| Definition | Cupriavidus metallidurans CH34 chromosome, complete genome. |
|---|---|
| Accession | NC_007973 |
| Length | 3,928,089 |
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The map label for this gene is gno [H]
Identifier: 94310789
GI number: 94310789
Start: 2004493
End: 2005275
Strand: Reverse
Name: gno [H]
Synonym: Rmet_1851
Alternate gene names: 94310789
Gene position: 2005275-2004493 (Counterclockwise)
Preceding gene: 94310790
Following gene: 94310788
Centisome position: 51.05
GC content: 65.01
Gene sequence:
>783_bases ATGAGGACCATCCAGCAATTGTTCGACCTCAAGGGCCGTACAGCGCTGATTACTGGCGGATCGCGCGGCCTGGGGCTGCA GATTGCCGAAGCACTTGGTGAACAGGGCGCCCGCGTGGTGCTGTCGGCCCGCAAGGCCGATGAGCTCCAGACCGCGCAGG AACACCTGAAGTCGCGTGGCATTGCGGCGGAGTGGATCGCCGCGGATGGTTCGCGCGATGCCGAAATCGCCCGGCTGGCC GATGAGGCGCTGGCGAAGCTCGGACACGTCGATATCCTCGTCAACAACGCCGGGGCCACCTGGGGCGCGCCGGCCGAGGA TCATCCGGTCGAGGCCTGGGACAAGGTGATGAACCTGAACATCCGTGGCCTGTTCCTGCTGACGCAGCGGATTGGCAAGC TGTCGATGATTCCGCGTCGCAGTGGCCGGGTTATCAACGTCGCGTCGATCGCGGGCCTGGCCGGGAACCCGCCGGGTTCG ATGGAGACCATTGCCTACAACACTTCGAAGGGCGCCGTGGTCAACTTCACGCGCACGCTGGCGGGCGAGTGGGGCGAGCA CAACATCACCGTCAACGCGCTGGCTCCGGGCTTCTTCCCGTCGAAGATGACGCAGGGGTCGCTGGACCGCATGGGCGTGG ACAAAATGTGCGAAGGGGTTCCGCTGCATCGCCTGGGTGATGACGACGATCTGAAGGGCGCGGCACTGTTGTTTGCCTCG GATGCCGGCAAGCACATCACCGGCCAGATCCTGGCGGTAGATGGGGGCGTCAGCGCAGTCTGA
Upstream 100 bases:
>100_bases TGGTTCTGAACGCAAGCCGCCAAGAGGCAATTCTGGCGTCTAGCCAGAGCCGCTTCGCTTCATTTGTGTAGCGGCGAAGA AGGATAAAACGGGAGACAAC
Downstream 100 bases:
>100_bases TCACGCGCGGCTGCTTCCCTTTCCCGCATGCGGGAAAGGGAAGGAGACAAAGAGCATAATTGCGCAATCTGTTTTTCACT GCCCCCAAGGATATGACGCA
Product: gluconate 5-dehydrogenase
Products: NA
Alternate protein names: 5-keto-D-gluconate 5-reductase [H]
Number of amino acids: Translated: 260; Mature: 260
Protein sequence:
>260_residues MRTIQQLFDLKGRTALITGGSRGLGLQIAEALGEQGARVVLSARKADELQTAQEHLKSRGIAAEWIAADGSRDAEIARLA DEALAKLGHVDILVNNAGATWGAPAEDHPVEAWDKVMNLNIRGLFLLTQRIGKLSMIPRRSGRVINVASIAGLAGNPPGS METIAYNTSKGAVVNFTRTLAGEWGEHNITVNALAPGFFPSKMTQGSLDRMGVDKMCEGVPLHRLGDDDDLKGAALLFAS DAGKHITGQILAVDGGVSAV
Sequences:
>Translated_260_residues MRTIQQLFDLKGRTALITGGSRGLGLQIAEALGEQGARVVLSARKADELQTAQEHLKSRGIAAEWIAADGSRDAEIARLA DEALAKLGHVDILVNNAGATWGAPAEDHPVEAWDKVMNLNIRGLFLLTQRIGKLSMIPRRSGRVINVASIAGLAGNPPGS METIAYNTSKGAVVNFTRTLAGEWGEHNITVNALAPGFFPSKMTQGSLDRMGVDKMCEGVPLHRLGDDDDLKGAALLFAS DAGKHITGQILAVDGGVSAV >Mature_260_residues MRTIQQLFDLKGRTALITGGSRGLGLQIAEALGEQGARVVLSARKADELQTAQEHLKSRGIAAEWIAADGSRDAEIARLA DEALAKLGHVDILVNNAGATWGAPAEDHPVEAWDKVMNLNIRGLFLLTQRIGKLSMIPRRSGRVINVASIAGLAGNPPGS METIAYNTSKGAVVNFTRTLAGEWGEHNITVNALAPGFFPSKMTQGSLDRMGVDKMCEGVPLHRLGDDDDLKGAALLFAS DAGKHITGQILAVDGGVSAV
Specific function: Involved in the non-phosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate. Dependent on NADP, almost inactive with NAD [H]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=249, Percent_Identity=32.1285140562249, Blast_Score=119, Evalue=2e-27, Organism=Homo sapiens, GI19923817, Length=257, Percent_Identity=28.0155642023346, Blast_Score=108, Evalue=4e-24, Organism=Homo sapiens, GI10190704, Length=253, Percent_Identity=31.2252964426877, Blast_Score=108, Evalue=5e-24, Organism=Homo sapiens, GI5031737, Length=255, Percent_Identity=32.156862745098, Blast_Score=104, Evalue=1e-22, Organism=Homo sapiens, GI40254992, Length=248, Percent_Identity=29.4354838709677, Blast_Score=103, Evalue=2e-22, Organism=Homo sapiens, GI15277342, Length=264, Percent_Identity=31.0606060606061, Blast_Score=97, Evalue=2e-20, Organism=Homo sapiens, GI33667109, Length=202, Percent_Identity=33.1683168316832, Blast_Score=94, Evalue=2e-19, Organism=Homo sapiens, GI126723750, Length=256, Percent_Identity=28.90625, Blast_Score=93, Evalue=2e-19, Organism=Homo sapiens, GI7705925, Length=254, Percent_Identity=30.7086614173228, Blast_Score=91, Evalue=8e-19, Organism=Homo sapiens, GI4503301, Length=252, Percent_Identity=28.5714285714286, Blast_Score=91, Evalue=8e-19, Organism=Homo sapiens, GI20149619, Length=214, Percent_Identity=30.8411214953271, Blast_Score=87, Evalue=2e-17, Organism=Homo sapiens, GI126723191, Length=186, Percent_Identity=32.258064516129, Blast_Score=82, Evalue=5e-16, Organism=Homo sapiens, GI66933014, Length=254, Percent_Identity=25.9842519685039, Blast_Score=82, Evalue=6e-16, Organism=Homo sapiens, GI4503817, Length=192, Percent_Identity=31.7708333333333, Blast_Score=82, Evalue=6e-16, Organism=Homo sapiens, GI40254986, Length=223, Percent_Identity=29.5964125560538, Blast_Score=79, Evalue=3e-15, Organism=Homo sapiens, GI210032110, Length=206, Percent_Identity=31.5533980582524, Blast_Score=79, Evalue=3e-15, Organism=Homo sapiens, GI157739938, Length=197, Percent_Identity=28.9340101522843, Blast_Score=79, Evalue=5e-15, Organism=Homo sapiens, GI4758504, Length=264, Percent_Identity=29.5454545454545, Blast_Score=78, Evalue=7e-15, Organism=Homo sapiens, GI209862901, Length=207, Percent_Identity=26.0869565217391, Blast_Score=77, Evalue=1e-14, Organism=Homo sapiens, GI19923983, Length=207, Percent_Identity=26.0869565217391, Blast_Score=77, Evalue=1e-14, Organism=Homo sapiens, GI7706318, Length=208, Percent_Identity=29.8076923076923, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI59889578, Length=235, Percent_Identity=28.0851063829787, Blast_Score=76, Evalue=4e-14, Organism=Homo sapiens, GI7705855, Length=199, Percent_Identity=29.1457286432161, Blast_Score=73, Evalue=3e-13, Organism=Homo sapiens, GI4557649, Length=198, Percent_Identity=31.3131313131313, Blast_Score=69, Evalue=5e-12, Organism=Homo sapiens, GI83715985, Length=265, Percent_Identity=29.0566037735849, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI4504505, Length=207, Percent_Identity=30.4347826086957, Blast_Score=66, Evalue=3e-11, Organism=Homo sapiens, GI32455239, Length=184, Percent_Identity=26.6304347826087, Blast_Score=66, Evalue=3e-11, Organism=Homo sapiens, GI5031765, Length=184, Percent_Identity=26.6304347826087, Blast_Score=66, Evalue=3e-11, Organism=Escherichia coli, GI1790717, Length=256, Percent_Identity=34.375, Blast_Score=150, Evalue=1e-37, Organism=Escherichia coli, GI87082160, Length=255, Percent_Identity=33.7254901960784, Blast_Score=145, Evalue=3e-36, Organism=Escherichia coli, GI1789208, Length=254, Percent_Identity=34.6456692913386, Blast_Score=137, Evalue=5e-34, Organism=Escherichia coli, GI1787335, Length=255, Percent_Identity=32.9411764705882, Blast_Score=130, Evalue=1e-31, Organism=Escherichia coli, GI87082100, Length=255, Percent_Identity=32.5490196078431, Blast_Score=115, Evalue=3e-27, Organism=Escherichia coli, GI1787905, Length=247, Percent_Identity=34.0080971659919, Blast_Score=114, Evalue=5e-27, Organism=Escherichia coli, GI1788459, Length=247, Percent_Identity=31.5789473684211, Blast_Score=107, Evalue=6e-25, Organism=Escherichia coli, GI2367175, Length=254, Percent_Identity=29.5275590551181, Blast_Score=90, Evalue=2e-19, Organism=Escherichia coli, GI1789378, Length=252, Percent_Identity=29.3650793650794, Blast_Score=87, Evalue=1e-18, Organism=Escherichia coli, GI1789057, Length=257, Percent_Identity=27.6264591439689, Blast_Score=84, Evalue=1e-17, Organism=Escherichia coli, GI1786812, Length=258, Percent_Identity=27.906976744186, Blast_Score=70, Evalue=1e-13, Organism=Escherichia coli, GI1787820, Length=184, Percent_Identity=28.804347826087, Blast_Score=68, Evalue=5e-13, Organism=Escherichia coli, GI1786701, Length=207, Percent_Identity=28.5024154589372, Blast_Score=62, Evalue=5e-11, Organism=Caenorhabditis elegans, GI17555706, Length=248, Percent_Identity=32.258064516129, Blast_Score=122, Evalue=2e-28, Organism=Caenorhabditis elegans, GI17561402, Length=259, Percent_Identity=33.2046332046332, Blast_Score=122, Evalue=2e-28, Organism=Caenorhabditis elegans, GI25147288, Length=257, Percent_Identity=33.0739299610895, Blast_Score=121, Evalue=3e-28, Organism=Caenorhabditis elegans, GI17560220, Length=271, Percent_Identity=32.4723247232472, Blast_Score=115, Evalue=2e-26, Organism=Caenorhabditis elegans, GI193204405, Length=267, Percent_Identity=31.8352059925094, Blast_Score=111, Evalue=5e-25, Organism=Caenorhabditis elegans, GI17562906, Length=270, Percent_Identity=31.1111111111111, Blast_Score=110, Evalue=9e-25, Organism=Caenorhabditis elegans, GI17562990, Length=271, Percent_Identity=29.8892988929889, Blast_Score=109, Evalue=1e-24, Organism=Caenorhabditis elegans, GI17559104, Length=267, Percent_Identity=28.8389513108614, Blast_Score=109, Evalue=2e-24, Organism=Caenorhabditis elegans, GI17560150, Length=267, Percent_Identity=29.2134831460674, Blast_Score=108, Evalue=3e-24, Organism=Caenorhabditis elegans, GI17562908, Length=271, Percent_Identity=31.7343173431734, Blast_Score=108, Evalue=3e-24, Organism=Caenorhabditis elegans, GI17560676, Length=255, Percent_Identity=30.1960784313725, Blast_Score=106, Evalue=1e-23, Organism=Caenorhabditis elegans, GI71994600, Length=251, Percent_Identity=32.2709163346614, Blast_Score=103, Evalue=6e-23, Organism=Caenorhabditis elegans, GI17561272, Length=254, Percent_Identity=32.2834645669291, Blast_Score=103, Evalue=1e-22, Organism=Caenorhabditis elegans, GI17531453, Length=272, Percent_Identity=30.1470588235294, Blast_Score=102, Evalue=2e-22, Organism=Caenorhabditis elegans, GI17536025, Length=253, Percent_Identity=30.4347826086957, Blast_Score=101, Evalue=3e-22, Organism=Caenorhabditis elegans, GI17562904, Length=269, Percent_Identity=25.6505576208178, Blast_Score=100, Evalue=1e-21, Organism=Caenorhabditis elegans, GI17538480, Length=274, Percent_Identity=28.1021897810219, Blast_Score=99, Evalue=3e-21, Organism=Caenorhabditis elegans, GI71994604, Length=250, Percent_Identity=30, Blast_Score=97, Evalue=6e-21, Organism=Caenorhabditis elegans, GI17560332, Length=267, Percent_Identity=26.2172284644195, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17536651, Length=253, Percent_Identity=28.8537549407115, Blast_Score=96, Evalue=3e-20, Organism=Caenorhabditis elegans, GI115534694, Length=256, Percent_Identity=30.078125, Blast_Score=95, Evalue=3e-20, Organism=Caenorhabditis elegans, GI17551412, Length=267, Percent_Identity=27.7153558052434, Blast_Score=93, Evalue=2e-19, Organism=Caenorhabditis elegans, GI17562910, Length=266, Percent_Identity=27.0676691729323, Blast_Score=92, Evalue=4e-19, Organism=Caenorhabditis elegans, GI17538486, Length=268, Percent_Identity=27.2388059701493, Blast_Score=88, Evalue=4e-18, Organism=Caenorhabditis elegans, GI71982365, Length=199, Percent_Identity=32.6633165829146, Blast_Score=87, Evalue=8e-18, Organism=Caenorhabditis elegans, GI17565030, Length=264, Percent_Identity=28.7878787878788, Blast_Score=87, Evalue=9e-18, Organism=Caenorhabditis elegans, GI193203115, Length=200, Percent_Identity=31.5, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17544670, Length=267, Percent_Identity=26.2172284644195, Blast_Score=86, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17563726, Length=272, Percent_Identity=26.1029411764706, Blast_Score=85, Evalue=4e-17, Organism=Caenorhabditis elegans, GI193203117, Length=202, Percent_Identity=30.6930693069307, Blast_Score=84, Evalue=9e-17, Organism=Caenorhabditis elegans, GI72000259, Length=275, Percent_Identity=26.9090909090909, Blast_Score=81, Evalue=6e-16, Organism=Caenorhabditis elegans, GI71997099, Length=256, Percent_Identity=26.953125, Blast_Score=77, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17564282, Length=200, Percent_Identity=27, Blast_Score=75, Evalue=2e-14, Organism=Caenorhabditis elegans, GI17555612, Length=226, Percent_Identity=30.5309734513274, Blast_Score=74, Evalue=9e-14, Organism=Caenorhabditis elegans, GI17568967, Length=260, Percent_Identity=25, Blast_Score=67, Evalue=8e-12, Organism=Caenorhabditis elegans, GI17558628, Length=207, Percent_Identity=30.9178743961353, Blast_Score=66, Evalue=2e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=212, Percent_Identity=31.1320754716981, Blast_Score=75, Evalue=7e-15, Organism=Saccharomyces cerevisiae, GI6323882, Length=202, Percent_Identity=29.2079207920792, Blast_Score=64, Evalue=2e-11, Organism=Drosophila melanogaster, GI23397609, Length=254, Percent_Identity=31.8897637795276, Blast_Score=122, Evalue=2e-28, Organism=Drosophila melanogaster, GI21357041, Length=253, Percent_Identity=33.201581027668, Blast_Score=119, Evalue=2e-27, Organism=Drosophila melanogaster, GI28571526, Length=253, Percent_Identity=33.201581027668, Blast_Score=118, Evalue=5e-27, Organism=Drosophila melanogaster, GI24644339, Length=255, Percent_Identity=32.5490196078431, Blast_Score=112, Evalue=3e-25, Organism=Drosophila melanogaster, GI21355319, Length=255, Percent_Identity=28.6274509803922, Blast_Score=110, Evalue=9e-25, Organism=Drosophila melanogaster, GI24639444, Length=251, Percent_Identity=27.8884462151394, Blast_Score=95, Evalue=4e-20, Organism=Drosophila melanogaster, GI24644337, Length=255, Percent_Identity=30.1960784313725, Blast_Score=91, Evalue=7e-19, Organism=Drosophila melanogaster, GI21358495, Length=203, Percent_Identity=30.5418719211823, Blast_Score=89, Evalue=2e-18, Organism=Drosophila melanogaster, GI24584748, Length=211, Percent_Identity=31.2796208530806, Blast_Score=88, Evalue=5e-18, Organism=Drosophila melanogaster, GI161076933, Length=211, Percent_Identity=31.2796208530806, Blast_Score=88, Evalue=5e-18, Organism=Drosophila melanogaster, GI24584744, Length=201, Percent_Identity=31.8407960199005, Blast_Score=88, Evalue=6e-18, Organism=Drosophila melanogaster, GI28574402, Length=201, Percent_Identity=31.8407960199005, Blast_Score=88, Evalue=6e-18, Organism=Drosophila melanogaster, GI24643142, Length=258, Percent_Identity=27.906976744186, Blast_Score=82, Evalue=3e-16, Organism=Drosophila melanogaster, GI21357673, Length=200, Percent_Identity=28.5, Blast_Score=80, Evalue=1e-15, Organism=Drosophila melanogaster, GI17737361, Length=260, Percent_Identity=26.1538461538462, Blast_Score=79, Evalue=3e-15, Organism=Drosophila melanogaster, GI24640442, Length=202, Percent_Identity=28.2178217821782, Blast_Score=76, Evalue=2e-14, Organism=Drosophila melanogaster, GI20129347, Length=204, Percent_Identity=26.9607843137255, Blast_Score=74, Evalue=1e-13, Organism=Drosophila melanogaster, GI116007236, Length=240, Percent_Identity=29.1666666666667, Blast_Score=74, Evalue=1e-13, Organism=Drosophila melanogaster, GI18859837, Length=209, Percent_Identity=30.1435406698565, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI116007238, Length=182, Percent_Identity=31.8681318681319, Blast_Score=69, Evalue=4e-12, Organism=Drosophila melanogaster, GI21355631, Length=176, Percent_Identity=28.9772727272727, Blast_Score=67, Evalue=2e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.69 [H]
Molecular weight: Translated: 27422; Mature: 27422
Theoretical pI: Translated: 6.80; Mature: 6.80
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 2.7 %Met (Translated Protein) 3.1 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 2.7 %Met (Mature Protein) 3.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRTIQQLFDLKGRTALITGGSRGLGLQIAEALGEQGARVVLSARKADELQTAQEHLKSRG CCHHHHHHCCCCCEEEEECCCCCCCHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCC IAAEWIAADGSRDAEIARLADEALAKLGHVDILVNNAGATWGAPAEDHPVEAWDKVMNLN CEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCC IRGLFLLTQRIGKLSMIPRRSGRVINVASIAGLAGNPPGSMETIAYNTSKGAVVNFTRTL CHHHHHHHHHHCCEEECCCCCCCEEEEEEECCCCCCCCCCCEEEEEECCCCEEEEEHHHH AGEWGEHNITVNALAPGFFPSKMTQGSLDRMGVDKMCEGVPLHRLGDDDDLKGAALLFAS CCCCCCCCEEEEEECCCCCCCCCCCCCHHHCCHHHHHCCCCCCCCCCCCCCCCEEEEEEC DAGKHITGQILAVDGGVSAV CCCCCEEEEEEEECCCCCCC >Mature Secondary Structure MRTIQQLFDLKGRTALITGGSRGLGLQIAEALGEQGARVVLSARKADELQTAQEHLKSRG CCHHHHHHCCCCCEEEEECCCCCCCHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCC IAAEWIAADGSRDAEIARLADEALAKLGHVDILVNNAGATWGAPAEDHPVEAWDKVMNLN CEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCC IRGLFLLTQRIGKLSMIPRRSGRVINVASIAGLAGNPPGSMETIAYNTSKGAVVNFTRTL CHHHHHHHHHHCCEEECCCCCCCEEEEEEECCCCCCCCCCCEEEEEECCCCEEEEEHHHH AGEWGEHNITVNALAPGFFPSKMTQGSLDRMGVDKMCEGVPLHRLGDDDDLKGAALLFAS CCCCCCCCEEEEEECCCCCCCCCCCCCHHHCCHHHHHCCCCCCCCCCCCCCCCEEEEEEC DAGKHITGQILAVDGGVSAV CCCCCEEEEEEEECCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 7751271 [H]