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The map label for this gene is clpP [H]

Identifier: 93007058

GI number: 93007058

Start: 2742289

End: 2742984

Strand: Direct

Name: clpP [H]

Synonym: Pcryo_2234

Alternate gene names: 93007058

Gene position: 2742289-2742984 (Clockwise)

Preceding gene: 93007057

Following gene: 93007059

Centisome position: 89.62

GC content: 45.98

Gene sequence:

>696_bases
ATGACAGATTATGATCGCATCACTGCCAACCCGCATTTTGATATGCTGATGAGCGCACACACTACTGCCCAGAGCGCACA
GTATAATCAAAGCGCAACCCAAGCAGCATTAGTTCCTATGGTAGTTGAGCAATCAGCTCGCGGCGAACGCTCGTTTGATA
TTTTCTCGCGTCTACTACGTGAGCGCGTTATCTTTTTGACCGGTCAAGTTGAAGACCATATGGCCAATCTTATTGTGGCG
CAGCTGCTATTTTTGGAAGCCGAAAACCCTGATAAAGACATTCATTTATATATCAACTCACCAGGCGGCTCGGTCAGTGC
TGGTTTGGCCATTTTTGATACGATGAACTTTATCAAACCTGAAGTATCAACCATCTGTATGGGCGGTGCTTATAGCATGG
GCTCATTCCTGCTGGCTGCTGGTGAAAAAGGCAAACGCTATGCCCTAGCCAATGCTCGCGTCATGATTCATCAACCTTCA
GGCGGCGCACAAGGTCAAGCAACAGATATCGAAATCAATGCACGTGAAATCCTAAAAACTCGTGCGCGCTTAAACGAGAT
TTTGGCTGAGCGTACGGGTCAGCCAGTAGATAAAATTGAAAAAGACGTCGAGCGTGATTATTGGTTAGATGCTAAAGAAG
CCAAAGAATATGGTCTGATCGATGAAGTATTAGAGCGTCGCCCTGCTTCTTTATAA

Upstream 100 bases:

>100_bases
GGTTTTATTATAAACCGACAATGTTTACAATGATAAACACCAATAAAAATTTAACGATTTTCTACTTTTTATCTTCTATC
TTTATAAACAGGATATTTTT

Downstream 100 bases:

>100_bases
TAGCCATTCTATGAGCAGCTGTATCGATGTAGCTAGTAGCACTGCTTATGCTTAAGTGCTCTATATTAGGCACTTAAGCG
TTGATACGCACATCAGAATA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 231; Mature: 230

Protein sequence:

>231_residues
MTDYDRITANPHFDMLMSAHTTAQSAQYNQSATQAALVPMVVEQSARGERSFDIFSRLLRERVIFLTGQVEDHMANLIVA
QLLFLEAENPDKDIHLYINSPGGSVSAGLAIFDTMNFIKPEVSTICMGGAYSMGSFLLAAGEKGKRYALANARVMIHQPS
GGAQGQATDIEINAREILKTRARLNEILAERTGQPVDKIEKDVERDYWLDAKEAKEYGLIDEVLERRPASL

Sequences:

>Translated_231_residues
MTDYDRITANPHFDMLMSAHTTAQSAQYNQSATQAALVPMVVEQSARGERSFDIFSRLLRERVIFLTGQVEDHMANLIVA
QLLFLEAENPDKDIHLYINSPGGSVSAGLAIFDTMNFIKPEVSTICMGGAYSMGSFLLAAGEKGKRYALANARVMIHQPS
GGAQGQATDIEINAREILKTRARLNEILAERTGQPVDKIEKDVERDYWLDAKEAKEYGLIDEVLERRPASL
>Mature_230_residues
TDYDRITANPHFDMLMSAHTTAQSAQYNQSATQAALVPMVVEQSARGERSFDIFSRLLRERVIFLTGQVEDHMANLIVAQ
LLFLEAENPDKDIHLYINSPGGSVSAGLAIFDTMNFIKPEVSTICMGGAYSMGSFLLAAGEKGKRYALANARVMIHQPSG
GAQGQATDIEINAREILKTRARLNEILAERTGQPVDKIEKDVERDYWLDAKEAKEYGLIDEVLERRPASL

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=199, Percent_Identity=54.7738693467337, Blast_Score=232, Evalue=2e-61,
Organism=Escherichia coli, GI1786641, Length=203, Percent_Identity=69.9507389162562, Blast_Score=306, Evalue=6e-85,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=53.763440860215, Blast_Score=218, Evalue=2e-57,
Organism=Drosophila melanogaster, GI20129427, Length=211, Percent_Identity=53.5545023696682, Blast_Score=241, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 25621; Mature: 25490

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDYDRITANPHFDMLMSAHTTAQSAQYNQSATQAALVPMVVEQSARGERSFDIFSRLLR
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
ERVIFLTGQVEDHMANLIVAQLLFLEAENPDKDIHLYINSPGGSVSAGLAIFDTMNFIKP
HHHEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCC
EVSTICMGGAYSMGSFLLAAGEKGKRYALANARVMIHQPSGGAQGQATDIEINAREILKT
CHHHEECCCCHHHHHHHEECCCCCCEEEEECCEEEEECCCCCCCCCCEEEEECHHHHHHH
RARLNEILAERTGQPVDKIEKDVERDYWLDAKEAKEYGLIDEVLERRPASL
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHCCCCCC
>Mature Secondary Structure 
TDYDRITANPHFDMLMSAHTTAQSAQYNQSATQAALVPMVVEQSARGERSFDIFSRLLR
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
ERVIFLTGQVEDHMANLIVAQLLFLEAENPDKDIHLYINSPGGSVSAGLAIFDTMNFIKP
HHHEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCC
EVSTICMGGAYSMGSFLLAAGEKGKRYALANARVMIHQPSGGAQGQATDIEINAREILKT
CHHHEECCCCHHHHHHHEECCCCCCEEEEECCEEEEECCCCCCCCCCEEEEECHHHHHHH
RARLNEILAERTGQPVDKIEKDVERDYWLDAKEAKEYGLIDEVLERRPASL
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA