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The map label for this gene is nhaA [H]

Identifier: 92113719

GI number: 92113719

Start: 1817562

End: 1818635

Strand: Direct

Name: nhaA [H]

Synonym: Csal_1595

Alternate gene names: 92113719

Gene position: 1817562-1818635 (Clockwise)

Preceding gene: 92113718

Following gene: 92113721

Centisome position: 49.17

GC content: 68.72

Gene sequence:

>1074_bases
ATGGGTGATGACAAGCGTGACGACGCCTGGACGCAAGGCCCCGAGGTGGGGCGCGGGTCGCGAGACGAGGACCGCCGGCG
CGCCGAGGAGGCCGCCGCCGGCGACCCCGAGCAGCTGCGCGAGCTGCGCCGCCTGCGCGAGCAGCACATGCTCGATCGCT
GGATCGATGGCGTTCTCGTCGAACAGCGCCGTACGCGACGCTGGAAGCTGTTCTTCCGCTTTGTCTTCGCGGCGCTGATT
GCCGCCTCGCTGGCGATGACGACCTATGCGGTATTTTTCGCCGGGCGCGACATGACGGGCGCCGCGGGACCGCACCTGGG
CGTCGTCGAGGTGCAGGGCGTGATCGATGCGCAGGGCGAGGCGAGTGCCGAGCGCATCATCGAGGGGCTGCGTGACGCCT
GGAAAGCGCCGTCGTCGCGGGGCGTGGTGCTGCACATCAACAGTCCGGGCGGCAGTCCGGTACAGTCGCAGCGCGTCTAC
GACGAGGTTCGCCGTCTGGCGGCGCAGGGCGACAAGCCCGTGGTGGCGGTGATCGAGGACATCGGCGCCAGCGGTGCTTA
CTACATGGCCTCGGCGGCGGACGACATCTATGCGTCGCCGGCCAGTCTGGTGGGGTCGATCGGGGTGATCTATTCGGGAT
TCGGGCTGCAGGAAGCCATCGACAAGGTCGGTGTGGAGCGGCGTGTTTTCACTTCCGGTGACAACAAGGCGTTTCTGGAT
CCCTTCTCGCCGATACGCGACGAGCAGCGCGCGTTCTGGCAGACGGTGCTGGATACCACGCACCGTCAGTTCATCGACGA
CGTCAAGGCGGGGCGCGGCGAGCGGCTCGACGACGACCCTCGTCTCTTCTCGGGCCTGATCTGGACGGGCGAGCAGGCCC
TCGGGCTGGGGCTGGTCGACGGGCTGAGCAGCCTCGATGCATTGTCGCGGGAGCGCTTCGGTGGCGTGCCGCGGCGGGAT
TACACGCCCGCCCTCGACCCCCTGTCGCGCTTGTCGCGTCAGCTCGGGCGCGTCGCCGCCGAATGGACCGGCATGGCCCA
TCACGCCTCGCCCGTGCGCTATCAGGTGCAGTGA

Upstream 100 bases:

>100_bases
GCATGGTGGATACCTTTCCTGCGTTGCTCGAGGCGCTGTACGCGCCCATGGCCGAGCCCCGGCACGCCCCCGCGACGATG
ATGGCACGGAGTGAGACATG

Downstream 100 bases:

>100_bases
CGGTGTCGCCTCAGCCGAGCGGGTCCAGGCCCGCTTCGCGCAGCATCTCGCACAGGCGGATGAGCGGCAGCCCGATCAAG
GTATTGGGGTCACGCCCCTC

Product: signal peptide peptidase SppA, 36K type

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MGDDKRDDAWTQGPEVGRGSRDEDRRRAEEAAAGDPEQLRELRRLREQHMLDRWIDGVLVEQRRTRRWKLFFRFVFAALI
AASLAMTTYAVFFAGRDMTGAAGPHLGVVEVQGVIDAQGEASAERIIEGLRDAWKAPSSRGVVLHINSPGGSPVQSQRVY
DEVRRLAAQGDKPVVAVIEDIGASGAYYMASAADDIYASPASLVGSIGVIYSGFGLQEAIDKVGVERRVFTSGDNKAFLD
PFSPIRDEQRAFWQTVLDTTHRQFIDDVKAGRGERLDDDPRLFSGLIWTGEQALGLGLVDGLSSLDALSRERFGGVPRRD
YTPALDPLSRLSRQLGRVAAEWTGMAHHASPVRYQVQ

Sequences:

>Translated_357_residues
MGDDKRDDAWTQGPEVGRGSRDEDRRRAEEAAAGDPEQLRELRRLREQHMLDRWIDGVLVEQRRTRRWKLFFRFVFAALI
AASLAMTTYAVFFAGRDMTGAAGPHLGVVEVQGVIDAQGEASAERIIEGLRDAWKAPSSRGVVLHINSPGGSPVQSQRVY
DEVRRLAAQGDKPVVAVIEDIGASGAYYMASAADDIYASPASLVGSIGVIYSGFGLQEAIDKVGVERRVFTSGDNKAFLD
PFSPIRDEQRAFWQTVLDTTHRQFIDDVKAGRGERLDDDPRLFSGLIWTGEQALGLGLVDGLSSLDALSRERFGGVPRRD
YTPALDPLSRLSRQLGRVAAEWTGMAHHASPVRYQVQ
>Mature_356_residues
GDDKRDDAWTQGPEVGRGSRDEDRRRAEEAAAGDPEQLRELRRLREQHMLDRWIDGVLVEQRRTRRWKLFFRFVFAALIA
ASLAMTTYAVFFAGRDMTGAAGPHLGVVEVQGVIDAQGEASAERIIEGLRDAWKAPSSRGVVLHINSPGGSPVQSQRVYD
EVRRLAAQGDKPVVAVIEDIGASGAYYMASAADDIYASPASLVGSIGVIYSGFGLQEAIDKVGVERRVFTSGDNKAFLDP
FSPIRDEQRAFWQTVLDTTHRQFIDDVKAGRGERLDDDPRLFSGLIWTGEQALGLGLVDGLSSLDALSRERFGGVPRRDY
TPALDPLSRLSRQLGRVAAEWTGMAHHASPVRYQVQ

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=211, Percent_Identity=31.2796208530806, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787527, Length=212, Percent_Identity=29.2452830188679, Blast_Score=80, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 39396; Mature: 39264

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDDKRDDAWTQGPEVGRGSRDEDRRRAEEAAAGDPEQLRELRRLREQHMLDRWIDGVLV
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EQRRTRRWKLFFRFVFAALIAASLAMTTYAVFFAGRDMTGAAGPHLGVVEVQGVIDAQGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCHHCCCCC
ASAERIIEGLRDAWKAPSSRGVVLHINSPGGSPVQSQRVYDEVRRLAAQGDKPVVAVIED
HHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEHHHHH
IGASGAYYMASAADDIYASPASLVGSIGVIYSGFGLQEAIDKVGVERRVFTSGDNKAFLD
CCCCCCEEEHHCCHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEECCCCCEECC
PFSPIRDEQRAFWQTVLDTTHRQFIDDVKAGRGERLDDDPRLFSGLIWTGEQALGLGLVD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHH
GLSSLDALSRERFGGVPRRDYTPALDPLSRLSRQLGRVAAEWTGMAHHASPVRYQVQ
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHCCCCCEEECC
>Mature Secondary Structure 
GDDKRDDAWTQGPEVGRGSRDEDRRRAEEAAAGDPEQLRELRRLREQHMLDRWIDGVLV
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EQRRTRRWKLFFRFVFAALIAASLAMTTYAVFFAGRDMTGAAGPHLGVVEVQGVIDAQGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCHHCCCCC
ASAERIIEGLRDAWKAPSSRGVVLHINSPGGSPVQSQRVYDEVRRLAAQGDKPVVAVIED
HHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEHHHHH
IGASGAYYMASAADDIYASPASLVGSIGVIYSGFGLQEAIDKVGVERRVFTSGDNKAFLD
CCCCCCEEEHHCCHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEECCCCCEECC
PFSPIRDEQRAFWQTVLDTTHRQFIDDVKAGRGERLDDDPRLFSGLIWTGEQALGLGLVD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHH
GLSSLDALSRERFGGVPRRDYTPALDPLSRLSRQLGRVAAEWTGMAHHASPVRYQVQ
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA