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The map label for this gene is relA [H]

Identifier: 92113762

GI number: 92113762

Start: 1862384

End: 1864636

Strand: Direct

Name: relA [H]

Synonym: Csal_1638

Alternate gene names: 92113762

Gene position: 1862384-1864636 (Clockwise)

Preceding gene: 92113761

Following gene: 92113763

Centisome position: 50.38

GC content: 65.11

Gene sequence:

>2253_bases
ATGGTCAAGGTCCGTGAAGACCAGCCGTTGACGCAGGCCGGCGAGGTCGATATCGCATTGTGGCTCAAGCGCCTCCAGGA
CGATGTCGCGCTGCGCGATGTCGAGGAGTTGCGCGAGGCCTGCGAGCTGGCCCGGCACCTGGCGTACAACGCGGAAAAGC
CTCACCACAACTGGGCGGAGCCGGCCTCGAGCTTTCGCACCGGCCTGGAAATGGCCGATATCCTGGGCGAGCTCAAGCTC
GATCAGGCGATTCTCGAGGCGGCCGTGCTGTATCGTGTGGTGCGCGAGGGACTGATCACGCTGGAAGCCATCGAGAAGCG
CTTCGGCGCCGAGGTGGCCTCGCTGATCGACGGCGTCCTGCACATGGCAGCGATCAGCCAGCTGCAGGCGCCTCGCCAGG
GCCTGTCGCAGCACAACCAGCAGGAAAACCTGCGCAAGATGCTGGTGGCCATGGTCGACGACGTGCGCGTGGCCCTGATC
AAGATCGCCGAGCGTACCTGCGCCTTGCGCATGGTGCGCGACGCCCCGCGCGAAAAGCGCCTGCGCGTGGCCCGCGAGGT
CTTCGACATCTACGCGCCGCTGGCCCACCGCCTGGGCATCGGGCAGCTCAAGTGGGAACTCGAGGACCTGTCGTTCCGCT
ATCTGCAGGAGGACGACTACAAGACCATCGCCAAGCAGCTGGCCGAGAAGCGCCTCGACCGCGACCGCTACATTCACGAC
GTGGTGGAGACCCTCAAGGGGCTCCTCGACCAGCAGGGCATCGCTCCGTACGACGTAGACGGACGCGCCAAGCACATCTA
TTCGATCTGGCGCAAGATGCAGCGCAAGCATATCGACTTCTCCCAGGTGTACGACGTGCGCGCGGTGCGCATCCTGGTGC
CGGAAGTCGCCGATTGCTATACCGCGCTGGGCATCGTGCATTCGCGCTGGCATCACGTACCGCACGAGTTCGACGACTAC
ATCGCCAATCCCAAGCGCAACGGCTATCAGTCGCTGCATACCGCGGTGATCGGCCCGGAGAACAAGGTGCTGGAGATCCA
GATCCGCACCTTCTCCATGCACGAGGAGGCCGAGCTCGGGGTATGCGCCCACTGGCGCTACAAGGGTCACGACGTCGACT
CCAAGAGCCGCAGCTACGAAGAAAAGATCGCCTGGCTGCGTCAGGTGCTGGAATGGCAGGAAGAGGTCGGCGAGCTGGGC
GATCTGCGCGAAGGGCTCTCCAGCGACGTGGCGCCGGACCGCATCTACGTCTTCACGCCGGACGGTCACGTCATCGACAT
GCCCAAGGTCGCCACGCCCATCGACTTCGCCTACCGCGTGCACACCGAGATCGGGCACCGCTGCCGCGGCGCCAAGGTCG
ACGGGCGTATCGTGCCGCTGACCTATCAGCTCGAGACGGGTCAGCAGGTCGAGATCCTGACCGCCACCAAGGGCGGGCCG
AGTCGCGACTGGCTCAACCCCAACCTGGGCTACGTCAAGACCTCGCGGGCGCGGGCCAAGATCCAGTCATGGTTCAAGTA
CCAGGCGCGCAGCCAGAACCTCGAGGAAGGGCGCACCTTGTTCGAGAAGGCGTTCCGGCGCCTGGACATCGAGGGCGTGG
ATTTCGACGCCCTGGCGCAGGCCGTCAATTACCAGACGGTCGACGACATGTACGCCGCCATCGGCGCCGGCGACCTGCGT
ATCGGTCAGGTGCTGCATCAGGCGCAGCAGCTCTTCGGCGACACCGACGACCAGGAGCAGCTCGACCGCCTGCTGGCCAA
GCCGCGGCGGACCACGAAGGAGGCGGTGGACGACATCACCGTGCTCGGCGTCGGCAATCTCAAGACCTCGATGGCCAACT
GCTGCCATCCGGTGCCCGGCGATCAGATCGTCGGCTACATCACCCAGGGGCGCGGCGTCACCATTCACCGCCAGGATTGC
CCCAACATCCTGCAGTTGCGCGCCGAGGAGCCGCGTCGCATCGTCGACGTGGAGTGGGGCAACGCCAGCGCCCAGTACCC
GGTGGACATCGAGATCGAGGCCTGGGATCGCTCGGGGCTGTTGCGCGACGTCACGCACATCCTCACGGGCGATCGCATCA
ACGTGCTGTCGGTCAACACGCTCACCGACAAGCACGACAACCTGGCGCGCATGAAGATCACCCTGGAAGTCGAGGGACTC
GAGGCGCTGGAGCGTATCTTTTCGCGGATTCAGCAACTGCCCAACGTCATCGACGTCAAGCGGCTGCGCAGCGGAGGAGG
CAAGCAGGCATGA

Upstream 100 bases:

>100_bases
CTGGCCGATATGTTTCCACACACCGCGCATTTGGAATCGATGCTGCTACTGACCCGCGACACGCCGCGCGGTCGGTCCAC
ATCCGTAGAAAGGGAAGATC

Downstream 100 bases:

>100_bases
GCGACGCGCGAACGCGTTACGATCTCGACGATCTGTTGACCCTGATGGCGGTCCTGCGCGACCCGGCCCAGGGGTGCCCG
TGGGACGTCAAGCAAGACTG

Product: (p)ppGpp synthetase I SpoT/RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 750; Mature: 750

Protein sequence:

>750_residues
MVKVREDQPLTQAGEVDIALWLKRLQDDVALRDVEELREACELARHLAYNAEKPHHNWAEPASSFRTGLEMADILGELKL
DQAILEAAVLYRVVREGLITLEAIEKRFGAEVASLIDGVLHMAAISQLQAPRQGLSQHNQQENLRKMLVAMVDDVRVALI
KIAERTCALRMVRDAPREKRLRVAREVFDIYAPLAHRLGIGQLKWELEDLSFRYLQEDDYKTIAKQLAEKRLDRDRYIHD
VVETLKGLLDQQGIAPYDVDGRAKHIYSIWRKMQRKHIDFSQVYDVRAVRILVPEVADCYTALGIVHSRWHHVPHEFDDY
IANPKRNGYQSLHTAVIGPENKVLEIQIRTFSMHEEAELGVCAHWRYKGHDVDSKSRSYEEKIAWLRQVLEWQEEVGELG
DLREGLSSDVAPDRIYVFTPDGHVIDMPKVATPIDFAYRVHTEIGHRCRGAKVDGRIVPLTYQLETGQQVEILTATKGGP
SRDWLNPNLGYVKTSRARAKIQSWFKYQARSQNLEEGRTLFEKAFRRLDIEGVDFDALAQAVNYQTVDDMYAAIGAGDLR
IGQVLHQAQQLFGDTDDQEQLDRLLAKPRRTTKEAVDDITVLGVGNLKTSMANCCHPVPGDQIVGYITQGRGVTIHRQDC
PNILQLRAEEPRRIVDVEWGNASAQYPVDIEIEAWDRSGLLRDVTHILTGDRINVLSVNTLTDKHDNLARMKITLEVEGL
EALERIFSRIQQLPNVIDVKRLRSGGGKQA

Sequences:

>Translated_750_residues
MVKVREDQPLTQAGEVDIALWLKRLQDDVALRDVEELREACELARHLAYNAEKPHHNWAEPASSFRTGLEMADILGELKL
DQAILEAAVLYRVVREGLITLEAIEKRFGAEVASLIDGVLHMAAISQLQAPRQGLSQHNQQENLRKMLVAMVDDVRVALI
KIAERTCALRMVRDAPREKRLRVAREVFDIYAPLAHRLGIGQLKWELEDLSFRYLQEDDYKTIAKQLAEKRLDRDRYIHD
VVETLKGLLDQQGIAPYDVDGRAKHIYSIWRKMQRKHIDFSQVYDVRAVRILVPEVADCYTALGIVHSRWHHVPHEFDDY
IANPKRNGYQSLHTAVIGPENKVLEIQIRTFSMHEEAELGVCAHWRYKGHDVDSKSRSYEEKIAWLRQVLEWQEEVGELG
DLREGLSSDVAPDRIYVFTPDGHVIDMPKVATPIDFAYRVHTEIGHRCRGAKVDGRIVPLTYQLETGQQVEILTATKGGP
SRDWLNPNLGYVKTSRARAKIQSWFKYQARSQNLEEGRTLFEKAFRRLDIEGVDFDALAQAVNYQTVDDMYAAIGAGDLR
IGQVLHQAQQLFGDTDDQEQLDRLLAKPRRTTKEAVDDITVLGVGNLKTSMANCCHPVPGDQIVGYITQGRGVTIHRQDC
PNILQLRAEEPRRIVDVEWGNASAQYPVDIEIEAWDRSGLLRDVTHILTGDRINVLSVNTLTDKHDNLARMKITLEVEGL
EALERIFSRIQQLPNVIDVKRLRSGGGKQA
>Mature_750_residues
MVKVREDQPLTQAGEVDIALWLKRLQDDVALRDVEELREACELARHLAYNAEKPHHNWAEPASSFRTGLEMADILGELKL
DQAILEAAVLYRVVREGLITLEAIEKRFGAEVASLIDGVLHMAAISQLQAPRQGLSQHNQQENLRKMLVAMVDDVRVALI
KIAERTCALRMVRDAPREKRLRVAREVFDIYAPLAHRLGIGQLKWELEDLSFRYLQEDDYKTIAKQLAEKRLDRDRYIHD
VVETLKGLLDQQGIAPYDVDGRAKHIYSIWRKMQRKHIDFSQVYDVRAVRILVPEVADCYTALGIVHSRWHHVPHEFDDY
IANPKRNGYQSLHTAVIGPENKVLEIQIRTFSMHEEAELGVCAHWRYKGHDVDSKSRSYEEKIAWLRQVLEWQEEVGELG
DLREGLSSDVAPDRIYVFTPDGHVIDMPKVATPIDFAYRVHTEIGHRCRGAKVDGRIVPLTYQLETGQQVEILTATKGGP
SRDWLNPNLGYVKTSRARAKIQSWFKYQARSQNLEEGRTLFEKAFRRLDIEGVDFDALAQAVNYQTVDDMYAAIGAGDLR
IGQVLHQAQQLFGDTDDQEQLDRLLAKPRRTTKEAVDDITVLGVGNLKTSMANCCHPVPGDQIVGYITQGRGVTIHRQDC
PNILQLRAEEPRRIVDVEWGNASAQYPVDIEIEAWDRSGLLRDVTHILTGDRINVLSVNTLTDKHDNLARMKITLEVEGL
EALERIFSRIQQLPNVIDVKRLRSGGGKQA

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1789147, Length=754, Percent_Identity=46.4190981432361, Blast_Score=680, Evalue=0.0,
Organism=Escherichia coli, GI1790082, Length=679, Percent_Identity=37.5552282768778, Blast_Score=428, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 85470; Mature: 85470

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKVREDQPLTQAGEVDIALWLKRLQDDVALRDVEELREACELARHLAYNAEKPHHNWAE
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
PASSFRTGLEMADILGELKLDQAILEAAVLYRVVREGLITLEAIEKRFGAEVASLIDGVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HMAAISQLQAPRQGLSQHNQQENLRKMLVAMVDDVRVALIKIAERTCALRMVRDAPREKR
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
LRVAREVFDIYAPLAHRLGIGQLKWELEDLSFRYLQEDDYKTIAKQLAEKRLDRDRYIHD
HHHHHHHHHHHHHHHHHCCCCHHEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
VVETLKGLLDQQGIAPYDVDGRAKHIYSIWRKMQRKHIDFSQVYDVRAVRILVPEVADCY
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
TALGIVHSRWHHVPHEFDDYIANPKRNGYQSLHTAVIGPENKVLEIQIRTFSMHEEAELG
HHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHEECCCCCEEEEEEEEECCCCCCCCC
VCAHWRYKGHDVDSKSRSYEEKIAWLRQVLEWQEEVGELGDLREGLSSDVAPDRIYVFTP
EEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
DGHVIDMPKVATPIDFAYRVHTEIGHRCRGAKVDGRIVPLTYQLETGQQVEILTATKGGP
CCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCEEEEEEECCCCC
SRDWLNPNLGYVKTSRARAKIQSWFKYQARSQNLEEGRTLFEKAFRRLDIEGVDFDALAQ
CCCCCCCCCCCEECHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHH
AVNYQTVDDMYAAIGAGDLRIGQVLHQAQQLFGDTDDQEQLDRLLAKPRRTTKEAVDDIT
HHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHCCEE
VLGVGNLKTSMANCCHPVPGDQIVGYITQGRGVTIHRQDCPNILQLRAEEPRRIVDVEWG
EEECCCHHHHHHHCCCCCCCCCEEEEEECCCCEEEECCCCCHHHHHCCCCCCEEEEEEEC
NASAQYPVDIEIEAWDRSGLLRDVTHILTGDRINVLSVNTLTDKHDNLARMKITLEVEGL
CCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEEEECCH
EALERIFSRIQQLPNVIDVKRLRSGGGKQA
HHHHHHHHHHHHCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MVKVREDQPLTQAGEVDIALWLKRLQDDVALRDVEELREACELARHLAYNAEKPHHNWAE
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
PASSFRTGLEMADILGELKLDQAILEAAVLYRVVREGLITLEAIEKRFGAEVASLIDGVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HMAAISQLQAPRQGLSQHNQQENLRKMLVAMVDDVRVALIKIAERTCALRMVRDAPREKR
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
LRVAREVFDIYAPLAHRLGIGQLKWELEDLSFRYLQEDDYKTIAKQLAEKRLDRDRYIHD
HHHHHHHHHHHHHHHHHCCCCHHEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
VVETLKGLLDQQGIAPYDVDGRAKHIYSIWRKMQRKHIDFSQVYDVRAVRILVPEVADCY
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
TALGIVHSRWHHVPHEFDDYIANPKRNGYQSLHTAVIGPENKVLEIQIRTFSMHEEAELG
HHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHEECCCCCEEEEEEEEECCCCCCCCC
VCAHWRYKGHDVDSKSRSYEEKIAWLRQVLEWQEEVGELGDLREGLSSDVAPDRIYVFTP
EEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
DGHVIDMPKVATPIDFAYRVHTEIGHRCRGAKVDGRIVPLTYQLETGQQVEILTATKGGP
CCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCEEEEEEECCCCC
SRDWLNPNLGYVKTSRARAKIQSWFKYQARSQNLEEGRTLFEKAFRRLDIEGVDFDALAQ
CCCCCCCCCCCEECHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHH
AVNYQTVDDMYAAIGAGDLRIGQVLHQAQQLFGDTDDQEQLDRLLAKPRRTTKEAVDDIT
HHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHCCEE
VLGVGNLKTSMANCCHPVPGDQIVGYITQGRGVTIHRQDCPNILQLRAEEPRRIVDVEWG
EEECCCHHHHHHHCCCCCCCCCEEEEEECCCCEEEECCCCCHHHHHCCCCCCEEEEEEEC
NASAQYPVDIEIEAWDRSGLLRDVTHILTGDRINVLSVNTLTDKHDNLARMKITLEVEGL
CCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEEEECCH
EALERIFSRIQQLPNVIDVKRLRSGGGKQA
HHHHHHHHHHHHCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]