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The map label for this gene is vipA [H]

Identifier: 93005443

GI number: 93005443

Start: 730440

End: 731717

Strand: Direct

Name: vipA [H]

Synonym: Pcryo_0613

Alternate gene names: 93005443

Gene position: 730440-731717 (Clockwise)

Preceding gene: 93005442

Following gene: 93005444

Centisome position: 23.87

GC content: 39.05

Gene sequence:

>1278_bases
ATGATAGATATCAATAGTATCAAAATAGCTGTAATTGGTCTTGGTTATGTGGGGCTACCTTTAGCAGTTGAATTTGGTAA
GCATTTTTCTGTAATTGGCTTTGATATTAACACTAAGCGCGTGCAAGAGTTAAGAGATGGCTTTGATGGTACGCTTGAAG
TCAACAGTGAAGAGCTCAAATCTGCTAGTTCATTAAAATTTACCACTGAATTGGGCGATATTGCTGATTATAATTTTTAT
ATCGTTACCGTACCTACGCCCATTGATGAAAATAACGCACCAGATCTTACCCCTTTAGAGAGTGCCTCAGCTGCTGTGGG
AAAAGTGATAAAAGCTGGTGATATCGTGGTTTATGAATCGACTGTCTACCCTGGTGCGACAGAAGAAGTTTGTATTCCTA
TTATAGAAAAAGTATCTGGTTTAACTTTTAACCAAGATTTTTATGTTGGATATAGCCCAGAACGTATCAATCCAGGTGAT
AAGGTAAATACCCTAACTAAAATTACCAAGATTACTTCAGGCTCAACCCCAGAGGCGGCTGACTTAATCGATAGTCTCTA
TGCTTCTATTATTACGGCTGGTACTTATCGCGCAACATCAATCAAAGTCGCTGAAGCTGCAAAGGTCATTGAAAATACCC
AGCGCGACTTAAATATCGCTATCGTTAATGAGTTTGCTAAGATATTTAATATCATCGGCATAGACACTCAAGCGGTATTG
GATGCTGCAGGTAGTAAATGGAATTTTCTTAAATTTAAGCCGGGTTTGGTTGGTGGGCATTGTATTAGTGTCGATCCTTA
TTATTTAACTCATAAAGCACAAGAAGTTGGTTATCGTCCAGAAGTTATCCTTGCTGGCAGACGTATCAACGACGGTATGG
GGCAATATGTGGCCACGCAGATGGTTAAAAAACTGGCGCGTAATAAAATACATATCGATGAAGCGAAGGTATTGGTACTC
GGTTTTACTTTTAAAGGCGACTGTCCTGATACCCGTAATACCAAGGTCATTGATATTATCAAAGAGCTAAAAAGCTTTAA
TATCAATGTTGATGTTTATGATGATTGGGCTGATAAGCAAGAAGTATGTGAGCATTACGGCATTGAATTGATTAATGATT
TGCAGAAAGGCTATTACGATGGCGTCGTGGTTGCCGTTGATCACAGCAAGTATAAGAAGATGGGCGTAGAAGCCATTAGA
GCGCTAGCTAAATCAAACCATGTTGTTTACGACGTCAAGCATGTATTCCAAGAAGGCGAAACAGATATTCGTTTATAA

Upstream 100 bases:

>100_bases
GATGGTTATAGACAAGGTTCTTAGCTTGTATAGAAAAATGTAATGACTGAAATACTCACATTATTACCCATCAACTAGTA
AGATTATTTAAAGAGAATTT

Downstream 100 bases:

>100_bases
AAACTTAAGGACATTATAATGAAAAAATTTGCATTAATTGGTGCGGCTGGGTATATCGCTCCTCGTCATATGAAAGCTAT
CAAAGAAACGAATAATCAGC

Product: UDP-glucose/GDP-mannose dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MIDINSIKIAVIGLGYVGLPLAVEFGKHFSVIGFDINTKRVQELRDGFDGTLEVNSEELKSASSLKFTTELGDIADYNFY
IVTVPTPIDENNAPDLTPLESASAAVGKVIKAGDIVVYESTVYPGATEEVCIPIIEKVSGLTFNQDFYVGYSPERINPGD
KVNTLTKITKITSGSTPEAADLIDSLYASIITAGTYRATSIKVAEAAKVIENTQRDLNIAIVNEFAKIFNIIGIDTQAVL
DAAGSKWNFLKFKPGLVGGHCISVDPYYLTHKAQEVGYRPEVILAGRRINDGMGQYVATQMVKKLARNKIHIDEAKVLVL
GFTFKGDCPDTRNTKVIDIIKELKSFNINVDVYDDWADKQEVCEHYGIELINDLQKGYYDGVVVAVDHSKYKKMGVEAIR
ALAKSNHVVYDVKHVFQEGETDIRL

Sequences:

>Translated_425_residues
MIDINSIKIAVIGLGYVGLPLAVEFGKHFSVIGFDINTKRVQELRDGFDGTLEVNSEELKSASSLKFTTELGDIADYNFY
IVTVPTPIDENNAPDLTPLESASAAVGKVIKAGDIVVYESTVYPGATEEVCIPIIEKVSGLTFNQDFYVGYSPERINPGD
KVNTLTKITKITSGSTPEAADLIDSLYASIITAGTYRATSIKVAEAAKVIENTQRDLNIAIVNEFAKIFNIIGIDTQAVL
DAAGSKWNFLKFKPGLVGGHCISVDPYYLTHKAQEVGYRPEVILAGRRINDGMGQYVATQMVKKLARNKIHIDEAKVLVL
GFTFKGDCPDTRNTKVIDIIKELKSFNINVDVYDDWADKQEVCEHYGIELINDLQKGYYDGVVVAVDHSKYKKMGVEAIR
ALAKSNHVVYDVKHVFQEGETDIRL
>Mature_425_residues
MIDINSIKIAVIGLGYVGLPLAVEFGKHFSVIGFDINTKRVQELRDGFDGTLEVNSEELKSASSLKFTTELGDIADYNFY
IVTVPTPIDENNAPDLTPLESASAAVGKVIKAGDIVVYESTVYPGATEEVCIPIIEKVSGLTFNQDFYVGYSPERINPGD
KVNTLTKITKITSGSTPEAADLIDSLYASIITAGTYRATSIKVAEAAKVIENTQRDLNIAIVNEFAKIFNIIGIDTQAVL
DAAGSKWNFLKFKPGLVGGHCISVDPYYLTHKAQEVGYRPEVILAGRRINDGMGQYVATQMVKKLARNKIHIDEAKVLVL
GFTFKGDCPDTRNTKVIDIIKELKSFNINVDVYDDWADKQEVCEHYGIELINDLQKGYYDGVVVAVDHSKYKKMGVEAIR
ALAKSNHVVYDVKHVFQEGETDIRL

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=453, Percent_Identity=23.1788079470199, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI48994968, Length=405, Percent_Identity=30.6172839506173, Blast_Score=162, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17560350, Length=394, Percent_Identity=24.8730964467005, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17136908, Length=384, Percent_Identity=24.4791666666667, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 46789; Mature: 46789

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDINSIKIAVIGLGYVGLPLAVEFGKHFSVIGFDINTKRVQELRDGFDGTLEVNSEELK
CCCCCEEEEEEEEECHHCCHHHEECCCCEEEEEECCCHHHHHHHHCCCCCEEEECHHHHC
SASSLKFTTELGDIADYNFYIVTVPTPIDENNAPDLTPLESASAAVGKVIKAGDIVVYES
CCCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEC
TVYPGATEEVCIPIIEKVSGLTFNQDFYVGYSPERINPGDKVNTLTKITKITSGSTPEAA
CCCCCCCHHHHHHHHHHHCCCEECCCEEEECCCCCCCCCCHHHHHHHHHEECCCCCCHHH
DLIDSLYASIITAGTYRATSIKVAEAAKVIENTQRDLNIAIVNEFAKIFNIIGIDTQAVL
HHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCCHHHHH
DAAGSKWNFLKFKPGLVGGHCISVDPYYLTHKAQEVGYRPEVILAGRRINDGMGQYVATQ
HCCCCCCCEEEECCCCCCCEEEEECCEEEECCHHHCCCCCCEEEECCCCCCCHHHHHHHH
MVKKLARNKIHIDEAKVLVLGFTFKGDCPDTRNTKVIDIIKELKSFNINVDVYDDWADKQ
HHHHHHHCCEEECCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCHH
EVCEHYGIELINDLQKGYYDGVVVAVDHSKYKKMGVEAIRALAKSNHVVYDVKHVFQEGE
HHHHHHCHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCEEEEHHHHHHCCC
TDIRL
CCCCC
>Mature Secondary Structure
MIDINSIKIAVIGLGYVGLPLAVEFGKHFSVIGFDINTKRVQELRDGFDGTLEVNSEELK
CCCCCEEEEEEEEECHHCCHHHEECCCCEEEEEECCCHHHHHHHHCCCCCEEEECHHHHC
SASSLKFTTELGDIADYNFYIVTVPTPIDENNAPDLTPLESASAAVGKVIKAGDIVVYES
CCCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEC
TVYPGATEEVCIPIIEKVSGLTFNQDFYVGYSPERINPGDKVNTLTKITKITSGSTPEAA
CCCCCCCHHHHHHHHHHHCCCEECCCEEEECCCCCCCCCCHHHHHHHHHEECCCCCCHHH
DLIDSLYASIITAGTYRATSIKVAEAAKVIENTQRDLNIAIVNEFAKIFNIIGIDTQAVL
HHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCCHHHHH
DAAGSKWNFLKFKPGLVGGHCISVDPYYLTHKAQEVGYRPEVILAGRRINDGMGQYVATQ
HCCCCCCCEEEECCCCCCCEEEEECCEEEECCHHHCCCCCCEEEECCCCCCCHHHHHHHH
MVKKLARNKIHIDEAKVLVLGFTFKGDCPDTRNTKVIDIIKELKSFNINVDVYDDWADKQ
HHHHHHHCCEEECCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCHH
EVCEHYGIELINDLQKGYYDGVVVAVDHSKYKKMGVEAIRALAKSNHVVYDVKHVFQEGE
HHHHHHCHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCEEEEHHHHHHCCC
TDIRL
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8248629; 8331073; 11677608; 12644504 [H]