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The map label for this gene is ccmA

Identifier: 99080840

GI number: 99080840

Start: 1071433

End: 1072047

Strand: Direct

Name: ccmA

Synonym: TM1040_0999

Alternate gene names: 99080840

Gene position: 1071433-1072047 (Clockwise)

Preceding gene: 99080839

Following gene: 99080841

Centisome position: 33.47

GC content: 65.69

Gene sequence:

>615_bases
ATGATTGAGGTCAGGGATCTAGGGGTCAGCCGGGGCGGGCTGCCGGTGCTCGCGGGGGTGAACTTCGCGTTGTCGGGCGG
TGAGGCGCTTGTGCTGCGCGGGCCCAACGGGATCGGCAAAACCACGCTTCTGCGCACGCTGGCGCGTCTGCAGCTGCCTT
TGGCGGGCGAGATCCTCGGGGACGCCGAGGATATTGCCTATGCCGCCCATGCGGATGGGGTAAAACTCACTTTGACCGTG
GCCGAGAACCTGTCGTTCTGGTCGCGTGTCTTTGCGGGGGGCGACCCTGCGGTGGCCATCGCGGCGTTTAATCTCGATGC
GCTACAGCATCGCCCGGCCGGCGGGCTCTCGGCGGGGCAGAAACGCAGGCTTTCCTTGGCGCGGCTCATGGTGACGGGGC
GGCGGCTGTGGATCCTGGATGAGCCGACCGTGAGCCTTGATGCAGCCTCTGTGCAATTGTTTGCCTCAAGCATCCGCGCC
CATCTGGCGTCGGGCGGAGCGGCGATCATGGCGACCCATATCGACCTTGGGATCGAGGGCAGGGTGCTGGACCTTGGTCC
CTTTAAGGCCAAGCTTCCGGCGCTGGACGCCGAGGATCTGGGGGGCTTCTTGTGA

Upstream 100 bases:

>100_bases
GGCATTGCCGGTTTGATCTGGCGCAAGGATGCGCTGAGCTTTTGATGCGCAGAGTGCGCCGTGGCGCGGCAGGCTGCGCA
AGCGATATATCGGGACACGC

Downstream 100 bases:

>100_bases
TTGCACTCTTGATGCGGGATCTGCGGCTGGCGTTGCGGGCCGGGGGAGGATTTGGGCTTGGGCTTGCGTTTTTCCTGATC
GTGACCGTGATGGTGCCTTT

Product: cytochrome c biogenesis protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A

Number of amino acids: Translated: 204; Mature: 204

Protein sequence:

>204_residues
MIEVRDLGVSRGGLPVLAGVNFALSGGEALVLRGPNGIGKTTLLRTLARLQLPLAGEILGDAEDIAYAAHADGVKLTLTV
AENLSFWSRVFAGGDPAVAIAAFNLDALQHRPAGGLSAGQKRRLSLARLMVTGRRLWILDEPTVSLDAASVQLFASSIRA
HLASGGAAIMATHIDLGIEGRVLDLGPFKAKLPALDAEDLGGFL

Sequences:

>Translated_204_residues
MIEVRDLGVSRGGLPVLAGVNFALSGGEALVLRGPNGIGKTTLLRTLARLQLPLAGEILGDAEDIAYAAHADGVKLTLTV
AENLSFWSRVFAGGDPAVAIAAFNLDALQHRPAGGLSAGQKRRLSLARLMVTGRRLWILDEPTVSLDAASVQLFASSIRA
HLASGGAAIMATHIDLGIEGRVLDLGPFKAKLPALDAEDLGGFL
>Mature_204_residues
MIEVRDLGVSRGGLPVLAGVNFALSGGEALVLRGPNGIGKTTLLRTLARLQLPLAGEILGDAEDIAYAAHADGVKLTLTV
AENLSFWSRVFAGGDPAVAIAAFNLDALQHRPAGGLSAGQKRRLSLARLMVTGRRLWILDEPTVSLDAASVQLFASSIRA
HLASGGAAIMATHIDLGIEGRVLDLGPFKAKLPALDAEDLGGFL

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain

Homologues:

Organism=Homo sapiens, GI9961252, Length=165, Percent_Identity=28.4848484848485, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI4505771, Length=173, Percent_Identity=27.1676300578035, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI42741659, Length=165, Percent_Identity=30.3030303030303, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI9955963, Length=196, Percent_Identity=31.1224489795918, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI87082064, Length=189, Percent_Identity=36.5079365079365, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1788897, Length=186, Percent_Identity=33.8709677419355, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI1786698, Length=206, Percent_Identity=28.1553398058252, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI87081709, Length=166, Percent_Identity=27.1084337349398, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787370, Length=180, Percent_Identity=30.5555555555556, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI87081782, Length=191, Percent_Identity=29.3193717277487, Blast_Score=70, Evalue=8e-14,
Organism=Escherichia coli, GI1787041, Length=168, Percent_Identity=31.547619047619, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790467, Length=190, Percent_Identity=31.0526315789474, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1790739, Length=206, Percent_Identity=30.0970873786408, Blast_Score=67, Evalue=6e-13,
Organism=Escherichia coli, GI87081791, Length=194, Percent_Identity=28.3505154639175, Blast_Score=65, Evalue=2e-12,
Organism=Escherichia coli, GI2367384, Length=180, Percent_Identity=30, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1786345, Length=203, Percent_Identity=28.5714285714286, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1786563, Length=188, Percent_Identity=28.7234042553192, Blast_Score=61, Evalue=4e-11,
Organism=Escherichia coli, GI1787029, Length=203, Percent_Identity=25.1231527093596, Blast_Score=61, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI115533608, Length=181, Percent_Identity=29.8342541436464, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17567265, Length=187, Percent_Identity=27.807486631016, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCMA_SILST (Q1GHY4)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_612994.1
- ProteinModelPortal:   Q1GHY4
- SMR:   Q1GHY4
- STRING:   Q1GHY4
- GeneID:   4078219
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_0999
- NMPDR:   fig|292414.1.peg.3073
- eggNOG:   COG4133
- HOGENOM:   HBG758042
- OMA:   IMATHID
- PhylomeDB:   Q1GHY4
- ProtClustDB:   PRK13539
- BioCyc:   SSP292414:TM1040_0999-MONOMER
- HAMAP:   MF_01707
- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR005895
- InterPro:   IPR003593
- PANTHER:   PTHR19222:SF5
- SMART:   SM00382
- TIGRFAMs:   TIGR01189

Pfam domain/function: PF00005 ABC_tran

EC number: =3.6.3.41

Molecular weight: Translated: 21178; Mature: 21178

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS00211 ABC_TRANSPORTER_1; PS50893 ABC_TRANSPORTER_2; PS51243 CCMA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEVRDLGVSRGGLPVLAGVNFALSGGEALVLRGPNGIGKTTLLRTLARLQLPLAGEILG
CEEEECCCCCCCCCEEEECCEEEECCCCEEEEECCCCCCHHHHHHHHHHHCCCCCHHHCC
DAEDIAYAAHADGVKLTLTVAENLSFWSRVFAGGDPAVAIAAFNLDALQHRPAGGLSAGQ
CHHHHEEEECCCCEEEEEEEECCCHHHHHHHCCCCCEEEEEEECHHHHHCCCCCCCCCCH
KRRLSLARLMVTGRRLWILDEPTVSLDAASVQLFASSIRAHLASGGAAIMATHIDLGIEG
HHHHHHHHHHHCCCEEEEEECCCCEECHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCC
RVLDLGPFKAKLPALDAEDLGGFL
EEEECCCCCCCCCCCCHHHCCCCC
>Mature Secondary Structure
MIEVRDLGVSRGGLPVLAGVNFALSGGEALVLRGPNGIGKTTLLRTLARLQLPLAGEILG
CEEEECCCCCCCCCEEEECCEEEECCCCEEEEECCCCCCHHHHHHHHHHHCCCCCHHHCC
DAEDIAYAAHADGVKLTLTVAENLSFWSRVFAGGDPAVAIAAFNLDALQHRPAGGLSAGQ
CHHHHEEEECCCCEEEEEEEECCCHHHHHHHCCCCCEEEEEEECHHHHHCCCCCCCCCCH
KRRLSLARLMVTGRRLWILDEPTVSLDAASVQLFASSIRAHLASGGAAIMATHIDLGIEG
HHHHHHHHHHHCCCEEEEEECCCCEECHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCC
RVLDLGPFKAKLPALDAEDLGGFL
EEEECCCCCCCCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA