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The map label for this gene is tmk

Identifier: 92113730

GI number: 92113730

Start: 1826561

End: 1827199

Strand: Direct

Name: tmk

Synonym: Csal_1606

Alternate gene names: 92113730

Gene position: 1826561-1827199 (Clockwise)

Preceding gene: 92113729

Following gene: 92113731

Centisome position: 49.41

GC content: 69.33

Gene sequence:

>639_bases
ATGACGCCAGGACGTTTCATCACCCTCGAGGGGGGCGAAGGGGTGGGGAAGTCCACCAACGTGGCCTTCGTCTGCGACTG
GCTGAGCGCGCGGGGCATCGAGGTGGTGCGTACGCGCGAGCCGGGGGGAACCCCCCGCGCCGAGGCGATTCGCGAGCTGC
TGCTCGATCCCGCGCCGCAGGAGCCACTCGACGAGACCGCCGAGCTGTTGCTGATGTTCGCCGCGCGTGCCCAGCATCTG
GCCGCGCGGATCCGTCCGGCCCTGGCGCGCGGTGCCTGGGTGGTATGCGACCGCTTCACCGATGCCACCTTCGCCTATCA
AGGCGGCGGGCGAGGGCTGGACGAGACGCGTATCGCCACCCTGGAAGCCCTGGTGCAGCAAGGCTTGCAGCCGGACTTGA
CGCTGCTGCTGGACATGCCGGTGGAAGCCGCGCAGCGCCGGGTCGAACGACGCGGCATCGAACGGGACCGCTTCGAGCGC
GAGCGCGGGGCATTCTTCAATGCCGTGCGCGAGAGCTATCTTGCCCGGGCCGCCCAGGCGCCGACGCGTTTCGCCGTGAT
CGATGCCGATCGCAGCCTGGAGGCGGTGCAAGCGTCGATCGCCGCACACCTGACCGAGAGGTTGGCATCATGGTCATGA

Upstream 100 bases:

>100_bases
CCGGGGCGACGGATCGCACTATTTTTCCAGTACGCTGGCCGAACACAATGCCGCGGTACGCCGCTATATCCTCAACCGCT
GAGCGAGGGCGACCATCACC

Downstream 100 bases:

>100_bases
CGCCGTTGCCCTGGCAGCGGGATCTGTGGACGCGGCTGGTGCGTCAGCAGGACGCCCAGCGTCTGCCTCACGCGCTGCTG
ATCTCGGGCCCCCACGGGGT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MTPGRFITLEGGEGVGKSTNVAFVCDWLSARGIEVVRTREPGGTPRAEAIRELLLDPAPQEPLDETAELLLMFAARAQHL
AARIRPALARGAWVVCDRFTDATFAYQGGGRGLDETRIATLEALVQQGLQPDLTLLLDMPVEAAQRRVERRGIERDRFER
ERGAFFNAVRESYLARAAQAPTRFAVIDADRSLEAVQASIAAHLTERLASWS

Sequences:

>Translated_212_residues
MTPGRFITLEGGEGVGKSTNVAFVCDWLSARGIEVVRTREPGGTPRAEAIRELLLDPAPQEPLDETAELLLMFAARAQHL
AARIRPALARGAWVVCDRFTDATFAYQGGGRGLDETRIATLEALVQQGLQPDLTLLLDMPVEAAQRRVERRGIERDRFER
ERGAFFNAVRESYLARAAQAPTRFAVIDADRSLEAVQASIAAHLTERLASWS
>Mature_211_residues
TPGRFITLEGGEGVGKSTNVAFVCDWLSARGIEVVRTREPGGTPRAEAIRELLLDPAPQEPLDETAELLLMFAARAQHLA
ARIRPALARGAWVVCDRFTDATFAYQGGGRGLDETRIATLEALVQQGLQPDLTLLLDMPVEAAQRRVERRGIERDRFERE
RGAFFNAVRESYLARAAQAPTRFAVIDADRSLEAVQASIAAHLTERLASWS

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=205, Percent_Identity=44.8780487804878, Blast_Score=148, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_CHRSD (Q1QX49)

Other databases:

- EMBL:   CP000285
- RefSeq:   YP_573658.1
- ProteinModelPortal:   Q1QX49
- SMR:   Q1QX49
- STRING:   Q1QX49
- GeneID:   4027568
- GenomeReviews:   CP000285_GR
- KEGG:   csa:Csal_1606
- NMPDR:   fig|290398.4.peg.3158
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- BioCyc:   CSAL290398:CSAL_1606-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23342; Mature: 23211

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPGRFITLEGGEGVGKSTNVAFVCDWLSARGIEVVRTREPGGTPRAEAIRELLLDPAPQ
CCCCCEEEEECCCCCCCCCCEEEEEECHHHCCEEEEEECCCCCCCHHHHHHHHHCCCCCC
EPLDETAELLLMFAARAQHLAARIRPALARGAWVVCDRFTDATFAYQGGGRGLDETRIAT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEECCCCCCCCHHHHHH
LEALVQQGLQPDLTLLLDMPVEAAQRRVERRGIERDRFERERGAFFNAVRESYLARAAQA
HHHHHHCCCCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
PTRFAVIDADRSLEAVQASIAAHLTERLASWS
CCEEEEEECCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TPGRFITLEGGEGVGKSTNVAFVCDWLSARGIEVVRTREPGGTPRAEAIRELLLDPAPQ
CCCCEEEEECCCCCCCCCCEEEEEECHHHCCEEEEEECCCCCCCHHHHHHHHHCCCCCC
EPLDETAELLLMFAARAQHLAARIRPALARGAWVVCDRFTDATFAYQGGGRGLDETRIAT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEECCCCCCCCHHHHHH
LEALVQQGLQPDLTLLLDMPVEAAQRRVERRGIERDRFERERGAFFNAVRESYLARAAQA
HHHHHHCCCCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
PTRFAVIDADRSLEAVQASIAAHLTERLASWS
CCEEEEEECCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA