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The map label for this gene is aaeR [H]

Identifier: 94312798

GI number: 94312798

Start: 413830

End: 414699

Strand: Direct

Name: aaeR [H]

Synonym: Rmet_3870

Alternate gene names: 94312798

Gene position: 413830-414699 (Clockwise)

Preceding gene: 94312796

Following gene: 94312803

Centisome position: 16.04

GC content: 63.1

Gene sequence:

>870_bases
GTGGAACTACTGAATGACATGGCCTTGTTCGTGGAGGTCGTCAAGGCGAAGGGGTTTCGCAGTGCTGCGGATGTTCTGGA
TATGCCGAGTTCGACGCTGTCCCGGCGGATCAGCGCCTTGGAAAAGGCGATCGGGTTGCGCCTGCTGCACCGCACGACGC
GCAAGATCGAGCTGACCGAGGCCGGCCGGATCTACTTCGAGCGATGCAAGCGCATCGTGGGCGATGCCAGGCTGGCTCAC
GAACAGCTCGGTACCATGCTGGCGGAGCCAGTGGGCGTGCTCCGCGCGTCATTTCCAGTTGATTTCGCGGTGACCTATCT
GGCGCCACTGATTGCCGAGTTTGCTGGCCGCTACCCGGGACTGAGCTTCGACTTCGATCTCACGCCCCGGCGTGTGGATC
TGGTGAGCGAGCCGTTCGATGTCGCCATCCGCGCGGGGGAGCCCGAAGTCTCGCAACTGATCGCGCGTCAGCTGGCGTCG
TTCCGGACCTATCTCTATGCCTCGCCCGGATATATCAAACGCGCGGGAGAACCGCGCGCTCCCGCCGATCTGAATCATCA
CGAATGTCTGGGCATACAGCGGGGCGGTGCGTGGACACTGCATCGCGGCGAAGACACCACCACGATCCCGGTGGGCAGCC
GCTTTACGTTGAACAGCGTCGGGATGGCGCGCCGCTTGGCCGCGCTCGACATGGGCATCGTGCTGATGGCCGAAGCGATC
GTGGCGGATGATCTCGCCACGGGACAGCTACGCCGGCTGATGCCCGAATGGCAGGGAACGCCGGTACCGGTCTACGCCAT
GACCGAGACGCGCCTGCTTCCGGCCAAGACGCAGCGATTCATAGAATTCCTGCGTGAACGATTCGAGTAA

Upstream 100 bases:

>100_bases
TCGCGCGGATCAGGCTTCCATGGCGCCATCATCGGTGGCTTCCTGTTCGAGATAAATCTGCTAATTTGCAATGCATTGAT
CCACTGATGGAGCAATCGGC

Downstream 100 bases:

>100_bases
CAGGCGCGTAGCCGCGCGCTCAACGATTTGAAAAGCCAACAATCGAGAGAGCTTCTAATGCCACGTCTTATCCCACGTCT
TGTGCCAACGCCGACGAAGG

Product: putative transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MELLNDMALFVEVVKAKGFRSAADVLDMPSSTLSRRISALEKAIGLRLLHRTTRKIELTEAGRIYFERCKRIVGDARLAH
EQLGTMLAEPVGVLRASFPVDFAVTYLAPLIAEFAGRYPGLSFDFDLTPRRVDLVSEPFDVAIRAGEPEVSQLIARQLAS
FRTYLYASPGYIKRAGEPRAPADLNHHECLGIQRGGAWTLHRGEDTTTIPVGSRFTLNSVGMARRLAALDMGIVLMAEAI
VADDLATGQLRRLMPEWQGTPVPVYAMTETRLLPAKTQRFIEFLRERFE

Sequences:

>Translated_289_residues
MELLNDMALFVEVVKAKGFRSAADVLDMPSSTLSRRISALEKAIGLRLLHRTTRKIELTEAGRIYFERCKRIVGDARLAH
EQLGTMLAEPVGVLRASFPVDFAVTYLAPLIAEFAGRYPGLSFDFDLTPRRVDLVSEPFDVAIRAGEPEVSQLIARQLAS
FRTYLYASPGYIKRAGEPRAPADLNHHECLGIQRGGAWTLHRGEDTTTIPVGSRFTLNSVGMARRLAALDMGIVLMAEAI
VADDLATGQLRRLMPEWQGTPVPVYAMTETRLLPAKTQRFIEFLRERFE
>Mature_289_residues
MELLNDMALFVEVVKAKGFRSAADVLDMPSSTLSRRISALEKAIGLRLLHRTTRKIELTEAGRIYFERCKRIVGDARLAH
EQLGTMLAEPVGVLRASFPVDFAVTYLAPLIAEFAGRYPGLSFDFDLTPRRVDLVSEPFDVAIRAGEPEVSQLIARQLAS
FRTYLYASPGYIKRAGEPRAPADLNHHECLGIQRGGAWTLHRGEDTTTIPVGSRFTLNSVGMARRLAALDMGIVLMAEAI
VADDLATGQLRRLMPEWQGTPVPVYAMTETRLLPAKTQRFIEFLRERFE

Specific function: Activates transcription of the aaeXAB operon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789639, Length=293, Percent_Identity=35.4948805460751, Blast_Score=158, Evalue=4e-40,
Organism=Escherichia coli, GI87081978, Length=293, Percent_Identity=33.7883959044369, Blast_Score=144, Evalue=6e-36,
Organism=Escherichia coli, GI1786401, Length=290, Percent_Identity=32.0689655172414, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1789440, Length=259, Percent_Identity=28.1853281853282, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI145693193, Length=291, Percent_Identity=28.1786941580756, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1787128, Length=261, Percent_Identity=26.4367816091954, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1787589, Length=231, Percent_Identity=29.4372294372294, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788706, Length=299, Percent_Identity=25.0836120401338, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1789173, Length=250, Percent_Identity=26, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1786448, Length=249, Percent_Identity=25.7028112449799, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32232; Mature: 32232

Theoretical pI: Translated: 8.67; Mature: 8.67

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELLNDMALFVEVVKAKGFRSAADVLDMPSSTLSRRISALEKAIGLRLLHRTTRKIELTE
CCHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECH
AGRIYFERCKRIVGDARLAHEQLGTMLAEPVGVLRASFPVDFAVTYLAPLIAEFAGRYPG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC
LSFDFDLTPRRVDLVSEPFDVAIRAGEPEVSQLIARQLASFRTYLYASPGYIKRAGEPRA
CCEECCCCCCHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCC
PADLNHHECLGIQRGGAWTLHRGEDTTTIPVGSRFTLNSVGMARRLAALDMGIVLMAEAI
CCCCCCHHEEEEECCCEEEEECCCCCEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
VADDLATGQLRRLMPEWQGTPVPVYAMTETRLLPAKTQRFIEFLRERFE
HHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MELLNDMALFVEVVKAKGFRSAADVLDMPSSTLSRRISALEKAIGLRLLHRTTRKIELTE
CCHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECH
AGRIYFERCKRIVGDARLAHEQLGTMLAEPVGVLRASFPVDFAVTYLAPLIAEFAGRYPG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC
LSFDFDLTPRRVDLVSEPFDVAIRAGEPEVSQLIARQLASFRTYLYASPGYIKRAGEPRA
CCEECCCCCCHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCC
PADLNHHECLGIQRGGAWTLHRGEDTTTIPVGSRFTLNSVGMARRLAALDMGIVLMAEAI
CCCCCCHHEEEEECCCEEEEECCCCCEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
VADDLATGQLRRLMPEWQGTPVPVYAMTETRLLPAKTQRFIEFLRERFE
HHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]