Click here to switch to the map view.

The map label for this gene is czcD [H]

Identifier: 93006832

GI number: 93006832

Start: 2470233

End: 2471429

Strand: Direct

Name: czcD [H]

Synonym: Pcryo_2008

Alternate gene names: 93006832

Gene position: 2470233-2471429 (Clockwise)

Preceding gene: 93006831

Following gene: 93006834

Centisome position: 80.73

GC content: 44.7

Gene sequence:

>1197_bases
ATGAATCCAGACCATCCAAACTCTAAAAAAAACGACCATGCTCATCAGAGTATACCGGCTGATACGCATGGACACGTTGA
GGAAGGTGAGGAAAGTGGTGGAAAAAGTAATACTGCTTATAGGAATCAAGACAGCCACGATCATGATGAACATCTAGAGC
AAACAGTCGCCACGCGAGATACCAAAGGCTATCAGCGCACTTTACTGATAAGTTTTTTGATCATTACAGGCTACATGTTT
GTAGAAGCAATCGGCGGTTGGCTCACTGGCAGTTTGGCATTATTGTCCGATGCCGGTCACATGCTGAGTGACGCGATAGC
ACTTGGCGCTACCTTAATGGCATTTAAAATTGGGGAAAAAGCAGCTACTCATCAGAAAACGTTCGGTTATAAACGCTTTG
AGATTTTAGTTGCCTCTGTGAATGGGGCGACACTTGTCATTATTGCCCTAATGATTTTTTATGAGGCCATTAAACGCTTT
AATTCGCCACCTGAAATTGCGACCCAAGGCATGCTTATCGTCGCCACTATCGGTATGCTGATCAATATTTTGGTTGCGTG
GCTTATGCACCGAGGTAGCCGTAGTGGCGATACTCACGGTCATGATCATGATCATGGAGCCAATGAAGGCACAGCAACGG
TCAAAACATCGGATGACAAAGAGCCGGTCAATCTCAATATGCAAAGTGCTTATTTGCACGTATTAAGTGATTTAATGGGT
TCAGTGGCTGCCATTATCGCCGCATTATTAATGATGAGTTTTGGCTGGGTATGGGCAGATGCGGTAGCGTCCGTAATTGT
AGCGATACTTATTTTATTTAGTGGCTACCGTGTCATACGGGATTCCGTACATATCTTAATGGAAGGTACACCGGAAGGCA
TCTCTCTAGTGAATGTTGAGGAAAAACTCCTTGCTCATCCACAGGTGCAAAAAGTTCATGACCTACACGTTTGGAGTATT
ACCAGTGGTTTAAATGCCTTATCTTGTCATGTGGTCGTCGATGGTGAAATGAGTATTCATGAGTCTAGTATATTGATTGG
CAGTCTAGAACGAAGCCTGCTTGAGCTCGGCATCCATCACGCTACTATTCAGGTAGAAAGTGCGGCACACCCACAAACGA
GTACCCATAGCGAAGCCCTAGTCTGCAATATCTCAGAGCGACCAGCAGAGAATAACCATATCGGGCACAATCATTAA

Upstream 100 bases:

>100_bases
TTTACAATAACAAGTTGATCATTGTTATCAAAAACCATCCTACCTTATGTAGAGTAGATATTGCTCATCAAATCCATTAT
CAGCAAAATTGAGTGTTGTT

Downstream 100 bases:

>100_bases
AATAGTTTGTCATTGAAAAAGTCTGGTTTAAAAAAATGCTGCCAGTCATCTAGACGTCATTAATTATTTAAGTATCGTCA
ATTGTTAATGACGTCTAATC

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MNPDHPNSKKNDHAHQSIPADTHGHVEEGEESGGKSNTAYRNQDSHDHDEHLEQTVATRDTKGYQRTLLISFLIITGYMF
VEAIGGWLTGSLALLSDAGHMLSDAIALGATLMAFKIGEKAATHQKTFGYKRFEILVASVNGATLVIIALMIFYEAIKRF
NSPPEIATQGMLIVATIGMLINILVAWLMHRGSRSGDTHGHDHDHGANEGTATVKTSDDKEPVNLNMQSAYLHVLSDLMG
SVAAIIAALLMMSFGWVWADAVASVIVAILILFSGYRVIRDSVHILMEGTPEGISLVNVEEKLLAHPQVQKVHDLHVWSI
TSGLNALSCHVVVDGEMSIHESSILIGSLERSLLELGIHHATIQVESAAHPQTSTHSEALVCNISERPAENNHIGHNH

Sequences:

>Translated_398_residues
MNPDHPNSKKNDHAHQSIPADTHGHVEEGEESGGKSNTAYRNQDSHDHDEHLEQTVATRDTKGYQRTLLISFLIITGYMF
VEAIGGWLTGSLALLSDAGHMLSDAIALGATLMAFKIGEKAATHQKTFGYKRFEILVASVNGATLVIIALMIFYEAIKRF
NSPPEIATQGMLIVATIGMLINILVAWLMHRGSRSGDTHGHDHDHGANEGTATVKTSDDKEPVNLNMQSAYLHVLSDLMG
SVAAIIAALLMMSFGWVWADAVASVIVAILILFSGYRVIRDSVHILMEGTPEGISLVNVEEKLLAHPQVQKVHDLHVWSI
TSGLNALSCHVVVDGEMSIHESSILIGSLERSLLELGIHHATIQVESAAHPQTSTHSEALVCNISERPAENNHIGHNH
>Mature_398_residues
MNPDHPNSKKNDHAHQSIPADTHGHVEEGEESGGKSNTAYRNQDSHDHDEHLEQTVATRDTKGYQRTLLISFLIITGYMF
VEAIGGWLTGSLALLSDAGHMLSDAIALGATLMAFKIGEKAATHQKTFGYKRFEILVASVNGATLVIIALMIFYEAIKRF
NSPPEIATQGMLIVATIGMLINILVAWLMHRGSRSGDTHGHDHDHGANEGTATVKTSDDKEPVNLNMQSAYLHVLSDLMG
SVAAIIAALLMMSFGWVWADAVASVIVAILILFSGYRVIRDSVHILMEGTPEGISLVNVEEKLLAHPQVQKVHDLHVWSI
TSGLNALSCHVVVDGEMSIHESSILIGSLERSLLELGIHHATIQVESAAHPQTSTHSEALVCNISERPAENNHIGHNH

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI20070323, Length=350, Percent_Identity=29.4285714285714, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI21361112, Length=326, Percent_Identity=28.5276073619632, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI52352805, Length=304, Percent_Identity=29.2763157894737, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI21359890, Length=329, Percent_Identity=28.5714285714286, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI222080086, Length=346, Percent_Identity=25.1445086705202, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI40255009, Length=346, Percent_Identity=25.1445086705202, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI64762489, Length=293, Percent_Identity=29.3515358361775, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI289803013, Length=293, Percent_Identity=28.6689419795222, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI289803009, Length=293, Percent_Identity=28.6689419795222, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI289803007, Length=293, Percent_Identity=28.6689419795222, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI289803003, Length=293, Percent_Identity=28.6689419795222, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI52351208, Length=400, Percent_Identity=25.25, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI14210520, Length=235, Percent_Identity=28.0851063829787, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI52352803, Length=131, Percent_Identity=37.4045801526718, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1786966, Length=303, Percent_Identity=38.2838283828383, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17555794, Length=346, Percent_Identity=30.635838150289, Blast_Score=140, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI17555796, Length=337, Percent_Identity=30.2670623145401, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI193210990, Length=344, Percent_Identity=28.7790697674419, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI32564488, Length=385, Percent_Identity=30.9090909090909, Blast_Score=128, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6323899, Length=367, Percent_Identity=29.1553133514986, Blast_Score=123, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6324892, Length=390, Percent_Identity=25.8974358974359, Blast_Score=119, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6320411, Length=219, Percent_Identity=31.0502283105023, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24583858, Length=347, Percent_Identity=25.9365994236311, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24656728, Length=355, Percent_Identity=29.2957746478873, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24656724, Length=355, Percent_Identity=29.2957746478873, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24656720, Length=355, Percent_Identity=29.2957746478873, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24656715, Length=355, Percent_Identity=29.2957746478873, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI21357035, Length=355, Percent_Identity=29.2957746478873, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24645863, Length=281, Percent_Identity=29.8932384341637, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24585900, Length=411, Percent_Identity=22.8710462287105, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24585898, Length=411, Percent_Identity=22.8710462287105, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24585896, Length=411, Percent_Identity=22.8710462287105, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI19921672, Length=411, Percent_Identity=22.8710462287105, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI28574430, Length=197, Percent_Identity=25.8883248730964, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24584409, Length=197, Percent_Identity=25.8883248730964, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 43235; Mature: 43235

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPDHPNSKKNDHAHQSIPADTHGHVEEGEESGGKSNTAYRNQDSHDHDEHLEQTVATRD
CCCCCCCCCCCCCHHHCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
TKGYQRTLLISFLIITGYMFVEAIGGWLTGSLALLSDAGHMLSDAIALGATLMAFKIGEK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
AATHQKTFGYKRFEILVASVNGATLVIIALMIFYEAIKRFNSPPEIATQGMLIVATIGML
HHHHHHHCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHH
INILVAWLMHRGSRSGDTHGHDHDHGANEGTATVKTSDDKEPVNLNMQSAYLHVLSDLMG
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHH
SVAAIIAALLMMSFGWVWADAVASVIVAILILFSGYRVIRDSVHILMEGTPEGISLVNVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCHHEEEECCCCCCEEEEHH
EKLLAHPQVQKVHDLHVWSITSGLNALSCHVVVDGEMSIHESSILIGSLERSLLELGIHH
HHHHCCCCHHHHHHEEEEEHHCCCCEEEEEEEECCCCEECHHHHHHHHHHHHHHHHCCHH
ATIQVESAAHPQTSTHSEALVCNISERPAENNHIGHNH
EEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MNPDHPNSKKNDHAHQSIPADTHGHVEEGEESGGKSNTAYRNQDSHDHDEHLEQTVATRD
CCCCCCCCCCCCCHHHCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
TKGYQRTLLISFLIITGYMFVEAIGGWLTGSLALLSDAGHMLSDAIALGATLMAFKIGEK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
AATHQKTFGYKRFEILVASVNGATLVIIALMIFYEAIKRFNSPPEIATQGMLIVATIGML
HHHHHHHCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHH
INILVAWLMHRGSRSGDTHGHDHDHGANEGTATVKTSDDKEPVNLNMQSAYLHVLSDLMG
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHH
SVAAIIAALLMMSFGWVWADAVASVIVAILILFSGYRVIRDSVHILMEGTPEGISLVNVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCHHEEEECCCCCCEEEEHH
EKLLAHPQVQKVHDLHVWSITSGLNALSCHVVVDGEMSIHESSILIGSLERSLLELGIHH
HHHHCCCCHHHHHHEEEEEHHCCCCEEEEEEEECCCCEECHHHHHHHHHHHHHHHHCCHH
ATIQVESAAHPQTSTHSEALVCNISERPAENNHIGHNH
EEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]