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The map label for this gene is panC

Identifier: 93004957

GI number: 93004957

Start: 149617

End: 150480

Strand: Direct

Name: panC

Synonym: Pcryo_0126

Alternate gene names: 93004957

Gene position: 149617-150480 (Clockwise)

Preceding gene: 93004956

Following gene: 93004958

Centisome position: 4.89

GC content: 43.98

Gene sequence:

>864_bases
ATGCCGACGATTCATTACCATATCTCAGACTTACGCGTTGCTCTACGGCCTTACCGAACAGCGCAGCGCATTGCCTTAGT
ACCTACAATGGGTAATCTACACGATGGTCATCTGGAGCTGGTAAAAATTGCCAAACAGCATGCAGATATCGTGGTGGTTA
GTATTTTCGTCAATCCAACGCAGTTTGGGGTTGGTGAAGACTTTGATAGCTACCCTCGTACCTTAGATGAAGATGTAGCA
AAGCTTGCCATGGTTGGCGCTGACTATGTTTTTGCTCCTACTATTGATGAGATGTATCCGGTACTACCGCCGCCGACCAC
TATTCTCGCTGGGACTATTACTGAGCAACTATGTGGCAAAACTCGCCCCAATCATTTCGATGGTGTCGGTATTGTTGTCT
CTAAGCTCTTCAATATCGTGCAACCTAACATAGCCGTATTTGGGCAAAAAGATTATCAGCAATTAGCCATTATTAAGCAG
TTGGTTCGTGATTTGAGCTATTCAATCGATATTATTGGCGCGCCTATTATTCGTGCTACTGATGGCTTAGCGTTATCATC
GCGCAATCAGTATTTAAGCGAGTCTGAGCGCCAAACAGCACCTATCTTACAGCAGGAGCTGCAGTATTCAGCCAAACAGA
TTAGTGATAATAAACAGCCGTTAGAGGTGCTTTTGACAGCAGCTCACGAGCGTATTACTAGTGCGGGGTTTATTATTGAT
TATCTAGAAGTAAAAACAACTGAGCTAACGGCTGTTGATGATGAGAGTATCAATAACCATCAAGACTTGGTTATTTTAGT
GGCTGCATGGCTAGGTCGTGCACGCTTGCTAGACAATCGATTGGTCACGATTAATAAAGTTTGA

Upstream 100 bases:

>100_bases
GTCAGTAAAGGAAGGTAGTTTTCCAACAGAGCAGCACCAGTTTAGCTAAGCAAATATAGAATTTCAGTAATTAGGTCCAC
CAGTAAAAGAGCAGTTAACC

Downstream 100 bases:

>100_bases
TCACACTGCTATTTATAATATTGTAATTTGCGGGATGCAATTTATAAGGATGACGGAACATGCAGGCAAATCAAGACACC
CATAATGCTCAATCAAAGCT

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MPTIHYHISDLRVALRPYRTAQRIALVPTMGNLHDGHLELVKIAKQHADIVVVSIFVNPTQFGVGEDFDSYPRTLDEDVA
KLAMVGADYVFAPTIDEMYPVLPPPTTILAGTITEQLCGKTRPNHFDGVGIVVSKLFNIVQPNIAVFGQKDYQQLAIIKQ
LVRDLSYSIDIIGAPIIRATDGLALSSRNQYLSESERQTAPILQQELQYSAKQISDNKQPLEVLLTAAHERITSAGFIID
YLEVKTTELTAVDDESINNHQDLVILVAAWLGRARLLDNRLVTINKV

Sequences:

>Translated_287_residues
MPTIHYHISDLRVALRPYRTAQRIALVPTMGNLHDGHLELVKIAKQHADIVVVSIFVNPTQFGVGEDFDSYPRTLDEDVA
KLAMVGADYVFAPTIDEMYPVLPPPTTILAGTITEQLCGKTRPNHFDGVGIVVSKLFNIVQPNIAVFGQKDYQQLAIIKQ
LVRDLSYSIDIIGAPIIRATDGLALSSRNQYLSESERQTAPILQQELQYSAKQISDNKQPLEVLLTAAHERITSAGFIID
YLEVKTTELTAVDDESINNHQDLVILVAAWLGRARLLDNRLVTINKV
>Mature_286_residues
PTIHYHISDLRVALRPYRTAQRIALVPTMGNLHDGHLELVKIAKQHADIVVVSIFVNPTQFGVGEDFDSYPRTLDEDVAK
LAMVGADYVFAPTIDEMYPVLPPPTTILAGTITEQLCGKTRPNHFDGVGIVVSKLFNIVQPNIAVFGQKDYQQLAIIKQL
VRDLSYSIDIIGAPIIRATDGLALSSRNQYLSESERQTAPILQQELQYSAKQISDNKQPLEVLLTAAHERITSAGFIIDY
LEVKTTELTAVDDESINNHQDLVILVAAWLGRARLLDNRLVTINKV

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=286, Percent_Identity=46.5034965034965, Blast_Score=252, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6322046, Length=291, Percent_Identity=36.426116838488, Blast_Score=161, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_PSYCK (Q1QEJ3)

Other databases:

- EMBL:   CP000323
- RefSeq:   YP_579394.1
- ProteinModelPortal:   Q1QEJ3
- SMR:   Q1QEJ3
- STRING:   Q1QEJ3
- GeneID:   4034250
- GenomeReviews:   CP000323_GR
- KEGG:   pcr:Pcryo_0126
- NMPDR:   fig|335284.3.peg.702
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- PhylomeDB:   Q1QEJ3
- ProtClustDB:   PRK00380
- BioCyc:   PCRY335284:PCRYO_0126-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 31892; Mature: 31761

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 154-154 BINDING 177-177

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTIHYHISDLRVALRPYRTAQRIALVPTMGNLHDGHLELVKIAKQHADIVVVSIFVNPT
CCEEEEEHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEEEECCC
QFGVGEDFDSYPRTLDEDVAKLAMVGADYVFAPTIDEMYPVLPPPTTILAGTITEQLCGK
CCCCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCHHHHCCCCCCCHHHHHHHHHHHHHCC
TRPNHFDGVGIVVSKLFNIVQPNIAVFGQKDYQQLAIIKQLVRDLSYSIDIIGAPIIRAT
CCCCCCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHCCCEEEECCCCEECC
DGLALSSRNQYLSESERQTAPILQQELQYSAKQISDNKQPLEVLLTAAHERITSAGFIID
CCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEE
YLEVKTTELTAVDDESINNHQDLVILVAAWLGRARLLDNRLVTINKV
EEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECC
>Mature Secondary Structure 
PTIHYHISDLRVALRPYRTAQRIALVPTMGNLHDGHLELVKIAKQHADIVVVSIFVNPT
CEEEEEHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEEEECCC
QFGVGEDFDSYPRTLDEDVAKLAMVGADYVFAPTIDEMYPVLPPPTTILAGTITEQLCGK
CCCCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCHHHHCCCCCCCHHHHHHHHHHHHHCC
TRPNHFDGVGIVVSKLFNIVQPNIAVFGQKDYQQLAIIKQLVRDLSYSIDIIGAPIIRAT
CCCCCCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHCCCEEEECCCCEECC
DGLALSSRNQYLSESERQTAPILQQELQYSAKQISDNKQPLEVLLTAAHERITSAGFIID
CCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEE
YLEVKTTELTAVDDESINNHQDLVILVAAWLGRARLLDNRLVTINKV
EEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA