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The map label for this gene is yedX [H]

Identifier: 93006740

GI number: 93006740

Start: 2366669

End: 2367037

Strand: Direct

Name: yedX [H]

Synonym: Pcryo_1916

Alternate gene names: 93006740

Gene position: 2366669-2367037 (Clockwise)

Preceding gene: 93006739

Following gene: 93006741

Centisome position: 77.35

GC content: 45.8

Gene sequence:

>369_bases
ATGTCAGGTACTCTTTCATCACATATTTTAGACACCCATCTTGGCAAGCCTGCCGCTGATATCGCAGTGACGTTACATCG
TATTAGTGCCAGTGGCGAGCCATCATTATTGGCAAACGGTGTCACCAACGCTGATGGTCGCGTGACGCCAGATAGCTGGG
CATTTAATCCAGAAATTGATATTGCCGAGTATCATTTAGATATCGGTCGCTATACGCTGACCTTTGATACCCAAGCATAT
TTTGATACGCAAAACCTCACAGTATTTTATCCGCAAGTAGTCATCGATTTTATGATACAAGATAACGGTCACTACCATGT
GCCGCTACTGCTTAGCGCACACGGCTACGGCACTTATCGCGGATCATGA

Upstream 100 bases:

>100_bases
CGGCTACTGAACAAAATAAAATCACGCGTTTGCGTTTACAAAAACTGTTAGGCGACGCTTAAATCTTGCTTTGTCTCTCT
CATACATAAAAGGAATTATT

Downstream 100 bases:

>100_bases
TTCTATAGCTTTATGACTCGAAACCTTATAAAAACAAGGCTAAACGAGTTCTGGAAACTTTAAACAACTGACAATGAGGT
CAGTGATTTAAGACCAAATG

Product: transthyretin

Products: NA

Alternate protein names: HIU hydrolase; HIUHase; Transthyretin-like protein; TLP [H]

Number of amino acids: Translated: 122; Mature: 121

Protein sequence:

>122_residues
MSGTLSSHILDTHLGKPAADIAVTLHRISASGEPSLLANGVTNADGRVTPDSWAFNPEIDIAEYHLDIGRYTLTFDTQAY
FDTQNLTVFYPQVVIDFMIQDNGHYHVPLLLSAHGYGTYRGS

Sequences:

>Translated_122_residues
MSGTLSSHILDTHLGKPAADIAVTLHRISASGEPSLLANGVTNADGRVTPDSWAFNPEIDIAEYHLDIGRYTLTFDTQAY
FDTQNLTVFYPQVVIDFMIQDNGHYHVPLLLSAHGYGTYRGS
>Mature_121_residues
SGTLSSHILDTHLGKPAADIAVTLHRISASGEPSLLANGVTNADGRVTPDSWAFNPEIDIAEYHLDIGRYTLTFDTQAYF
DTQNLTVFYPQVVIDFMIQDNGHYHVPLLLSAHGYGTYRGS

Specific function: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) [H]

COG id: COG2351

COG function: function code R; Transthyretin-like protein

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788281, Length=119, Percent_Identity=44.5378151260504, Blast_Score=90, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI115534555, Length=124, Percent_Identity=37.0967741935484, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI115532922, Length=125, Percent_Identity=35.2, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI115532920, Length=125, Percent_Identity=35.2, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24652571, Length=118, Percent_Identity=36.4406779661017, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014306
- InterPro:   IPR000895 [H]

Pfam domain/function: PF00576 Transthyretin [H]

EC number: =3.5.2.17 [H]

Molecular weight: Translated: 13396; Mature: 13265

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00768 TRANSTHYRETIN_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGTLSSHILDTHLGKPAADIAVTLHRISASGEPSLLANGVTNADGRVTPDSWAFNPEID
CCCCCCHHHHHHHCCCCCHHEEEEEEEECCCCCCCEEECCCCCCCCEECCCCCCCCCCCE
IAEYHLDIGRYTLTFDTQAYFDTQNLTVFYPQVVIDFMIQDNGHYHVPLLLSAHGYGTYR
EEEEEEECCEEEEEECCCEEEECCCEEEEEHHHEEEEEECCCCCEEEEEEEEECCCEEEC
GS
CC
>Mature Secondary Structure 
SGTLSSHILDTHLGKPAADIAVTLHRISASGEPSLLANGVTNADGRVTPDSWAFNPEID
CCCCCHHHHHHHCCCCCHHEEEEEEEECCCCCCCEEECCCCCCCCEECCCCCCCCCCCE
IAEYHLDIGRYTLTFDTQAYFDTQNLTVFYPQVVIDFMIQDNGHYHVPLLLSAHGYGTYR
EEEEEEECCEEEEEECCCEEEECCCEEEEEHHHEEEEEECCCCCEEEEEEEEECCCEEEC
GS
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]