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The map label for this gene is norM [H]

Identifier: 92114013

GI number: 92114013

Start: 2149396

End: 2150724

Strand: Direct

Name: norM [H]

Synonym: Csal_1890

Alternate gene names: 92114013

Gene position: 2149396-2150724 (Clockwise)

Preceding gene: 92114012

Following gene: 92114014

Centisome position: 58.14

GC content: 67.64

Gene sequence:

>1329_bases
TTGAACGCTCCGCTATCGCGCTTTGCCCTGTTGCTGCGACTGGCCCTGCCGATCATGGGCGGCATGCTCTCGCAGAGCCT
GCTCAACCTGGTCGACGCCGCCCTGGTGGGCGGCCTGGGCGAGACGGCCCTGGCCGGCGTCGGCATCGGCGGCTATGCCA
TGTTCATGGTCACCGCCCTGCTGTTCGGATTGTCCTCGGGGGTGCAGGCACAAACCGCGCGCCGCCATGGCGAGCAGGTG
GTCGCGCGTCGCGCCGAGGCGCTCAACGCCGGCTTGCTCATCGCGCTGTGCCTGGCCATCCCCGTGAGCGCGGCCGGCCT
GTGGCAAGCGCCGCGGGTGATCGCCTGGCTCAACGGCGACGACGCCATCCAGCGGGTCGCGGTCGACTATTTCCGCTGGC
GGATCGCCGGCCTGCTGCCGGTGGCGCTGATCTTCTGCTTCCGCGGTTACTGGTACGGCATCCAGCGTACCGACGTGTAC
TTGCGGATCATGCTCGTCACCCAGGTCGTCAATGTCGCGGCCAGCGCAGCGCTGATCTATGGCTGGGCGGGCTTGCCCCG
CCTGGGTCCTGCCGGTGCGGGTGCGGGCACCACGCTATCGCTGCTCGTCGGTGTCCTGATGTGGGCCATGCTCAGCCGTC
GCCATGCCCGCGGCAACGGCTTTCTGTCGCGCCGTCCTCCGCTGGCGGTATACGTGCGCACCCTGCGTCTGGCGGCGCCT
CATTCCTTTCAGCAATTCTGCTTTGCGGCGGGCTATGCCGTGCTGTTCTGGATTCTCGGGCATGTCAGCGGTGCCAGCGT
CGCGGTCGGCCATGTGCTGGTCAATCTCTCGCTGTTCCTGATCCTCCCCGGCGTCGGCCTCGGGCTGGCAGCGATGAGTC
TGGTGGGCCAGTCGCTGGGGCAGGCCTCGCCCGAAGACGCCCATCGCTGGGGATGGGACGCGGTACGGCTCGCCTGGCTA
TGCCTCGCGCTCCTGGCCTTGCCGATGGCATGGGCCCCCGAGTGGCTGCTGGGCATGTTCCTGCATGATCCCGCCCTGAT
CGACATGGGGCGTCTGCCACTACGCCTGACCGCCGCCATGATCGTGCTCGATGCGGCAGCCATCGTGCTCGCTCAGGCAC
TGCTCGGCGCGGGCGCCAATCGCACGGTGATGAAAGTGACGCTGCTGCTACAATGGGTGGCCTTCCTGCCATTGGCATGG
TGGGTGGGCGTCTCGCTCGGCCACGGTCTGGCCGGGGTCTGGTGGGTTCAGTTAGGCTACCGCTGCATGAACTCGTTATG
GTTCACGACGATCTGGCAGCGTCGCCACTGGCAACGCCTCGCCCTGTAA

Upstream 100 bases:

>100_bases
CTCGAGCGCTGGCTGTCGCCGGTACTGTCCTACGATCCCGAATGAGGGCGAACGTGCAGACCGGGTGGGCGGCCGCCGAC
CAGCGAGAGGCGGAGTCGCC

Downstream 100 bases:

>100_bases
CGCCATGCATGGCGTTTTTAATAACATAAAAGCAATAACCTATTATTATTTATTCTTTCAAAGAATATAGAAGGCAGGGT
AAGGTGCCCTGCTACGGCAA

Product: MATE efflux family protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MNAPLSRFALLLRLALPIMGGMLSQSLLNLVDAALVGGLGETALAGVGIGGYAMFMVTALLFGLSSGVQAQTARRHGEQV
VARRAEALNAGLLIALCLAIPVSAAGLWQAPRVIAWLNGDDAIQRVAVDYFRWRIAGLLPVALIFCFRGYWYGIQRTDVY
LRIMLVTQVVNVAASAALIYGWAGLPRLGPAGAGAGTTLSLLVGVLMWAMLSRRHARGNGFLSRRPPLAVYVRTLRLAAP
HSFQQFCFAAGYAVLFWILGHVSGASVAVGHVLVNLSLFLILPGVGLGLAAMSLVGQSLGQASPEDAHRWGWDAVRLAWL
CLALLALPMAWAPEWLLGMFLHDPALIDMGRLPLRLTAAMIVLDAAAIVLAQALLGAGANRTVMKVTLLLQWVAFLPLAW
WVGVSLGHGLAGVWWVQLGYRCMNSLWFTTIWQRRHWQRLAL

Sequences:

>Translated_442_residues
MNAPLSRFALLLRLALPIMGGMLSQSLLNLVDAALVGGLGETALAGVGIGGYAMFMVTALLFGLSSGVQAQTARRHGEQV
VARRAEALNAGLLIALCLAIPVSAAGLWQAPRVIAWLNGDDAIQRVAVDYFRWRIAGLLPVALIFCFRGYWYGIQRTDVY
LRIMLVTQVVNVAASAALIYGWAGLPRLGPAGAGAGTTLSLLVGVLMWAMLSRRHARGNGFLSRRPPLAVYVRTLRLAAP
HSFQQFCFAAGYAVLFWILGHVSGASVAVGHVLVNLSLFLILPGVGLGLAAMSLVGQSLGQASPEDAHRWGWDAVRLAWL
CLALLALPMAWAPEWLLGMFLHDPALIDMGRLPLRLTAAMIVLDAAAIVLAQALLGAGANRTVMKVTLLLQWVAFLPLAW
WVGVSLGHGLAGVWWVQLGYRCMNSLWFTTIWQRRHWQRLAL
>Mature_442_residues
MNAPLSRFALLLRLALPIMGGMLSQSLLNLVDAALVGGLGETALAGVGIGGYAMFMVTALLFGLSSGVQAQTARRHGEQV
VARRAEALNAGLLIALCLAIPVSAAGLWQAPRVIAWLNGDDAIQRVAVDYFRWRIAGLLPVALIFCFRGYWYGIQRTDVY
LRIMLVTQVVNVAASAALIYGWAGLPRLGPAGAGAGTTLSLLVGVLMWAMLSRRHARGNGFLSRRPPLAVYVRTLRLAAP
HSFQQFCFAAGYAVLFWILGHVSGASVAVGHVLVNLSLFLILPGVGLGLAAMSLVGQSLGQASPEDAHRWGWDAVRLAWL
CLALLALPMAWAPEWLLGMFLHDPALIDMGRLPLRLTAAMIVLDAAAIVLAQALLGAGANRTVMKVTLLLQWVAFLPLAW
WVGVSLGHGLAGVWWVQLGYRCMNSLWFTTIWQRRHWQRLAL

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI48994890, Length=411, Percent_Identity=26.0340632603406, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI226510954, Length=413, Percent_Identity=23.728813559322, Blast_Score=72, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 47688; Mature: 47688

Theoretical pI: Translated: 11.10; Mature: 11.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAPLSRFALLLRLALPIMGGMLSQSLLNLVDAALVGGLGETALAGVGIGGYAMFMVTAL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHH
LFGLSSGVQAQTARRHGEQVVARRAEALNAGLLIALCLAIPVSAAGLWQAPRVIAWLNGD
HHHHCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCEEEEECCH
DAIQRVAVDYFRWRIAGLLPVALIFCFRGYWYGIQRTDVYLRIMLVTQVVNVAASAALIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GWAGLPRLGPAGAGAGTTLSLLVGVLMWAMLSRRHARGNGFLSRRPPLAVYVRTLRLAAP
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCC
HSFQQFCFAAGYAVLFWILGHVSGASVAVGHVLVNLSLFLILPGVGLGLAAMSLVGQSLG
CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
QASPEDAHRWGWDAVRLAWLCLALLALPMAWAPEWLLGMFLHDPALIDMGRLPLRLTAAM
CCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHCCCCCHHHHHHHH
IVLDAAAIVLAQALLGAGANRTVMKVTLLLQWVAFLPLAWWVGVSLGHGLAGVWWVQLGY
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
RCMNSLWFTTIWQRRHWQRLAL
HHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNAPLSRFALLLRLALPIMGGMLSQSLLNLVDAALVGGLGETALAGVGIGGYAMFMVTAL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHH
LFGLSSGVQAQTARRHGEQVVARRAEALNAGLLIALCLAIPVSAAGLWQAPRVIAWLNGD
HHHHCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCEEEEECCH
DAIQRVAVDYFRWRIAGLLPVALIFCFRGYWYGIQRTDVYLRIMLVTQVVNVAASAALIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GWAGLPRLGPAGAGAGTTLSLLVGVLMWAMLSRRHARGNGFLSRRPPLAVYVRTLRLAAP
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCC
HSFQQFCFAAGYAVLFWILGHVSGASVAVGHVLVNLSLFLILPGVGLGLAAMSLVGQSLG
CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
QASPEDAHRWGWDAVRLAWLCLALLALPMAWAPEWLLGMFLHDPALIDMGRLPLRLTAAM
CCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHCCCCCHHHHHHHH
IVLDAAAIVLAQALLGAGANRTVMKVTLLLQWVAFLPLAWWVGVSLGHGLAGVWWVQLGY
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
RCMNSLWFTTIWQRRHWQRLAL
HHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]