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The map label for this gene is fabB [H]

Identifier: 93007013

GI number: 93007013

Start: 2691266

End: 2692501

Strand: Direct

Name: fabB [H]

Synonym: Pcryo_2189

Alternate gene names: 93007013

Gene position: 2691266-2692501 (Clockwise)

Preceding gene: 93006998

Following gene: 93007014

Centisome position: 87.95

GC content: 46.93

Gene sequence:

>1236_bases
ATGCGCCGCGTTGTTATCACTGGAGCAGGGATTGTCTCTTGTATCGGACATGATTTGGCTACTGTCACAGAGGCTCTTAA
ACAAGGACGCTCTGGCATCACGTTCAACGAATCTTATGCTGAGCACGAGTTCAAATCACACGTCAGCGGCAGTATTGATC
ACTCACAGCTTGATACCTCAGCTATTGACCGCAAACTAAAACGGTTTTTTAGTGACGCAAGCCTATATGCTTATGTCAGT
GCGTTAAGTGCCATTAAGCACGCTGGACTCTCTTTAGAAACCATCAATAACAATCCGCGTGTGGGCGTGGTCGCCAGCTC
AGGCGGCGCGTCAACAGAAAATATCGCCAATGCAATAGACGCCATGCGAGAAAAAGGGTTACGCGGCGTTGGTGCGATGG
CTGTACCAAAAACAATGGGCAGCTCAGTATCAGCGGCGCTTGCTACGGGTCTAAAAATCCAAGGTATCTCATACTCATTA
ACCTCGGCTTGTGCCACGTCAACGCATTGTATCGGTCATGCTGCCGAGCTTATTCAATTGGGTAAAGCCGATGTGATACT
CGCTGGTGGTAGTGAGGCAGAACATTGGACTCAGTCTTGTATGTTTGATGCCATGGGCGCTGTTAGCACTCAATACAACG
GTACTCCAGAGCTTGCCTCAAGAGCTTATGATAAAGACCGTGATGGTTTTGTTATCGCGGCAGGTGGCGCGATGGTAGTC
GTTGAAAGTCTTGAGCATGCCCAAGCACGCGGTGCCAATATTTTGGCTGAAATTGTCGGTTATGGTGCCAGCTCTGATGG
CGCAGAAATGGTTGCGCCAAGCGGTGAAGGCGCAGTACGCTGCATGAAACTAGCACTTGCTGAAGCGGGTTTAGAAAGCG
TAGATTATATCAATAGCCATGGTACCAGTACGCCACTTGGTGACATCACTGAGCTTAAAGCTATTGCTAAAGTATTTGAT
AACGATATCAGTAAAGTGCCTGCCATTAGCTCGACTAAGTCTATGACAGGTCATAGCTTAGGTGCGGTTGGTGCACAAGA
GCTGATTTATTGCTTACTGATGTTACAAGACAGATTTATTGCACCAAGTATCAATATTACAGAATTAGATCCGGCTGCCA
AAGGCTTTGATATCGTCACTGAAAAACGCGATCTTGAGCTTGAAACTCTTATGAGCAATAGCTTTGGCTTTGGCGGTACC
AATGCAACACTAATCATCAAAAAGTTTGACGCTTAA

Upstream 100 bases:

>100_bases
CAAAAACAGATAGAGATGAAGTGATATGGTAGAAGTAGATATTTTAAAACGATGATTAAAAGTAATTATCAAAAAAATCG
TTACTAATAAGGAATATTGT

Downstream 100 bases:

>100_bases
ACTATGGTTGTAATAGATACTCATACCACTGTGCAGACAGATTCTGCCCTACCGCCAGCTAGCAAAACTAGCTGGCGTTT
TGGTGACTTATCTGCTGCCG

Product: beta-ketoacyl synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MRRVVITGAGIVSCIGHDLATVTEALKQGRSGITFNESYAEHEFKSHVSGSIDHSQLDTSAIDRKLKRFFSDASLYAYVS
ALSAIKHAGLSLETINNNPRVGVVASSGGASTENIANAIDAMREKGLRGVGAMAVPKTMGSSVSAALATGLKIQGISYSL
TSACATSTHCIGHAAELIQLGKADVILAGGSEAEHWTQSCMFDAMGAVSTQYNGTPELASRAYDKDRDGFVIAAGGAMVV
VESLEHAQARGANILAEIVGYGASSDGAEMVAPSGEGAVRCMKLALAEAGLESVDYINSHGTSTPLGDITELKAIAKVFD
NDISKVPAISSTKSMTGHSLGAVGAQELIYCLLMLQDRFIAPSINITELDPAAKGFDIVTEKRDLELETLMSNSFGFGGT
NATLIIKKFDA

Sequences:

>Translated_411_residues
MRRVVITGAGIVSCIGHDLATVTEALKQGRSGITFNESYAEHEFKSHVSGSIDHSQLDTSAIDRKLKRFFSDASLYAYVS
ALSAIKHAGLSLETINNNPRVGVVASSGGASTENIANAIDAMREKGLRGVGAMAVPKTMGSSVSAALATGLKIQGISYSL
TSACATSTHCIGHAAELIQLGKADVILAGGSEAEHWTQSCMFDAMGAVSTQYNGTPELASRAYDKDRDGFVIAAGGAMVV
VESLEHAQARGANILAEIVGYGASSDGAEMVAPSGEGAVRCMKLALAEAGLESVDYINSHGTSTPLGDITELKAIAKVFD
NDISKVPAISSTKSMTGHSLGAVGAQELIYCLLMLQDRFIAPSINITELDPAAKGFDIVTEKRDLELETLMSNSFGFGGT
NATLIIKKFDA
>Mature_411_residues
MRRVVITGAGIVSCIGHDLATVTEALKQGRSGITFNESYAEHEFKSHVSGSIDHSQLDTSAIDRKLKRFFSDASLYAYVS
ALSAIKHAGLSLETINNNPRVGVVASSGGASTENIANAIDAMREKGLRGVGAMAVPKTMGSSVSAALATGLKIQGISYSL
TSACATSTHCIGHAAELIQLGKADVILAGGSEAEHWTQSCMFDAMGAVSTQYNGTPELASRAYDKDRDGFVIAAGGAMVV
VESLEHAQARGANILAEIVGYGASSDGAEMVAPSGEGAVRCMKLALAEAGLESVDYINSHGTSTPLGDITELKAIAKVFD
NDISKVPAISSTKSMTGHSLGAVGAQELIYCLLMLQDRFIAPSINITELDPAAKGFDIVTEKRDLELETLMSNSFGFGGT
NATLIIKKFDA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=431, Percent_Identity=36.1948955916473, Blast_Score=215, Evalue=7e-56,
Organism=Homo sapiens, GI223972627, Length=167, Percent_Identity=43.1137724550898, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI41872631, Length=273, Percent_Identity=27.1062271062271, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1788663, Length=412, Percent_Identity=61.4077669902913, Blast_Score=486, Evalue=1e-138,
Organism=Escherichia coli, GI1787337, Length=413, Percent_Identity=39.225181598063, Blast_Score=236, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI71983541, Length=424, Percent_Identity=34.6698113207547, Blast_Score=192, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI71983535, Length=269, Percent_Identity=40.1486988847584, Blast_Score=157, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI17550940, Length=339, Percent_Identity=29.4985250737463, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI212642053, Length=281, Percent_Identity=29.1814946619217, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320904, Length=444, Percent_Identity=34.4594594594595, Blast_Score=190, Evalue=4e-49,
Organism=Drosophila melanogaster, GI24644341, Length=430, Percent_Identity=35.8139534883721, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI19920632, Length=266, Percent_Identity=27.0676691729323, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI221330659, Length=266, Percent_Identity=27.0676691729323, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24581345, Length=267, Percent_Identity=24.3445692883895, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 42832; Mature: 42832

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVITGAGIVSCIGHDLATVTEALKQGRSGITFNESYAEHEFKSHVSGSIDHSQLDTS
CCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHCCCCCHHHHHHH
AIDRKLKRFFSDASLYAYVSALSAIKHAGLSLETINNNPRVGVVASSGGASTENIANAID
HHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCCHHHHHHHHH
AMREKGLRGVGAMAVPKTMGSSVSAALATGLKIQGISYSLTSACATSTHCIGHAAELIQL
HHHHCCCCCCCCHHCCHHHCCHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHC
GKADVILAGGSEAEHWTQSCMFDAMGAVSTQYNGTPELASRAYDKDRDGFVIAAGGAMVV
CCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCEEEEECCCEEH
VESLEHAQARGANILAEIVGYGASSDGAEMVAPSGEGAVRCMKLALAEAGLESVDYINSH
HHHHHHHHHCCHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCHHHHHHHCC
GTSTPLGDITELKAIAKVFDNDISKVPAISSTKSMTGHSLGAVGAQELIYCLLMLQDRFI
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
APSINITELDPAAKGFDIVTEKRDLELETLMSNSFGFGGTNATLIIKKFDA
CCCCCEEECCCCCCCCEEEECCCCCHHHHHHCCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MRRVVITGAGIVSCIGHDLATVTEALKQGRSGITFNESYAEHEFKSHVSGSIDHSQLDTS
CCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHCCCCCHHHHHHH
AIDRKLKRFFSDASLYAYVSALSAIKHAGLSLETINNNPRVGVVASSGGASTENIANAID
HHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCCHHHHHHHHH
AMREKGLRGVGAMAVPKTMGSSVSAALATGLKIQGISYSLTSACATSTHCIGHAAELIQL
HHHHCCCCCCCCHHCCHHHCCHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHC
GKADVILAGGSEAEHWTQSCMFDAMGAVSTQYNGTPELASRAYDKDRDGFVIAAGGAMVV
CCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCEEEEECCCEEH
VESLEHAQARGANILAEIVGYGASSDGAEMVAPSGEGAVRCMKLALAEAGLESVDYINSH
HHHHHHHHHCCHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCHHHHHHHCC
GTSTPLGDITELKAIAKVFDNDISKVPAISSTKSMTGHSLGAVGAQELIYCLLMLQDRFI
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
APSINITELDPAAKGFDIVTEKRDLELETLMSNSFGFGGTNATLIIKKFDA
CCCCCEEECCCCCCCCEEEECCCCCHHHHHHCCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]