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The map label for this gene is envZ [H]

Identifier: 94312810

GI number: 94312810

Start: 426322

End: 427635

Strand: Direct

Name: envZ [H]

Synonym: Rmet_3882

Alternate gene names: 94312810

Gene position: 426322-427635 (Clockwise)

Preceding gene: 94312809

Following gene: 94312811

Centisome position: 16.52

GC content: 67.05

Gene sequence:

>1314_bases
ATGCGAATCGGACTGCCGCGCTCGCTGCTGGCTCGCAACATCGCGCTGCTGGTGGCGCTGGTGGCGTTCACGCAGGTGTG
TTCGCTGATGGTGCTGCTGCACTTCGCGCAACGCCCGCGCGTGGAGCGCGCCGCGACGGTGTTCGCGCACTACGTGTCAA
TGCTCGATGGCGTGATGGCGGCCATGCCGGCCGAAGAAGCCAGAGTGGCCGTGGCGCGCCTGGGTGGTCAGACGGACGCG
CCGGCAGTGGACGATGTGATGGAAGCGCGGGCGCTGCATCCGTTCCGCACCTGGCAGCGCGACGTGTTCATGGACGAGCT
GCACAAGGCCCTGCCACCCGATATGCCGGTGCAGTGGCAGGATGCGGGCGACAACGAGCGGCTCTGGATCCGCATTCGCG
CAGCCGGGATGCCAACGTGGGTGGCCTTGCCGATGACCGCCGATGCGCAGGCCAGCGGCATCACGGCTGCCATTGCGCTT
TCCGCGGCGCTCGGGCTGCTGGCAGCGCTGACCGGATACCTGATCCAGCGCCATATCAATCGGCCGTTGCAGGACCTGGC
GCGCGCGGCGTTGCACGTCAGCGCCGGAGAGACGCCCGCGCCGCTGCCCACCGATGGGCCGACCGAGATATCGCAGGTCA
GCAGTGCGTTCAATCGCATGACTGAAGCCCTGCAGCAGACCGAGAAGACGCGCGCGCTGATGCTGGCCGGTATTTCGCAC
GATATCCGCACGCCGCTGACCAAGTTGCGTCTGGCGATGGCGATGGCGTTGCCGCGCGGGACGGACGATGCGTTCGTGGG
CTCGGTGGAAGGCTACCTCGATCGCATCGACACGATCCTCCAGCAGTTCATGGACTACGCGGGCAGTGGCGAACGCGAGG
CCCCGCAGCCGGGTGACCTCAATGCGCTGGTGCGCCAACTCGCGTCCGACTTCGCCGGGCTCGGCCATGAATTCGAACTC
GATCTCGGCGATCTGCCGCCGGTTTCGTATCGCCCGACGAGCATGTTGCGCCTGTTGATGAACCTGATGCAGAACGCCAT
TAACTATGGCCGTACGGGACTGATGGTGCGCACATGGAAGGAAGGCGGCGCCGCGCATGTTGCCGTTTGCGATCGTGGCA
TCGGTATCAGCGTGGCCGAGCTCGAACAGCTGCGCGCCCCGTTCAGCCGCGGCGACAATGCGCGCGGGCACTCGGGCGGC
ACGGGGCTCGGGCTGGCCATCGTCGAGCGGATCGCGCGACTGCACGGCGGATCACTCGCGTTCCGTCCGCGCGAGGGCGG
AGGACTGGAAGTGGTGGTGTCGTTGCCCGTATGA

Upstream 100 bases:

>100_bases
TGAGGCTGCGCCAGATCGTCGAGGAAGATCCGTCCAAACCACGCTTCATCAAGACGGTTTGGGGGGTGGGATACATGCTG
GTGGCCGGCGTGGAGGCGTG

Downstream 100 bases:

>100_bases
CATTGAATGAAATAGTTCTTGCCTGGCCTGTTGCATGGCCGCATCCGATACTGGGTCTGCCGGCGCCGAAACCACGCAGC
CCCCAAATAGACCCATTAGC

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MRIGLPRSLLARNIALLVALVAFTQVCSLMVLLHFAQRPRVERAATVFAHYVSMLDGVMAAMPAEEARVAVARLGGQTDA
PAVDDVMEARALHPFRTWQRDVFMDELHKALPPDMPVQWQDAGDNERLWIRIRAAGMPTWVALPMTADAQASGITAAIAL
SAALGLLAALTGYLIQRHINRPLQDLARAALHVSAGETPAPLPTDGPTEISQVSSAFNRMTEALQQTEKTRALMLAGISH
DIRTPLTKLRLAMAMALPRGTDDAFVGSVEGYLDRIDTILQQFMDYAGSGEREAPQPGDLNALVRQLASDFAGLGHEFEL
DLGDLPPVSYRPTSMLRLLMNLMQNAINYGRTGLMVRTWKEGGAAHVAVCDRGIGISVAELEQLRAPFSRGDNARGHSGG
TGLGLAIVERIARLHGGSLAFRPREGGGLEVVVSLPV

Sequences:

>Translated_437_residues
MRIGLPRSLLARNIALLVALVAFTQVCSLMVLLHFAQRPRVERAATVFAHYVSMLDGVMAAMPAEEARVAVARLGGQTDA
PAVDDVMEARALHPFRTWQRDVFMDELHKALPPDMPVQWQDAGDNERLWIRIRAAGMPTWVALPMTADAQASGITAAIAL
SAALGLLAALTGYLIQRHINRPLQDLARAALHVSAGETPAPLPTDGPTEISQVSSAFNRMTEALQQTEKTRALMLAGISH
DIRTPLTKLRLAMAMALPRGTDDAFVGSVEGYLDRIDTILQQFMDYAGSGEREAPQPGDLNALVRQLASDFAGLGHEFEL
DLGDLPPVSYRPTSMLRLLMNLMQNAINYGRTGLMVRTWKEGGAAHVAVCDRGIGISVAELEQLRAPFSRGDNARGHSGG
TGLGLAIVERIARLHGGSLAFRPREGGGLEVVVSLPV
>Mature_437_residues
MRIGLPRSLLARNIALLVALVAFTQVCSLMVLLHFAQRPRVERAATVFAHYVSMLDGVMAAMPAEEARVAVARLGGQTDA
PAVDDVMEARALHPFRTWQRDVFMDELHKALPPDMPVQWQDAGDNERLWIRIRAAGMPTWVALPMTADAQASGITAAIAL
SAALGLLAALTGYLIQRHINRPLQDLARAALHVSAGETPAPLPTDGPTEISQVSSAFNRMTEALQQTEKTRALMLAGISH
DIRTPLTKLRLAMAMALPRGTDDAFVGSVEGYLDRIDTILQQFMDYAGSGEREAPQPGDLNALVRQLASDFAGLGHEFEL
DLGDLPPVSYRPTSMLRLLMNLMQNAINYGRTGLMVRTWKEGGAAHVAVCDRGIGISVAELEQLRAPFSRGDNARGHSGG
TGLGLAIVERIARLHGGSLAFRPREGGGLEVVVSLPV

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=448, Percent_Identity=32.3660714285714, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI1790346, Length=266, Percent_Identity=29.3233082706767, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1786783, Length=285, Percent_Identity=28.4210526315789, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1787894, Length=288, Percent_Identity=26.0416666666667, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1790436, Length=232, Percent_Identity=30.6034482758621, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1788393, Length=268, Percent_Identity=25, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI145693157, Length=241, Percent_Identity=25.3112033195021, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788549, Length=216, Percent_Identity=25.9259259259259, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI48994928, Length=231, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI87081816, Length=303, Percent_Identity=26.7326732673267, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786600, Length=283, Percent_Identity=24.7349823321555, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47133; Mature: 47133

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGLPRSLLARNIALLVALVAFTQVCSLMVLLHFAQRPRVERAATVFAHYVSMLDGVMA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
AMPAEEARVAVARLGGQTDAPAVDDVMEARALHPFRTWQRDVFMDELHKALPPDMPVQWQ
HCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEC
DAGDNERLWIRIRAAGMPTWVALPMTADAQASGITAAIALSAALGLLAALTGYLIQRHIN
CCCCCCEEEEEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
RPLQDLARAALHVSAGETPAPLPTDGPTEISQVSSAFNRMTEALQQTEKTRALMLAGISH
CHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
DIRTPLTKLRLAMAMALPRGTDDAFVGSVEGYLDRIDTILQQFMDYAGSGEREAPQPGDL
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
NALVRQLASDFAGLGHEFELDLGDLPPVSYRPTSMLRLLMNLMQNAINYGRTGLMVRTWK
HHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
EGGAAHVAVCDRGIGISVAELEQLRAPFSRGDNARGHSGGTGLGLAIVERIARLHGGSLA
CCCCEEEEEECCCCCCCHHHHHHHHCCHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEE
FRPREGGGLEVVVSLPV
ECCCCCCCEEEEEECCC
>Mature Secondary Structure
MRIGLPRSLLARNIALLVALVAFTQVCSLMVLLHFAQRPRVERAATVFAHYVSMLDGVMA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
AMPAEEARVAVARLGGQTDAPAVDDVMEARALHPFRTWQRDVFMDELHKALPPDMPVQWQ
HCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEC
DAGDNERLWIRIRAAGMPTWVALPMTADAQASGITAAIALSAALGLLAALTGYLIQRHIN
CCCCCCEEEEEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
RPLQDLARAALHVSAGETPAPLPTDGPTEISQVSSAFNRMTEALQQTEKTRALMLAGISH
CHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
DIRTPLTKLRLAMAMALPRGTDDAFVGSVEGYLDRIDTILQQFMDYAGSGEREAPQPGDL
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
NALVRQLASDFAGLGHEFELDLGDLPPVSYRPTSMLRLLMNLMQNAINYGRTGLMVRTWK
HHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
EGGAAHVAVCDRGIGISVAELEQLRAPFSRGDNARGHSGGTGLGLAIVERIARLHGGSLA
CCCCEEEEEECCCCCCCHHHHHHHHCCHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEE
FRPREGGGLEVVVSLPV
ECCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]