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The map label for this gene is kdgA [H]

Identifier: 94972277

GI number: 94972277

Start: 215224

End: 215850

Strand: Direct

Name: kdgA [H]

Synonym: Dgeo_2812

Alternate gene names: 94972277

Gene position: 215224-215850 (Clockwise)

Preceding gene: 94972278

Following gene: 94972276

Centisome position: 37.49

GC content: 64.75

Gene sequence:

>627_bases
ATGGTTGATCTGCTCAGCGAGCTGCGCCGCAGCAGAATTCTGGCTATTCTGCGGGGCGTACCGCCTCAACACGCCCCCCG
GCTGGTGGCGACCCTGCGAGAAGCGGGCATCCAACTCTTCGAGGTCGCCCTCAGTGACGACCTGGGTCTGCCCACCTTGC
AGGCCATCCGCACAGCCTTTCCTGATCTCACTCTGGGCGCAGGAACGGTCGTCACGCCAGACCTTGCTCGGCAAGCGCAG
GCGGCGGGGGCGACCTTTCTGGTCACGCCGCATCTGGTACCGGACGTGAATGCCTATGCCCGCGCTCAGCGTCTGGAACT
CCTCAGCGGCGCATTCTCTCCCACCGAAATTGACACTGCCCACACACAGGGGAGCGTGGCGGTCAAGGTCTTTCCGGCAG
GAAGTCTCGGCCCAGACTACTTCCGCCAGCTGCGCGGCCCCTATCCACACCTTCCGCTGCTGGCCGTGGGAGGGGTAGAT
GCCAGGAACCTCAAGGCCTATCTCCAGGCTGGCGTCATCGGCGTGGGCATCGGCGGGGCGCTGACCCGGACCGACTGGAG
CAACCCCAACTGGGCCGAGCTCCAGCAGGTCGCTGAGGAAATGATGCAGTGCGCAACCAATCCATGA

Upstream 100 bases:

>100_bases
TGGGGAGAAACAGGCCGCCCTGGATATGGCCTCTATGACCGTGCCCTGGGAGCCATGTACCTGCAGGGGCTGATCGATGC
CATGCGGGAACGGAGGCAGC

Downstream 100 bases:

>100_bases
TCCTTTTGTCAAGCTCCGGAGTTACAGAATGAAGATCACCAATATCGAAACCTTTCTGGTGCCGCCACGCTGGTGCTTTT
TGAAACTTGAAACGGACGAG

Product: KDPG and KHG aldolase

Products: NA

Alternate protein names: 4-hydroxy-2-oxoglutarate aldolase; 2-keto-4-hydroxyglutarate aldolase; KHG-aldolase; 2-dehydro-3-deoxy-phosphogluconate aldolase; 2-keto-3-deoxy-6-phosphogluconate aldolase; KDPG-aldolase; Phospho-2-dehydro-3-deoxygluconate aldolase; Phospho-2-keto-3-deoxygluconate aldolase [H]

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MVDLLSELRRSRILAILRGVPPQHAPRLVATLREAGIQLFEVALSDDLGLPTLQAIRTAFPDLTLGAGTVVTPDLARQAQ
AAGATFLVTPHLVPDVNAYARAQRLELLSGAFSPTEIDTAHTQGSVAVKVFPAGSLGPDYFRQLRGPYPHLPLLAVGGVD
ARNLKAYLQAGVIGVGIGGALTRTDWSNPNWAELQQVAEEMMQCATNP

Sequences:

>Translated_208_residues
MVDLLSELRRSRILAILRGVPPQHAPRLVATLREAGIQLFEVALSDDLGLPTLQAIRTAFPDLTLGAGTVVTPDLARQAQ
AAGATFLVTPHLVPDVNAYARAQRLELLSGAFSPTEIDTAHTQGSVAVKVFPAGSLGPDYFRQLRGPYPHLPLLAVGGVD
ARNLKAYLQAGVIGVGIGGALTRTDWSNPNWAELQQVAEEMMQCATNP
>Mature_208_residues
MVDLLSELRRSRILAILRGVPPQHAPRLVATLREAGIQLFEVALSDDLGLPTLQAIRTAFPDLTLGAGTVVTPDLARQAQ
AAGATFLVTPHLVPDVNAYARAQRLELLSGAFSPTEIDTAHTQGSVAVKVFPAGSLGPDYFRQLRGPYPHLPLLAVGGVD
ARNLKAYLQAGVIGVGIGGALTRTDWSNPNWAELQQVAEEMMQCATNP

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. PARTICIPATES IN THE REGULATION OF THE INTRACELLULAR LEVEL OF GLYOXYLATE. [C]

COG id: COG0800

COG function: function code G; 2-keto-3-deoxy-6-phosphogluconate aldolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the KHG/KDPG aldolase family [H]

Homologues:

Organism=Escherichia coli, GI48994954, Length=177, Percent_Identity=33.3333333333333, Blast_Score=89, Evalue=2e-19,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000887
- InterPro:   IPR013785 [H]

Pfam domain/function: PF01081 Aldolase [H]

EC number: =4.1.3.16; =4.1.2.14 [H]

Molecular weight: Translated: 22149; Mature: 22149

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDLLSELRRSRILAILRGVPPQHAPRLVATLREAGIQLFEVALSDDLGLPTLQAIRTAF
CHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
PDLTLGAGTVVTPDLARQAQAAGATFLVTPHLVPDVNAYARAQRLELLSGAFSPTEIDTA
CCCCCCCCCEECHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
HTQGSVAVKVFPAGSLGPDYFRQLRGPYPHLPLLAVGGVDARNLKAYLQAGVIGVGIGGA
CCCCCEEEEEEECCCCCHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHCEEEECCCCC
LTRTDWSNPNWAELQQVAEEMMQCATNP
EEECCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVDLLSELRRSRILAILRGVPPQHAPRLVATLREAGIQLFEVALSDDLGLPTLQAIRTAF
CHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
PDLTLGAGTVVTPDLARQAQAAGATFLVTPHLVPDVNAYARAQRLELLSGAFSPTEIDTA
CCCCCCCCCEECHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
HTQGSVAVKVFPAGSLGPDYFRQLRGPYPHLPLLAVGGVDARNLKAYLQAGVIGVGIGGA
CCCCCEEEEEEECCCCCHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHCEEEECCCCC
LTRTDWSNPNWAELQQVAEEMMQCATNP
EEECCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377 [H]