Click here to switch to the map view.

The map label for this gene is map [H]

Identifier: 93005272

GI number: 93005272

Start: 542776

End: 543570

Strand: Reverse

Name: map [H]

Synonym: Pcryo_0442

Alternate gene names: 93005272

Gene position: 543570-542776 (Counterclockwise)

Preceding gene: 93005279

Following gene: 93005271

Centisome position: 17.76

GC content: 45.66

Gene sequence:

>795_bases
ATGATGACTAAAAAATCTCTTATTCAATCTCCTGAAGCCATAGAAAAAATGCGCGTGGCTGGTAAACTTGCCAGCGATGT
CCTTGTGATGCTTGATGAGCATGTCAGAGTGGGCATCAGTACTGAAGCACTGAACCAAATTGCCCATGATTATATCGTTA
ATGTGCAACAAGCTATTCCTGCACCGCTTAATTACAATGGTTTTCCAAAATCTATCTGCACCTCGATTAACCACGTGGTT
TGTCATGGTATTCCATCCGAAAATAAATTGCTAAAAGACGGCGACATCATCAATATCGATGTGACCGTGATTAAAGATGG
CTATTATGGTGATACCTCAAAAATGTGGATCGTCGGCAATGGCTCTATCATGGCGCAGCGTATCTGCAAAGTAGCACAAG
ACGCACTATATGCTGGCATGAGCGTGGTCAAAAACGGCGCGCGTTTGGGCGACGTTGGTGCGGCTATCCAAGCAGTGGTT
GAGCCTGAGCGTTTTAGTATCGTGCGTGAGTTCTGTGGTCACGGTATCAGTAATGAGTTCCACCATGAGCCGCAAGTCAT
GCACTATGGCCAAAAAGGTACGGGCTTTGAGCTAAAAACTGGCATGACTTTTACCATCGAGCCTATGATTAACGAAGGCA
AATGGCAGACTAAGATTTTACCGGATGAATGGACTGCGATTACCAAAGACCGCAAGCTATCCGCCCAGTGGGAGCATACC
ATGGTCGTAACGGATAATGGCTGTGAAGTATTCACCACGCGCCCTGAAGAAGATTTGAGTTTCTTGACTCAGTAA

Upstream 100 bases:

>100_bases
TATCAATACGATTGAAATATTCAATAACTTGCATTCAAGCAGCAACTTGTGCGTTTATGCTATAATTGATGACCTAAATT
CTATAACTATAAGTACGACG

Downstream 100 bases:

>100_bases
TACAATAAAAGATCGCTTAGGCGGTCTTTTTTTTGTCTATTATTAATGGTTGTCCCCCACTATTCTTGATGGTTTTTTAT
CTTTATACTTTCTCTATCTT

Product: methionine aminopeptidase, type I

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MMTKKSLIQSPEAIEKMRVAGKLASDVLVMLDEHVRVGISTEALNQIAHDYIVNVQQAIPAPLNYNGFPKSICTSINHVV
CHGIPSENKLLKDGDIINIDVTVIKDGYYGDTSKMWIVGNGSIMAQRICKVAQDALYAGMSVVKNGARLGDVGAAIQAVV
EPERFSIVREFCGHGISNEFHHEPQVMHYGQKGTGFELKTGMTFTIEPMINEGKWQTKILPDEWTAITKDRKLSAQWEHT
MVVTDNGCEVFTTRPEEDLSFLTQ

Sequences:

>Translated_264_residues
MMTKKSLIQSPEAIEKMRVAGKLASDVLVMLDEHVRVGISTEALNQIAHDYIVNVQQAIPAPLNYNGFPKSICTSINHVV
CHGIPSENKLLKDGDIINIDVTVIKDGYYGDTSKMWIVGNGSIMAQRICKVAQDALYAGMSVVKNGARLGDVGAAIQAVV
EPERFSIVREFCGHGISNEFHHEPQVMHYGQKGTGFELKTGMTFTIEPMINEGKWQTKILPDEWTAITKDRKLSAQWEHT
MVVTDNGCEVFTTRPEEDLSFLTQ
>Mature_264_residues
MMTKKSLIQSPEAIEKMRVAGKLASDVLVMLDEHVRVGISTEALNQIAHDYIVNVQQAIPAPLNYNGFPKSICTSINHVV
CHGIPSENKLLKDGDIINIDVTVIKDGYYGDTSKMWIVGNGSIMAQRICKVAQDALYAGMSVVKNGARLGDVGAAIQAVV
EPERFSIVREFCGHGISNEFHHEPQVMHYGQKGTGFELKTGMTFTIEPMINEGKWQTKILPDEWTAITKDRKLSAQWEHT
MVVTDNGCEVFTTRPEEDLSFLTQ

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=252, Percent_Identity=42.0634920634921, Blast_Score=221, Evalue=6e-58,
Organism=Homo sapiens, GI40385867, Length=250, Percent_Identity=38, Blast_Score=199, Evalue=2e-51,
Organism=Escherichia coli, GI1786364, Length=252, Percent_Identity=59.5238095238095, Blast_Score=328, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI71996291, Length=254, Percent_Identity=38.9763779527559, Blast_Score=199, Evalue=8e-52,
Organism=Saccharomyces cerevisiae, GI6323273, Length=248, Percent_Identity=41.9354838709677, Blast_Score=213, Evalue=2e-56,
Organism=Drosophila melanogaster, GI21355531, Length=247, Percent_Identity=43.3198380566802, Blast_Score=218, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24583427, Length=245, Percent_Identity=40, Blast_Score=193, Evalue=1e-49,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 29279; Mature: 29279

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTKKSLIQSPEAIEKMRVAGKLASDVLVMLDEHVRVGISTEALNQIAHDYIVNVQQAIP
CCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHCC
APLNYNGFPKSICTSINHVVCHGIPSENKLLKDGDIINIDVTVIKDGYYGDTSKMWIVGN
CCCCCCCCCHHHHHHHHHEEEECCCCCCCEECCCCEEEEEEEEEECCCCCCCCEEEEEEC
GSIMAQRICKVAQDALYAGMSVVKNGARLGDVGAAIQAVVEPERFSIVREFCGHGISNEF
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCC
HHEPQVMHYGQKGTGFELKTGMTFTIEPMINEGKWQTKILPDEWTAITKDRKLSAQWEHT
CCCCHHEECCCCCCCEEEECCCEEEEEECCCCCCEEEEECCCCHHECCCCCCCCCCCCEE
MVVTDNGCEVFTTRPEEDLSFLTQ
EEEECCCCEEEEECCHHHHHHHCC
>Mature Secondary Structure
MMTKKSLIQSPEAIEKMRVAGKLASDVLVMLDEHVRVGISTEALNQIAHDYIVNVQQAIP
CCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHCC
APLNYNGFPKSICTSINHVVCHGIPSENKLLKDGDIINIDVTVIKDGYYGDTSKMWIVGN
CCCCCCCCCHHHHHHHHHEEEECCCCCCCEECCCCEEEEEEEEEECCCCCCCCEEEEEEC
GSIMAQRICKVAQDALYAGMSVVKNGARLGDVGAAIQAVVEPERFSIVREFCGHGISNEF
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCC
HHEPQVMHYGQKGTGFELKTGMTFTIEPMINEGKWQTKILPDEWTAITKDRKLSAQWEHT
CCCCHHEECCCCCCCEEEECCCEEEEEECCCCCCEEEEECCCCHHECCCCCCCCCCCCEE
MVVTDNGCEVFTTRPEEDLSFLTQ
EEEECCCCEEEEECCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]