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The map label for this gene is manC [H]

Identifier: 92113815

GI number: 92113815

Start: 1921965

End: 1923368

Strand: Direct

Name: manC [H]

Synonym: Csal_1692

Alternate gene names: 92113815

Gene position: 1921965-1923368 (Clockwise)

Preceding gene: 92113814

Following gene: 92113816

Centisome position: 51.99

GC content: 46.94

Gene sequence:

>1404_bases
ATGATCGTTCCCGTAATACTTGCAGGTGGTGCTGGATCAAGGTTATGGCCATTATCAAGAAGTCAGCATCCCAAGCAATT
TATGCCATTGATTGATAATAACTCTATGCTGCAGGAAACCCTGAAGCGGGTTGATGGGATCACGGATGCAGATCCTGTTT
TAATCTGTAACGAGGAGCACCGTTTTTTGGCGGCTGAACAAGTACGTCAAATTGGCAAGACACCATCTATCCTACTGGAG
CCGGAGGGACGGAATACAGCTCCCGCAATTGCGTTGGCAGCATTGAAAGAATTGGATCGTAAAGAAGATCCTCTGCTGTT
GGTGTTGGCAGCGGATCATTATATTAAGAAGATAGATGCTTTCCACTTGGCAATTGAATCTGCCTTGTCGCTAGCCCGAG
AGGGGAAATTGGTTACTTTCGGTATTGTCCCTACACATGCAGAAACGGGCTATGGCTACATCCAGCAGGGCAATGCTTTG
GGAAAGCAGGGGTTTAAAGTTGCATCTTTTGTAGAAAAGCCAGACTCTTCGACAGCTGAAAGCTATTTGGCAAGCGGGGA
CTTTTTCTGGAATAGTGGGATGTTTTTGTTCCGAGCTAGTCGTTATATTGAAGAGTTAGAGCTTCATGCGCCGGACATTC
TCAGAGCATGTCGAAGAGCTATTGATGAAGGACAACAAGATCTCGACTTTCTGCGCGTCGGAAGCGAAGCATTTAAGGGC
TGCCCTGAGAACTCTATCGACTATGCTGTCATGGAAAAAACTGATAGCGCCGCTATGGTTAGCCTAGATGCTGGATGGAG
CGACATTGGTTCTTGGGCGTCTTTGTGGGATATAAGCGATAAGGATGCTAACAGTAACGTGCTGCATGGTGATGTGCTCG
CGGAGGCGACGTCCAAAACTCTGGTACAGGCCGAGCACCGCCTTGTAGCCACACTTGGGGTAGATGATCTAGTGATAGTC
GAAACCAAGGACGCTGTCCTCGTCGCACACAAAAACAAAGTGCAAGATGTAAAAAAAATCGCCACTGCACTCAAGCAATC
GGGGCGGACTGAACAATCGAATCATCGTGAAGTCTACCGCCCGTGGGGGGTCTATGACTCGGTGGATCGTGGTCAGCGTT
ATCAAGTCAAGCGTATTACAGTGAATCCGGGGGCTAAACTGTCCGTTCAAATGCATTACCACCGCGCGGAGCATTGGGTT
GTGGTTTCTGGAACAGCAAAAGTCACTAATGGTGAAAAGAGTTATTTAGTAACAGAAAATGAGTCAACGTTTATTCCTGT
TGGACAGGTTCATGCACTAGAAAATCCAGGAGTTGTTCCGCTTGAACTGATTGAAATACAGTCTGGGACTTATCTTGGTG
AAGACGATATTGTACGTTTTGATGATAATTATGGAAGAGCCTAG

Upstream 100 bases:

>100_bases
TTGTTTATTTGGTGAATGCGGTATTGAAAAGAAAGTGCAAGCTATATAAGCCTGTTTACCTCCCCTTTAACATTTCTGCC
AGTTTAAAAAAGGAAGATGC

Downstream 100 bases:

>100_bases
GGTTATTCAAGTAGGGAGAGGTGAGAGCTCGTGCGTCTTAACTTAATGGGGGCACCTTATGTCTCTTGGTGATAGAGGAA
TAGGTGAGCGTTACCCAGCT

Product: mannose-1-phosphate guanylyltransferase (GDP)

Products: NA

Alternate protein names: GDP-mannose pyrophosphorylase; GMP; GMPP [H]

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MIVPVILAGGAGSRLWPLSRSQHPKQFMPLIDNNSMLQETLKRVDGITDADPVLICNEEHRFLAAEQVRQIGKTPSILLE
PEGRNTAPAIALAALKELDRKEDPLLLVLAADHYIKKIDAFHLAIESALSLAREGKLVTFGIVPTHAETGYGYIQQGNAL
GKQGFKVASFVEKPDSSTAESYLASGDFFWNSGMFLFRASRYIEELELHAPDILRACRRAIDEGQQDLDFLRVGSEAFKG
CPENSIDYAVMEKTDSAAMVSLDAGWSDIGSWASLWDISDKDANSNVLHGDVLAEATSKTLVQAEHRLVATLGVDDLVIV
ETKDAVLVAHKNKVQDVKKIATALKQSGRTEQSNHREVYRPWGVYDSVDRGQRYQVKRITVNPGAKLSVQMHYHRAEHWV
VVSGTAKVTNGEKSYLVTENESTFIPVGQVHALENPGVVPLELIEIQSGTYLGEDDIVRFDDNYGRA

Sequences:

>Translated_467_residues
MIVPVILAGGAGSRLWPLSRSQHPKQFMPLIDNNSMLQETLKRVDGITDADPVLICNEEHRFLAAEQVRQIGKTPSILLE
PEGRNTAPAIALAALKELDRKEDPLLLVLAADHYIKKIDAFHLAIESALSLAREGKLVTFGIVPTHAETGYGYIQQGNAL
GKQGFKVASFVEKPDSSTAESYLASGDFFWNSGMFLFRASRYIEELELHAPDILRACRRAIDEGQQDLDFLRVGSEAFKG
CPENSIDYAVMEKTDSAAMVSLDAGWSDIGSWASLWDISDKDANSNVLHGDVLAEATSKTLVQAEHRLVATLGVDDLVIV
ETKDAVLVAHKNKVQDVKKIATALKQSGRTEQSNHREVYRPWGVYDSVDRGQRYQVKRITVNPGAKLSVQMHYHRAEHWV
VVSGTAKVTNGEKSYLVTENESTFIPVGQVHALENPGVVPLELIEIQSGTYLGEDDIVRFDDNYGRA
>Mature_467_residues
MIVPVILAGGAGSRLWPLSRSQHPKQFMPLIDNNSMLQETLKRVDGITDADPVLICNEEHRFLAAEQVRQIGKTPSILLE
PEGRNTAPAIALAALKELDRKEDPLLLVLAADHYIKKIDAFHLAIESALSLAREGKLVTFGIVPTHAETGYGYIQQGNAL
GKQGFKVASFVEKPDSSTAESYLASGDFFWNSGMFLFRASRYIEELELHAPDILRACRRAIDEGQQDLDFLRVGSEAFKG
CPENSIDYAVMEKTDSAAMVSLDAGWSDIGSWASLWDISDKDANSNVLHGDVLAEATSKTLVQAEHRLVATLGVDDLVIV
ETKDAVLVAHKNKVQDVKKIATALKQSGRTEQSNHREVYRPWGVYDSVDRGQRYQVKRITVNPGAKLSVQMHYHRAEHWV
VVSGTAKVTNGEKSYLVTENESTFIPVGQVHALENPGVVPLELIEIQSGTYLGEDDIVRFDDNYGRA

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O antigen [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=472, Percent_Identity=60.1694915254237, Blast_Score=565, Evalue=1e-162,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR018247
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 51547; Mature: 51547

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVPVILAGGAGSRLWPLSRSQHPKQFMPLIDNNSMLQETLKRVDGITDADPVLICNEEH
CEEEEEEECCCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHCCCCCCCCEEEECCCC
RFLAAEQVRQIGKTPSILLEPEGRNTAPAIALAALKELDRKEDPLLLVLAADHYIKKIDA
CHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHH
FHLAIESALSLAREGKLVTFGIVPTHAETGYGYIQQGNALGKQGFKVASFVEKPDSSTAE
HHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEECCCCCCCCCCHHHHHHCCCCCCHHH
SYLASGDFFWNSGMFLFRASRYIEELELHAPDILRACRRAIDEGQQDLDFLRVGSEAFKG
HHHHCCCEEECCCEEEHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHCHHHHCC
CPENSIDYAVMEKTDSAAMVSLDAGWSDIGSWASLWDISDKDANSNVLHGDVLAEATSKT
CCCCCCCEEEEECCCCEEEEEECCCCHHHCCHHHCCCCCCCCCCCCEEEHHHHHHHHHHH
LVQAEHRLVATLGVDDLVIVETKDAVLVAHKNKVQDVKKIATALKQSGRTEQSNHREVYR
HHHHHHEEEEEECCCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCEEEC
PWGVYDSVDRGQRYQVKRITVNPGAKLSVQMHYHRAEHWVVVSGTAKVTNGEKSYLVTEN
CCCCCCCCCCCCCEEEEEEEECCCCEEEEEEEEECCCEEEEEECCEEEECCCCEEEEECC
ESTFIPVGQVHALENPGVVPLELIEIQSGTYLGEDDIVRFDDNYGRA
CCEEEECCCEEECCCCCCCEEEEEEECCCCEECCCCEEEECCCCCCC
>Mature Secondary Structure
MIVPVILAGGAGSRLWPLSRSQHPKQFMPLIDNNSMLQETLKRVDGITDADPVLICNEEH
CEEEEEEECCCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHCCCCCCCCEEEECCCC
RFLAAEQVRQIGKTPSILLEPEGRNTAPAIALAALKELDRKEDPLLLVLAADHYIKKIDA
CHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHH
FHLAIESALSLAREGKLVTFGIVPTHAETGYGYIQQGNALGKQGFKVASFVEKPDSSTAE
HHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEECCCCCCCCCCHHHHHHCCCCCCHHH
SYLASGDFFWNSGMFLFRASRYIEELELHAPDILRACRRAIDEGQQDLDFLRVGSEAFKG
HHHHCCCEEECCCEEEHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHCHHHHCC
CPENSIDYAVMEKTDSAAMVSLDAGWSDIGSWASLWDISDKDANSNVLHGDVLAEATSKT
CCCCCCCEEEEECCCCEEEEEECCCCHHHCCHHHCCCCCCCCCCCCEEEHHHHHHHHHHH
LVQAEHRLVATLGVDDLVIVETKDAVLVAHKNKVQDVKKIATALKQSGRTEQSNHREVYR
HHHHHHEEEEEECCCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCEEEC
PWGVYDSVDRGQRYQVKRITVNPGAKLSVQMHYHRAEHWVVVSGTAKVTNGEKSYLVTEN
CCCCCCCCCCCCCEEEEEEEECCCCEEEEEEEEECCCEEEEEECCEEEECCCCEEEEECC
ESTFIPVGQVHALENPGVVPLELIEIQSGTYLGEDDIVRFDDNYGRA
CCEEEECCCEEECCCCCCCEEEEEEECCCCEECCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1383393 [H]