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The map label for this gene is uxaA [H]

Identifier: 92113872

GI number: 92113872

Start: 1993375

End: 1994907

Strand: Direct

Name: uxaA [H]

Synonym: Csal_1749

Alternate gene names: 92113872

Gene position: 1993375-1994907 (Clockwise)

Preceding gene: 92113866

Following gene: 92113873

Centisome position: 53.92

GC content: 66.54

Gene sequence:

>1533_bases
ATGCAGCTCATCAATACGACGCCGCCGGTCATCCGGCTCAACGATGCCGACAACGTGGGGGTCGCGACCCGGGCCCTGCC
ACAGGGACTGCCGCTGGACGGCGACGGCGAGCGGGTGGCGCGTCACAACATCGATGCCGGTCACAAGGTCGCCCTGACGG
CCATCGCCACGGGCGACGCCATCATCAAGTACGGCCAGGTCATCGGGCGGGCGAGCCGCGACATCGACGTCGGCGAGCAC
GTGCACACCCATAACGTGGCCATGCTCGAGCGGGACACGACCCTGACGGACTTCCAGCCGTTCCCGCGTTCGCCGACGCA
GGACTCCGATCGCACCTTCATGGGCTACCATCGGCCGAACGGCCAGGTCGGAACCCGCAATTACATCGGTATCCTGTCGA
CGGTGAACTGCTCGGCGACCGTGGCCAAGGTGGCCGCGGAGCAGCTCAATGCCAATCCCGAGATCGAGGCTCTCGGCTTC
GACGGCGTGGTGCCCATCACGCATGGCTCGGGATGCGCGATGAACACCGAATCCGAAGGCTTCGCGTTCCTCGAGCGGGT
GATCGCTGGCTATGCGCGGCATCCCAACTTCGCGCTGGTGGTGATCATCGGCCTGGGATGCGAAACCAACCAGGTCAAGC
AGCTGGTGGAAAGCGCCGGGTTGAGCGACGAGCGTCGCCTGGCCTATTTCAACATCCAGCAGGTCGGCGGTACCCGGGCC
AGCATCGGCAAGGCCTACGAGCAAGTGCTCGACATGGCGCGCGCACATGGGCGCGACGAGCGCCGTCCCGCGTCGCTCAA
GCACTTGAGCGTGGCCCTGCAGTGCGGCGGTTCCGACGGGTATTCGGGGATCACCGCGAACCCCGCCCTGGGCCACGCCG
CCGACTTGATCGTGCGTCACGGCGGCAGCGCCATCCTGAGCGAAACGCCGGAAATCTACGGCGCCGAGCACCTGCTGCTG
GACCGCGCGGTGGACGTGGAGGTGGCGCGCAAGCTGCTGGCGCGGATCGCCTGGTGGAAGCACTATACCGAGATCAACGG
CGCCGAGCTCAACAACAATCCGTCGCCCGGCAACAAGGCCGGCGGCCTCTCGACCATCCTCGAGAAGTCCCTGGGGGCCG
TGGCCAAGGGCGGCGCCTCGAGCCTGAACGACGTGCTCGAATACGCCGAGCCGCTCAAGGTCCCCGGGTTCAACTTCATG
GACAGCCCCGGGTACGATCCGGCCTCGGTCACCGGTCAGATCGCCTCCGGTGCCACCCTGGTGTGCTTCACCACGGGGCG
GGGGTCGGTCTCCGGCTTCAAGCCGGCGCCGTGTCTCAAGCTGGCCACCAACACGGCCATGTATGAGACCATGCACGAGG
ACATGGACATCAACTGCGGCGCCATCCTCGATGGCGAGATGAGCGTGGAGGCCATGGGCGAGGCGATTTTCGAGAAGATT
CTCGCGGTCGCCTCCGGCGAGGCGAGTGCCAGCGAGTCGCTGGGCTATGGCAGCAACGAGTTCGTGCCGTGGATGGTCGG
CGCCATCACCTGA

Upstream 100 bases:

>100_bases
AGTTATAATTGAACATTGCGTGCAATATTCAATATTGTGACGTTAGTCGAATCCGCGCCCTTCGCGCACGCCCTGACGGT
CAACGGTTACCGAGGTCATT

Downstream 100 bases:

>100_bases
GTGCGGTGTCCCGGTGCCGAAGCCGTACGAGAAGACGCAGGGAAGACAGTCCAGGAGGAAAAGACAGCCCCATGGCCAGA
TCGCTGAAAGAGCAGCTCTA

Product: Altronate dehydratase

Products: NA

Alternate protein names: Altronic acid hydratase [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MQLINTTPPVIRLNDADNVGVATRALPQGLPLDGDGERVARHNIDAGHKVALTAIATGDAIIKYGQVIGRASRDIDVGEH
VHTHNVAMLERDTTLTDFQPFPRSPTQDSDRTFMGYHRPNGQVGTRNYIGILSTVNCSATVAKVAAEQLNANPEIEALGF
DGVVPITHGSGCAMNTESEGFAFLERVIAGYARHPNFALVVIIGLGCETNQVKQLVESAGLSDERRLAYFNIQQVGGTRA
SIGKAYEQVLDMARAHGRDERRPASLKHLSVALQCGGSDGYSGITANPALGHAADLIVRHGGSAILSETPEIYGAEHLLL
DRAVDVEVARKLLARIAWWKHYTEINGAELNNNPSPGNKAGGLSTILEKSLGAVAKGGASSLNDVLEYAEPLKVPGFNFM
DSPGYDPASVTGQIASGATLVCFTTGRGSVSGFKPAPCLKLATNTAMYETMHEDMDINCGAILDGEMSVEAMGEAIFEKI
LAVASGEASASESLGYGSNEFVPWMVGAIT

Sequences:

>Translated_510_residues
MQLINTTPPVIRLNDADNVGVATRALPQGLPLDGDGERVARHNIDAGHKVALTAIATGDAIIKYGQVIGRASRDIDVGEH
VHTHNVAMLERDTTLTDFQPFPRSPTQDSDRTFMGYHRPNGQVGTRNYIGILSTVNCSATVAKVAAEQLNANPEIEALGF
DGVVPITHGSGCAMNTESEGFAFLERVIAGYARHPNFALVVIIGLGCETNQVKQLVESAGLSDERRLAYFNIQQVGGTRA
SIGKAYEQVLDMARAHGRDERRPASLKHLSVALQCGGSDGYSGITANPALGHAADLIVRHGGSAILSETPEIYGAEHLLL
DRAVDVEVARKLLARIAWWKHYTEINGAELNNNPSPGNKAGGLSTILEKSLGAVAKGGASSLNDVLEYAEPLKVPGFNFM
DSPGYDPASVTGQIASGATLVCFTTGRGSVSGFKPAPCLKLATNTAMYETMHEDMDINCGAILDGEMSVEAMGEAIFEKI
LAVASGEASASESLGYGSNEFVPWMVGAIT
>Mature_510_residues
MQLINTTPPVIRLNDADNVGVATRALPQGLPLDGDGERVARHNIDAGHKVALTAIATGDAIIKYGQVIGRASRDIDVGEH
VHTHNVAMLERDTTLTDFQPFPRSPTQDSDRTFMGYHRPNGQVGTRNYIGILSTVNCSATVAKVAAEQLNANPEIEALGF
DGVVPITHGSGCAMNTESEGFAFLERVIAGYARHPNFALVVIIGLGCETNQVKQLVESAGLSDERRLAYFNIQQVGGTRA
SIGKAYEQVLDMARAHGRDERRPASLKHLSVALQCGGSDGYSGITANPALGHAADLIVRHGGSAILSETPEIYGAEHLLL
DRAVDVEVARKLLARIAWWKHYTEINGAELNNNPSPGNKAGGLSTILEKSLGAVAKGGASSLNDVLEYAEPLKVPGFNFM
DSPGYDPASVTGQIASGATLVCFTTGRGSVSGFKPAPCLKLATNTAMYETMHEDMDINCGAILDGEMSVEAMGEAIFEKI
LAVASGEASASESLGYGSNEFVPWMVGAIT

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG2721

COG function: function code G; Altronate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uxaA family [H]

Homologues:

Organism=Escherichia coli, GI1789475, Length=491, Percent_Identity=37.0672097759674, Blast_Score=299, Evalue=2e-82,
Organism=Escherichia coli, GI1789516, Length=502, Percent_Identity=35.6573705179283, Blast_Score=271, Evalue=6e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007392
- InterPro:   IPR013974 [H]

Pfam domain/function: PF04295 GD_AH_C; PF08666 SAF [H]

EC number: =4.2.1.7 [H]

Molecular weight: Translated: 53981; Mature: 53981

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLINTTPPVIRLNDADNVGVATRALPQGLPLDGDGERVARHNIDAGHKVALTAIATGDA
CCCCCCCCCEEEECCCCCCCHHHHHCCCCCCCCCCCCHHHHCCCCCCCEEEEEEEECCHH
IIKYGQVIGRASRDIDVGEHVHTHNVAMLERDTTLTDFQPFPRSPTQDSDRTFMGYHRPN
HHHHHHHHHCCCCCCCCCCCEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCC
GQVGTRNYIGILSTVNCSATVAKVAAEQLNANPEIEALGFDGVVPITHGSGCAMNTESEG
CCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCEEEECCCCEEEEECCCCCCCCCCCCH
FAFLERVIAGYARHPNFALVVIIGLGCETNQVKQLVESAGLSDERRLAYFNIQQVGGTRA
HHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCEEEEEEHHHHCCCHH
SIGKAYEQVLDMARAHGRDERRPASLKHLSVALQCGGSDGYSGITANPALGHAADLIVRH
HHHHHHHHHHHHHHHCCCCCCCCCHHHEEEEEEEECCCCCCCCEECCCCCCHHHHHHHHC
GGSAILSETPEIYGAEHLLLDRAVDVEVARKLLARIAWWKHYTEINGAELNNNPSPGNKA
CCCCHHHCCCCHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
GGLSTILEKSLGAVAKGGASSLNDVLEYAEPLKVPGFNFMDSPGYDPASVTGQIASGATL
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHCCEEECCCCEE
VCFTTGRGSVSGFKPAPCLKLATNTAMYETMHEDMDINCGAILDGEMSVEAMGEAIFEKI
EEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHH
LAVASGEASASESLGYGSNEFVPWMVGAIT
HHHHCCCCCCHHHCCCCCCCCCCEEEEECC
>Mature Secondary Structure
MQLINTTPPVIRLNDADNVGVATRALPQGLPLDGDGERVARHNIDAGHKVALTAIATGDA
CCCCCCCCCEEEECCCCCCCHHHHHCCCCCCCCCCCCHHHHCCCCCCCEEEEEEEECCHH
IIKYGQVIGRASRDIDVGEHVHTHNVAMLERDTTLTDFQPFPRSPTQDSDRTFMGYHRPN
HHHHHHHHHCCCCCCCCCCCEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCC
GQVGTRNYIGILSTVNCSATVAKVAAEQLNANPEIEALGFDGVVPITHGSGCAMNTESEG
CCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCEEEECCCCEEEEECCCCCCCCCCCCH
FAFLERVIAGYARHPNFALVVIIGLGCETNQVKQLVESAGLSDERRLAYFNIQQVGGTRA
HHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCEEEEEEHHHHCCCHH
SIGKAYEQVLDMARAHGRDERRPASLKHLSVALQCGGSDGYSGITANPALGHAADLIVRH
HHHHHHHHHHHHHHHCCCCCCCCCHHHEEEEEEEECCCCCCCCEECCCCCCHHHHHHHHC
GGSAILSETPEIYGAEHLLLDRAVDVEVARKLLARIAWWKHYTEINGAELNNNPSPGNKA
CCCCHHHCCCCHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
GGLSTILEKSLGAVAKGGASSLNDVLEYAEPLKVPGFNFMDSPGYDPASVTGQIASGATL
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHCCEEECCCCEE
VCFTTGRGSVSGFKPAPCLKLATNTAMYETMHEDMDINCGAILDGEMSVEAMGEAIFEKI
EEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHH
LAVASGEASASESLGYGSNEFVPWMVGAIT
HHHHCCCCCCHHHCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579062; 9384377 [H]