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The map label for this gene is helX [H]

Identifier: 99080844

GI number: 99080844

Start: 1073620

End: 1074156

Strand: Direct

Name: helX [H]

Synonym: TM1040_1003

Alternate gene names: 99080844

Gene position: 1073620-1074156 (Clockwise)

Preceding gene: 99080843

Following gene: 99080848

Centisome position: 33.54

GC content: 62.76

Gene sequence:

>537_bases
ATGGCTAAGATCTCTTTGATGATGGCTATTCCAGTGGTCGTCTTTTCCGGCTTTGTTGGCCTTGCCCTCGTGGGCATGGG
CCGCGACGATCCCGAAAGCCTGCCCTCGGCGCGCGAAGGCAAAGCAGCGCCCTCCGTCGCGCTCAGCGATTTTCCCGGCA
AAGAGAGCTTTGACGACGCCACCCTGCGCGACGGCACCGTAAAGCTTGTCAATTACTGGGCGAGCTGGTGTGGCCCCTGC
CGCGCCGAACACCCGAGCCTGACCGCGCTTTCCGAGGAAGGCGTGCCGATCTACGGCGTGAACTACAAGGATCAGCTGGC
CAATGCCCAGAGTTTCCTCGAGGAACTCGGCGATCCCTATGCCGGTGTGGGTCGGGATGAACAGGGGCGTATGGCGCTGG
ATTGGGGGCTGTATGGCGTGCCCGAAACGTATGTCATCGACGGCGACGGCACGGTGGTTCTGCGCTTTGCCGGGCCGATT
ACCAGCCGGGTTCTGGAAGAGACCATTCGCCCCGCCATGGAGCGCGCGGCCCAGTAA

Upstream 100 bases:

>100_bases
GTCTCGCTGGTGTTGCTGGTCGCGCTCCTGGTCGTGACCTTCCTGCGCGGGGCCAAGGTGCGCGCTGCGCTCAAAGACGT
TGAGGAAAGGGTGCGCCGAA

Downstream 100 bases:

>100_bases
GCTCAGAGCCGGTAGCCGCCCGCGACCGTCAGGATTTCGCCAGTGATAAAGCTCGCCTCCTCGGAGGCGAGAAAACGCAC
GGCCTTGGCGATGTCGTCGG

Product: periplasmic protein thiol

Products: NA

Alternate protein names: Cytochrome c biogenesis protein helX [H]

Number of amino acids: Translated: 178; Mature: 177

Protein sequence:

>178_residues
MAKISLMMAIPVVVFSGFVGLALVGMGRDDPESLPSAREGKAAPSVALSDFPGKESFDDATLRDGTVKLVNYWASWCGPC
RAEHPSLTALSEEGVPIYGVNYKDQLANAQSFLEELGDPYAGVGRDEQGRMALDWGLYGVPETYVIDGDGTVVLRFAGPI
TSRVLEETIRPAMERAAQ

Sequences:

>Translated_178_residues
MAKISLMMAIPVVVFSGFVGLALVGMGRDDPESLPSAREGKAAPSVALSDFPGKESFDDATLRDGTVKLVNYWASWCGPC
RAEHPSLTALSEEGVPIYGVNYKDQLANAQSFLEELGDPYAGVGRDEQGRMALDWGLYGVPETYVIDGDGTVVLRFAGPI
TSRVLEETIRPAMERAAQ
>Mature_177_residues
AKISLMMAIPVVVFSGFVGLALVGMGRDDPESLPSAREGKAAPSVALSDFPGKESFDDATLRDGTVKLVNYWASWCGPCR
AEHPSLTALSEEGVPIYGVNYKDQLANAQSFLEELGDPYAGVGRDEQGRMALDWGLYGVPETYVIDGDGTVVLRFAGPIT
SRVLEETIRPAMERAAQ

Specific function: Required for disulfide bond formation in some periplasmic proteins. Also act as a disulfide oxidoreductase in cytochromes c biogenesis. The cysteines of apocytochromes c must be in the reduced state for covalent linkage between the two moieties to occur [

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1788523, Length=178, Percent_Identity=41.0112359550562, Blast_Score=134, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004799
- InterPro:   IPR013740
- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR012335 [H]

Pfam domain/function: PF08534 Redoxin [H]

EC number: NA

Molecular weight: Translated: 19115; Mature: 18984

Theoretical pI: Translated: 4.27; Mature: 4.27

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKISLMMAIPVVVFSGFVGLALVGMGRDDPESLPSAREGKAAPSVALSDFPGKESFDDA
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCEEECCCCCCCCCCCC
TLRDGTVKLVNYWASWCGPCRAEHPSLTALSEEGVPIYGVNYKDQLANAQSFLEELGDPY
CCCCCHHHHHHHHHHHCCCCCCCCCCCEEECCCCCEEEECCHHHHHHHHHHHHHHHCCCC
AGVGRDEQGRMALDWGLYGVPETYVIDGDGTVVLRFAGPITSRVLEETIRPAMERAAQ
CCCCCCCCCCEEEECCCCCCCCEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKISLMMAIPVVVFSGFVGLALVGMGRDDPESLPSAREGKAAPSVALSDFPGKESFDDA
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCEEECCCCCCCCCCCC
TLRDGTVKLVNYWASWCGPCRAEHPSLTALSEEGVPIYGVNYKDQLANAQSFLEELGDPY
CCCCCHHHHHHHHHHHCCCCCCCCCCCEEECCCCCEEEECCHHHHHHHHHHHHHHHCCCC
AGVGRDEQGRMALDWGLYGVPETYVIDGDGTVVLRFAGPITSRVLEETIRPAMERAAQ
CCCCCCCCCCEEEECCCCCCCCEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8384715 [H]