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The map label for this gene is tmk [H]

Identifier: 93004986

GI number: 93004986

Start: 183162

End: 183839

Strand: Direct

Name: tmk [H]

Synonym: Pcryo_0155

Alternate gene names: 93004986

Gene position: 183162-183839 (Clockwise)

Preceding gene: 93004985

Following gene: 93004988

Centisome position: 5.99

GC content: 49.71

Gene sequence:

>678_bases
ATGTCAGCATCCATACAAGCGTCGTTTTCTCAAACCACCACTACGCCCACTCAAGGGCGTTTTATTAGTTTTGAGGGCAC
TGAAGGCGTTGGTAAAACCACGGCGATTGAGCAACTATGTGCGCGTCTGCAAGCGCATGGCATTGATTATCTGCGCACCC
GCGAGCCGGGTGGTAGTCCGTTTGCTGAACGCTTGCGCGAGATATTGTTAGACCCGAATACCGCTATCAATGATGATACA
GAGTTGCTACTCATGTTTGCTGCGCGCTGTGATCATATGCAGCAAGTCATTTTGCCAGCGCTGCAACGTGGTACATGGGT
AATATGTGACCGCTTTACCGACTCGACGGTTGCTTATCAAGGCTTTGGACGTGCAGATGGCGATGCGATTGTCCGTGCCA
AAATTGACATGCTTATCGAGCAGTTTGTGATGCAGTTACCCGAGCTTACACTGTGGCTAGATCTACCAGTATTAGAAGGC
ATGGCACGTGCTAATAAACGCAGTGCCGCTGACCGCTTTGAACAGCAAGCGACGGAATTTTTTACCAGAGTACATCAAGG
TTTTAGCGTCCTTGCTAGCGAGCAGCCTGAACGTATCCAGCGTATTGATGCCTCAGGCAGCGCTAATGAGGTCAGCGCAC
GAATATGGCAGACGATCGAAGAGAAGTTGGATATTTAA

Upstream 100 bases:

>100_bases
GTTGCTATTTATATTGCTTTAAAAAACCATCATTTATTGAGCATTATCGTTATAAAAATAAAAGTAATGATAACGCTCAA
CAATGACATAAGGTCATATC

Downstream 100 bases:

>100_bases
TAGACATTTTCATAAAGAAATAAGCTTGCTCCAATAAAAAGCCCCAACTAACTAGTTGGGGCTTTGTTCATTGATAGGCA
TTTAATAAACACTATTTAAG

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MSASIQASFSQTTTTPTQGRFISFEGTEGVGKTTAIEQLCARLQAHGIDYLRTREPGGSPFAERLREILLDPNTAINDDT
ELLLMFAARCDHMQQVILPALQRGTWVICDRFTDSTVAYQGFGRADGDAIVRAKIDMLIEQFVMQLPELTLWLDLPVLEG
MARANKRSAADRFEQQATEFFTRVHQGFSVLASEQPERIQRIDASGSANEVSARIWQTIEEKLDI

Sequences:

>Translated_225_residues
MSASIQASFSQTTTTPTQGRFISFEGTEGVGKTTAIEQLCARLQAHGIDYLRTREPGGSPFAERLREILLDPNTAINDDT
ELLLMFAARCDHMQQVILPALQRGTWVICDRFTDSTVAYQGFGRADGDAIVRAKIDMLIEQFVMQLPELTLWLDLPVLEG
MARANKRSAADRFEQQATEFFTRVHQGFSVLASEQPERIQRIDASGSANEVSARIWQTIEEKLDI
>Mature_224_residues
SASIQASFSQTTTTPTQGRFISFEGTEGVGKTTAIEQLCARLQAHGIDYLRTREPGGSPFAERLREILLDPNTAINDDTE
LLLMFAARCDHMQQVILPALQRGTWVICDRFTDSTVAYQGFGRADGDAIVRAKIDMLIEQFVMQLPELTLWLDLPVLEGM
ARANKRSAADRFEQQATEFFTRVHQGFSVLASEQPERIQRIDASGSANEVSARIWQTIEEKLDI

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=207, Percent_Identity=39.6135265700483, Blast_Score=127, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 25170; Mature: 25039

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASIQASFSQTTTTPTQGRFISFEGTEGVGKTTAIEQLCARLQAHGIDYLRTREPGGSP
CCCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHCCCCCCCCH
FAERLREILLDPNTAINDDTELLLMFAARCDHMQQVILPALQRGTWVICDRFTDSTVAYQ
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHCC
GFGRADGDAIVRAKIDMLIEQFVMQLPELTLWLDLPVLEGMARANKRSAADRFEQQATEF
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
FTRVHQGFSVLASEQPERIQRIDASGSANEVSARIWQTIEEKLDI
HHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SASIQASFSQTTTTPTQGRFISFEGTEGVGKTTAIEQLCARLQAHGIDYLRTREPGGSP
CCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHCCCCCCCCH
FAERLREILLDPNTAINDDTELLLMFAARCDHMQQVILPALQRGTWVICDRFTDSTVAYQ
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHCC
GFGRADGDAIVRAKIDMLIEQFVMQLPELTLWLDLPVLEGMARANKRSAADRFEQQATEF
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
FTRVHQGFSVLASEQPERIQRIDASGSANEVSARIWQTIEEKLDI
HHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA