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The map label for this gene is rutR [H]

Identifier: 92113913

GI number: 92113913

Start: 2037884

End: 2038639

Strand: Direct

Name: rutR [H]

Synonym: Csal_1790

Alternate gene names: 92113913

Gene position: 2037884-2038639 (Clockwise)

Preceding gene: 92113904

Following gene: 92113914

Centisome position: 55.13

GC content: 63.36

Gene sequence:

>756_bases
GTGTCTTCTCGTCGGGCATTCGACACGGCGTGCGGCAGGCGACGGGCACGGGTGCGTTGCACCGGCTGCGCTCGCTGGGG
CAGACTTTCTTACCCGGCAACGAAGAGAGCGGCCATGACGACGATGAAAGTGCCCGGATCGGGAACGCGGGCGCGCAATG
AAAGCGTGATTCTCGAGGCGGCGGAGCGGATTTTCGCGCGCCATGGCTATCGTGGGGCGAGCGTGCAGGCCATCGCCGAG
GCGGCCGGTTTGCCCAAGTCCAATGTGCTGTATTATGTCGGCAGCAAGCGCGAGCTCTATGTCTCGCTGCTCGAGCGTAT
GATGGCGCGCTGGAATGCCATGCTCGACGATATCGACGAAGACGACGATCCCGGCGAGGTACTGGAGAGCTTCATTCGCA
GCAAGATGCGTCTCACGCAGCAGCATCCCCAGGGGTCTCGCCTGTTCGCGGCGGAAGTGCTCCAGGGCGCGCCTTTCCTG
CAGTCCTACCTGCATGGCGAGTTGCGCGAATGGGTGCGTTCCCGGGCGCGCATCTTCGAGCGCTGGGCGGAAAAGGGGCT
GATGGATCCCGTCGATCCGGTGTGGCTGATCTTCCTGATCTGGTCGGCGACCCAGCATTACGCGGATTTCGAGGCGCAGA
TACTGGGCATCACCGATCAGGCACAGCTCGACGACGGCTACTATCGTGCGATTACCGACTTCCTGTGCCAGGTCATCCTC
AAGGGATGCGGCGTTCGCGCGCCGTCTGCCACCTAG

Upstream 100 bases:

>100_bases
GTCGGGCTACATGGTATGACCATCTGGTCAACTTTTATAAGCGTTGATCAAAATGTCGCCGATGACAACCCCTGCGAGCG
CGGGATGAGGATGGATCTTC

Downstream 100 bases:

>100_bases
CGTAGAGTGGCGCATCGACATGAGCCGCTAACCGATACCATGACGTGTAAGGAGAGAACATGAAGCTCTGGGGCATCTTG
CTGCTGGTGAGCGGTGGCCT

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: Rut operon repressor [H]

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MSSRRAFDTACGRRRARVRCTGCARWGRLSYPATKRAAMTTMKVPGSGTRARNESVILEAAERIFARHGYRGASVQAIAE
AAGLPKSNVLYYVGSKRELYVSLLERMMARWNAMLDDIDEDDDPGEVLESFIRSKMRLTQQHPQGSRLFAAEVLQGAPFL
QSYLHGELREWVRSRARIFERWAEKGLMDPVDPVWLIFLIWSATQHYADFEAQILGITDQAQLDDGYYRAITDFLCQVIL
KGCGVRAPSAT

Sequences:

>Translated_251_residues
MSSRRAFDTACGRRRARVRCTGCARWGRLSYPATKRAAMTTMKVPGSGTRARNESVILEAAERIFARHGYRGASVQAIAE
AAGLPKSNVLYYVGSKRELYVSLLERMMARWNAMLDDIDEDDDPGEVLESFIRSKMRLTQQHPQGSRLFAAEVLQGAPFL
QSYLHGELREWVRSRARIFERWAEKGLMDPVDPVWLIFLIWSATQHYADFEAQILGITDQAQLDDGYYRAITDFLCQVIL
KGCGVRAPSAT
>Mature_250_residues
SSRRAFDTACGRRRARVRCTGCARWGRLSYPATKRAAMTTMKVPGSGTRARNESVILEAAERIFARHGYRGASVQAIAEA
AGLPKSNVLYYVGSKRELYVSLLERMMARWNAMLDDIDEDDDPGEVLESFIRSKMRLTQQHPQGSRLFAAEVLQGAPFLQ
SYLHGELREWVRSRARIFERWAEKGLMDPVDPVWLIFLIWSATQHYADFEAQILGITDQAQLDDGYYRAITDFLCQVILK
GCGVRAPSAT

Specific function: Master transcription regulator which represses the degradation of pyrimidines (rutABCDEFG) and purines (gcl operon) for maintenance of metabolic balance between pyrimidines and purines. It also regulates the synthesis of pyrimidine nucleotides and arginin

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787249, Length=209, Percent_Identity=35.4066985645933, Blast_Score=150, Evalue=6e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR019915
- InterPro:   IPR001647
- InterPro:   IPR013573 [H]

Pfam domain/function: PF08362 TetR_C_3; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 28387; Mature: 28256

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSRRAFDTACGRRRARVRCTGCARWGRLSYPATKRAAMTTMKVPGSGTRARNESVILEA
CCCCHHHHHHHHHHCCCEEEHHHHHCCCCCCCCHHHHHHHEEECCCCCCCCCCHHHHHHH
AERIFARHGYRGASVQAIAEAAGLPKSNVLYYVGSKRELYVSLLERMMARWNAMLDDIDE
HHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCC
DDDPGEVLESFIRSKMRLTQQHPQGSRLFAAEVLQGAPFLQSYLHGELREWVRSRARIFE
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
RWAEKGLMDPVDPVWLIFLIWSATQHYADFEAQILGITDQAQLDDGYYRAITDFLCQVIL
HHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHEEECCCCHHHHCCHHHHHHHHHHHHHHH
KGCGVRAPSAT
HHCCCCCCCCC
>Mature Secondary Structure 
SSRRAFDTACGRRRARVRCTGCARWGRLSYPATKRAAMTTMKVPGSGTRARNESVILEA
CCCHHHHHHHHHHCCCEEEHHHHHCCCCCCCCHHHHHHHEEECCCCCCCCCCHHHHHHH
AERIFARHGYRGASVQAIAEAAGLPKSNVLYYVGSKRELYVSLLERMMARWNAMLDDIDE
HHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCC
DDDPGEVLESFIRSKMRLTQQHPQGSRLFAAEVLQGAPFLQSYLHGELREWVRSRARIFE
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
RWAEKGLMDPVDPVWLIFLIWSATQHYADFEAQILGITDQAQLDDGYYRAITDFLCQVIL
HHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHEEECCCCHHHHCCHHHHHHHHHHHHHHH
KGCGVRAPSAT
HHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]