCGCCCGCTTCGACAGTTGCGGCGTGTGAGAAATTAGTTTAACGGTAAACTAGTTTTTGGATC
TTAGTTCATGAGGGAACACA

Downstream 100 bases:

>100_bases
TTTCGCCAGCATATGTTTGATGAAAGGCCGGGTCTCATGCCCGGCCTTTTTTGTGGGGTTTGTGTGGGTACAAAATAGCG
CGTTATCGATCTGGCGCCCC

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MAAASYDVIVIGAGPGGYVAAIRASQLGLKTCVVEREHLGGICLNWGCIPTKALLRSSEVFHLMERAKDFGLKAENIGYD
LGAVVKRSRGVAKQLSSGVKGLLKKHKIDVIMGEATLPAKGKVAVKTDKGSEELTGKNIILATGARARELPGLEADGDLV
WTYKHALDPKRMPKKLLVIGSGAIGIEFASFYNTLGADTTVVEVMERVLPVEDEEISKFAKKAFEKQGMKIMQKAMVKQL
DRASGKVTAHIEVGGKVEKHEFDTVISAVGIVGNVEGLGLEGLGVKIDRTHVITDEYCRTGVDGLYAIGDIAGAPWLAHK
ASHEGVMVAELIAGKHAHPVKPESIAGCTYCHPQVASVGYTEAKAKELGYKVKVGRFPFIGNGKAIALGEPEGLIKTVFD
EKTGELLGAHMIGAEVTELIQGYVVGRQLETTEEDLMNTVFPHPTLSEMMHESVLDAFDRVIHI

Sequences:

>Translated_464_residues
MAAASYDVIVIGAGPGGYVAAIRASQLGLKTCVVEREHLGGICLNWGCIPTKALLRSSEVFHLMERAKDFGLKAENIGYD
LGAVVKRSRGVAKQLSSGVKGLLKKHKIDVIMGEATLPAKGKVAVKTDKGSEELTGKNIILATGARARELPGLEADGDLV
WTYKHALDPKRMPKKLLVIGSGAIGIEFASFYNTLGADTTVVEVMERVLPVEDEEISKFAKKAFEKQGMKIMQKAMVKQL
DRASGKVTAHIEVGGKVEKHEFDTVISAVGIVGNVEGLGLEGLGVKIDRTHVITDEYCRTGVDGLYAIGDIAGAPWLAHK
ASHEGVMVAELIAGKHAHPVKPESIAGCTYCHPQVASVGYTEAKAKELGYKVKVGRFPFIGNGKAIALGEPEGLIKTVFD
EKTGELLGAHMIGAEVTELIQGYVVGRQLETTEEDLMNTVFPHPTLSEMMHESVLDAFDRVIHI
>Mature_463_residues
AAASYDVIVIGAGPGGYVAAIRASQLGLKTCVVEREHLGGICLNWGCIPTKALLRSSEVFHLMERAKDFGLKAENIGYDL
GAVVKRSRGVAKQLSSGVKGLLKKHKIDVIMGEATLPAKGKVAVKTDKGSEELTGKNIILATGARARELPGLEADGDLVW
TYKHALDPKRMPKKLLVIGSGAIGIEFASFYNTLGADTTVVEVMERVLPVEDEEISKFAKKAFEKQGMKIMQKAMVKQLD
RASGKVTAHIEVGGKVEKHEFDTVISAVGIVGNVEGLGLEGLGVKIDRTHVITDEYCRTGVDGLYAIGDIAGAPWLAHKA
SHEGVMVAELIAGKHAHPVKPESIAGCTYCHPQVASVGYTEAKAKELGYKVKVGRFPFIGNGKAIALGEPEGLIKTVFDE
KTGELLGAHMIGAEVTELIQGYVVGRQLETTEEDLMNTVFPHPTLSEMMHESVLDAFDRVIHI

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=469, Percent_Identity=37.3134328358209, Blast_Score=290, Evalue=3e-78,
Organism=Homo sapiens, GI50301238, Length=460, Percent_Identity=28.695652173913, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI22035672, Length=479, Percent_Identity=27.7661795407098, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI291045266, Length=429, Percent_Identity=25.1748251748252, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI33519430, Length=481, Percent_Identity=25.1559251559252, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI33519428, Length=481, Percent_Identity=25.1559251559252, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI33519426, Length=481, Percent_Identity=25.1559251559252, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI148277065, Length=479, Percent_Identity=25.2609603340292, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI148277071, Length=478, Percent_Identity=25.3138075313808, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI291045268, Length=468, Percent_Identity=25.8547008547009, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI1786307, Length=452, Percent_Identity=35.3982300884956, Blast_Score=256, Evalue=3e-69,
Organism=Escherichia coli, GI87082354, Length=463, Percent_Identity=26.5658747300216, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1789915, Length=440, Percent_Identity=27.7272727272727, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI87081717, Length=453, Percent_Identity=24.9448123620309, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1788892, Length=192, Percent_Identity=29.1666666666667, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI32565766, Length=460, Percent_Identity=36.9565217391304, Blast_Score=288, Evalue=6e-78,
Organism=Caenorhabditis elegans, GI17557007, Length=475, Percent_Identity=27.5789473684211, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI71983429, Length=442, Percent_Identity=27.8280542986425, Blast_Score=128, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI71983419, Length=442, Percent_Identity=27.8280542986425, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71982272, Length=478, Percent_Identity=23.8493723849372, Blast_Score=82, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6321091, Length=474, Percent_Identity=36.9198312236287, Blast_Score=273, Evalue=3e-74,
Organism=Saccharomyces cerevisiae, GI6325240, Length=477, Percent_Identity=28.9308176100629, Blast_Score=178, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6325166, Length=463, Percent_Identity=28.0777537796976, Blast_Score=163, Evalue=6e-41,
Organism=Drosophila melanogaster, GI21358499, Length=468, Percent_Identity=38.6752136752137, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI24640553, Length=469, Percent_Identity=27.2921108742004, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24640549, Length=470, Percent_Identity=27.2340425531915, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24640551, Length=469, Percent_Identity=27.2921108742004, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17737741, Length=473, Percent_Identity=26.4270613107822, Blast_Score=129, Evalue=6e-30,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 49740; Mature: 49609

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAASYDVIVIGAGPGGYVAAIRASQLGLKTCVVEREHLGGICLNWGCIPTKALLRSSEV
CCCCCCCEEEEECCCCCEEEEEEHHHCCHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHH
FHLMERAKDFGLKAENIGYDLGAVVKRSRGVAKQLSSGVKGLLKKHKIDVIMGEATLPAK
HHHHHHHHHCCCCHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCC
GKVAVKTDKGSEELTGKNIILATGARARELPGLEADGDLVWTYKHALDPKRMPKKLLVIG
CEEEEEECCCCCCCCCCEEEEECCCCHHHCCCCCCCCCEEEEEHHHCCHHHCCCEEEEEE
SGAIGIEFASFYNTLGADTTVVEVMERVLPVEDEEISKFAKKAFEKQGMKIMQKAMVKQL
CCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DRASGKVTAHIEVGGKVEKHEFDTVISAVGIVGNVEGLGLEGLGVKIDRTHVITDEYCRT
HHCCCCEEEEEEECCEECHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECEEEECHHHHHC
GVDGLYAIGDIAGAPWLAHKASHEGVMVAELIAGKHAHPVKPESIAGCTYCHPQVASVGY
CCCHHHHHHHHCCCCHHHHCCCCCCEEHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCC
TEAKAKELGYKVKVGRFPFIGNGKAIALGEPEGLIKTVFDEKTGELLGAHMIGAEVTELI
CHHHHHHCCCEEEECCCCEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGYVVGRQLETTEEDLMNTVFPHPTLSEMMHESVLDAFDRVIHI
HHHHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AAASYDVIVIGAGPGGYVAAIRASQLGLKTCVVEREHLGGICLNWGCIPTKALLRSSEV
CCCCCCEEEEECCCCCEEEEEEHHHCCHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHH
FHLMERAKDFGLKAENIGYDLGAVVKRSRGVAKQLSSGVKGLLKKHKIDVIMGEATLPAK
HHHHHHHHHCCCCHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCC
GKVAVKTDKGSEELTGKNIILATGARARELPGLEADGDLVWTYKHALDPKRMPKKLLVIG
CEEEEEECCCCCCCCCCEEEEECCCCHHHCCCCCCCCCEEEEEHHHCCHHHCCCEEEEEE
SGAIGIEFASFYNTLGADTTVVEVMERVLPVEDEEISKFAKKAFEKQGMKIMQKAMVKQL
CCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DRASGKVTAHIEVGGKVEKHEFDTVISAVGIVGNVEGLGLEGLGVKIDRTHVITDEYCRT
HHCCCCEEEEEEECCEECHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECEEEECHHHHHC
GVDGLYAIGDIAGAPWLAHKASHEGVMVAELIAGKHAHPVKPESIAGCTYCHPQVASVGY
CCCHHHHHHHHCCCCHHHHCCCCCCEEHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCC
TEAKAKELGYKVKVGRFPFIGNGKAIALGEPEGLIKTVFDEKTGELLGAHMIGAEVTELI
CHHHHHHCCCEEEECCCCEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGYVVGRQLETTEEDLMNTVFPHPTLSEMMHESVLDAFDRVIHI
HHHHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9515924 [H]