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The map label for this gene is iclR [H]

Identifier: 93006609

GI number: 93006609

Start: 2209344

End: 2210162

Strand: Direct

Name: iclR [H]

Synonym: Pcryo_1785

Alternate gene names: 93006609

Gene position: 2209344-2210162 (Clockwise)

Preceding gene: 93006598

Following gene: 93006610

Centisome position: 72.2

GC content: 42.0

Gene sequence:

>819_bases
ATGGACGTAGCTATGCGGCGTTGTGTCGCTAAGGATATGAATCAAACCATGAATAATGCGAAAAAAAAAGGCTCAAGCGT
TGAGCGTGTGTTGCAGATAGTTGAAATGTTAGCCAAGTCTCAAAGACCTATGAGCGTCAGCGACTTAGCAGAAGCGTTAG
ACATACCGATACCAAGTATGTATCGATTGCTAGAACAATTACAGAATCTCGGATTCGTCCAATTAGATCTGCCTGGAAAA
GTAACATGCGGAAAACGAACTTATCAGCTAGCCATAGATTTATGGCAAAACAATCATTTCAAAACTGAAAGGCTGGCAAT
CTTGCAACGGCTTTCGGCAAAAATAGGCGAAACGGTAGGTATTGCGATTATGCAAGATTTAGATGTGGTTTACGTCGATC
GCGTATTGTCTGATTGGCCCCTGCAAATATACTTACCTGCGGGTTCTCATATTCCAGTTTGGGCAAGTGCCAGTGGTAAA
TTGCTTCTAGCACAACTACCTACAGATAAGTGCGAACGTATTATTGATAAAATGTCGATACATGCCTTGACCACCAATAC
ACAGATCGATAAAAATCAGCTACTGCAGACAATCGCTAAAACGCGTGATACTCAGATAGGGATAGATAACGAAGAGTTTA
TTCCAGGCATGGTCGCCTGTGCGGTACTCATTCCAAATGGTGAGCAGCAAGCATTTGCCACCGTATTTACTCATGGTCCC
ACTGTCAAAAAGTCTTTAGAAACGTTATTAAGCCATGTACCTCTTTTACAGGAAGCTGCAAATGAGCTGTCTGTTGTTTT
TAATCAAGACTCTCTATAG

Upstream 100 bases:

>100_bases
CACATTAATTTTCATATATCGATAGATAAATTATCGTTATGTAAAATAACATAATTGATTTATCATAACAAGATGTAAAC
GCTCAAGCCTTCTCGTTATA

Downstream 100 bases:

>100_bases
TCATTTGTCCAATTAGGTCACTAGCAAAACACCATAGCCGTTTTTTTCTTCTTGATTAACAGGGTATAGATCATAAGTAA
TATAGTTCAAGCAGAACACA

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MDVAMRRCVAKDMNQTMNNAKKKGSSVERVLQIVEMLAKSQRPMSVSDLAEALDIPIPSMYRLLEQLQNLGFVQLDLPGK
VTCGKRTYQLAIDLWQNNHFKTERLAILQRLSAKIGETVGIAIMQDLDVVYVDRVLSDWPLQIYLPAGSHIPVWASASGK
LLLAQLPTDKCERIIDKMSIHALTTNTQIDKNQLLQTIAKTRDTQIGIDNEEFIPGMVACAVLIPNGEQQAFATVFTHGP
TVKKSLETLLSHVPLLQEAANELSVVFNQDSL

Sequences:

>Translated_272_residues
MDVAMRRCVAKDMNQTMNNAKKKGSSVERVLQIVEMLAKSQRPMSVSDLAEALDIPIPSMYRLLEQLQNLGFVQLDLPGK
VTCGKRTYQLAIDLWQNNHFKTERLAILQRLSAKIGETVGIAIMQDLDVVYVDRVLSDWPLQIYLPAGSHIPVWASASGK
LLLAQLPTDKCERIIDKMSIHALTTNTQIDKNQLLQTIAKTRDTQIGIDNEEFIPGMVACAVLIPNGEQQAFATVFTHGP
TVKKSLETLLSHVPLLQEAANELSVVFNQDSL
>Mature_272_residues
MDVAMRRCVAKDMNQTMNNAKKKGSSVERVLQIVEMLAKSQRPMSVSDLAEALDIPIPSMYRLLEQLQNLGFVQLDLPGK
VTCGKRTYQLAIDLWQNNHFKTERLAILQRLSAKIGETVGIAIMQDLDVVYVDRVLSDWPLQIYLPAGSHIPVWASASGK
LLLAQLPTDKCERIIDKMSIHALTTNTQIDKNQLLQTIAKTRDTQIGIDNEEFIPGMVACAVLIPNGEQQAFATVFTHGP
TVKKSLETLLSHVPLLQEAANELSVVFNQDSL

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=246, Percent_Identity=25.609756097561, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786715, Length=250, Percent_Identity=26.8, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1788131, Length=241, Percent_Identity=25.7261410788382, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1786468, Length=235, Percent_Identity=26.3829787234043, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1790752, Length=229, Percent_Identity=24.8908296943231, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 30248; Mature: 30248

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVAMRRCVAKDMNQTMNNAKKKGSSVERVLQIVEMLAKSQRPMSVSDLAEALDIPIPSM
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHH
YRLLEQLQNLGFVQLDLPGKVTCGKRTYQLAIDLWQNNHFKTERLAILQRLSAKIGETVG
HHHHHHHHHCCEEEEECCCCEECCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCHHH
IAIMQDLDVVYVDRVLSDWPLQIYLPAGSHIPVWASASGKLLLAQLPTDKCERIIDKMSI
HHHHHHCHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCCEEEEECCHHHHHHHHHHHHH
HALTTNTQIDKNQLLQTIAKTRDTQIGIDNEEFIPGMVACAVLIPNGEQQAFATVFTHGP
HEEECCCCCCHHHHHHHHHHCCCCCCCCCCCHHCCHHHHHEEECCCCCCHHHHHHHCCCC
TVKKSLETLLSHVPLLQEAANELSVVFNQDSL
HHHHHHHHHHHHCHHHHHHHHHHEEEECCCCC
>Mature Secondary Structure
MDVAMRRCVAKDMNQTMNNAKKKGSSVERVLQIVEMLAKSQRPMSVSDLAEALDIPIPSM
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHH
YRLLEQLQNLGFVQLDLPGKVTCGKRTYQLAIDLWQNNHFKTERLAILQRLSAKIGETVG
HHHHHHHHHCCEEEEECCCCEECCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCHHH
IAIMQDLDVVYVDRVLSDWPLQIYLPAGSHIPVWASASGKLLLAQLPTDKCERIIDKMSI
HHHHHHCHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCCEEEEECCHHHHHHHHHHHHH
HALTTNTQIDKNQLLQTIAKTRDTQIGIDNEEFIPGMVACAVLIPNGEQQAFATVFTHGP
HEEECCCCCCHHHHHHHHHHCCCCCCCCCCCHHCCHHHHHEEECCCCCCHHHHHHHCCCC
TVKKSLETLLSHVPLLQEAANELSVVFNQDSL
HHHHHHHHHHHHCHHHHHHHHHHEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]