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The map label for this gene is mmgC [H]

Identifier: 94310754

GI number: 94310754

Start: 1969903

End: 1971192

Strand: Reverse

Name: mmgC [H]

Synonym: Rmet_1816

Alternate gene names: 94310754

Gene position: 1971192-1969903 (Counterclockwise)

Preceding gene: 94310759

Following gene: 94310753

Centisome position: 50.18

GC content: 64.73

Gene sequence:

>1290_bases
TTGGCGTTCATCTTACCGAAGCGATGTGCCGATTGCGCAATGGTTGTTCAAGATAGCGAAACAACGGTGCCGACATTCGG
GAGGCGCGCGTACGCTCCTCGACATCAAAAATCATGGTGGAGCGAGACGATGATCCGGGACCCCGAAGCTTTCGATGCCT
TTCTGCAGACCCTGCGGCGCTTCGTGCGCGAGAAGCTCGTGCCGCGCGAGGCCGAGGTGGCCGAACATGACGAGGTGGCG
CAGGATCTGGTCGACGCCATGGCCGCGCAGGGCATGTTCGGCTACTCGATTCCCGAACAGTACGGCGGCGCCGGCATGAC
CACCGAGGAGTTGGTGCTGGCGGCGATGGAGTTGTCGCAGTGCTCGGTGGCGTTTCGGGCGCGGGTCGGCACCAATACCG
GCATCGGCTCAGAAGCGCTGGTGGCTGATGGCACGCCCGCGCAGAAGCAGCACTATCTGCCGCTGCTGGCCAGCGGGCAG
CTCACCGGATCGTTTGCGCTGACCGAGCCCGAGGCCGGCTCCGACGCCACCGCGCTGCAGACCACGGCCGTGCGCGACGG
CGATGCCTACATCCTCAACGGCACCAAGTGCTTCATTACCAATGCGCCGATTGCTGGCCTGTTCACGGTCATGGCACGTA
CCGATCCCGCCAATCTGGGCGCAGGCGGTATCTCGGCCTTCATCGTGCCGCGCGAGACACCGGGGCTAAGCACGGGCCGG
CCGTACCAGAAGATGGGCCAGGCCGGATCGCCGGTGTCCGAGGTGCATTTCGACAACTGCCGCGTGCCGGCGGTCAACCT
GATCGGCGGCGAGGAAGGCAAGGGCTTCCGCACCGCGATGAAGGTGCTCAACAAGCAGCGTATCCATCTGGCCGCGCTGT
GCACCGGGCCCGCGATCCGGATGCTCGAAGACGCGGTGCGCTTCGTCACCGAGCGCAAGCAGTTCGGGCAGGTGCTGGCC
GATTTCCAGTTGGTGCAGGCCATGATCGCCGACTGCCAGACCGATATCCACGCGGCGCGGGCGCTGATTCTGGAAACGGC
ACGCAAGCGAGATCTGGGTGAGGACGTGACGATGCAGGCGTCGATCTGCAAGTACTTCGCGTCCGAGATGTGCGGCCGCG
TGGCCGACCGCTGTGTGCAGTTGTTTGGCGGCTACGGCTACATCGCCGACTACGGCATCGAGCGCTTCTATCGCGATGTG
CGCCTGTTCCGCCTGTACGAAGGCACCAGCCAGATTCACCAGATCAACATCGCCAAGCGGACCTTTGCCCAGGCCGGCGG
CCAGCGCTGA

Upstream 100 bases:

>100_bases
CGCCCACGCGAAAGCACTGCAGCAACGCCAGGCCGTGGGCCAGCGTGGTGGCAAAGGCGGGATCGGGGTGATGGGGGCGC
GTTGGCATCTGGCGTTTGGT

Downstream 100 bases:

>100_bases
GCGGGCTATCCAGGCCCCAGACCCCAGACCCCAAAACCCAGATTCACGGAGACAATCATGATCAAGCCCTTGATCGCGGC
GGCCGGCATGTCGTTCGGCC

Product: acyl-CoA dehydrogenase, short-chain specific

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MAFILPKRCADCAMVVQDSETTVPTFGRRAYAPRHQKSWWSETMIRDPEAFDAFLQTLRRFVREKLVPREAEVAEHDEVA
QDLVDAMAAQGMFGYSIPEQYGGAGMTTEELVLAAMELSQCSVAFRARVGTNTGIGSEALVADGTPAQKQHYLPLLASGQ
LTGSFALTEPEAGSDATALQTTAVRDGDAYILNGTKCFITNAPIAGLFTVMARTDPANLGAGGISAFIVPRETPGLSTGR
PYQKMGQAGSPVSEVHFDNCRVPAVNLIGGEEGKGFRTAMKVLNKQRIHLAALCTGPAIRMLEDAVRFVTERKQFGQVLA
DFQLVQAMIADCQTDIHAARALILETARKRDLGEDVTMQASICKYFASEMCGRVADRCVQLFGGYGYIADYGIERFYRDV
RLFRLYEGTSQIHQINIAKRTFAQAGGQR

Sequences:

>Translated_429_residues
MAFILPKRCADCAMVVQDSETTVPTFGRRAYAPRHQKSWWSETMIRDPEAFDAFLQTLRRFVREKLVPREAEVAEHDEVA
QDLVDAMAAQGMFGYSIPEQYGGAGMTTEELVLAAMELSQCSVAFRARVGTNTGIGSEALVADGTPAQKQHYLPLLASGQ
LTGSFALTEPEAGSDATALQTTAVRDGDAYILNGTKCFITNAPIAGLFTVMARTDPANLGAGGISAFIVPRETPGLSTGR
PYQKMGQAGSPVSEVHFDNCRVPAVNLIGGEEGKGFRTAMKVLNKQRIHLAALCTGPAIRMLEDAVRFVTERKQFGQVLA
DFQLVQAMIADCQTDIHAARALILETARKRDLGEDVTMQASICKYFASEMCGRVADRCVQLFGGYGYIADYGIERFYRDV
RLFRLYEGTSQIHQINIAKRTFAQAGGQR
>Mature_428_residues
AFILPKRCADCAMVVQDSETTVPTFGRRAYAPRHQKSWWSETMIRDPEAFDAFLQTLRRFVREKLVPREAEVAEHDEVAQ
DLVDAMAAQGMFGYSIPEQYGGAGMTTEELVLAAMELSQCSVAFRARVGTNTGIGSEALVADGTPAQKQHYLPLLASGQL
TGSFALTEPEAGSDATALQTTAVRDGDAYILNGTKCFITNAPIAGLFTVMARTDPANLGAGGISAFIVPRETPGLSTGRP
YQKMGQAGSPVSEVHFDNCRVPAVNLIGGEEGKGFRTAMKVLNKQRIHLAALCTGPAIRMLEDAVRFVTERKQFGQVLAD
FQLVQAMIADCQTDIHAARALILETARKRDLGEDVTMQASICKYFASEMCGRVADRCVQLFGGYGYIADYGIERFYRDVR
LFRLYEGTSQIHQINIAKRTFAQAGGQR

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501859, Length=368, Percent_Identity=35.8695652173913, Blast_Score=248, Evalue=6e-66,
Organism=Homo sapiens, GI226958412, Length=367, Percent_Identity=35.4223433242507, Blast_Score=231, Evalue=7e-61,
Organism=Homo sapiens, GI4557233, Length=392, Percent_Identity=35.7142857142857, Blast_Score=231, Evalue=9e-61,
Organism=Homo sapiens, GI21361497, Length=388, Percent_Identity=32.4742268041237, Blast_Score=221, Evalue=9e-58,
Organism=Homo sapiens, GI76496475, Length=373, Percent_Identity=35.3887399463807, Blast_Score=221, Evalue=9e-58,
Organism=Homo sapiens, GI4557235, Length=373, Percent_Identity=35.3887399463807, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI226958414, Length=344, Percent_Identity=36.046511627907, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI4501857, Length=400, Percent_Identity=33, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI187960098, Length=423, Percent_Identity=31.6784869976359, Blast_Score=215, Evalue=5e-56,
Organism=Homo sapiens, GI4557231, Length=368, Percent_Identity=33.695652173913, Blast_Score=215, Evalue=8e-56,
Organism=Homo sapiens, GI7656849, Length=360, Percent_Identity=32.2222222222222, Blast_Score=189, Evalue=6e-48,
Organism=Homo sapiens, GI48976061, Length=410, Percent_Identity=30.7317073170732, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI4503943, Length=397, Percent_Identity=29.4710327455919, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI211971008, Length=410, Percent_Identity=30.7317073170732, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI7669494, Length=385, Percent_Identity=29.3506493506493, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI38505218, Length=389, Percent_Identity=29.8200514138817, Blast_Score=141, Evalue=1e-33,
Organism=Escherichia coli, GI1786223, Length=364, Percent_Identity=30.2197802197802, Blast_Score=159, Evalue=5e-40,
Organism=Escherichia coli, GI87081958, Length=341, Percent_Identity=30.4985337243402, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI87081702, Length=323, Percent_Identity=29.7213622291022, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082384, Length=289, Percent_Identity=27.3356401384083, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17508101, Length=371, Percent_Identity=36.3881401617251, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17506239, Length=377, Percent_Identity=35.8090185676393, Blast_Score=238, Evalue=5e-63,
Organism=Caenorhabditis elegans, GI71985184, Length=376, Percent_Identity=35.9042553191489, Blast_Score=234, Evalue=8e-62,
Organism=Caenorhabditis elegans, GI17569725, Length=376, Percent_Identity=36.436170212766, Blast_Score=232, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17570075, Length=380, Percent_Identity=36.3157894736842, Blast_Score=227, Evalue=7e-60,
Organism=Caenorhabditis elegans, GI17534899, Length=366, Percent_Identity=34.9726775956284, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17538396, Length=369, Percent_Identity=32.520325203252, Blast_Score=214, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI17533517, Length=368, Percent_Identity=31.7934782608696, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI71985192, Length=322, Percent_Identity=34.7826086956522, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI71990804, Length=291, Percent_Identity=36.7697594501718, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17505929, Length=383, Percent_Identity=30.2872062663185, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17551932, Length=371, Percent_Identity=30.4582210242588, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17534353, Length=370, Percent_Identity=30.2702702702703, Blast_Score=164, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI71982178, Length=269, Percent_Identity=34.5724907063197, Blast_Score=158, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI32563615, Length=232, Percent_Identity=38.7931034482759, Blast_Score=157, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI17531909, Length=241, Percent_Identity=36.0995850622407, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17562446, Length=342, Percent_Identity=30.9941520467836, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17531913, Length=175, Percent_Identity=32.5714285714286, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI86563383, Length=273, Percent_Identity=27.4725274725275, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI86563381, Length=273, Percent_Identity=27.4725274725275, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24666513, Length=364, Percent_Identity=36.8131868131868, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI24660351, Length=377, Percent_Identity=34.4827586206897, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI281363737, Length=350, Percent_Identity=34.8571428571429, Blast_Score=225, Evalue=4e-59,
Organism=Drosophila melanogaster, GI21356377, Length=370, Percent_Identity=35.4054054054054, Blast_Score=217, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24646207, Length=378, Percent_Identity=33.3333333333333, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI21355753, Length=393, Percent_Identity=30.5343511450382, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI19920834, Length=372, Percent_Identity=29.8387096774194, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24652780, Length=352, Percent_Identity=23.0113636363636, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 46851; Mature: 46720

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFILPKRCADCAMVVQDSETTVPTFGRRAYAPRHQKSWWSETMIRDPEAFDAFLQTLRR
CCEECCHHHCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
FVREKLVPREAEVAEHDEVAQDLVDAMAAQGMFGYSIPEQYGGAGMTTEELVLAAMELSQ
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHH
CSVAFRARVGTNTGIGSEALVADGTPAQKQHYLPLLASGQLTGSFALTEPEAGSDATALQ
HHHHHHHCCCCCCCCCCCCEEECCCCCCHHCCCCEEECCCCCCEEEECCCCCCCCCHHEE
TTAVRDGDAYILNGTKCFITNAPIAGLFTVMARTDPANLGAGGISAFIVPRETPGLSTGR
EEEEECCCEEEECCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCC
PYQKMGQAGSPVSEVHFDNCRVPAVNLIGGEEGKGFRTAMKVLNKQRIHLAALCTGPAIR
CHHHHCCCCCCHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCEEEEEEECCHHHH
MLEDAVRFVTERKQFGQVLADFQLVQAMIADCQTDIHAARALILETARKRDLGEDVTMQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
SICKYFASEMCGRVADRCVQLFGGYGYIADYGIERFYRDVRLFRLYEGTSQIHQINIAKR
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
TFAQAGGQR
HHHHCCCCC
>Mature Secondary Structure 
AFILPKRCADCAMVVQDSETTVPTFGRRAYAPRHQKSWWSETMIRDPEAFDAFLQTLRR
CEECCHHHCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
FVREKLVPREAEVAEHDEVAQDLVDAMAAQGMFGYSIPEQYGGAGMTTEELVLAAMELSQ
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHH
CSVAFRARVGTNTGIGSEALVADGTPAQKQHYLPLLASGQLTGSFALTEPEAGSDATALQ
HHHHHHHCCCCCCCCCCCCEEECCCCCCHHCCCCEEECCCCCCEEEECCCCCCCCCHHEE
TTAVRDGDAYILNGTKCFITNAPIAGLFTVMARTDPANLGAGGISAFIVPRETPGLSTGR
EEEEECCCEEEECCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCC
PYQKMGQAGSPVSEVHFDNCRVPAVNLIGGEEGKGFRTAMKVLNKQRIHLAALCTGPAIR
CHHHHCCCCCCHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCEEEEEEECCHHHH
MLEDAVRFVTERKQFGQVLADFQLVQAMIADCQTDIHAARALILETARKRDLGEDVTMQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
SICKYFASEMCGRVADRCVQLFGGYGYIADYGIERFYRDVRLFRLYEGTSQIHQINIAKR
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
TFAQAGGQR
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]