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The map label for this gene is guaD [H]

Identifier: 94312654

GI number: 94312654

Start: 262884

End: 263354

Strand: Direct

Name: guaD [H]

Synonym: Rmet_3722

Alternate gene names: 94312654

Gene position: 262884-263354 (Clockwise)

Preceding gene: 291481483

Following gene: 94312656

Centisome position: 10.19

GC content: 63.48

Gene sequence:

>471_bases
ATGAACACGAATCACGCGGAACGATATCTGGGCGAAGCCATTGAGCTGGCTCGCACCAACCTGGAACAGGGCGGCCGGCC
GTTCGGGGCCGTCATCGTGAAGGACGGTGAAGTGATCGCCACCGGCGTCAATCAGATCCTGAGCACCAACGACCCCACCG
CTCATGCGGAACTGACGGCCATCCGCGCCGCCAGCCAGAAGCTCGGCAGCCCCAGCCTGGATGGCTGTGCCGTGTATGCC
AGCGGACATCCTTGCCCAATGTGCATGGCGGCGATGCGGATGGCGGGCGTGAAGGAAGTGACCTACGCCTATTCGAACGA
CGATGGCGAGCCATACGGTCTTTCCACCGCGGCCATCTATGCTGACCTGGCGAAGCCGTTCGCCGAGCAGTCGATGAAGA
TCCGGTACATGCCGGTGCGGCCGGCATCGTGCCCGGATCTTTACGCGGAATGGAAGCGCAGGGCCGGCTGA

Upstream 100 bases:

>100_bases
CAATGCAAATGTGCGATAAGCGAACGAAGCGAGGATGCGTCGTCCGCGGTTACCATTGGCCCGCCGCCAGAGCGGCAATC
CATAAAGAGCAGGAAGCAAC

Downstream 100 bases:

>100_bases
TCAGGCCTGCAGCAGGCGTTCGTCCAGCTTGAACACGGCGACCACGCGATTGAGCACGGTCGCCTGATCCTCGAGCGATT
TCGCGGCGGCGGCCGCCTGC

Product: CMP/dCMP deaminase

Products: NA

Alternate protein names: GDEase; Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MNTNHAERYLGEAIELARTNLEQGGRPFGAVIVKDGEVIATGVNQILSTNDPTAHAELTAIRAASQKLGSPSLDGCAVYA
SGHPCPMCMAAMRMAGVKEVTYAYSNDDGEPYGLSTAAIYADLAKPFAEQSMKIRYMPVRPASCPDLYAEWKRRAG

Sequences:

>Translated_156_residues
MNTNHAERYLGEAIELARTNLEQGGRPFGAVIVKDGEVIATGVNQILSTNDPTAHAELTAIRAASQKLGSPSLDGCAVYA
SGHPCPMCMAAMRMAGVKEVTYAYSNDDGEPYGLSTAAIYADLAKPFAEQSMKIRYMPVRPASCPDLYAEWKRRAG
>Mature_156_residues
MNTNHAERYLGEAIELARTNLEQGGRPFGAVIVKDGEVIATGVNQILSTNDPTAHAELTAIRAASQKLGSPSLDGCAVYA
SGHPCPMCMAAMRMAGVKEVTYAYSNDDGEPYGLSTAAIYADLAKPFAEQSMKIRYMPVRPASCPDLYAEWKRRAG

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17554608, Length=148, Percent_Identity=37.8378378378378, Blast_Score=107, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17555996, Length=136, Percent_Identity=37.5, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17541138, Length=101, Percent_Identity=34.6534653465347, Blast_Score=66, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 16743; Mature: 16743

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTNHAERYLGEAIELARTNLEQGGRPFGAVIVKDGEVIATGVNQILSTNDPTAHAELTA
CCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEHHHHHHHCCCCCCCHHHHHH
IRAASQKLGSPSLDGCAVYASGHPCPMCMAAMRMAGVKEVTYAYSNDDGEPYGLSTAAIY
HHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHCCHHHHEEEEECCCCCCCCCHHHHHH
ADLAKPFAEQSMKIRYMPVRPASCPDLYAEWKRRAG
HHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MNTNHAERYLGEAIELARTNLEQGGRPFGAVIVKDGEVIATGVNQILSTNDPTAHAELTA
CCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEHHHHHHHCCCCCCCHHHHHH
IRAASQKLGSPSLDGCAVYASGHPCPMCMAAMRMAGVKEVTYAYSNDDGEPYGLSTAAIY
HHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHCCHHHHEEEEECCCCCCCCCHHHHHH
ADLAKPFAEQSMKIRYMPVRPASCPDLYAEWKRRAG
HHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 11101664 [H]