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The map label for this gene is hutH

Identifier: 93006756

GI number: 93006756

Start: 2384067

End: 2385629

Strand: Direct

Name: hutH

Synonym: Pcryo_1932

Alternate gene names: 93006756

Gene position: 2384067-2385629 (Clockwise)

Preceding gene: 93006755

Following gene: 93006757

Centisome position: 77.91

GC content: 47.86

Gene sequence:

>1563_bases
ATGACTGCTATCAAAAAATTAACCCTACAGCCACGTCAGCTTAGCTTTGAGATACTACGCGATATCTATGAACAGCCCGT
CATATTGACCTTGCCTGATAGCGCTTATGAGGCAATAGATGCCTCACACGAAGATGTACAAACGATTATCCGCCGTGATA
AAAGCGCTTATGGTATCAATACCGGTTTTGGTCTGTTGGCAAAAACCCGTATCAGTGATGATCAATTAGAATTACTACAG
CGCAATCTTATCGTGTCTCACTCTGTGGGCACTGGCGAAGCATTACCAGCCAACGTGGTTCGACTGATTATGGTAATGAA
GGTCACCAGTTTGGCACAAGGCGTTTCTGGTGTCCGCCGCGCCGTGGTCGACAGCTTACTGGGCTTAATTAATAACCAAA
TTACCCCAAACATCCCTGCCAAAGGCTCAGTTGGCGCTTCAGGAGATCTCGCACCTTTATCGCATATGACACTGGCGATG
ATGGGCGAAGGTCATGTTTATGTTGATGGTAACAAAGTACTGGCCGCTGATGCTTTAGCACAGCATGGTCTTGAGCCAAT
CACCCTTGCGGCAAAAGAAGGTCTTGCCCTGATTAATGGCACTCAAGTATCCACCGCACTGGCACTACGTGGTTATTTCT
TAGCACGTGATTTGCTTGAGACAGCAACCATCGTCGGCTCACTGTCTATCGATGCGGCTAAAGGCTCAGATGCGCCATTT
GATGCGCGTATTCATGAAGTACGTGGTCATCATGGTCAAATTGAAATCGCCAAAGCACACCGTCAGCTCATTAAAGGCAG
TGCCATTCGCGCCTCACACGATGGCGAGCAAGACGACAGAGTACAAGATCCTTACTGCCTGCGTTGCCAGCCACAAGTGA
TGGGCGCTTGCCTCGATATCATCAATCAAGCAGGCAAGACGCTATTGATTGAATCTAATGCTGTAACCGATAATCCACTT
ATCTTTAACAATGAAGACGGTCCAGTTGCCATCTCAGGTGGTAACTTCCATGCTGAGCCAGTGGCTTTTGCTGCTGATAT
TTTAGCCTTAGCGATTGCTGAGATTGGTTCTATGTCTGAGCGCCGTATCGCTTTGCTGATCGATGCTACTCTGTCAGGTG
GTTTGCCGCCATTCTTAGTGGATAATGCTGGGGTCAACTCAGGCTTTATGATTGCCCATGTCACTGCAGCAGCGCTCGCT
TCAGAGAATAAATCTATCGCCCATCCCGGTAGTGTCGACAGCATTCCAACTTCTGCCAATCAAGAAGATCATGTGTCGAT
GGCAACTTATTGCGCCCGTCGCTTATATGAGATGGCGCAAAATACCGCCACCATTATCGGTATTGAGCTCTTGGCTGCTG
GTCAAGGTATCGATTTCCATCGCGGGTTAGAGACCTCAGAGCCTTTGACTATGGCACATCAGAAACTTCGCGAGCAAGTG
ACCTTTTATGATAAAGATCGTTACCTAGCCCCTGATATCGAAGCGGCAAAGCAGCTGGTATTAGATGGTACACTTGCTGA
GCATTGGCAGCCATTGCGTAGTAATTGGTACGACTCTAAATAA

Upstream 100 bases:

>100_bases
GATAAGTTAGGATAGATTGCACCTATTAATACAAGCACAACATCAATACCCCACCATATTATAAATACAGCTAATAACAT
TTAACACTAGGATTACCATC

Downstream 100 bases:

>100_bases
AGGCTGATTGCAAAAAGGAATCTGGCGATGACAGCTCTAACAAATAAAGCAGTAAGCACGATTACCCATACAGAAGCCGT
GAGCCATACGGTAGCTGATA

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase

Number of amino acids: Translated: 520; Mature: 519

Protein sequence:

>520_residues
MTAIKKLTLQPRQLSFEILRDIYEQPVILTLPDSAYEAIDASHEDVQTIIRRDKSAYGINTGFGLLAKTRISDDQLELLQ
RNLIVSHSVGTGEALPANVVRLIMVMKVTSLAQGVSGVRRAVVDSLLGLINNQITPNIPAKGSVGASGDLAPLSHMTLAM
MGEGHVYVDGNKVLAADALAQHGLEPITLAAKEGLALINGTQVSTALALRGYFLARDLLETATIVGSLSIDAAKGSDAPF
DARIHEVRGHHGQIEIAKAHRQLIKGSAIRASHDGEQDDRVQDPYCLRCQPQVMGACLDIINQAGKTLLIESNAVTDNPL
IFNNEDGPVAISGGNFHAEPVAFAADILALAIAEIGSMSERRIALLIDATLSGGLPPFLVDNAGVNSGFMIAHVTAAALA
SENKSIAHPGSVDSIPTSANQEDHVSMATYCARRLYEMAQNTATIIGIELLAAGQGIDFHRGLETSEPLTMAHQKLREQV
TFYDKDRYLAPDIEAAKQLVLDGTLAEHWQPLRSNWYDSK

Sequences:

>Translated_520_residues
MTAIKKLTLQPRQLSFEILRDIYEQPVILTLPDSAYEAIDASHEDVQTIIRRDKSAYGINTGFGLLAKTRISDDQLELLQ
RNLIVSHSVGTGEALPANVVRLIMVMKVTSLAQGVSGVRRAVVDSLLGLINNQITPNIPAKGSVGASGDLAPLSHMTLAM
MGEGHVYVDGNKVLAADALAQHGLEPITLAAKEGLALINGTQVSTALALRGYFLARDLLETATIVGSLSIDAAKGSDAPF
DARIHEVRGHHGQIEIAKAHRQLIKGSAIRASHDGEQDDRVQDPYCLRCQPQVMGACLDIINQAGKTLLIESNAVTDNPL
IFNNEDGPVAISGGNFHAEPVAFAADILALAIAEIGSMSERRIALLIDATLSGGLPPFLVDNAGVNSGFMIAHVTAAALA
SENKSIAHPGSVDSIPTSANQEDHVSMATYCARRLYEMAQNTATIIGIELLAAGQGIDFHRGLETSEPLTMAHQKLREQV
TFYDKDRYLAPDIEAAKQLVLDGTLAEHWQPLRSNWYDSK
>Mature_519_residues
TAIKKLTLQPRQLSFEILRDIYEQPVILTLPDSAYEAIDASHEDVQTIIRRDKSAYGINTGFGLLAKTRISDDQLELLQR
NLIVSHSVGTGEALPANVVRLIMVMKVTSLAQGVSGVRRAVVDSLLGLINNQITPNIPAKGSVGASGDLAPLSHMTLAMM
GEGHVYVDGNKVLAADALAQHGLEPITLAAKEGLALINGTQVSTALALRGYFLARDLLETATIVGSLSIDAAKGSDAPFD
ARIHEVRGHHGQIEIAKAHRQLIKGSAIRASHDGEQDDRVQDPYCLRCQPQVMGACLDIINQAGKTLLIESNAVTDNPLI
FNNEDGPVAISGGNFHAEPVAFAADILALAIAEIGSMSERRIALLIDATLSGGLPPFLVDNAGVNSGFMIAHVTAAALAS
ENKSIAHPGSVDSIPTSANQEDHVSMATYCARRLYEMAQNTATIIGIELLAAGQGIDFHRGLETSEPLTMAHQKLREQVT
FYDKDRYLAPDIEAAKQLVLDGTLAEHWQPLRSNWYDSK

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family

Homologues:

Organism=Homo sapiens, GI4504333, Length=510, Percent_Identity=43.3333333333333, Blast_Score=385, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17567831, Length=484, Percent_Identity=38.8429752066116, Blast_Score=328, Evalue=3e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTH_PSYCK (Q1Q9E4)

Other databases:

- EMBL:   CP000323
- RefSeq:   YP_581193.1
- ProteinModelPortal:   Q1Q9E4
- SMR:   Q1Q9E4
- STRING:   Q1Q9E4
- GeneID:   4034669
- GenomeReviews:   CP000323_GR
- KEGG:   pcr:Pcryo_1932
- NMPDR:   fig|335284.3.peg.2412
- eggNOG:   COG2986
- HOGENOM:   HBG510887
- OMA:   QKGQIDS
- ProtClustDB:   PRK09367
- BioCyc:   PCRY335284:PCRYO_1932-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00229
- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313
- TIGRFAMs:   TIGR01225

Pfam domain/function: PF00221 PAL; SSF48557 L-Aspartase-like

EC number: =4.3.1.3

Molecular weight: Translated: 55756; Mature: 55625

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAIKKLTLQPRQLSFEILRDIYEQPVILTLPDSAYEAIDASHEDVQTIIRRDKSAYGIN
CCCCHHCCCCCHHHHHHHHHHHHHCCEEEECCCHHHHHHCCCHHHHHHHHHCCCCCCCCC
TGFGLLAKTRISDDQLELLQRNLIVSHSVGTGEALPANVVRLIMVMKVTSLAQGVSGVRR
CCCCCEEECCCCHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AVVDSLLGLINNQITPNIPAKGSVGASGDLAPLSHMTLAMMGEGHVYVDGNKVLAADALA
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHEEEECCCEEEECCCEEEEHHHHH
QHGLEPITLAAKEGLALINGTQVSTALALRGYFLARDLLETATIVGSLSIDAAKGSDAPF
HCCCCCEEEEHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCC
DARIHEVRGHHGQIEIAKAHRQLIKGSAIRASHDGEQDDRVQDPYCLRCQPQVMGACLDI
CHHHHHHCCCCCEEEHHHHHHHHHCCCCEECCCCCCCCCCCCCCEEECCCHHHHHHHHHH
INQAGKTLLIESNAVTDNPLIFNNEDGPVAISGGNFHAEPVAFAADILALAIAEIGSMSE
HHHCCCEEEEECCCCCCCCEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCC
RRIALLIDATLSGGLPPFLVDNAGVNSGFMIAHVTAAALASENKSIAHPGSVDSIPTSAN
CEEEEEEEEHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
QEDHVSMATYCARRLYEMAQNTATIIGIELLAAGQGIDFHRGLETSEPLTMAHQKLREQV
CCHHHHHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCHHCCCCCCCCHHHHHHHHHHHC
TFYDKDRYLAPDIEAAKQLVLDGTLAEHWQPLRSNWYDSK
CEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TAIKKLTLQPRQLSFEILRDIYEQPVILTLPDSAYEAIDASHEDVQTIIRRDKSAYGIN
CCCHHCCCCCHHHHHHHHHHHHHCCEEEECCCHHHHHHCCCHHHHHHHHHCCCCCCCCC
TGFGLLAKTRISDDQLELLQRNLIVSHSVGTGEALPANVVRLIMVMKVTSLAQGVSGVRR
CCCCCEEECCCCHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AVVDSLLGLINNQITPNIPAKGSVGASGDLAPLSHMTLAMMGEGHVYVDGNKVLAADALA
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHEEEECCCEEEECCCEEEEHHHHH
QHGLEPITLAAKEGLALINGTQVSTALALRGYFLARDLLETATIVGSLSIDAAKGSDAPF
HCCCCCEEEEHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCC
DARIHEVRGHHGQIEIAKAHRQLIKGSAIRASHDGEQDDRVQDPYCLRCQPQVMGACLDI
CHHHHHHCCCCCEEEHHHHHHHHHCCCCEECCCCCCCCCCCCCCEEECCCHHHHHHHHHH
INQAGKTLLIESNAVTDNPLIFNNEDGPVAISGGNFHAEPVAFAADILALAIAEIGSMSE
HHHCCCEEEEECCCCCCCCEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCC
RRIALLIDATLSGGLPPFLVDNAGVNSGFMIAHVTAAALASENKSIAHPGSVDSIPTSAN
CEEEEEEEEHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
QEDHVSMATYCARRLYEMAQNTATIIGIELLAAGQGIDFHRGLETSEPLTMAHQKLREQV
CCHHHHHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCHHCCCCCCCCHHHHHHHHHHHC
TFYDKDRYLAPDIEAAKQLVLDGTLAEHWQPLRSNWYDSK
CEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA