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The map label for this gene is xanQ [H]

Identifier: 93006737

GI number: 93006737

Start: 2363539

End: 2364945

Strand: Direct

Name: xanQ [H]

Synonym: Pcryo_1913

Alternate gene names: 93006737

Gene position: 2363539-2364945 (Clockwise)

Preceding gene: 93006734

Following gene: 93006739

Centisome position: 77.24

GC content: 45.34

Gene sequence:

>1407_bases
ATGAGTGAGCATACTCAAGGAAATCCCGATTTATTGTACGGACTGCACGACCGTCCTGCGCCTGCAAAAGCATTCTTAGG
TGCGGTACAGCATGTACTCGCCGCTTTCGTTGGTGTTATTACGCCCTCATTGATTATTGGCGGTGCTTTGGGTCTAGGTG
AGCATATTCCCTACCTGATCAGTATGGCGCTAATGGTATCTGGGGTTTCAACCTTTATTCAAACCCGTAAATTTGGTCCT
GTCGGTTCAGGGCTAATGGCTCTGCAAGGCACCAGCTTTGGTTTTTTAGCGGCAGTGTTAGCAGCAGGTTTTGTAGTAAA
AAACCGAGGTGGTAGTCCTGAGGAGATTCTCTCTGTAATCTTTGGCGTGACATTCTTAGGCGCCTTTGTCGAGATATTCT
TGAGTCAGTTTATTACTAAACTTAAATCCTTGATGAGCCCTATCGTCACCGGCTGTGTCATTGTCACTATTGGTTTGTCC
CTAACCAAAGTTGGTCTAACCGATCTAGCAGGCGGTGTTGGCGCAGAGAATTTTGGTAGCATGGAGAATTTGCTACTGGG
CGGCGGGGTATTAATCAGTGTCGTGCTTATTAGTATCGTACCTAACAAAGTTATTCGCTCAAGCGCTATTTTTATTGGTC
TGATGTTAGGCTTGCTGGTAGCAGCATTTATGGGTCGTATTGACTTCTCATTAGTCTCACAAGCCCCGCTACTGACTGTA
CCTGTGCCTTTCAAGTTTGGCTTTAGTTTTGATTGGCAAGCGTTTATACCGATTGCTTTTATGTATATCATTACCAGTAT
CGAGACTGCTGGTGATTTGACCGCAACGTCGATGATCTCAGGTGAGCCTATCAAAGGTCCACTATATGAGAAACGTATCA
AAGGTGGGGTACTAGCTGACGGTGTCAACTCTGCCATTGCTGGTATCTTTAACAGCTTCCCAGTCACTACTTTTAGCCAG
AATAATGGCGTTATTCAGATGACGGGTATCGCTAGTCGCTATGTGGGCTTCTATGTCGGCGGTATCTTATTTTTTATGGG
TTTATTCCCTATCCTAGGTGCTATCTTCACTCAGCTACCAAAACCAGTAGTTGGTGGTGTGACACTGCTAATGTTTGCAA
CCGTAGCGACTGCTGGTATTCGCATACTTTCAACCGTAAACTTTACCCATCGTAATATCTTAATCATAGCCACCTCTCTA
GGTTTGGCGATGGGTGTTGCCTTTGTACCTGATGTATTTGCACAAATGCCGCAGATGTTCCGTAATATCTTTGGTTCAGC
AGTGACCGTATCGGGTATTATCGCGATTACGCTTGATATGATTTTACCAAAAAGTTTTGGCGCAGAGTTTGATACGGCTG
ACCAGCATGCTGAGGATGACGTGAAGCCTGCTCGTGAAGCCGCTTAA

Upstream 100 bases:

>100_bases
TTTATAGAGACCCTCATATGTCTCCTATTTATCAACGTAACGCTGTCTCTAAATATCTTTACAGAGCTTGGACTAAAAGT
CACTTTAGGAGAAAGCCAAA

Downstream 100 bases:

>100_bases
AAGTGAAGGGTTAGATGATTTTCTAAGACAATGTAAAAGACTTTGATGAGTGACAAAAGAAAAGGATTGCCTTAATGATA
AAGCGCTAATTAGCAGCGAT

Product: uracil-xanthine permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MSEHTQGNPDLLYGLHDRPAPAKAFLGAVQHVLAAFVGVITPSLIIGGALGLGEHIPYLISMALMVSGVSTFIQTRKFGP
VGSGLMALQGTSFGFLAAVLAAGFVVKNRGGSPEEILSVIFGVTFLGAFVEIFLSQFITKLKSLMSPIVTGCVIVTIGLS
LTKVGLTDLAGGVGAENFGSMENLLLGGGVLISVVLISIVPNKVIRSSAIFIGLMLGLLVAAFMGRIDFSLVSQAPLLTV
PVPFKFGFSFDWQAFIPIAFMYIITSIETAGDLTATSMISGEPIKGPLYEKRIKGGVLADGVNSAIAGIFNSFPVTTFSQ
NNGVIQMTGIASRYVGFYVGGILFFMGLFPILGAIFTQLPKPVVGGVTLLMFATVATAGIRILSTVNFTHRNILIIATSL
GLAMGVAFVPDVFAQMPQMFRNIFGSAVTVSGIIAITLDMILPKSFGAEFDTADQHAEDDVKPAREAA

Sequences:

>Translated_468_residues
MSEHTQGNPDLLYGLHDRPAPAKAFLGAVQHVLAAFVGVITPSLIIGGALGLGEHIPYLISMALMVSGVSTFIQTRKFGP
VGSGLMALQGTSFGFLAAVLAAGFVVKNRGGSPEEILSVIFGVTFLGAFVEIFLSQFITKLKSLMSPIVTGCVIVTIGLS
LTKVGLTDLAGGVGAENFGSMENLLLGGGVLISVVLISIVPNKVIRSSAIFIGLMLGLLVAAFMGRIDFSLVSQAPLLTV
PVPFKFGFSFDWQAFIPIAFMYIITSIETAGDLTATSMISGEPIKGPLYEKRIKGGVLADGVNSAIAGIFNSFPVTTFSQ
NNGVIQMTGIASRYVGFYVGGILFFMGLFPILGAIFTQLPKPVVGGVTLLMFATVATAGIRILSTVNFTHRNILIIATSL
GLAMGVAFVPDVFAQMPQMFRNIFGSAVTVSGIIAITLDMILPKSFGAEFDTADQHAEDDVKPAREAA
>Mature_467_residues
SEHTQGNPDLLYGLHDRPAPAKAFLGAVQHVLAAFVGVITPSLIIGGALGLGEHIPYLISMALMVSGVSTFIQTRKFGPV
GSGLMALQGTSFGFLAAVLAAGFVVKNRGGSPEEILSVIFGVTFLGAFVEIFLSQFITKLKSLMSPIVTGCVIVTIGLSL
TKVGLTDLAGGVGAENFGSMENLLLGGGVLISVVLISIVPNKVIRSSAIFIGLMLGLLVAAFMGRIDFSLVSQAPLLTVP
VPFKFGFSFDWQAFIPIAFMYIITSIETAGDLTATSMISGEPIKGPLYEKRIKGGVLADGVNSAIAGIFNSFPVTTFSQN
NGVIQMTGIASRYVGFYVGGILFFMGLFPILGAIFTQLPKPVVGGVTLLMFATVATAGIRILSTVNFTHRNILIIATSLG
LAMGVAFVPDVFAQMPQMFRNIFGSAVTVSGIIAITLDMILPKSFGAEFDTADQHAEDDVKPAREAA

Specific function: Specific, proton motive force-dependent high-affinity transporter for xanthine [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Escherichia coli, GI87082178, Length=453, Percent_Identity=43.046357615894, Blast_Score=351, Evalue=7e-98,
Organism=Escherichia coli, GI1790087, Length=446, Percent_Identity=42.8251121076233, Blast_Score=350, Evalue=1e-97,
Organism=Escherichia coli, GI87082181, Length=462, Percent_Identity=32.034632034632, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI87081818, Length=407, Percent_Identity=26.2899262899263, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788843, Length=286, Percent_Identity=28.6713286713287, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17541904, Length=464, Percent_Identity=24.7844827586207, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17558856, Length=443, Percent_Identity=25.2821670428894, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 49072; Mature: 48941

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHTQGNPDLLYGLHDRPAPAKAFLGAVQHVLAAFVGVITPSLIIGGALGLGEHIPYLI
CCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
SMALMVSGVSTFIQTRKFGPVGSGLMALQGTSFGFLAAVLAAGFVVKNRGGSPEEILSVI
HHHHHHHHHHHHHHHHCCCCCCCCHHEECCCCHHHHHHHHHHHHHEECCCCCHHHHHHHH
FGVTFLGAFVEIFLSQFITKLKSLMSPIVTGCVIVTIGLSLTKVGLTDLAGGVGAENFGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
MENLLLGGGVLISVVLISIVPNKVIRSSAIFIGLMLGLLVAAFMGRIDFSLVSQAPLLTV
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCEEEE
PVPFKFGFSFDWQAFIPIAFMYIITSIETAGDLTATSMISGEPIKGPLYEKRIKGGVLAD
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCHHHHHHCCCCHHC
GVNSAIAGIFNSFPVTTFSQNNGVIQMTGIASRYVGFYVGGILFFMGLFPILGAIFTQLP
CHHHHHHHHHHCCCCEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KPVVGGVTLLMFATVATAGIRILSTVNFTHRNILIIATSLGLAMGVAFVPDVFAQMPQMF
CHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHH
RNIFGSAVTVSGIIAITLDMILPKSFGAEFDTADQHAEDDVKPAREAA
HHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCC
>Mature Secondary Structure 
SEHTQGNPDLLYGLHDRPAPAKAFLGAVQHVLAAFVGVITPSLIIGGALGLGEHIPYLI
CCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
SMALMVSGVSTFIQTRKFGPVGSGLMALQGTSFGFLAAVLAAGFVVKNRGGSPEEILSVI
HHHHHHHHHHHHHHHHCCCCCCCCHHEECCCCHHHHHHHHHHHHHEECCCCCHHHHHHHH
FGVTFLGAFVEIFLSQFITKLKSLMSPIVTGCVIVTIGLSLTKVGLTDLAGGVGAENFGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
MENLLLGGGVLISVVLISIVPNKVIRSSAIFIGLMLGLLVAAFMGRIDFSLVSQAPLLTV
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCEEEE
PVPFKFGFSFDWQAFIPIAFMYIITSIETAGDLTATSMISGEPIKGPLYEKRIKGGVLAD
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCHHHHHHCCCCHHC
GVNSAIAGIFNSFPVTTFSQNNGVIQMTGIASRYVGFYVGGILFFMGLFPILGAIFTQLP
CHHHHHHHHHHCCCCEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KPVVGGVTLLMFATVATAGIRILSTVNFTHRNILIIATSLGLAMGVAFVPDVFAQMPQMF
CHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHH
RNIFGSAVTVSGIIAITLDMILPKSFGAEFDTADQHAEDDVKPAREAA
HHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]