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The map label for this gene is mazG [H]

Identifier: 92113763

GI number: 92113763

Start: 1864633

End: 1865475

Strand: Direct

Name: mazG [H]

Synonym: Csal_1639

Alternate gene names: 92113763

Gene position: 1864633-1865475 (Clockwise)

Preceding gene: 92113762

Following gene: 92113764

Centisome position: 50.44

GC content: 67.26

Gene sequence:

>843_bases
ATGAGCGACGCGCGAACGCGTTACGATCTCGACGATCTGTTGACCCTGATGGCGGTCCTGCGCGACCCGGCCCAGGGGTG
CCCGTGGGACGTCAAGCAAGACTGGCAGAGCATCGTCCCGCATACCCTGGAAGAGGCCTATGAAGTGGCCGATGCCATCG
AACGGCGTGCCTTCGACGAACTGCCCGGCGAGCTGGGGGACCTGCTCTTTCAGGTGGTGTATTACAGCCAGTTCGCGCGC
GAGGAGCAGCGCTTCGATTTCCATGACGTCGTCGACACGGTGACCGCCAAGATGGTCGCCCGGCATCCGCATGTGTTCCC
CGAGGGGACGCTGGCCTCGCGGCGTCCCGCCGGCGTGCCGGCCGAGGAAGTGGAAACGACGGACGTCAAGACGCGCTGGG
AAGCCCTCAAGGCCCGCGAACGCGAAACCCGCGAGGCGGTGTCGGTGCTCGACGATGTCCCCGCGTCCCTGCCGGCGCTG
TCTCGCGGTACCAAGCTGTCCAAGCGCGCTGCCCGGGTCGGCTTCGACTGGCCCGACGACCAGGGCGTGTTCGCCAAGGT
GCGCGAGGAACTCGCCGAGGTCGAGGAGGCGGTGCGTGACGGCGATGCCGCGCACGTGCGCGAGGAAATCGGCGATTTGC
TGTTCGCCGTGACCAACCTGGCCAGGCGTTTCGATATCGACCCCGAGCAGGCGTTGCGGCACGCCAACCTCAAGTTCGAG
CGGCGCTTTCGCCATGTCGAGCAGGCCCTGTCGGCCAGGGCGGGCGGCCTCGAGGCGGCGAGCCTCGACGAGATGGAACG
CCACTGGCAAGCCGCCAAGGAAAGCGAAACCAGCAACGCCTGA

Upstream 100 bases:

>100_bases
TCGAGGGACTCGAGGCGCTGGAGCGTATCTTTTCGCGGATTCAGCAACTGCCCAACGTCATCGACGTCAAGCGGCTGCGC
AGCGGAGGAGGCAAGCAGGC

Downstream 100 bases:

>100_bases
GCGTGGCATGCGTTGTGGGCATCGCCGAGCCCGAGTAACGTAGTCAGGACAACGGCTTTTCAAAACAACCACGCTTCAAA
ACAACGACTTGCCATCGTCG

Product: MazG family protein

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MSDARTRYDLDDLLTLMAVLRDPAQGCPWDVKQDWQSIVPHTLEEAYEVADAIERRAFDELPGELGDLLFQVVYYSQFAR
EEQRFDFHDVVDTVTAKMVARHPHVFPEGTLASRRPAGVPAEEVETTDVKTRWEALKARERETREAVSVLDDVPASLPAL
SRGTKLSKRAARVGFDWPDDQGVFAKVREELAEVEEAVRDGDAAHVREEIGDLLFAVTNLARRFDIDPEQALRHANLKFE
RRFRHVEQALSARAGGLEAASLDEMERHWQAAKESETSNA

Sequences:

>Translated_280_residues
MSDARTRYDLDDLLTLMAVLRDPAQGCPWDVKQDWQSIVPHTLEEAYEVADAIERRAFDELPGELGDLLFQVVYYSQFAR
EEQRFDFHDVVDTVTAKMVARHPHVFPEGTLASRRPAGVPAEEVETTDVKTRWEALKARERETREAVSVLDDVPASLPAL
SRGTKLSKRAARVGFDWPDDQGVFAKVREELAEVEEAVRDGDAAHVREEIGDLLFAVTNLARRFDIDPEQALRHANLKFE
RRFRHVEQALSARAGGLEAASLDEMERHWQAAKESETSNA
>Mature_279_residues
SDARTRYDLDDLLTLMAVLRDPAQGCPWDVKQDWQSIVPHTLEEAYEVADAIERRAFDELPGELGDLLFQVVYYSQFARE
EQRFDFHDVVDTVTAKMVARHPHVFPEGTLASRRPAGVPAEEVETTDVKTRWEALKARERETREAVSVLDDVPASLPALS
RGTKLSKRAARVGFDWPDDQGVFAKVREELAEVEEAVRDGDAAHVREEIGDLLFAVTNLARRFDIDPEQALRHANLKFER
RFRHVEQALSARAGGLEAASLDEMERHWQAAKESETSNA

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=269, Percent_Identity=48.6988847583643, Blast_Score=245, Evalue=2e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 31723; Mature: 31591

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDARTRYDLDDLLTLMAVLRDPAQGCPWDVKQDWQSIVPHTLEEAYEVADAIERRAFDE
CCCCCHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPGELGDLLFQVVYYSQFAREEQRFDFHDVVDTVTAKMVARHPHVFPEGTLASRRPAGVP
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
AEEVETTDVKTRWEALKARERETREAVSVLDDVPASLPALSRGTKLSKRAARVGFDWPDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHCCCCCCCC
QGVFAKVREELAEVEEAVRDGDAAHVREEIGDLLFAVTNLARRFDIDPEQALRHANLKFE
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHH
RRFRHVEQALSARAGGLEAASLDEMERHWQAAKESETSNA
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SDARTRYDLDDLLTLMAVLRDPAQGCPWDVKQDWQSIVPHTLEEAYEVADAIERRAFDE
CCCCHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPGELGDLLFQVVYYSQFAREEQRFDFHDVVDTVTAKMVARHPHVFPEGTLASRRPAGVP
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
AEEVETTDVKTRWEALKARERETREAVSVLDDVPASLPALSRGTKLSKRAARVGFDWPDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHCCCCCCCC
QGVFAKVREELAEVEEAVRDGDAAHVREEIGDLLFAVTNLARRFDIDPEQALRHANLKFE
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHH
RRFRHVEQALSARAGGLEAASLDEMERHWQAAKESETSNA
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]