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The map label for this gene is lon [H]

Identifier: 93006723

GI number: 93006723

Start: 2344292

End: 2346916

Strand: Direct

Name: lon [H]

Synonym: Pcryo_1899

Alternate gene names: 93006723

Gene position: 2344292-2346916 (Clockwise)

Preceding gene: 93006720

Following gene: 93006724

Centisome position: 76.61

GC content: 44.72

Gene sequence:

>2625_bases
ATGAGTGAACATAAAATTGATAAAGACAATATCGACATCGATGTCGACGTATCACCTAACGTTGCTGATGACAACAAGCA
GCAAAGTGAGCTAGAAAACGAGCAACAGAACGAGCTAAAAACCTCGTCTGATAACGCAGTAGAAAACAAGTCAGCGTCTG
ACGCTGATCAGGAAGATGACACTGCGAAAGACAGTAAAGAAGATGCTGTTGAAGACTATCTGCCATTATTGGCACTGCGC
GATGTCGTTGTTTATCCGCATATGCAAATTGCCTTGTTTGTCGGTCGTGAGCCTTCAGTCAAAGCGGTTGAATTGGCGCA
AGCTGAGTACGGCAATAAGGTTTTGGTCGTTGCTCAAAAAGACTCGCTCACCGAAGACATTGATCACGATAACTTATACC
AATACGGCACAGTATGTCGTATCGTCAGCACCATGCCACATGATAGCGATGAGAATTGCATCAAAGTATTGATCGAAGGT
CAATATCGCGCTCGTGTTGATTCGATAGAGAGTCATGATGATTTATTGATGGCAGGCTTTGAGCGTGCAGACCTTGATGT
CAGCATGGATGAAAGCCAGCAGAAAAACACGATTCAAGCTTTAACCTCGCTGTTTGAAAGCTATGCCGATGCACGTTTAC
GTAATGCGCGTGAGCTAACGCGCGTTGCAAAACGTATCGATGATTTGCTTGAGTTGGTCTACTTTATCTCAACTCGTGTG
TCGATGGATCTTGATATCAAACAGTCATTTTTAGAGCAAAATGATATCAAAACTCATATCAACACTTTGACCGAATACTT
GGTCAAGCAAAGTGCTGAGCAAAACATCGAACAAGATATCCAAGAAGCTGTCCGTCAACAAATGGAAGACAATCAGCGCG
AATACTTCTTAAACGAGAAGATGAAAGCCATTAAAAACGAGCTGTCAGATATGAATGACGGTGCGTTCGATGGTGAAGAT
GACGTGGCTGAGCTTGAACAACGTCTTGATGAAGCTGACTTGCCAGAAGATGTGCGCAAAAAAGCTGAGCAAGAAATGAA
AAAGCTCAAAATGATGCCACCGGCTTCGAGCGAATCTTCAGTAGTGCGTAACTATATTGAATGGATTTTGGACACGCCGT
GGAATGCGACGACTAAAGTTTCTATCAATTTAGATAAAGCTAAAACTGTCCTAGATGAAGACCATTATGGCTTACAAGAT
GTCAAAGATCGCATCTTAGAGTATCTCGCTGTACAATCACGAGTGAAAAAACTGCGCGGTCCTATTCTTTGCTTAGTCGG
TCCTCCGGGTGTTGGTAAAACTTCATTGGGCGAATCAATTGCTCGTGCAACCGGTCGCAAGTTTGTACGTATGGCGCTTG
GCGGCGTACGTGATGAAGCGGAGATTCGTGGTCATCGCCGTACGTATATCGGTGCAATGCCAGGTAAAATCGTGCAGTCA
TTGGCAAAGGTAGAAGTTAAAAACCCGCTATTCTTATTAGATGAAATCGATAAGATGGCGCATGATTTCCGTGGTGATCC
AGCATCAGCATTGCTTGAAGTGTTAGACCCATCACAGAATGATACTTTCAATGACCATTATTTAGATATGGACTTAGATT
TATCACAAGTGATGTTTATCTGTACCGCTAACAGTATGGATATTCCAGCCGCGCTACTTGACCGTATGGAAGTTATTCGC
CTACCGGGTTATACCGAAGCAGAAAAAGTGAATATCGCCCAGAAGTATCTAGTGCCAAAAGCCATTAAAAATAACGGTCT
CAAAGAAGGCGAGATTGAGATTGTAGAAGCGGCATTGCATAGCATCGTCCGTAGCTATACACGTGAAGCGGGTGTACGTA
ACCTTGAGCGTGAAGTGAATAAAATCTGCCGTAAAGTGGTTCGCGGTTCGGTTGAAACGCATGGTGCCCGCGCTCCGAAA
AAAGCAGAACGTGAGCTGGTCGTGGTCGATGACAAAAACATCGATGACTATCTAGGTGTCCATCAGTATGACTATGGTCT
AGCGGAAGAAGAGCCTGAGATTGGTCGTATTACTGGGCTTGCATGGACACAAGTCGGTGGTGAGCTACTCACTATCGAAG
CGGTTGCGATGAAAGGCAAAGGTGAGCTTATCTTTACCGGTTCACTCGGCGATGTGATGAAAGAATCTATCCGTGCAGCG
ATGAGTGTAGTACGTGCTCGCGGCGATAGCTTAGGGATTGATTACGAGACCTTTAAAACGACTGACGTCCACGTACATAT
GCCAGAAGGCGCCACTCCAAAAGATGGTCCATCTGCTGGTGGTGCGCTAACGACAGCTTTAGTATCTGCCTTAACTGGTA
TTGCTATTCGTCCAGATATTGCCATGACAGGTGAGATTACCCTGCGTGGTAAAATCTTACGTATCGGTGGTCTTAAAGAG
AAACTGCTCGCAGCGCATCGTGGTGGTATCAAGCATGTGTTGATTCCAGATACTAACGAGCGTGACTTAGCCGACATCCC
TGATAACGTCAAAGAAGGCTTAACCATTCAGCCAGTCGCGACGATTGATGAGATATTAAAAGTAGCGTTGGTCAGTATGC
CAGTACCAATTAAACCTGCCAAAGTAACGGTTGATAAGACCAAAGGTAAAGCGCTACACAATTAA

Upstream 100 bases:

>100_bases
CTGTTGATAACAGAGCCTTGCAATTTTATATAGCAGCACCATTTATCTAAACATGAACCACTAACTTGACTTTACAAGTC
TGGTGAACGAGGAAGAATAT

Downstream 100 bases:

>100_bases
TAAGTTAACGTAAGAAAAAGACCGTAATATTAGTTACGGTCTTTTTTTTGTTCAGGATTTTTAAATTTGCTATTTATTTT
CTCTTGGATTAAATCCCTTC

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 874; Mature: 873

Protein sequence:

>874_residues
MSEHKIDKDNIDIDVDVSPNVADDNKQQSELENEQQNELKTSSDNAVENKSASDADQEDDTAKDSKEDAVEDYLPLLALR
DVVVYPHMQIALFVGREPSVKAVELAQAEYGNKVLVVAQKDSLTEDIDHDNLYQYGTVCRIVSTMPHDSDENCIKVLIEG
QYRARVDSIESHDDLLMAGFERADLDVSMDESQQKNTIQALTSLFESYADARLRNARELTRVAKRIDDLLELVYFISTRV
SMDLDIKQSFLEQNDIKTHINTLTEYLVKQSAEQNIEQDIQEAVRQQMEDNQREYFLNEKMKAIKNELSDMNDGAFDGED
DVAELEQRLDEADLPEDVRKKAEQEMKKLKMMPPASSESSVVRNYIEWILDTPWNATTKVSINLDKAKTVLDEDHYGLQD
VKDRILEYLAVQSRVKKLRGPILCLVGPPGVGKTSLGESIARATGRKFVRMALGGVRDEAEIRGHRRTYIGAMPGKIVQS
LAKVEVKNPLFLLDEIDKMAHDFRGDPASALLEVLDPSQNDTFNDHYLDMDLDLSQVMFICTANSMDIPAALLDRMEVIR
LPGYTEAEKVNIAQKYLVPKAIKNNGLKEGEIEIVEAALHSIVRSYTREAGVRNLEREVNKICRKVVRGSVETHGARAPK
KAERELVVVDDKNIDDYLGVHQYDYGLAEEEPEIGRITGLAWTQVGGELLTIEAVAMKGKGELIFTGSLGDVMKESIRAA
MSVVRARGDSLGIDYETFKTTDVHVHMPEGATPKDGPSAGGALTTALVSALTGIAIRPDIAMTGEITLRGKILRIGGLKE
KLLAAHRGGIKHVLIPDTNERDLADIPDNVKEGLTIQPVATIDEILKVALVSMPVPIKPAKVTVDKTKGKALHN

Sequences:

>Translated_874_residues
MSEHKIDKDNIDIDVDVSPNVADDNKQQSELENEQQNELKTSSDNAVENKSASDADQEDDTAKDSKEDAVEDYLPLLALR
DVVVYPHMQIALFVGREPSVKAVELAQAEYGNKVLVVAQKDSLTEDIDHDNLYQYGTVCRIVSTMPHDSDENCIKVLIEG
QYRARVDSIESHDDLLMAGFERADLDVSMDESQQKNTIQALTSLFESYADARLRNARELTRVAKRIDDLLELVYFISTRV
SMDLDIKQSFLEQNDIKTHINTLTEYLVKQSAEQNIEQDIQEAVRQQMEDNQREYFLNEKMKAIKNELSDMNDGAFDGED
DVAELEQRLDEADLPEDVRKKAEQEMKKLKMMPPASSESSVVRNYIEWILDTPWNATTKVSINLDKAKTVLDEDHYGLQD
VKDRILEYLAVQSRVKKLRGPILCLVGPPGVGKTSLGESIARATGRKFVRMALGGVRDEAEIRGHRRTYIGAMPGKIVQS
LAKVEVKNPLFLLDEIDKMAHDFRGDPASALLEVLDPSQNDTFNDHYLDMDLDLSQVMFICTANSMDIPAALLDRMEVIR
LPGYTEAEKVNIAQKYLVPKAIKNNGLKEGEIEIVEAALHSIVRSYTREAGVRNLEREVNKICRKVVRGSVETHGARAPK
KAERELVVVDDKNIDDYLGVHQYDYGLAEEEPEIGRITGLAWTQVGGELLTIEAVAMKGKGELIFTGSLGDVMKESIRAA
MSVVRARGDSLGIDYETFKTTDVHVHMPEGATPKDGPSAGGALTTALVSALTGIAIRPDIAMTGEITLRGKILRIGGLKE
KLLAAHRGGIKHVLIPDTNERDLADIPDNVKEGLTIQPVATIDEILKVALVSMPVPIKPAKVTVDKTKGKALHN
>Mature_873_residues
SEHKIDKDNIDIDVDVSPNVADDNKQQSELENEQQNELKTSSDNAVENKSASDADQEDDTAKDSKEDAVEDYLPLLALRD
VVVYPHMQIALFVGREPSVKAVELAQAEYGNKVLVVAQKDSLTEDIDHDNLYQYGTVCRIVSTMPHDSDENCIKVLIEGQ
YRARVDSIESHDDLLMAGFERADLDVSMDESQQKNTIQALTSLFESYADARLRNARELTRVAKRIDDLLELVYFISTRVS
MDLDIKQSFLEQNDIKTHINTLTEYLVKQSAEQNIEQDIQEAVRQQMEDNQREYFLNEKMKAIKNELSDMNDGAFDGEDD
VAELEQRLDEADLPEDVRKKAEQEMKKLKMMPPASSESSVVRNYIEWILDTPWNATTKVSINLDKAKTVLDEDHYGLQDV
KDRILEYLAVQSRVKKLRGPILCLVGPPGVGKTSLGESIARATGRKFVRMALGGVRDEAEIRGHRRTYIGAMPGKIVQSL
AKVEVKNPLFLLDEIDKMAHDFRGDPASALLEVLDPSQNDTFNDHYLDMDLDLSQVMFICTANSMDIPAALLDRMEVIRL
PGYTEAEKVNIAQKYLVPKAIKNNGLKEGEIEIVEAALHSIVRSYTREAGVRNLEREVNKICRKVVRGSVETHGARAPKK
AERELVVVDDKNIDDYLGVHQYDYGLAEEEPEIGRITGLAWTQVGGELLTIEAVAMKGKGELIFTGSLGDVMKESIRAAM
SVVRARGDSLGIDYETFKTTDVHVHMPEGATPKDGPSAGGALTTALVSALTGIAIRPDIAMTGEITLRGKILRIGGLKEK
LLAAHRGGIKHVLIPDTNERDLADIPDNVKEGLTIQPVATIDEILKVALVSMPVPIKPAKVTVDKTKGKALHN

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=566, Percent_Identity=44.8763250883392, Blast_Score=517, Evalue=1e-146,
Organism=Homo sapiens, GI21396489, Length=613, Percent_Identity=41.5986949429038, Blast_Score=483, Evalue=1e-136,
Organism=Escherichia coli, GI1786643, Length=781, Percent_Identity=54.1613316261204, Blast_Score=833, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=656, Percent_Identity=40.5487804878049, Blast_Score=479, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI17556486, Length=545, Percent_Identity=40.7339449541284, Blast_Score=427, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6319449, Length=627, Percent_Identity=43.7001594896332, Blast_Score=504, Evalue=1e-143,
Organism=Drosophila melanogaster, GI24666867, Length=616, Percent_Identity=42.5324675324675, Blast_Score=507, Evalue=1e-143,
Organism=Drosophila melanogaster, GI221513036, Length=616, Percent_Identity=42.5324675324675, Blast_Score=507, Evalue=1e-143,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 97233; Mature: 97102

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHKIDKDNIDIDVDVSPNVADDNKQQSELENEQQNELKTSSDNAVENKSASDADQEDD
CCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
TAKDSKEDAVEDYLPLLALRDVVVYPHMQIALFVGREPSVKAVELAQAEYGNKVLVVAQK
CCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHCCCEEEEEEEC
DSLTEDIDHDNLYQYGTVCRIVSTMPHDSDENCIKVLIEGQYRARVDSIESHDDLLMAGF
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHCCCCCCCHHHHCC
ERADLDVSMDESQQKNTIQALTSLFESYADARLRNARELTRVAKRIDDLLELVYFISTRV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SMDLDIKQSFLEQNDIKTHINTLTEYLVKQSAEQNIEQDIQEAVRQQMEDNQREYFLNEK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
MKAIKNELSDMNDGAFDGEDDVAELEQRLDEADLPEDVRKKAEQEMKKLKMMPPASSESS
HHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHH
VVRNYIEWILDTPWNATTKVSINLDKAKTVLDEDHYGLQDVKDRILEYLAVQSRVKKLRG
HHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
PILCLVGPPGVGKTSLGESIARATGRKFVRMALGGVRDEAEIRGHRRTYIGAMPGKIVQS
CEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCEEECCCCHHHHHH
LAKVEVKNPLFLLDEIDKMAHDFRGDPASALLEVLDPSQNDTFNDHYLDMDLDLSQVMFI
HHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCEEECCCCHHHEEEE
CTANSMDIPAALLDRMEVIRLPGYTEAEKVNIAQKYLVPKAIKNNGLKEGEIEIVEAALH
EECCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
SIVRSYTREAGVRNLEREVNKICRKVVRGSVETHGARAPKKAERELVVVDDKNIDDYLGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCEEEEECCCCHHHHCC
HQYDYGLAEEEPEIGRITGLAWTQVGGELLTIEAVAMKGKGELIFTGSLGDVMKESIRAA
HHCCCCCCCCCCCCCCEECCHHHHCCCEEEEEEEEEECCCCCEEEECCHHHHHHHHHHHH
MSVVRARGDSLGIDYETFKTTDVHVHMPEGATPKDGPSAGGALTTALVSALTGIAIRPDI
HHHHHHCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCEECCCE
AMTGEITLRGKILRIGGLKEKLLAAHRGGIKHVLIPDTNERDLADIPDNVKEGLTIQPVA
EEECEEEEEEEEEEECCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHCCCEECCHH
TIDEILKVALVSMPVPIKPAKVTVDKTKGKALHN
HHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure 
SEHKIDKDNIDIDVDVSPNVADDNKQQSELENEQQNELKTSSDNAVENKSASDADQEDD
CCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
TAKDSKEDAVEDYLPLLALRDVVVYPHMQIALFVGREPSVKAVELAQAEYGNKVLVVAQK
CCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHCCCEEEEEEEC
DSLTEDIDHDNLYQYGTVCRIVSTMPHDSDENCIKVLIEGQYRARVDSIESHDDLLMAGF
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHCCCCCCCHHHHCC
ERADLDVSMDESQQKNTIQALTSLFESYADARLRNARELTRVAKRIDDLLELVYFISTRV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SMDLDIKQSFLEQNDIKTHINTLTEYLVKQSAEQNIEQDIQEAVRQQMEDNQREYFLNEK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
MKAIKNELSDMNDGAFDGEDDVAELEQRLDEADLPEDVRKKAEQEMKKLKMMPPASSESS
HHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHH
VVRNYIEWILDTPWNATTKVSINLDKAKTVLDEDHYGLQDVKDRILEYLAVQSRVKKLRG
HHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
PILCLVGPPGVGKTSLGESIARATGRKFVRMALGGVRDEAEIRGHRRTYIGAMPGKIVQS
CEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCEEECCCCHHHHHH
LAKVEVKNPLFLLDEIDKMAHDFRGDPASALLEVLDPSQNDTFNDHYLDMDLDLSQVMFI
HHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCEEECCCCHHHEEEE
CTANSMDIPAALLDRMEVIRLPGYTEAEKVNIAQKYLVPKAIKNNGLKEGEIEIVEAALH
EECCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
SIVRSYTREAGVRNLEREVNKICRKVVRGSVETHGARAPKKAERELVVVDDKNIDDYLGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCEEEEECCCCHHHHCC
HQYDYGLAEEEPEIGRITGLAWTQVGGELLTIEAVAMKGKGELIFTGSLGDVMKESIRAA
HHCCCCCCCCCCCCCCEECCHHHHCCCEEEEEEEEEECCCCCEEEECCHHHHHHHHHHHH
MSVVRARGDSLGIDYETFKTTDVHVHMPEGATPKDGPSAGGALTTALVSALTGIAIRPDI
HHHHHHCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCEECCCE
AMTGEITLRGKILRIGGLKEKLLAAHRGGIKHVLIPDTNERDLADIPDNVKEGLTIQPVA
EEECEEEEEEEEEEECCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHCCCEECCHH
TIDEILKVALVSMPVPIKPAKVTVDKTKGKALHN
HHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA