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The map label for this gene is serA [H]

Identifier: 92113893

GI number: 92113893

Start: 2015094

End: 2016023

Strand: Direct

Name: serA [H]

Synonym: Csal_1770

Alternate gene names: 92113893

Gene position: 2015094-2016023 (Clockwise)

Preceding gene: 92113892

Following gene: 92113894

Centisome position: 54.51

GC content: 67.74

Gene sequence:

>930_bases
ATGTCTGACGTACTCATCAGTGAATTCATGGACGAGGCGGCCGTCGCCGATCTCGAAAGGGACTGCTCGGTGACCTTCGA
TGCCACGCTGGTCGACGATCGCGCTCGCTTGCTGTCATCCGGGGCCGGGGTGCGTGCCCTGATCGTGCGCAATCGTACCC
GCGTCGACCGCGAGCTCCTGGCGCGCTTTCCCGACCTGAGAGCGGTGGGCCGGCTGGGCGTGGGGCTCGACAACATCGAC
GTGGATGCCTGTCGTGAGTCCGATATCGCCGTCCTGCCGGCGACCGGTGGCAATACCGTGTCGGTGGCGGAGTACGTGCT
GACCGGGATCTTCATGCTGCGCCGCGGCGCCTATCTGTCGACGCCGCGCGTGCTGGCGGGCGAGTGGCCGCGTCAGGCGC
TGATGGGGCACGAGACGCAAGGGGCGACCCTGGGGCTCGTGGGGTTCGGCGGCATCGCCCGCGACCTGGCCCGGCGCGCC
CAGTGCCTGGGCATGCAGGTGATGGCCCATGATCCCTTCGTGCCCGCGGATGACGCCGCCTGGCAGACGGTCGAGCGTGC
CGAGCGGCTGGCGACGCTGCTGGAGAAGGCGGATGCGGTCAGTCTGCACGTGCCGTTGAGCGAGGGGACCCGGCATCTGA
TCGATGGCGAAGCGCTGGCGACGATGAAGCCGGGAAGCCTGCTGATCAACACTGCGCGTGGCGGCATCGTCGATGAAAGG
GCATTGGCCGCCAGCCTGCGTGACAGACATCTGGGCGGGGCGATGCTGGATGTCTTCGAGGAAGAGCCGTTGACCGCCGA
CTCGGTGTTGAGCGGTGTCGAAGGCTTGATCGCCACGCCGCACATCGCCGGCGTGACCCACGAGTCCAACGAGCGGATCA
GCTGGATCACCGTCGACAACGTGCGCCGTGCGCTGGGGGTGAGGGCATGA

Upstream 100 bases:

>100_bases
GATCATCGGCGGCTTCTACATCCTGTTCGCCATCGTCCTCAACGTACCGCTCCCGGCGGGACTCCTGTGGCGCCATTTCT
AACCGAACGAGACTTCTGAC

Downstream 100 bases:

>100_bases
GCCGCATGATATCGCTGCGCGAGGCCGAAACGCTGGCGGTCGCGGCACTCGAGGCGGTCGGCGTGCCGCGCTGGGAGGCC
GAGGTCACGGCCCGGGCACT

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MSDVLISEFMDEAAVADLERDCSVTFDATLVDDRARLLSSGAGVRALIVRNRTRVDRELLARFPDLRAVGRLGVGLDNID
VDACRESDIAVLPATGGNTVSVAEYVLTGIFMLRRGAYLSTPRVLAGEWPRQALMGHETQGATLGLVGFGGIARDLARRA
QCLGMQVMAHDPFVPADDAAWQTVERAERLATLLEKADAVSLHVPLSEGTRHLIDGEALATMKPGSLLINTARGGIVDER
ALAASLRDRHLGGAMLDVFEEEPLTADSVLSGVEGLIATPHIAGVTHESNERISWITVDNVRRALGVRA

Sequences:

>Translated_309_residues
MSDVLISEFMDEAAVADLERDCSVTFDATLVDDRARLLSSGAGVRALIVRNRTRVDRELLARFPDLRAVGRLGVGLDNID
VDACRESDIAVLPATGGNTVSVAEYVLTGIFMLRRGAYLSTPRVLAGEWPRQALMGHETQGATLGLVGFGGIARDLARRA
QCLGMQVMAHDPFVPADDAAWQTVERAERLATLLEKADAVSLHVPLSEGTRHLIDGEALATMKPGSLLINTARGGIVDER
ALAASLRDRHLGGAMLDVFEEEPLTADSVLSGVEGLIATPHIAGVTHESNERISWITVDNVRRALGVRA
>Mature_308_residues
SDVLISEFMDEAAVADLERDCSVTFDATLVDDRARLLSSGAGVRALIVRNRTRVDRELLARFPDLRAVGRLGVGLDNIDV
DACRESDIAVLPATGGNTVSVAEYVLTGIFMLRRGAYLSTPRVLAGEWPRQALMGHETQGATLGLVGFGGIARDLARRAQ
CLGMQVMAHDPFVPADDAAWQTVERAERLATLLEKADAVSLHVPLSEGTRHLIDGEALATMKPGSLLINTARGGIVDERA
LAASLRDRHLGGAMLDVFEEEPLTADSVLSGVEGLIATPHIAGVTHESNERISWITVDNVRRALGVRA

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=260, Percent_Identity=35, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI145580578, Length=257, Percent_Identity=35.7976653696498, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI4557499, Length=257, Percent_Identity=35.7976653696498, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI145580575, Length=260, Percent_Identity=35.7692307692308, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI61743967, Length=260, Percent_Identity=34.2307692307692, Blast_Score=134, Evalue=9e-32,
Organism=Homo sapiens, GI4557497, Length=260, Percent_Identity=34.2307692307692, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI6912396, Length=266, Percent_Identity=25.187969924812, Blast_Score=82, Evalue=8e-16,
Organism=Escherichia coli, GI1789279, Length=277, Percent_Identity=34.2960288808664, Blast_Score=144, Evalue=9e-36,
Organism=Escherichia coli, GI87082289, Length=278, Percent_Identity=33.8129496402878, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI1787645, Length=240, Percent_Identity=29.5833333333333, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1788660, Length=270, Percent_Identity=31.8518518518519, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17532191, Length=303, Percent_Identity=36.6336633663366, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI25147481, Length=273, Percent_Identity=30.03663003663, Blast_Score=127, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6320925, Length=303, Percent_Identity=29.042904290429, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6322116, Length=262, Percent_Identity=30.5343511450382, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6324055, Length=268, Percent_Identity=30.5970149253731, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6324964, Length=315, Percent_Identity=26.031746031746, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6321253, Length=179, Percent_Identity=26.2569832402235, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI19921140, Length=296, Percent_Identity=33.7837837837838, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24646446, Length=257, Percent_Identity=36.9649805447471, Blast_Score=141, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24646448, Length=257, Percent_Identity=36.9649805447471, Blast_Score=141, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24646452, Length=257, Percent_Identity=36.9649805447471, Blast_Score=141, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24646450, Length=257, Percent_Identity=36.9649805447471, Blast_Score=141, Evalue=6e-34,
Organism=Drosophila melanogaster, GI62472511, Length=257, Percent_Identity=36.9649805447471, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI28571528, Length=312, Percent_Identity=30.4487179487179, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24585516, Length=247, Percent_Identity=26.3157894736842, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28574286, Length=282, Percent_Identity=25.177304964539, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24585514, Length=304, Percent_Identity=24.3421052631579, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI28574282, Length=304, Percent_Identity=24.3421052631579, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI28574284, Length=304, Percent_Identity=24.3421052631579, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI45552429, Length=305, Percent_Identity=24.2622950819672, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI45551003, Length=304, Percent_Identity=24.3421052631579, Blast_Score=91, Evalue=7e-19,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 33135; Mature: 33004

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDVLISEFMDEAAVADLERDCSVTFDATLVDDRARLLSSGAGVRALIVRNRTRVDRELL
CCCHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHCCCCEEEEEECCCHHHHHHHH
ARFPDLRAVGRLGVGLDNIDVDACRESDIAVLPATGGNTVSVAEYVLTGIFMLRRGAYLS
HHCCCHHHHHHHCCCCCCCCHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCC
TPRVLAGEWPRQALMGHETQGATLGLVGFGGIARDLARRAQCLGMQVMAHDPFVPADDAA
CCCHHCCCCCHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCEEEECCCCCCCCCHH
WQTVERAERLATLLEKADAVSLHVPLSEGTRHLIDGEALATMKPGSLLINTARGGIVDER
HHHHHHHHHHHHHHHHCCEEEEEEEHHHCCHHHCCCCEEEEECCCCEEEECCCCCCCHHH
ALAASLRDRHLGGAMLDVFEEEPLTADSVLSGVEGLIATPHIAGVTHESNERISWITVDN
HHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHCCCCEECCCCCCCCEEEEEEHHH
VRRALGVRA
HHHHHCCCC
>Mature Secondary Structure 
SDVLISEFMDEAAVADLERDCSVTFDATLVDDRARLLSSGAGVRALIVRNRTRVDRELL
CCHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHCCCCEEEEEECCCHHHHHHHH
ARFPDLRAVGRLGVGLDNIDVDACRESDIAVLPATGGNTVSVAEYVLTGIFMLRRGAYLS
HHCCCHHHHHHHCCCCCCCCHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCC
TPRVLAGEWPRQALMGHETQGATLGLVGFGGIARDLARRAQCLGMQVMAHDPFVPADDAA
CCCHHCCCCCHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCEEEECCCCCCCCCHH
WQTVERAERLATLLEKADAVSLHVPLSEGTRHLIDGEALATMKPGSLLINTARGGIVDER
HHHHHHHHHHHHHHHHCCEEEEEEEHHHCCHHHCCCCEEEEECCCCEEEECCCCCCCHHH
ALAASLRDRHLGGAMLDVFEEEPLTADSVLSGVEGLIATPHIAGVTHESNERISWITVDN
HHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHCCCCEECCCCCCCCEEEEEEHHH
VRRALGVRA
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]