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The map label for this gene is nadC [H]

Identifier: 93005432

GI number: 93005432

Start: 717957

End: 718817

Strand: Direct

Name: nadC [H]

Synonym: Pcryo_0602

Alternate gene names: 93005432

Gene position: 717957-718817 (Clockwise)

Preceding gene: 93005431

Following gene: 93005433

Centisome position: 23.46

GC content: 45.06

Gene sequence:

>861_bases
ATGACAGTTAAACGAGAGCCAGCATTGGCTAAAGTATTACTTAAACCATTGGTTGAAGCGGCATTAACAGAAGATTTGGG
CAGACGTGGTGATGTCACTTCGCAAGCGACTATTCCAGCCGACATGCAAGCGCAATTACAGATTAAGGCAAGGCAAGCAG
GCGTAATATGTGGTATGGATTTAGCACGCTTATCTTTTGCTTTGATTGATGAGCAGATAGAATTCGTTGCTCAAGTCTAT
GATGGTGAAGTGGTCGAAGCTGGCGCAGTATTAGCAACTGTCCATGGCAATGCGCGTAATTTGCTGACAGCAGAGCGTAC
GGCGCTTAACTTTATGACTCATCTTAGCGGTATTGCGACAGATACTAAGAAGGTTGTCGATAGCGTGGCAGCATATCCAG
CGCAAATTACTTGTACGCGTAAAACCATTCCAGGCTTACGTATCGTCCAAAAATATGCGGTACGCTGCGGTGGCGGGCGT
AATCATCGCTTGGGTTTAGATGATGCGATTTTAATTAAAGACAACCATATTGCTATCGCAGGTGATATTAAAACAGCGAT
TGAGCAAGCGCAAGAATTTGCTGGGCATCTGATTCCAATCGAAGTGGAAGTCGATACATTAGCACAGTTAGAGCAAGCAC
TAGATGCTGGTGTGAGCTTAGTGCTTTTGGACAATATGTCGCCTGAGATATTGTCGCAGGCAGTCGCTATGTGTAAAGGT
CGTGCTAAAACCGAAGCATCAGGTGGTATCACTCCTAAAACAGTGCAAGCCGTTGCGGAAACAGGCGTTGATTTTATCGC
GATGGGTTATTTGACCCACAGCACGACTGCATTAGATATTGGTTTGGATTTTAGCATTTAG

Upstream 100 bases:

>100_bases
AGGATATTTTCTTGCGAGACAATAAACTTTACGTTATATTTATGCTCATTTTGAGTTTATATAATATATATTCAGAATAT
AAGCATAATAAGGGCTAAAA

Downstream 100 bases:

>100_bases
CTTTAACGCTTGGTCTAAGTATAGTGAGTCCCAAATAGAAGAAGTACAAATGTTATAAAGCACTGCTGGGGTTACTTTTT
CTTGCTTGCTGTGCCTGCGC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MTVKREPALAKVLLKPLVEAALTEDLGRRGDVTSQATIPADMQAQLQIKARQAGVICGMDLARLSFALIDEQIEFVAQVY
DGEVVEAGAVLATVHGNARNLLTAERTALNFMTHLSGIATDTKKVVDSVAAYPAQITCTRKTIPGLRIVQKYAVRCGGGR
NHRLGLDDAILIKDNHIAIAGDIKTAIEQAQEFAGHLIPIEVEVDTLAQLEQALDAGVSLVLLDNMSPEILSQAVAMCKG
RAKTEASGGITPKTVQAVAETGVDFIAMGYLTHSTTALDIGLDFSI

Sequences:

>Translated_286_residues
MTVKREPALAKVLLKPLVEAALTEDLGRRGDVTSQATIPADMQAQLQIKARQAGVICGMDLARLSFALIDEQIEFVAQVY
DGEVVEAGAVLATVHGNARNLLTAERTALNFMTHLSGIATDTKKVVDSVAAYPAQITCTRKTIPGLRIVQKYAVRCGGGR
NHRLGLDDAILIKDNHIAIAGDIKTAIEQAQEFAGHLIPIEVEVDTLAQLEQALDAGVSLVLLDNMSPEILSQAVAMCKG
RAKTEASGGITPKTVQAVAETGVDFIAMGYLTHSTTALDIGLDFSI
>Mature_285_residues
TVKREPALAKVLLKPLVEAALTEDLGRRGDVTSQATIPADMQAQLQIKARQAGVICGMDLARLSFALIDEQIEFVAQVYD
GEVVEAGAVLATVHGNARNLLTAERTALNFMTHLSGIATDTKKVVDSVAAYPAQITCTRKTIPGLRIVQKYAVRCGGGRN
HRLGLDDAILIKDNHIAIAGDIKTAIEQAQEFAGHLIPIEVEVDTLAQLEQALDAGVSLVLLDNMSPEILSQAVAMCKGR
AKTEASGGITPKTVQAVAETGVDFIAMGYLTHSTTALDIGLDFSI

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=278, Percent_Identity=33.0935251798561, Blast_Score=135, Evalue=4e-32,
Organism=Escherichia coli, GI1786299, Length=271, Percent_Identity=42.4354243542435, Blast_Score=192, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6321162, Length=293, Percent_Identity=28.6689419795222, Blast_Score=128, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30382; Mature: 30251

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVKREPALAKVLLKPLVEAALTEDLGRRGDVTSQATIPADMQAQLQIKARQAGVICGMD
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEHHCCEEECCH
LARLSFALIDEQIEFVAQVYDGEVVEAGAVLATVHGNARNLLTAERTALNFMTHLSGIAT
HHHHHHHHHHHHHHHHHHHHCCCEEECCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCC
DTKKVVDSVAAYPAQITCTRKTIPGLRIVQKYAVRCGGGRNHRLGLDDAILIKDNHIAIA
HHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCEEEE
GDIKTAIEQAQEFAGHLIPIEVEVDTLAQLEQALDAGVSLVLLDNMSPEILSQAVAMCKG
CHHHHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCC
RAKTEASGGITPKTVQAVAETGVDFIAMGYLTHSTTALDIGLDFSI
CCCCCCCCCCCHHHHHHHHHCCCCEEEEHHHHCCCEEEEEECCCCC
>Mature Secondary Structure 
TVKREPALAKVLLKPLVEAALTEDLGRRGDVTSQATIPADMQAQLQIKARQAGVICGMD
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEHHCCEEECCH
LARLSFALIDEQIEFVAQVYDGEVVEAGAVLATVHGNARNLLTAERTALNFMTHLSGIAT
HHHHHHHHHHHHHHHHHHHHCCCEEECCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCC
DTKKVVDSVAAYPAQITCTRKTIPGLRIVQKYAVRCGGGRNHRLGLDDAILIKDNHIAIA
HHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCEEEE
GDIKTAIEQAQEFAGHLIPIEVEVDTLAQLEQALDAGVSLVLLDNMSPEILSQAVAMCKG
CHHHHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCC
RAKTEASGGITPKTVQAVAETGVDFIAMGYLTHSTTALDIGLDFSI
CCCCCCCCCCCHHHHHHHHHCCCCEEEEHHHHCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]