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The map label for this gene is fabH

Identifier: 99080755

GI number: 99080755

Start: 976013

End: 976984

Strand: Reverse

Name: fabH

Synonym: TM1040_0914

Alternate gene names: 99080755

Gene position: 976984-976013 (Counterclockwise)

Preceding gene: 99080756

Following gene: 99080754

Centisome position: 30.52

GC content: 61.52

Gene sequence:

>972_bases
ATGACGCGACGCGCAGTTGTGATTGGCGCAGGGCACTACCTCCCAGACCGCATTGTAGAGAACGCTGAATTCGAGGCTAC
GCTGGATACCTCTGACGAATGGATTCGCTCGCGTTCCGGGATCGAACGCCGCCATTTCGCCGCCGAAGGGGAAACCACCT
CGCACATGGCCACTCGTGCCGCCGAGGCCGCGCTCAAATCCGCAGGACGCAGCGCAGATGATGTCGACGCCATTGTTCTG
GCCACATCGACGGCAGATCTGACCTTTCCCTCCGCCGCAACCATGGTGCAATCGCAGCTTGGCATGACCAAGGGGTTTGC
CTTTGATGTGCAGGCGGTGTGCGCGGGCTTTGTCTATGCGCTCTCAAACGCCAACGCGCTGATTGCCTCTGGTCAGGCCG
ATCGCGTTCTGGTCATTGGTGCCGAGACGTTTTCGCGCATCATGGACTGGACGGATCGTTCGACCTGCGTGCTTTTTGGA
GACGGCGCGGGCGCGCTTCTGCTGGAGGCGCAGGAGGGCGAAGGCACCTCCAAGGATCGCGGCATTCTGGCGACGGATCT
GAATTCTGACGGTCGTTACAAGGACTTGCTCTATGTCGATGGTGGCGTGTCGACCCAATCGACGGGCTATCTGCGCATGC
AGGGCAACCAGGTCTTCCGCCACGCAGTCGAAAAACTCGCCTCCACAGCCCATACGGCTCTGGAGCGCGCCGGTGCCAGC
ACCGACGAGGTGGATTGGATCGTCCCCCATCAGGCCAACATCCGCATCATTCAGGGCACCGCCAAGAAAATGGGCCTGCC
CATGGACAAGGTGGTCGTGACCGTTCAGGATCACGGGAACACCTCCGCTGCCTCCATCCCGCTGGCCCTGTCCGTCGGGG
TTGAGCGCGGCCAGATCAAACCCGGCGATCTCATCGTTACCGAGGCCATTGGTGGCGGTCTGGCGTGGGGTGCTGTGGTT
TTGCGGTGGTAA

Upstream 100 bases:

>100_bases
ATCCGCCGTAGAGCTTGCCCAAGATGACGCAACGTCCGCAGACGCGGACGCACCCGGCGATTCTGAGACCGGGAGCACGA
ACTAGAAGGCAGGCAAACGA

Downstream 100 bases:

>100_bases
TGCGGGGGAAACCGCACCTTCCAATTCATTGATATTGACAGGGAAATTCCTGACCTCCTATTGTTTTGAGAAACAACGGG
GATGGCTATGACTGAAAAAA

Product: 3-oxoacyl-[acyl-carrier-protein] synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MTRRAVVIGAGHYLPDRIVENAEFEATLDTSDEWIRSRSGIERRHFAAEGETTSHMATRAAEAALKSAGRSADDVDAIVL
ATSTADLTFPSAATMVQSQLGMTKGFAFDVQAVCAGFVYALSNANALIASGQADRVLVIGAETFSRIMDWTDRSTCVLFG
DGAGALLLEAQEGEGTSKDRGILATDLNSDGRYKDLLYVDGGVSTQSTGYLRMQGNQVFRHAVEKLASTAHTALERAGAS
TDEVDWIVPHQANIRIIQGTAKKMGLPMDKVVVTVQDHGNTSAASIPLALSVGVERGQIKPGDLIVTEAIGGGLAWGAVV
LRW

Sequences:

>Translated_323_residues
MTRRAVVIGAGHYLPDRIVENAEFEATLDTSDEWIRSRSGIERRHFAAEGETTSHMATRAAEAALKSAGRSADDVDAIVL
ATSTADLTFPSAATMVQSQLGMTKGFAFDVQAVCAGFVYALSNANALIASGQADRVLVIGAETFSRIMDWTDRSTCVLFG
DGAGALLLEAQEGEGTSKDRGILATDLNSDGRYKDLLYVDGGVSTQSTGYLRMQGNQVFRHAVEKLASTAHTALERAGAS
TDEVDWIVPHQANIRIIQGTAKKMGLPMDKVVVTVQDHGNTSAASIPLALSVGVERGQIKPGDLIVTEAIGGGLAWGAVV
LRW
>Mature_322_residues
TRRAVVIGAGHYLPDRIVENAEFEATLDTSDEWIRSRSGIERRHFAAEGETTSHMATRAAEAALKSAGRSADDVDAIVLA
TSTADLTFPSAATMVQSQLGMTKGFAFDVQAVCAGFVYALSNANALIASGQADRVLVIGAETFSRIMDWTDRSTCVLFGD
GAGALLLEAQEGEGTSKDRGILATDLNSDGRYKDLLYVDGGVSTQSTGYLRMQGNQVFRHAVEKLASTAHTALERAGAST
DEVDWIVPHQANIRIIQGTAKKMGLPMDKVVVTVQDHGNTSAASIPLALSVGVERGQIKPGDLIVTEAIGGGLAWGAVVL
RW

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=319, Percent_Identity=47.3354231974922, Blast_Score=293, Evalue=1e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_SILST (Q1GI69)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_612909.1
- ProteinModelPortal:   Q1GI69
- SMR:   Q1GI69
- STRING:   Q1GI69
- GeneID:   4076284
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_0914
- NMPDR:   fig|292414.1.peg.2995
- eggNOG:   COG0332
- HOGENOM:   HBG649927
- OMA:   TACIVQQ
- PhylomeDB:   Q1GI69
- ProtClustDB:   CLSK933877
- BioCyc:   SSP292414:TM1040_0914-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.41

Molecular weight: Translated: 34239; Mature: 34108

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: ACT_SITE 114-114 ACT_SITE 250-250 ACT_SITE 280-280

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRRAVVIGAGHYLPDRIVENAEFEATLDTSDEWIRSRSGIERRHFAAEGETTSHMATRA
CCCEEEEEECCCCCHHHHHCCCCEEEEECCCHHHHHHHCCCCHHHCCCCCCCHHHHHHHH
AEAALKSAGRSADDVDAIVLATSTADLTFPSAATMVQSQLGMTKGFAFDVQAVCAGFVYA
HHHHHHHCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEHHHHHHHHHHH
LSNANALIASGQADRVLVIGAETFSRIMDWTDRSTCVLFGDGAGALLLEAQEGEGTSKDR
HCCCCEEEECCCCCEEEEEEHHHHHHHHCCCCCCEEEEEECCCCEEEEEECCCCCCCCCC
GILATDLNSDGRYKDLLYVDGGVSTQSTGYLRMQGNQVFRHAVEKLASTAHTALERAGAS
CEEEEECCCCCCEEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCC
TDEVDWIVPHQANIRIIQGTAKKMGLPMDKVVVTVQDHGNTSAASIPLALSVGVERGQIK
CCCEEEEECCCCCEEEEECCHHHHCCCHHHEEEEEECCCCCCCEEEEEEEEECCCCCCCC
PGDLIVTEAIGGGLAWGAVVLRW
CCCEEEEECCCCCCEEEEEEEEC
>Mature Secondary Structure 
TRRAVVIGAGHYLPDRIVENAEFEATLDTSDEWIRSRSGIERRHFAAEGETTSHMATRA
CCEEEEEECCCCCHHHHHCCCCEEEEECCCHHHHHHHCCCCHHHCCCCCCCHHHHHHHH
AEAALKSAGRSADDVDAIVLATSTADLTFPSAATMVQSQLGMTKGFAFDVQAVCAGFVYA
HHHHHHHCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEHHHHHHHHHHH
LSNANALIASGQADRVLVIGAETFSRIMDWTDRSTCVLFGDGAGALLLEAQEGEGTSKDR
HCCCCEEEECCCCCEEEEEEHHHHHHHHCCCCCCEEEEEECCCCEEEEEECCCCCCCCCC
GILATDLNSDGRYKDLLYVDGGVSTQSTGYLRMQGNQVFRHAVEKLASTAHTALERAGAS
CEEEEECCCCCCEEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCC
TDEVDWIVPHQANIRIIQGTAKKMGLPMDKVVVTVQDHGNTSAASIPLALSVGVERGQIK
CCCEEEEECCCCCEEEEECCHHHHCCCHHHEEEEEECCCCCCCEEEEEEEEECCCCCCCC
PGDLIVTEAIGGGLAWGAVVLRW
CCCEEEEECCCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA